JP7090593B2 - 癌の治療のための方法および組成物 - Google Patents

癌の治療のための方法および組成物 Download PDF

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Publication number
JP7090593B2
JP7090593B2 JP2019501644A JP2019501644A JP7090593B2 JP 7090593 B2 JP7090593 B2 JP 7090593B2 JP 2019501644 A JP2019501644 A JP 2019501644A JP 2019501644 A JP2019501644 A JP 2019501644A JP 7090593 B2 JP7090593 B2 JP 7090593B2
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polypeptide
seq
cell
functionally equivalent
myc
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JP2019525753A (ja
JP2019525753A5 (https=
Inventor
ソウセック、ラウラ
ゴンザレス、トニ ハウセト
ボーリュー、マリー－エーヴ
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Fundacio Privada Institut dInvestigacio Oncologica Vall dHebron
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Fundacio Privada Institut dInvestigacio Oncologica Vall dHebron
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6445—Haemoglobin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019501644A 2016-07-15 2017-07-17 癌の治療のための方法および組成物 Active JP7090593B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16382339.6 2016-07-15
EP16382339.6A EP3269734A1 (en) 2016-07-15 2016-07-15 Methods and compositions for the treatment of cancer
PCT/EP2017/067998 WO2018011433A1 (en) 2016-07-15 2017-07-17 Methods and compositions for the treatment of cancer

Publications (3)

Publication Number Publication Date
JP2019525753A JP2019525753A (ja) 2019-09-12
JP2019525753A5 JP2019525753A5 (https=) 2020-07-09
JP7090593B2 true JP7090593B2 (ja) 2022-06-24

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ID=56497695

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JP2019501644A Active JP7090593B2 (ja) 2016-07-15 2017-07-17 癌の治療のための方法および組成物

Country Status (21)

Country Link
US (1) US11427621B2 (https=)
EP (2) EP3269734A1 (https=)
JP (1) JP7090593B2 (https=)
KR (1) KR102232500B1 (https=)
CN (1) CN109563151B (https=)
AU (1) AU2017295071B2 (https=)
BR (1) BR112019000732A2 (https=)
EA (1) EA201990298A1 (https=)
ES (1) ES2985967T3 (https=)
HR (1) HRP20241153T1 (https=)
HU (1) HUE067973T2 (https=)
IL (1) IL264176B2 (https=)
MA (1) MA45675B1 (https=)
MD (1) MD3484913T2 (https=)
MX (1) MX2019000346A (https=)
PL (1) PL3484913T3 (https=)
RS (1) RS65983B1 (https=)
SG (1) SG11201900021PA (https=)
SM (1) SMT202400360T1 (https=)
WO (1) WO2018011433A1 (https=)
ZA (1) ZA201900960B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101729826B1 (ko) * 2015-01-09 2017-05-11 주식회사 동희산업 플라스틱 연료탱크의 제조방법
KR101862239B1 (ko) * 2016-07-07 2018-05-30 주식회사 동희산업 플라스틱 연료탱크의 제조방법
KR101859583B1 (ko) * 2016-07-07 2018-06-27 주식회사 동희산업 플라스틱 연료탱크의 제조방법

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3269734A1 (en) 2016-07-15 2018-01-17 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Methods and compositions for the treatment of cancer
EP3841114A4 (en) * 2018-08-20 2022-06-08 Helix Nanotechnologies, Inc. METHODS AND COMPOSITIONS FOR RNA EXPRESSION OF MYC INHIBITORS
TWI829893B (zh) * 2019-03-19 2024-01-21 瓦爾希伯倫私人腫瘤研究基金會 診斷肺癌的方法
CN113795264A (zh) * 2019-03-19 2021-12-14 瓦尔希伯伦私人肿瘤研究基金会 采用Omomyc和结合PD-1或CTLA-4的抗体治疗癌症的联合疗法
KR102922015B1 (ko) * 2019-10-17 2026-02-04 주식회사 나이벡 Fer 티로신 키나아제 결합능이 있는 신규한 펩타이드 및 이의 용도
KR102398339B1 (ko) * 2020-01-09 2022-05-13 이화여자대학교 산학협력단 일산화질소 전달용 융합 펩타이드 및 이의 용도
CN115397843A (zh) * 2020-04-15 2022-11-25 杭州卫本医药科技有限公司 用于筛选药物的靶标多肽和筛选方法
EP4361633A1 (en) 2022-10-25 2024-05-01 Peptomyc, S.L. Method for predicting response to a cancer treatment
EP4446742A1 (en) 2023-04-14 2024-10-16 Peptomyc, S.L. Method for assessing or monitoring the response to a cancer treatment
EP4473974A1 (en) * 2023-06-07 2024-12-11 Peptomyc, S.L. Omomyc and kras inhibitors combination therapy for the treatment of cancer

