JP7090027B2 - 生物医学的応用のためのポリマー材料 - Google Patents

生物医学的応用のためのポリマー材料 Download PDF

Info

Publication number
JP7090027B2
JP7090027B2 JP2018547859A JP2018547859A JP7090027B2 JP 7090027 B2 JP7090027 B2 JP 7090027B2 JP 2018547859 A JP2018547859 A JP 2018547859A JP 2018547859 A JP2018547859 A JP 2018547859A JP 7090027 B2 JP7090027 B2 JP 7090027B2
Authority
JP
Japan
Prior art keywords
medical device
polymer
poly
oligomer
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018547859A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019504922A5 (enExample
JP2019504922A (ja
Inventor
リウ，チャオ
ヤン，ジエン
Original Assignee
アレオ ビーエムイー，インコーポレイテッド
ザ・ペン・ステート・リサーチ・ファンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アレオ ビーエムイー，インコーポレイテッド, ザ・ペン・ステート・リサーチ・ファンデーション filed Critical アレオ ビーエムイー，インコーポレイテッド
Publication of JP2019504922A publication Critical patent/JP2019504922A/ja
Publication of JP2019504922A5 publication Critical patent/JP2019504922A5/ja
Application granted granted Critical
Publication of JP7090027B2 publication Critical patent/JP7090027B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/16—Catalysts
    • C08G18/22—Catalysts containing metal compounds
    • C08G18/24—Catalysts containing metal compounds of tin
    • C08G18/244—Catalysts containing metal compounds of tin tin salts of carboxylic acids
    • C08G18/246—Catalysts containing metal compounds of tin tin salts of carboxylic acids containing also tin-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4236—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
    • C08G18/4277—Caprolactone and/or substituted caprolactone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/06—Unsaturated polyesters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04—Polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Polyethers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
JP2018547859A 2015-11-30 2016-11-29 生物医学的応用のためのポリマー材料 Active JP7090027B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562260752P 2015-11-30 2015-11-30
US62/260,752 2015-11-30
PCT/US2016/064018 WO2017095816A1 (en) 2015-11-30 2016-11-29 Polymeric materials for biomedical applications

Publications (3)

Publication Number Publication Date
JP2019504922A JP2019504922A (ja) 2019-02-21
JP2019504922A5 JP2019504922A5 (enExample) 2020-01-16
JP7090027B2 true JP7090027B2 (ja) 2022-06-23

Family

ID=58798058

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018547859A Active JP7090027B2 (ja) 2015-11-30 2016-11-29 生物医学的応用のためのポリマー材料

Country Status (6)

