JP7082574B2 - 免疫療法用改変細胞 - Google Patents

免疫療法用改変細胞 Download PDF

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JP7082574B2
JP7082574B2 JP2018545230A JP2018545230A JP7082574B2 JP 7082574 B2 JP7082574 B2 JP 7082574B2 JP 2018545230 A JP2018545230 A JP 2018545230A JP 2018545230 A JP2018545230 A JP 2018545230A JP 7082574 B2 JP7082574 B2 JP 7082574B2
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cells
scfv
antibody
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car
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JP2019513009A5 (OSRAM
JP2019513009A (ja
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ドッティ,ギアンピエトロ
ランドニ,エリザ
シャムシーブ,アディジャパー
クレッチュマー,タイタス
ドロステ,ミリアム
フィリップス,ダグラス
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セル メディカ スイッツァランド アーゲー
ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル
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JP2018545230A 2016-02-25 2017-02-24 免疫療法用改変細胞 Active JP7082574B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022088103A JP2022116230A (ja) 2016-02-25 2022-05-30 免疫療法用改変細胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16020057 2016-02-25
EP16020057.2 2016-02-25
PCT/US2017/019301 WO2017147383A1 (en) 2016-02-25 2017-02-24 Modified cells for immunotherapy

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JP2019513009A JP2019513009A (ja) 2019-05-23
JP2019513009A5 JP2019513009A5 (OSRAM) 2020-04-02
JP7082574B2 true JP7082574B2 (ja) 2022-06-08

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JP2018544554A Active JP7080819B2 (ja) 2016-02-25 2017-02-24 Pd-l1に対する結合メンバー
JP2018545230A Active JP7082574B2 (ja) 2016-02-25 2017-02-24 免疫療法用改変細胞
JP2022088103A Pending JP2022116230A (ja) 2016-02-25 2022-05-30 免疫療法用改変細胞

