JP7082610B2 - ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法 - Google Patents

ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法 Download PDF

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JP7082610B2
JP7082610B2 JP2019511384A JP2019511384A JP7082610B2 JP 7082610 B2 JP7082610 B2 JP 7082610B2 JP 2019511384 A JP2019511384 A JP 2019511384A JP 2019511384 A JP2019511384 A JP 2019511384A JP 7082610 B2 JP7082610 B2 JP 7082610B2
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seq
rnai construct
sequence
asgr1
sense strand
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JP2019524151A5 (enExample
JP2019524151A (ja
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マイケル オルマン，
ヤン リ，
ジュン ジャン，
カウスタヴ ビスワス，
オリバー ホーマン，
レスリー ピー． ミランダ，
ジャスティン ケー． マリー，
ビン ウー，
オ キュ ユン，
ジョン ゴードン アレン，
チャウィタ ネティロッジャナクル，
ユアン チェン，
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Amgen Inc
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Amgen Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C07K2317/526—CH3 domain
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2019511384A 2016-08-26 2017-08-25 ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法 Active JP7082610B2 (ja)

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JP2022022163A JP7472180B2 (ja) 2016-08-26 2022-02-16 ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法
JP2024000208A JP2024019733A (ja) 2016-08-26 2024-01-04 ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法

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US201662380216P 2016-08-26 2016-08-26
US62/380,216 2016-08-26
PCT/US2017/048757 WO2018039647A1 (en) 2016-08-26 2017-08-25 Rnai constructs for inhibiting asgr1 expression and methods of use thereof

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JP2022022163A Active JP7472180B2 (ja) 2016-08-26 2022-02-16 ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法
JP2024000208A Pending JP2024019733A (ja) 2016-08-26 2024-01-04 ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法

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JP2024000208A Pending JP2024019733A (ja) 2016-08-26 2024-01-04 ＡＳＧＲ１発現を阻害するためのＲＮＡｉコンストラクトおよびその使用方法

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CA (1) CA3034463C (enExample)
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CN111212909A (zh) * 2017-10-17 2020-05-29 箭头药业股份有限公司 用于抑制去唾液酸糖蛋白受体1的表达的RNAi试剂和组合物
AU2018360697A1 (en) * 2017-11-01 2020-05-14 Alnylam Pharmaceuticals, Inc. Complement component C3 iRNA compositions and methods of use thereof
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US20220307022A1 (en) * 2019-05-30 2022-09-29 Amgen Inc. Rnai constructs for inhibiting scap expression and methods of use thereof
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WO2021194999A1 (en) 2020-03-23 2021-09-30 Amgen Inc. Monoclonal antibodies to chemically-modified nucleic acids and uses thereof
CN111705063B (zh) * 2020-06-02 2023-08-08 成都中科奥格生物科技有限公司 Asgr1突变基因及其在制备哺乳动物肝损伤敏感模型中的应用
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JP7472180B2 (ja) 2024-04-22
AU2017315952A1 (en) 2019-03-14
JP2022060357A (ja) 2022-04-14
CA3034463C (en) 2025-09-16
TW201823461A (zh) 2018-07-01
US11732266B2 (en) 2023-08-22
MX2019002271A (es) 2019-06-20
US20190309306A1 (en) 2019-10-10
MX2024009873A (es) 2024-08-20
AU2017315952B2 (en) 2023-11-30
WO2018039647A1 (en) 2018-03-01
EP3504333A1 (en) 2019-07-03
UY37376A (es) 2018-03-23
CA3034463A1 (en) 2018-03-01
AU2024201349A1 (en) 2024-04-11
JP2024019733A (ja) 2024-02-09
US20210108212A1 (en) 2021-04-15
JP2019524151A (ja) 2019-09-05
AR110629A1 (es) 2019-04-17
US10870856B2 (en) 2020-12-22

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