JP7090081B2 - インライン比色テスター付き吸引器 - Google Patents
インライン比色テスター付き吸引器 Download PDFInfo
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Description
サンプルを使用して、pH検出、酵素検出および二酸化炭素検出のための手段を有する本発明による装置を現在の臨床標準(pH紙)と比較して以下の真理値表を作成した。
サンプルを使用して、pH検出、酵素検出および二酸化炭素検出のための手段を有する本発明による装置を現在の臨床標準(pH紙)と比較して以下の真理値表を作成した。この実施例では、本発明による装置において試験された3つのマーカーは、本発明による装置の利点をより明確に示すために分離されている。
Claims (15)
- インラインテスター(10)であって、
使用時には吸引チューブ(18)に接続可能な入口(38)と、
使用時に真空源に接続可能な出口(33)と、
前記入口(38)と前記出口(33)との間に配置されたチャンバ(14)とを備え、 前記チャンバ(14)は、
標的物質の存在下で色の変化を示すように適合された第1の非色物質を含む第1のテスター(48)であって、前記真空源によって前記チャンバ(14)内に引き込まれた流体が接触するように配置されている第1のテスター(48)
を備え、
前記インラインテスター(10)は、乾燥時には前記入口(38)から前記出口(33)へのガスの通過を許容するが、液体で濡れた場合には前記入口(38)から前記出口(33)への流体の通過を阻止または防止する液体停止装置(52)をさらに備え、
前記チャンバ(14)は、
二酸化炭素の存在下で色の変化を示す比色カプノメータを含む第2のテスター(64)であって、前記真空源によって前記チャンバ(14)内に引き込まれた流体が通過するように配置された第2のテスター(64)、および、
前記第1のテスター(48)と前記第2のテスター(64)との間に配置されたリザーバ
をさらに備え、
前記第2のテスター(64)は、液体停止装置(52)の下流かつ前記出口(33)の前に配置されていることを特徴とする、インラインテスター(10)。 - 前記標的物質が酸を含み、前記比色物質が酸塩基指示薬を含む、請求項1に記載のインラインテスター(10)。
- 前記酸塩基指示薬がリトマス紙またはブロモチモールスルホンフタレインを含む、請求項2に記載のインラインテスター(10)。
- 前記標的物質が胃関連マーカーを含み、前記胃関連マーカーが、すべて患者の胃の中に見られる、化合物;細胞または細胞片などの生物学的構造;酵素;および化学物質、および、胃酵素;酵素基質;胃リパーゼ;胃ホルモン;ペプシン;ペプシノゲン;内因子(IF);ビタミンB12-IF複合体;ムチン;ガストリン;およびトリプシンを含む群のうちのいずれか1つまたは複数を含む、請求項1から3のいずれか一項に記載のインラインテスター(10)。
- 前記標的物質が胃リパーゼを含み、前記比色物質がトリブチリンを含み、これにより、酪酸の生成によって引き起こされる色の変化によってトリブチリンの代謝を検出する、請求項4に記載のインラインテスター(10)。
- 2つまたは3つ以上の胃関連マーカーの存在を検出するための手段を含み、2つまたは3つ以上の胃関連マーカーの存在を検出するための前記手段が前記第1のテスターの上または中に配置されており、前記第1のテスター(52)が別々の領域に分割された液体吸収層(48)を含み、各別々の領域が異なる標的物質の存在下で色の変化を示すように適合された異なる比色物質を含む、請求項1から5のいずれか一項に記載のインラインテスター(10)。
- 前記液体吸収層(48)が、使用中に前記インラインテスターに引き込まれる吸引物の酸性度/アルカリ度に従って色の変化を示すように適合された第1の比色物質を含み、標的胃関連マーカーの存在下で酸を生成するように適合された第2の比色物質を含む前記液体吸収層の領域をさらに含む、請求項6に記載のインラインテスター(10)。
- 前記液体吸収層(48)がpH指示薬紙を含み、前記pH指示薬紙の領域がトリブチリンで被覆または含浸されており、胃リパーゼの存在下で、前記トリブチリンがアルコールおよび酪酸を生成し、前記酪酸が前記pH指示薬紙と相互作用してその色を酸性pHの読み取り値に対応させることができる、請求項7に記載のインラインテスター(10)。
- 前記比色カプノメータ(64)が、二酸化炭素の存在下で色を変化させる染料で被覆または含浸された紙基材を含み、
前記染料は、随意的に、5%を超える二酸化炭素の存在下で色を変化させる、請求項1から8のいずれか一項に記載のインラインテスター(10)。 - 前記出口に、または前記出口(33)の下流に一方向弁(130)をさらに備え、前記一方向弁(130)の所与のガスに対するクラッキング圧力が、同じガスを前記液体停止装置(48,50)に押し込むのに必要な圧力よりも小さく、正のガス圧力が前記出口(33)で印加されたときに、ガスは前記インラインテスターを通って戻るのではなく、前記一方向弁(130)を通って優先的に排出される、請求項1から9のいずれか一項に記載のインラインテスター(10)。
- 前記チャンバを形成するために互いに嵌合する2つの部分を備える本体を備え、前記2つの部分はそれぞれ、互いに協働する合わせ面(166)を有し、これは他方の部品の前記合わせ面に接して配置されたときに液密シールを形成し、前記2つの部分の一方または両方が、それらの合わせ面に形成された凹部、溝または他のボイド(112)を含み、前記凹部、溝または他のボイドは、前記インラインテスター(10)の内部チャンバおよび流体通路を形成する、請求項1から10のいずれか一項に記載のインラインテスター(10)。
- チャンバ内に少なくとも部分的に配置されたインサートをさらに含み、前記インサートは、前記第1のテスターを支持する入口と、第1の通気開口とを含み、前記第1の通気開口は、前記比色カプノメータ上の前記インラインテスターを通過するガスの流れを導くように配列されている、請求項11に記載のインラインテスター(10)。
- 前記第1(52)または第2のテスター(64)と前記液体停止装置とが互いに接触している、または結合されて積層構造を形成する、請求項1から12のいずれか一項に記載のインラインテスター(10)。
- 前記液体停止装置が、細孔または穿孔を含む疎水性層(50)を含み、これは、乾燥時には空気を通過させることを可能にするが、液体で濡れたときには前記液体が前記疎水性層(50)の表面からはじかれ、前記細孔または穿孔の開口部を覆うように強制され、
前記疎水性層(50)の前記細孔または穿孔は、液滴のサイズよりも小さい、請求項1から13のいずれか一項に記載のインラインテスター(10)。 - 前記液体停止装置は、それを通る水蒸気の通過を許容するが、それを通る液滴の通過を防止または阻止する、請求項1から14のいずれか一項に記載のインラインテスター(10)。
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GB1613893.5A GB2552842B (en) | 2016-08-12 | 2016-08-12 | Aspirators |
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PCT/GB2017/052390 WO2018029492A1 (en) | 2016-08-12 | 2017-08-14 | Aspirators with in-line colorimetric testers |
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CN110987923A (zh) * | 2019-12-19 | 2020-04-10 | 厦门市兆泰云智能科技有限公司 | 一种监控锂离子电池燃烧起火的传感器 |
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US20240017683A1 (en) * | 2022-07-14 | 2024-01-18 | Zephyros, Inc. | Baffle with drain path |
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CA3033893A1 (en) | 2018-02-15 |
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