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US (3) US11434294B2 (OSRAM)
EP (3) EP4086285A1 (OSRAM)
JP (3) JP7080819B2 (OSRAM)
KR (2) KR20180111870A (OSRAM)
CN (3) CN108884164B (OSRAM)
AU (2) AU2017224843A1 (OSRAM)
BR (2) BR112018067696A2 (OSRAM)
CA (2) CA3014001A1 (OSRAM)
ES (1) ES2903408T3 (OSRAM)
RU (2) RU2018128464A (OSRAM)
SG (2) SG11201807188VA (OSRAM)
WO (2) WO2017144681A1 (OSRAM)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗pd-l1之人類抗體
GB201506642D0 (en) 2015-04-20 2015-06-03 Ucl Business Plc T cell receptor
EP3371208B8 (en) 2015-11-02 2024-10-23 Five Prime Therapeutics, Inc. Cd80 extracellular domain polypeptides and their use in cancer treatment
JP7080819B2 (ja) * 2016-02-25 2022-06-06 セル メディカ スイッツァランド アーゲー Pd-l1に対する結合メンバー
TWI755395B (zh) 2016-05-13 2022-02-21 美商再生元醫藥公司 抗-pd-1抗體與輻射治療癌症之組合
GB201617714D0 (en) * 2016-10-19 2016-11-30 Ucl Business Plc T Cell receptor
RS62865B1 (sr) 2016-12-08 2022-02-28 Immatics Biotechnologies Gmbh Novi t-ćelijski receptori i imunoterapija u kojoj se koriste
US11278570B2 (en) 2016-12-16 2022-03-22 B-Mogen Biotechnologies, Inc. Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
CA3047313A1 (en) 2016-12-16 2018-06-21 B-Mogen Biotechnologies, Inc. Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods
IL268479B2 (en) 2017-02-21 2024-06-01 Regeneron Pharma Anti-PD-1 antibodies for the treatment of lung cancer
AU2018251898A1 (en) 2017-04-13 2019-10-31 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
EA201992586A1 (ru) 2017-04-28 2020-03-03 Файв Прайм Терапьютикс, Инк. Способы лечения с помощью полипептидов внеклеточного домена cd80
KR102752985B1 (ko) 2017-12-20 2025-01-10 포세이다 테라퓨틱스, 인크. Vcar 조성물 및 사용 방법
CN111684061B (zh) * 2018-01-19 2024-07-30 美天施生物科技有限两合公司 表达嵌合抗原受体的调节性t细胞
CA3089230A1 (en) 2018-03-02 2019-09-06 Cdr-Life Ag Trispecific antigen binding proteins
CA3095076A1 (en) * 2018-03-29 2019-10-03 Adagene Inc. Anti-pd-l1 antibodies and use thereof
KR20210015842A (ko) * 2018-06-04 2021-02-10 디아테바 에스.알.엘. 항-cd99 다이아바디 또는 igg 항체 및 그의 용도
EP3810764A2 (en) 2018-06-21 2021-04-28 B-Mogen Biotechnologies, Inc. Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods
JP7003295B2 (ja) * 2018-06-29 2022-01-20 ワイ-バイオロジクス・インコーポレイテッド Lag-3に特異的に結合する単クローン抗体及びその用途
SG11202100208VA (en) 2018-07-09 2021-02-25 Precigen Inc Fusion constructs and methods of using thereof
AU2019354395A1 (en) * 2018-10-01 2021-05-06 Adicet Therapeutics, Inc. Compositions and methods regarding engineered and non-engineered γδ -T cells for treatment of solid tumors
AU2019359890B2 (en) 2018-10-17 2024-10-24 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US11419898B2 (en) 2018-10-17 2022-08-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US20210369776A1 (en) * 2018-12-06 2021-12-02 Guangdong Tcrcure Biopharma Technology Co., Ltd. Combinational tcr-t cell therapy targeting tumor antigens, tgf-beta, and immune checkpoints
US20220144960A1 (en) 2018-12-26 2022-05-12 Nanjing Legend Biotech Co., Ltd. Cd30-binding moieties, chimeric antigen receptors, and uses thereof
CN109652379B (zh) * 2018-12-29 2022-08-16 博生吉医药科技(苏州)有限公司 Cd7嵌合抗原受体修饰的nk-92mi细胞及其应用
CN111454358A (zh) * 2019-01-18 2020-07-28 四川科伦博泰生物医药股份有限公司 一种嵌合抗原受体及其应用
KR20210133225A (ko) * 2019-01-28 2021-11-05 사이포스 바이오사이언시스 인코포레이티드 부착된 이종 분자를 car-세포의 비천연 nkg2d 수용체에 선택적으로 전달하는 변형된 비천연 nkg2d 리간드
WO2020183131A1 (en) * 2019-03-08 2020-09-17 Autolus Limited Compositions and methods comprising engineered chimeric antigen receptor and modulator of car
