JP7121418B2 - 局所的な虚血－再灌流により誘発される細胞死の新型なアミノチオールによる減少 - Google Patents

局所的な虚血－再灌流により誘発される細胞死の新型なアミノチオールによる減少 Download PDF

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JP7121418B2
JP7121418B2 JP2020554358A JP2020554358A JP7121418B2 JP 7121418 B2 JP7121418 B2 JP 7121418B2 JP 2020554358 A JP2020554358 A JP 2020554358A JP 2020554358 A JP2020554358 A JP 2020554358A JP 7121418 B2 JP7121418 B2 JP 7121418B2
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pharmaceutical composition
organ
use according
prc
reperfusion
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JP2021506982A (ja
JP2021506982A5 (enExample
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ウィリアム イー ファール，
寧峰 李
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Obvia Pharmaceuticals Ltd
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Obvia Pharmaceuticals Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
JP2020554358A 2018-03-01 2019-01-04 局所的な虚血－再灌流により誘発される細胞死の新型なアミノチオールによる減少 Active JP7121418B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862710838P 2018-03-01 2018-03-01
US62/710,838 2018-03-01
PCT/CN2019/070444 WO2019165851A1 (en) 2018-03-01 2019-01-04 Novel aminothiol reduction of ischemia-reperfusion-induced cell death

Publications (3)

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JP2021506982A JP2021506982A (ja) 2021-02-22
JP2021506982A5 JP2021506982A5 (enExample) 2021-04-01
JP7121418B2 true JP7121418B2 (ja) 2022-08-18

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JP2020554358A Active JP7121418B2 (ja) 2018-03-01 2019-01-04 局所的な虚血－再灌流により誘発される細胞死の新型なアミノチオールによる減少

Country Status (8)

Country Link
US (1) US11690813B2 (enExample)
EP (2) EP4588472A1 (enExample)
JP (1) JP7121418B2 (enExample)
KR (1) KR102490204B1 (enExample)
CN (1) CN111801095A (enExample)
AU (1) AU2019228134B2 (enExample)
CA (1) CA3092596C (enExample)
WO (1) WO2019165851A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022312709A1 (en) * 2021-07-16 2024-01-18 Obvia Pharmaceuticals Ltd. Prc-210 for use in the treatment of acute tissue injury
CN120957712A (zh) * 2023-02-10 2025-11-14 欧维亚制药有限公司 用于治疗以蛋白质错误折叠或聚集、线粒体功能障碍或慢性炎症为特征的病症的氨基硫醇

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6031006A (en) * 1999-10-21 2000-02-29 Bionumerik Pharmaceuticals, Inc. Method of treating diabetic nephropathy
US7314959B2 (en) 2003-08-07 2008-01-01 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
EP1788092A1 (en) * 2004-07-30 2007-05-23 Japan Science and Technology Agency Method of inhibiting postischemic reperfusion-induced cell death and cell death inhibitor
BR112017028448A2 (pt) * 2015-07-02 2018-08-28 Horizon Orphan Llc análogos de cisteamina resistentes a ado e usos dos mesmos

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Cardiovascular Research，2000年，Vol.47,No.3，p.446-456
Int J Radiat Biol.，2013年，Vol.89,No.7，p.485-492
Oxidative Medicine and Cellular Longevity，2017年，Vol.2017，Article ID: 4130824, p.1-12

Also Published As

Publication number Publication date
JP2021506982A (ja) 2021-02-22
KR20200118851A (ko) 2020-10-16
US20210299066A1 (en) 2021-09-30
EP4588472A1 (en) 2025-07-23
AU2019228134B2 (en) 2022-03-03
WO2019165851A1 (en) 2019-09-06
CN111801095A (zh) 2020-10-20
US11690813B2 (en) 2023-07-04
AU2019228134A1 (en) 2020-10-22
EP3758691A4 (en) 2021-11-17
CA3092596A1 (en) 2019-09-06
EP3758691A1 (en) 2021-01-06
KR102490204B1 (ko) 2023-01-19
CA3092596C (en) 2024-05-21

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