JP7082610B2 - ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法 - Google Patents

ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法 Download PDF

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JP7082610B2
JP7082610B2 JP2019511384A JP2019511384A JP7082610B2 JP 7082610 B2 JP7082610 B2 JP 7082610B2 JP 2019511384 A JP2019511384 A JP 2019511384A JP 2019511384 A JP2019511384 A JP 2019511384A JP 7082610 B2 JP7082610 B2 JP 7082610B2
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seq
rnai construct
sequence
asgr1
sense strand
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JP2019524151A (ja
JP2019524151A5 (enExample
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マイケル オルマン,
ヤン リ,
ジュン ジャン,
カウスタヴ ビスワス,
オリバー ホーマン,
レスリー ピー. ミランダ,
ジャスティン ケー. マリー,
ビン ウー,
オ キュ ユン,
ジョン ゴードン アレン,
チャウィタ ネティロッジャナクル,
ユアン チェン,
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Amgen Inc
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/526—CH3 domain
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2019511384A 2016-08-26 2017-08-25 ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法 Active JP7082610B2 (ja)

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JP2022022163A JP7472180B2 (ja) 2016-08-26 2022-02-16 ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法
JP2024000208A JP7873261B2 (ja) 2016-08-26 2024-01-04 ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法
JP2026028691A JP2026083134A (ja) 2016-08-26 2026-02-25 ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法

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US201662380216P 2016-08-26 2016-08-26
US62/380,216 2016-08-26
PCT/US2017/048757 WO2018039647A1 (en) 2016-08-26 2017-08-25 Rnai constructs for inhibiting asgr1 expression and methods of use thereof

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JP2022022163A Active JP7472180B2 (ja) 2016-08-26 2022-02-16 ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法
JP2024000208A Active JP7873261B2 (ja) 2016-08-26 2024-01-04 ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法
JP2026028691A Pending JP2026083134A (ja) 2016-08-26 2026-02-25 ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法

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JP2024000208A Active JP7873261B2 (ja) 2016-08-26 2024-01-04 ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法
JP2026028691A Pending JP2026083134A (ja) 2016-08-26 2026-02-25 ASGR1発現を阻害するためのRNAiコンストラクトおよびその使用方法

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AU (2) AU2017315952B2 (enExample)
CA (2) CA3034463C (enExample)
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CA3078971A1 (en) * 2017-11-01 2019-05-09 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof
KR102798620B1 (ko) * 2018-06-07 2025-04-22 암젠 인크 단백질-폴리뉴클레오티드 접합체에 대한 검출 검정
SG11202105900UA (en) * 2018-12-10 2021-07-29 Amgen Inc CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF
SG11202113112WA (en) * 2019-05-30 2021-12-30 Amgen Inc Rnai constructs for inhibiting scap expression and methods of use thereof
CA3143047A1 (en) 2019-06-25 2020-12-30 Amgen Inc. Purification methods for carbohydrate-linked oligonucleotides
EP4126967A1 (en) 2020-03-23 2023-02-08 Amgen Inc. Monoclonal antibodies to chemically-modified nucleic acids and uses thereof
CN111705063B (zh) * 2020-06-02 2023-08-08 成都中科奥格生物科技有限公司 Asgr1突变基因及其在制备哺乳动物肝损伤敏感模型中的应用
KR20240082367A (ko) * 2021-09-23 2024-06-10 아르네이 사이언시스 엘엘씨 치료학적 물질로서 고리형 구조의 올리고뉴클레오티드
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JP2022060357A (ja) 2022-04-14
JP7472180B2 (ja) 2024-04-22
US11732266B2 (en) 2023-08-22
WO2018039647A1 (en) 2018-03-01
AU2024201349B2 (en) 2026-07-30
CA3277899A1 (en) 2026-03-02
US20210108212A1 (en) 2021-04-15
CA3034463A1 (en) 2018-03-01
JP2024019733A (ja) 2024-02-09
TW201823461A (zh) 2018-07-01
US20190309306A1 (en) 2019-10-10
AU2024201349A1 (en) 2024-04-11
JP2019524151A (ja) 2019-09-05
EP3504333A1 (en) 2019-07-03
AU2017315952A1 (en) 2019-03-14
CA3034463C (en) 2025-09-16
MX2024009873A (es) 2024-08-20
AU2017315952B2 (en) 2023-11-30
AR110629A1 (es) 2019-04-17
JP2026083134A (ja) 2026-05-19
JP7873261B2 (ja) 2026-06-11
US10870856B2 (en) 2020-12-22
UY37376A (es) 2018-03-23
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