JP2022527081A (ja) * 2019-03-26 2022-05-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 血液がんおよび固形がんの治療のためのキメラ抗原受容体改変t細胞(car-t)
CN110402892A (zh) * 2019-04-30 2019-11-05 梁廷波 选择性敲除胰腺上皮细胞程序性死亡配体1分子的自发胰腺癌小鼠模型的建立方法
CN112079924B (zh) * 2019-06-12 2024-02-06 苏州工业园区唯可达生物科技有限公司 Pd-l1靶向结合剂及其用途
WO2021000017A1 (en) * 2019-07-02 2021-01-07 Telix International Pty Ltd Antibodies against caix with reduced affinity for the neonatal fc receptor
WO2021057906A1 (zh) * 2019-09-25 2021-04-01 科济生物医药(上海)有限公司 表达il-15的免疫效应细胞
PH12022551078A1 (en) * 2019-11-04 2024-06-19 Regeneron Pharma Combination therapy to treat brain cancer
RU2733430C1 (ru) * 2019-11-19 2020-10-01 Общество с ограниченной ответственностью «Реал Таргет» Создание конъюгатов gd2-специфичных антител и фрагментов gd2-специфичных антител с препаратами
CN115925976A (zh) * 2019-11-21 2023-04-07 博生吉医药科技(苏州)有限公司 Cd7-car-t细胞及其制备和应用
AU2020396896A1 (en) * 2019-12-02 2022-06-09 Dana-Farber Cancer Institute, Inc. Antibodies against PD-L1 and methods of use thereof
WO2021130535A2 (en) * 2019-12-28 2021-07-01 Shanghai Cell Therapy Group Company Co., Ltd. Cell expressing immune modulatory molecules and system for expressing immune modulatory molecules
EP3878858A1 (en) * 2020-03-11 2021-09-15 Affilogic Variants of sac7d and their use in cancer therapy
AU2021243909B2 (en) * 2020-03-23 2025-04-10 Curigin Co.,Ltd. Structure of oncolytic virus comprising bispecific nucleic acid molecule
EP4149526A4 (en) * 2020-05-14 2024-08-07 Virtuoso Binco, Inc. HUMANIZED CD38 AND ICAM1 ANTIBODIES AND USES THEREOF
US20230293691A1 (en) * 2020-06-11 2023-09-21 Innovative Cellular Therapeutics Holdings, Ltd. Cell/gene therapies targeting mage-a4 peptide
US20230227557A1 (en) * 2020-06-25 2023-07-20 Promab Biotechnologies, Inc. Pd-l1-specific antibody and anti-pd-l1-car-t cells
WO2022011256A1 (en) 2020-07-10 2022-01-13 Precigen, Inc. Fusion constructs and methods of using thereof
WO2022098922A1 (en) * 2020-11-04 2022-05-12 Senti Biosciences, Inc. Protein payload release
CN112375743A (zh) * 2020-11-20 2021-02-19 山东省医学科学院附属医院 一种分泌型靶向her2抗原的嵌合抗原受体t细胞及其应用
CA3195317A1 (en) * 2020-11-30 2022-06-02 Fred Hutchinson Cancer Center Pd-l1 binding peptides and peptide complexes and methods of use thereof
CN113234152B (zh) * 2021-06-03 2023-05-02 天津科技大学 程序性死亡受体-配体1(pd-l1)特异性结合多肽及应用
WO2023274387A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向gd2的通用型car-t细胞及其制备方法和应用
US20250179196A1 (en) * 2021-07-30 2025-06-05 Janssen Biotech, Inc. Materials and methods of making or using il-23r binding proteins
CN117999364A (zh) 2021-08-13 2024-05-07 艾诺奥医药品有限公司 用以治疗脑癌的组合疗法
CN118176017A (zh) * 2021-10-26 2024-06-11 正大天晴药业集团股份有限公司 治疗肿瘤的联用药物
CN116410331B (zh) * 2021-12-31 2024-01-30 合源生物科技(天津)有限公司 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用
AU2023213978A1 (en) * 2022-01-28 2024-08-15 The University Of North Carolina At Chapel Hill Natural killer t-cells and methods of using the same
CN118005806A (zh) * 2024-02-08 2024-05-10 北京市眼科研究所 嵌合抗原受体、人多能干细胞分化的表达嵌合抗原受体的小胶质细胞及其应用
CN120518751B (zh) * 2025-07-23 2025-09-19 中国人民解放军军事科学院军事医学研究院 抗人4型腺病毒特异性纳米抗体lum44及在抗病毒治疗中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014134165A1 (en) 2013-02-26 2014-09-04 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4237113B4 (de) 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
DE19641876B4 (de) 1996-10-10 2011-09-29 Iba Gmbh Streptavidinmuteine