Country Link
US (1) US11267965B2 (enExample)
EP (1) EP3383315B1 (enExample)
JP (1) JP7090027B2 (enExample)
CN (1) CN108472120B (enExample)
CA (1) CA3005306C (enExample)
WO (1) WO2017095816A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10172974B2 (en) 2016-01-19 2019-01-08 The Penn State Research Foundation Antimicrobial polymers
CN109810666B (zh) * 2018-12-21 2020-10-30 中山市康和化工有限公司 一种具有降解特性的聚氨酯胶粘剂及其制备方法
CN109646159B (zh) * 2018-12-26 2021-02-05 上海纳米技术及应用国家工程研究中心有限公司 解剖型3d打印波纹管弹性体气管支架的制备方法及产品
CN109777090B (zh) * 2019-01-11 2021-02-19 齐鲁工业大学 一种有机聚合物/二氧化硅复合纳米膜及其制备方法
CN109971163B (zh) * 2019-04-04 2021-02-02 陕西科技大学 一种水性聚氨酯/Fe3+凝胶材料的制备方法
US20230087713A1 (en) * 2019-12-24 2023-03-23 The Penn State Research Foundation Bioadhesive compositions and methods of making the same
WO2021207331A1 (en) * 2020-04-07 2021-10-14 The Penn State Research Foundation Biodegradable and multifunctional neural block devices
CN111620997A (zh) * 2020-06-09 2020-09-04 林多炉 一种高强度的石墨烯改性聚氨酯导电材料及其制法
KR102553303B1 (ko) * 2020-07-08 2023-07-07 주식회사 아이센스 관능화된 열가소성 폴리우레탄, 이의 제조방법 및 이를 이용한 의료용 고기능성 복합재료의 제조 방법 및 이를 포함하는 의료장치
CN112029068B (zh) * 2020-09-08 2022-05-31 浙江德普斯医疗科技股份有限公司 聚氨酯化合物及其制备方法以及生物粘结剂
US20230389926A1 (en) * 2020-10-16 2023-12-07 The Johns Hopkins University Biodegradable nanofiber conical conduits for nerve repair
CN116782959A (zh) * 2020-12-23 2023-09-19 彼得斯外科公司 包括nco封端的氨基甲酸酯预聚物的止血组织粘合剂组合物
CN112940218B (zh) * 2021-02-04 2022-11-01 四川大学 可降解的电活性聚氨酯材料及其制备方法和应用
CN113817145B (zh) * 2021-05-20 2023-03-28 北京服装学院 一种基于聚ε-己内酯的聚酯型生物可降解形状记忆共聚物及其制备方法
CN113244451B (zh) * 2021-06-02 2022-06-03 青岛大学 一种仿生天然肌腱-骨梯度界面的补片材料及其制备方法
US20250090721A1 (en) * 2023-09-20 2025-03-20 Acuitive Technologies, Inc. Charged Citrate-Based Biomaterials
CN119680022B (zh) * 2025-02-21 2025-06-13 西湖大学 一种自粘接性材料和制备方法及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090093565A1 (en) 2007-10-04 2009-04-09 Board Of Regents, The University Of Texas System Bio-polymer and scaffold-sheet method for tissue engineering
CN103751148A (zh) 2014-01-10 2014-04-30 华南理工大学 一种以双亲性聚氨酯为载体的具有靶向和缓释作用的抗肿瘤药物纳米微球及其制备方法
WO2014107501A1 (en) 2013-01-04 2014-07-10 Board Of Regents, The University Of Texas System Compositions comprising citrate and applications thereof
WO2015035020A1 (en) 2013-09-05 2015-03-12 The Penn State Research Foundation Bioelastomers and applications thereof
JP2015513591A (ja) 2012-02-28 2015-05-14 サノフイ 機能性ｐｌａ−ｐｅｇ共重合体、そのナノ粒子、その製造、ならびに標的薬物送達およびイメージングのためのその使用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498685A (en) * 1993-04-27 1996-03-12 Minnesota Mining And Manufacturing Company Carboxylic-acid functional polyurethane polymers and their use in magnetic recording media
DE19926312A1 (de) * 1999-06-09 2000-12-14 Hilti Ag Einkomponenten-Polyurethanschäummassen mit verbesserter Aushärtung
US6866805B2 (en) 2001-12-27 2005-03-15 Advanced Cardiovascular Systems, Inc. Hybrid intravascular stent
GB2394418B (en) * 2002-10-25 2007-01-31 Johnson & Johnson Medical Ltd Fluid wound dressing
AU2003300380B2 (en) 2002-12-30 2008-11-06 Nektar Therapeutics Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles
JP4658249B2 (ja) * 2004-08-30 2011-03-23 コニシ株式会社 オレフィン系被着体の接着方法
US7964696B2 (en) * 2005-09-20 2011-06-21 Polynovo Biomaterials Pty Limited Chain extenders
US7776934B2 (en) * 2006-02-22 2010-08-17 Dow Global Technologies Inc. One-component polyurethane foam compositions and methods for their use
JP5007647B2 (ja) * 2007-10-11 2012-08-22 井関農機株式会社 乗用田植機
US20090299466A1 (en) 2008-06-02 2009-12-03 Medtronic Vascular, Inc. Local Delivery of Matrix Metalloproteinase Inhibitors
EP3119407A4 (en) * 2014-03-17 2017-03-29 The Penn State Research Foundation Methods of promoting bone growth and healing

