JP7110199B2 - 抗第ＸＩ／ＸＩａ因子抗体による処置法 - Google Patents

抗第ＸＩ／ＸＩａ因子抗体による処置法 Download PDF

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JP7110199B2
JP7110199B2 JP2019533396A JP2019533396A JP7110199B2 JP 7110199 B2 JP7110199 B2 JP 7110199B2 JP 2019533396 A JP2019533396 A JP 2019533396A JP 2019533396 A JP2019533396 A JP 2019533396A JP 7110199 B2 JP7110199 B2 JP 7110199B2
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antibody
fxi
seq
amino acid
fxia
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JP2020504110A5 (OSRAM
JP2020504110A (ja
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フリードマン，カローラ
キーダー，ヤセル
レフコウィッツ，マーティン
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019533396A 2016-12-23 2017-12-22 抗第ＸＩ／ＸＩａ因子抗体による処置法 Active JP7110199B2 (ja)

Priority Applications (2)

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JP2022115212A JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2024091065A JP2024116221A (ja) 2016-12-23 2024-06-05 抗第ＸＩ／ＸＩａ因子抗体による処置法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662438654P 2016-12-23 2016-12-23
US62/438,654 2016-12-23
US201762589851P 2017-11-22 2017-11-22
US62/589,851 2017-11-22
PCT/IB2017/058345 WO2018116267A2 (en) 2016-12-23 2017-12-22 Methods of treatment with anti-factor xi/xia antibodies

Related Child Applications (1)

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JP2022115212A Division JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法

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JP2020504110A JP2020504110A (ja) 2020-02-06
JP2020504110A5 JP2020504110A5 (OSRAM) 2021-04-30
JP7110199B2 true JP7110199B2 (ja) 2022-08-01

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JP2019533396A Active JP7110199B2 (ja) 2016-12-23 2017-12-22 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2022115212A Active JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2024091065A Pending JP2024116221A (ja) 2016-12-23 2024-06-05 抗第ＸＩ／ＸＩａ因子抗体による処置法

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JP2022115212A Active JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2024091065A Pending JP2024116221A (ja) 2016-12-23 2024-06-05 抗第ＸＩ／ＸＩａ因子抗体による処置法

Country Status (9)

Country Link
US (3) US20200231701A1 (OSRAM)
EP (1) EP3558370A2 (OSRAM)
JP (3) JP7110199B2 (OSRAM)
KR (2) KR20240134248A (OSRAM)
CN (2) CN118320078A (OSRAM)
AU (2) AU2017383537B2 (OSRAM)
CA (1) CA3048157A1 (OSRAM)
IL (2) IL316673A (OSRAM)
WO (1) WO2018116267A2 (OSRAM)

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KR102594117B1 (ko) 2014-10-01 2023-10-26 메디뮨 리미티드 티카그렐로에 대한 항체 및 이의 사용 방법
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
BR112019012667A2 (pt) 2016-12-23 2020-02-11 Novartis Ag Anticorpos do fator xi e métodos de uso
CN118320078A (zh) * 2016-12-23 2024-07-12 诺华股份有限公司 采用抗因子XI/XIa抗体治疗的方法
US20210347915A1 (en) 2018-09-20 2021-11-11 Phasebio Pharmaceuticals, Inc. Methods of reversing ticagrelor activity
US12258419B2 (en) 2019-04-16 2025-03-25 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Anti-FXI/FXIa antibody and use thereof
CN110423278B (zh) * 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用
IL293367A (en) * 2019-12-20 2022-07-01 Anthos Therapeutics Inc Pharmaceutical formulations and dosage regimens for factor xi/xia antibodies
TW202405022A (zh) * 2022-06-24 2024-02-01 美商安瑟斯治療公司 與抗因子ｘｉ／因子ｘｉａ抗體之組合療法

Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2015517305A (ja) 2012-05-10 2015-06-22 バイエル ファーマ アクチエンゲゼルシャフト 凝固因子ｘｉおよび／またはその活性化形態である因子ｘｉａに結合しうる抗体ならびにその用途
JP2018526976A (ja) 2015-06-26 2018-09-20 ノバルティス アーゲー 第ｘｉ因子抗体および使用方法

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JP2018526976A (ja) 2015-06-26 2018-09-20 ノバルティス アーゲー 第ｘｉ因子抗体および使用方法

Also Published As

Publication number Publication date
KR20190099256A (ko) 2019-08-26
WO2018116267A2 (en) 2018-06-28
IL267519B1 (en) 2024-12-01
IL316673A (en) 2024-12-01
AU2017383537A1 (en) 2019-06-27
AU2024287181A1 (en) 2025-03-06
US20230002507A1 (en) 2023-01-05
WO2018116267A3 (en) 2018-08-02
KR102702288B1 (ko) 2024-09-05
US20200231701A1 (en) 2020-07-23
JP2020504110A (ja) 2020-02-06
CN110325211A (zh) 2019-10-11
CA3048157A1 (en) 2018-06-28
IL267519B2 (en) 2025-04-01
US20250197522A1 (en) 2025-06-19
CN118320078A (zh) 2024-07-12
JP7500662B2 (ja) 2024-06-17
KR20240134248A (ko) 2024-09-06
JP2022141831A (ja) 2022-09-29
IL267519A (en) 2019-08-29
EP3558370A2 (en) 2019-10-30
AU2017383537B2 (en) 2024-10-03
JP2024116221A (ja) 2024-08-27

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