DE10113776B4 (de) 2001-03-21 2012-08-09 "Iba Gmbh" Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins
EP1445264B1 (en) 2001-07-31 2011-09-14 Ono Pharmaceutical Co., Ltd. Substance specific to pd-1
CN105175535A (zh) 2002-05-22 2015-12-23 艾斯巴技术-诺华有限责任公司 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法
GB0328363D0 (en) 2003-12-06 2004-01-14 Imp College Innovations Ltd Therapeutically useful molecules
ATE475669T1 (de) 2004-06-29 2010-08-15 Immunocore Ltd Einen modifizierten t-zellen-rezeptor exprimierende zellen
CA2947292C (en) 2006-12-27 2019-07-23 Emory University Compositions and methods for the treatment of infections and tumors
PL2158315T3 (pl) 2007-06-25 2016-10-31 Sposoby modyfikowania przeciwciał i zmodyfikowane przeciwciała o ulepszonych właściwościach funkcjonalnych
AU2009264566B2 (en) 2008-06-25 2014-05-08 Novartis Ag Solubility optimization of immunobinders
CN102164958A (zh) 2008-06-25 2011-08-24 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 使用通用抗体构架进行的兔抗体的人源化
TWI729512B (zh) 2008-12-09 2021-06-01 美商建南德克公司 抗pd-l1抗體及其於增進t細胞功能之用途
CN104961829B (zh) 2009-11-24 2018-08-21 米迪缪尼有限公司 针对b7-h1的靶向结合剂
EP3467101A3 (en) 2010-09-08 2019-06-19 Baylor College of Medicine Immunotherapy of brain tumor using geneticially engineered gd2-specific t cells
US20140255363A1 (en) 2011-09-16 2014-09-11 Baylor College Of Medicine Targeting the tumor microenvironment using manipulated nkt cells
KR101981873B1 (ko) 2011-11-28 2019-05-23 메르크 파텐트 게엠베하 항-pd-l1 항체 및 그의 용도
KR102410078B1 (ko) * 2012-05-31 2022-06-22 소렌토 쎄라퓨틱스, 인코포레이티드 Pd-l1에 결합하는 항원 결합 단백질
BR112014030750A2 (pt) 2012-06-06 2017-08-22 Inst Catalana Recerca Estudis Avancats Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar
WO2014206561A1 (en) 2013-06-26 2014-12-31 Numab Ag Novel antibody frameworks
WO2015038538A1 (en) 2013-09-10 2015-03-19 Medimmune, Llc Compositions and methods for treating sepsis
EP3074025A1 (en) 2013-11-27 2016-10-05 Baylor College Of Medicine Csgp4-specific chimeric antigen receptor for cancer
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗pd-l1之人類抗體
WO2015142675A2 (en) * 2014-03-15 2015-09-24 Novartis Ag Treatment of cancer using chimeric antigen receptor
EP4166148A1 (en) * 2014-06-06 2023-04-19 Memorial Sloan-Kettering Cancer Center Mesothelin-targeted chimeric antigen receptors and uses thereof
RU2715038C2 (ru) * 2014-07-11 2020-02-21 Дженентек, Инк. Антитела анти-pd-l1 и способы их диагностического применения
WO2016034666A1 (en) 2014-09-04 2016-03-10 Cellectis Trophoblast glycoprotein (5t4, tpbg) specific chimeric antigen receptors for cancer immunotherapy
WO2016049459A1 (en) 2014-09-26 2016-03-31 Baylor College Of Medicine Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy
CA2965521A1 (en) 2014-10-31 2016-05-06 Baylor College Of Medicine Survivin specific t-cell receptor targeting tumor but not t cells
CN108064252A (zh) 2014-12-19 2018-05-22 达纳-法伯癌症研究所公司 嵌合抗原受体及其使用方法
GB201506642D0 (en) 2015-04-20 2015-06-03 Ucl Business Plc T cell receptor
CN105331585A (zh) * 2015-11-13 2016-02-17 科济生物医药(上海)有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
JP7080819B2 (ja) * 2016-02-25 2022-06-06 セル メディカ スイッツァランド アーゲー Pd-l1に対する結合メンバー

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014134165A1 (en) 2013-02-26 2014-09-04 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BLOOD, 2014, Vol.124, No.18, p.2824-33

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