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090093565A1 (en) 2007-10-04 2009-04-09 Board Of Regents, The University Of Texas System Bio-polymer and scaffold-sheet method for tissue engineering
JP2015513591A (ja) 2012-02-28 2015-05-14 サノフイ 機能性ｐｌａ−ｐｅｇ共重合体、そのナノ粒子、その製造、ならびに標的薬物送達およびイメージングのためのその使用
WO2014107501A1 (en) 2013-01-04 2014-07-10 Board Of Regents, The University Of Texas System Compositions comprising citrate and applications thereof
WO2015035020A1 (en) 2013-09-05 2015-03-12 The Penn State Research Foundation Bioelastomers and applications thereof
CN103751148A (zh) 2014-01-10 2014-04-30 华南理工大学 一种以双亲性聚氨酯为载体的具有靶向和缓释作用的抗肿瘤药物纳米微球及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Siyan Zhang, Kiat Hwa Chan, Robert K. Prud'homme, and A.James Link，Synthesis and Evaluation of Clickable Block Copolymers for Targeted Nanoparticle Drug Delivery，Molecular Pharmaceutics，2012, Vol.9，2228-2236

Also Published As

Publication number Publication date
CN108472120A (zh) 2018-08-31
CA3005306C (en) 2021-08-10
EP3383315A1 (en) 2018-10-10
EP3383315B1 (en) 2023-09-27
CN108472120B (zh) 2022-02-25
US11267965B2 (en) 2022-03-08
US20180340063A1 (en) 2018-11-29
JP2019504922A (ja) 2019-02-21
EP3383315A4 (en) 2019-06-19
CA3005306A1 (en) 2017-06-08
WO2017095816A1 (en) 2017-06-08

Similar Documents

Publication Publication Date Title
JP7090027B2 (ja) 生物医学的応用のためのポリマー材料
US7649022B2 (en) Bioabsorbable elastomeric polymer networks, cross-linkers and methods of use
EP2428235B1 (de) Verwendung von durch Polymerisation härtbaren Zusammensetzungen zur Herstellung biologisch abbaubarer, bioverträglicher, vernetzter Polymere
JP3126637B2 (ja) 生体適合性ブロックコポリマー
US8597630B2 (en) Thermal-responsive polymer networks, compositions, and methods and applications related thereto
Park et al. Catalyst-free synthesis of high elongation degradable polyurethanes containing varying ratios of isosorbide and polycaprolactone: physical properties and biocompatibility
US20090022772A1 (en) Bioabsorbable elastomeric arterial support device and methods of use
JP2008539859A (ja) モジュール式生体吸収性又は生物医学用生物活性超分子材料
US10563012B2 (en) Biodegradable side chain liquid crystal elastomers: smart responsive scaffolds (SRS) for tissue regeneration
KR20080110473A (ko) 화학적 가교 결합을 가지는 포스파젠계 고분자 하이드로젤,그의 제조방법 및 그의 용도
JP2009513747A (ja) 分解可能で生体適合性があるブロックコポリマー
CA2563923A1 (en) Biodegradable and biocompatible peg-based poly(ester-urethanes)
Yu et al. A bilayered scaffold with segregated hydrophilicity-hydrophobicity enables reconstruction of goat hierarchical temporomandibular joint condyle cartilage
JP7675769B2 (ja) 生体医療用超分子ポリマー
Kim et al. Novel applications of urethane/urea chemistry in the field of biomaterials
Kaur Polymers as bioactive materials II: synthetic/biodegradable polymers and composites
Govender et al. Polyurethanes in Drug Delivery and Regenerative Medicine
Miceli Tailored Polymers for Advanced Biomedical Devices: Electroactive Bioadhesive Coatings for Drug Delivery and Electrospun Scaffolds for Improved Biointegration and Functionality
Xu Rational Design and Synthesis of Biodegradable Polyurethane Based Biomaterials
KS et al. Synthesis, Degradation, Biocompatibility and Drug Release Studies of Bis 2-Hydroxy Ethyl Terephthalate-based Poly (Mannitol-Citric-Sebacate) Ester
Stankus Functional Elastomeric Scaffold Development for Tissue Engineering

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191127

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191127

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200916

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201013

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20201214

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210311

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210412

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210803

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20211102

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20211222

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220114

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220118

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220531

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220613

R150 Certificate of patent or registration of utility model

Ref document number: 7090027

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250