Citations (1)

* Cited by examiner, † Cited by third party
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JP2016520056A (ja) 2013-05-07 2016-07-11 フンダシオ プリバダ インスティトゥト ディンベスティガシオ オンコロジカ デ バル エブロンＦｕｎｄａｃｉｏ Ｐｒｉｖａｄａ Ｉｎｓｔｉｔｕｔ Ｄ’Ｉｎｖｅｓｔｉｇａｃｉｏ Ｏｎｃｏｌｏｇｉｃａ Ｄｅ Ｖａｌｌ Ｈｅｂｒｏｎ 癌の治療方法および組成物

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US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
DE3169595D1 (en) 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
DE3474511D1 (en) 1983-11-01 1988-11-17 Terumo Corp Pharmaceutical composition containing urokinase
EP0786522A2 (en) 1992-07-17 1997-07-30 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecules for treatment of stenotic conditions
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
WO1997005249A2 (en) * 1995-07-31 1997-02-13 The Government Of The United States Of America, Represented By The Secretary, Department Of Healt H And Human Services Extension of a protein-protein interaction surface to inactivate the function of a cellular protein
US6395713B1 (en) 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
DE69941447D1 (de) 1998-01-05 2009-11-05 Univ Washington Erhöhter transport unter benutzung membranzerstörender stoffe
DE60040274D1 (de) 1999-03-10 2008-10-30 Phogen Ltd Verabreichung von nukleinsäuren und proteinen an zellen
US20020130430A1 (en) 2000-12-29 2002-09-19 Castor Trevor Percival Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
WO2002087541A1 (en) 2001-04-30 2002-11-07 Protiva Biotherapeutics Inc. Lipid-based formulations for gene transfer
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US7141540B2 (en) 2001-11-30 2006-11-28 Genta Salus Llc Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
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WO2013063560A2 (en) * 2011-10-27 2013-05-02 New York University INHIBITION OF c-MYC UBIQUITINATION TO PREVENT CANCER INITIATION AND PROGRESSION
EP3269734A1 (en) 2016-07-15 2018-01-17 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Methods and compositions for the treatment of cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520056A (ja) 2013-05-07 2016-07-11 フンダシオ プリバダ インスティトゥト ディンベスティガシオ オンコロジカ デ バル エブロンＦｕｎｄａｃｉｏ Ｐｒｉｖａｄａ Ｉｎｓｔｉｔｕｔ Ｄ’Ｉｎｖｅｓｔｉｇａｃｉｏ Ｏｎｃｏｌｏｇｉｃａ Ｄｅ Ｖａｌｌ Ｈｅｂｒｏｎ 癌の治療方法および組成物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101729826B1 (ko) * 2015-01-09 2017-05-11 주식회사 동희산업 플라스틱 연료탱크의 제조방법
KR101862239B1 (ko) * 2016-07-07 2018-05-30 주식회사 동희산업 플라스틱 연료탱크의 제조방법
KR101859583B1 (ko) * 2016-07-07 2018-06-27 주식회사 동희산업 플라스틱 연료탱크의 제조방법

Also Published As

Publication number Publication date
US11427621B2 (en) 2022-08-30
AU2017295071A1 (en) 2019-01-31
EP3484913B1 (en) 2024-07-03
AU2017295071B2 (en) 2022-06-09
IL264176B1 (en) 2023-03-01
IL264176A (en) 2019-02-28
KR20190032427A (ko) 2019-03-27
IL264176B2 (en) 2023-07-01
EA201990298A1 (ru) 2019-06-28
SMT202400360T1 (it) 2024-11-15
EP3269734A1 (en) 2018-01-17
EP3484913C0 (en) 2024-07-03
ZA201900960B (en) 2020-05-27
EP3484913A1 (en) 2019-05-22
MX2019000346A (es) 2019-04-01
MA45675B1 (fr) 2024-07-31
SG11201900021PA (en) 2019-01-30
RS65983B1 (sr) 2024-10-31
MA45675A (fr) 2021-04-21
JP2019525753A (ja) 2019-09-12
CA3029781A1 (en) 2018-01-18
CN109563151B (zh) 2023-03-07
CN109563151A (zh) 2019-04-02
ES2985967T3 (es) 2024-11-08
US20200247857A1 (en) 2020-08-06
MD3484913T2 (ro) 2024-10-31
HUE067973T2 (hu) 2024-11-28
KR102232500B1 (ko) 2021-03-26
HRP20241153T1 (hr) 2024-11-22
BR112019000732A2 (pt) 2019-07-30
PL3484913T3 (pl) 2025-01-07
WO2018011433A1 (en) 2018-01-18

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