JP7075937B2 - Ｓｅｑｕｅｎｃｉｎｇ－Ｂｙ－Ｓｙｎｔｈｅｓｉｓ法におけるイメージング試薬としての光防護性混合物 - Google Patents

Ｓｅｑｕｅｎｃｉｎｇ－Ｂｙ－Ｓｙｎｔｈｅｓｉｓ法におけるイメージング試薬としての光防護性混合物 Download PDF

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JP7075937B2
JP7075937B2 JP2019544801A JP2019544801A JP7075937B2 JP 7075937 B2 JP7075937 B2 JP 7075937B2 JP 2019544801 A JP2019544801 A JP 2019544801A JP 2019544801 A JP2019544801 A JP 2019544801A JP 7075937 B2 JP7075937 B2 JP 7075937B2
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imaging
acid
photoprotective
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ルイーザ アンドラジー，
マイケル パーボスト，
ドナ ヘブロニ，
ミナクシ グプタ，
オースティン リッカー，
ティモシー ペレティエ，
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キアゲン サイエンシーズ， エルエルシー
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2019544801A 2016-11-09 2017-10-31 Ｓｅｑｕｅｎｃｉｎｇ－Ｂｙ－Ｓｙｎｔｈｅｓｉｓ法におけるイメージング試薬としての光防護性混合物 Active JP7075937B2 (ja)

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US201662419702P 2016-11-09 2016-11-09
US62/419,702 2016-11-09
PCT/US2017/059318 WO2018089231A1 (en) 2016-11-09 2017-10-31 Photoprotective mixtures as imaging reagents in sequencing-by-synthesis

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JP2020511955A JP2020511955A (ja) 2020-04-23
JP2020511955A5 JP2020511955A5 (https=) 2020-10-08
JP7075937B2 true JP7075937B2 (ja) 2022-05-26

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US (2) US11162129B2 (https=)
EP (1) EP3538093B1 (https=)
JP (1) JP7075937B2 (https=)
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WO (1) WO2018089231A1 (https=)

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SG11202012746XA (en) * 2018-12-17 2021-01-28 Illumina Cambridge Ltd Compositions for use in polyunucleotide sequencing
US11761040B2 (en) 2020-04-20 2023-09-19 Mgi Tech Co., Ltd. DNA protection agent in DNA imaging buffer
US20220098658A1 (en) * 2020-09-21 2022-03-31 Quantum-Si Incorporated Methods to minimize photodamage during nucleic acid and peptide sequencing
CA3196800A1 (en) * 2020-10-30 2022-05-05 Element Biosciences, Inc. Reagents for massively parallel nucleic acid sequencing
CN115078315B (zh) * 2021-03-12 2025-12-26 郑州思昆生物工程有限公司 抑制荧光强度降低的成像试剂、试剂盒
CN115074425B (zh) * 2021-03-12 2026-04-21 郑州思昆生物工程有限公司 基于荧光的多循环核酸测序反应用成像试剂、试剂盒
CN115917006A (zh) * 2021-09-07 2023-04-04 深圳华大智造科技股份有限公司 一种用于分析靶多核苷酸的序列的方法
CA3230995A1 (en) * 2021-09-07 2023-03-16 Meihua Gong Method for analyzing sequence of target polynucleotide
KR20240089491A (ko) * 2021-10-11 2024-06-20 엠쥐아이 테크 컴퍼니 엘티디. 핵산 서열분석에서 사포닌 화합물의 용도
CN116926178B (zh) * 2022-04-02 2025-10-24 深圳市真迈生物科技有限公司 荧光检测试剂及其制备方法及应用
CN116334196A (zh) * 2022-08-12 2023-06-27 深圳赛陆医疗科技有限公司 一种优化的二代基因测序合成反应试剂
CN119095981A (zh) * 2022-09-09 2024-12-06 深圳华大智造科技股份有限公司 抗氧化剂组合物及其在核酸检测中的用途

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CN110121563A (zh) 2019-08-13
JP2020511955A (ja) 2020-04-23
EP3538093A1 (en) 2019-09-18
WO2018089231A1 (en) 2018-05-17
US11162129B2 (en) 2021-11-02
US20180127809A1 (en) 2018-05-10
EP3538093B1 (en) 2023-10-25
US20210403985A1 (en) 2021-12-30
EP3538093A4 (en) 2020-05-27

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