JP7063882B2 - 血液脳関門の超音波ガイド下開放 - Google Patents
血液脳関門の超音波ガイド下開放 Download PDFInfo
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- JP7063882B2 JP7063882B2 JP2019506422A JP2019506422A JP7063882B2 JP 7063882 B2 JP7063882 B2 JP 7063882B2 JP 2019506422 A JP2019506422 A JP 2019506422A JP 2019506422 A JP2019506422 A JP 2019506422A JP 7063882 B2 JP7063882 B2 JP 7063882B2
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022070338A JP7531542B2 (ja) | 2016-08-01 | 2022-04-21 | 血液脳関門の超音波ガイド下開放 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662369208P | 2016-08-01 | 2016-08-01 | |
| US62/369,208 | 2016-08-01 | ||
| PCT/US2017/044763 WO2018026738A1 (en) | 2016-08-01 | 2017-07-31 | Ultrasound guided opening of blood-brain barrier |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022070338A Division JP7531542B2 (ja) | 2016-08-01 | 2022-04-21 | 血液脳関門の超音波ガイド下開放 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524294A JP2019524294A (ja) | 2019-09-05 |
| JP2019524294A5 JP2019524294A5 (enExample) | 2020-09-10 |
| JP7063882B2 true JP7063882B2 (ja) | 2022-05-09 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506422A Active JP7063882B2 (ja) | 2016-08-01 | 2017-07-31 | 血液脳関門の超音波ガイド下開放 |
| JP2022070338A Active JP7531542B2 (ja) | 2016-08-01 | 2022-04-21 | 血液脳関門の超音波ガイド下開放 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022070338A Active JP7531542B2 (ja) | 2016-08-01 | 2022-04-21 | 血液脳関門の超音波ガイド下開放 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11534630B2 (enExample) |
| EP (1) | EP3487410B1 (enExample) |
| JP (2) | JP7063882B2 (enExample) |
| CN (1) | CN109688934A (enExample) |
| AU (2) | AU2017305228B2 (enExample) |
| WO (1) | WO2018026738A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3067610B1 (fr) * | 2017-06-19 | 2019-07-26 | Assistance Publique Hopitaux De Paris | Ensemble pour l'imagerie et/ou le traitement d'un tissu cerebral |
| WO2019055865A1 (en) * | 2017-09-14 | 2019-03-21 | Neural Analytics, Inc. | SYSTEMS AND METHODS FOR ALIGNING A HEADSET SYSTEM |
| EP3719164A4 (en) * | 2018-01-31 | 2020-10-07 | JFE Steel Corporation | FERRITE BASED STAINLESS STEEL |
| EP3549529A1 (en) * | 2018-04-05 | 2019-10-09 | Koninklijke Philips N.V. | Ultrasound imaging system and method |
| EP3801217A4 (en) | 2018-05-30 | 2022-07-20 | Zap Surgical Systems, Inc. | RADIOSURGICAL NEUROMODLATION CLOSE TO CRITICAL STRUCTURES |
| KR102141654B1 (ko) * | 2018-11-28 | 2020-08-05 | 재단법인 대구경북첨단의료산업진흥재단 | 송수신 듀얼 모드 집속 초음파 트랜스듀서 및 이를 이용한 미소기포 캐비테이션 이미지 가시화방법 |
| WO2020159888A1 (en) * | 2019-01-31 | 2020-08-06 | Synaptec Network, Inc. | Systems and methods for using low intensity ultrasonic transducer on the brain |
| JP7474773B2 (ja) | 2019-02-13 | 2024-04-25 | アルフェウス メディカル,インク. | 非侵襲的音響化学療法 |
| US11620789B2 (en) * | 2019-05-03 | 2023-04-04 | Novocure Gmbh | Methods, systems, and apparatuses for managing transducer array placement |
| US20220226471A1 (en) | 2019-05-29 | 2022-07-21 | Sonalasense,Inc. | Sonosensitization |
| CN110215601B (zh) * | 2019-06-14 | 2021-08-31 | 深圳先进技术研究院 | 一种血脑屏障开放的监测方法、系统及存储介质 |
| EP3804628A1 (en) * | 2019-10-07 | 2021-04-14 | Koninklijke Philips N.V. | Ultrasound interface unit and method |
| US20220392085A1 (en) * | 2019-09-24 | 2022-12-08 | Nuvasive, Inc. | Systems and methods for updating three-dimensional medical images using two-dimensional information |
| KR102247568B1 (ko) * | 2019-10-11 | 2021-05-04 | 재단법인 대구경북첨단의료산업진흥재단 | 집속초음파 조사 시스템 및 집속초음파를 이용한 혈액뇌장벽 개방 조절 방법 |
| CN111134776B (zh) | 2020-01-10 | 2025-08-08 | 深圳市奥昇医疗科技有限责任公司 | 高强度聚焦超声设备与控制方法 |
| EP4096527A4 (en) | 2020-01-27 | 2024-01-24 | Cordance Medical Inc. | ULTRASONIC TRANSDUCER ASSEMBLY |
| CN111729188B (zh) * | 2020-06-24 | 2023-07-14 | 南京超维景生物科技有限公司 | 超声引导的载药微泡递送方法及装置 |
| CA3185803A1 (en) | 2020-08-07 | 2022-02-10 | Vijay Agarwal | Ultrasound arrays for enhanced sonodynamic therapy for treating cancer |
| JP2024520222A (ja) | 2020-08-13 | 2024-05-23 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 画像診断アレイを使用した血液脳関門開放及びキャビテーションイメージングのためのシステム及び方法 |
| US11998393B2 (en) * | 2020-10-20 | 2024-06-04 | GE Precision Healthcare LLC | System and method of signal processing for ultrasound arrays with mechanically adjustable transducer shapes |
| CA3202517A1 (en) * | 2020-11-13 | 2022-05-19 | Decision Sciences Medical Company, LLC | Systems and methods for synthetic aperture ultrasound imaging of an object |
| IT202100003695A1 (it) * | 2021-02-17 | 2022-08-17 | Intelligenza Trasparente S R L | Sistema di trattamento ad ultrasuoni per l’encefalo |
| CN113057734A (zh) * | 2021-03-12 | 2021-07-02 | 上海微创医疗机器人(集团)股份有限公司 | 一种手术系统 |
| CN113205542A (zh) * | 2021-04-30 | 2021-08-03 | 深圳高性能医疗器械国家研究院有限公司 | 运用机器视觉的三维图像配准方法及血脑屏障开放装置 |
| KR102486573B1 (ko) * | 2021-12-08 | 2023-01-11 | (주)아이엠지티 | 뇌 질환용 초음파 영상 장치 및 이를 이용한 초음파 이미징 방법 |
| KR102486574B1 (ko) * | 2021-12-08 | 2023-01-11 | (주)아이엠지티 | 집속 초음파 장치 및 영상 트랜스듀서 보호 방법 |
| CA3255487A1 (en) * | 2022-05-26 | 2023-11-30 | Alpheus Medical Inc | ULTRASONIC NETWORKS FOR ENHANCED TISSUE THERAPY |
| CN119630347A (zh) * | 2022-07-07 | 2025-03-14 | 医视特有限公司 | 用于对使用不同成像模式获得的图像配准的系统和方法 |
| US20240042242A1 (en) | 2022-07-28 | 2024-02-08 | Cordance Medical Inc. | Rapid calculation of parameters for delivering ultrasound energy to selected locations in the brain |
| US12017093B2 (en) * | 2022-07-29 | 2024-06-25 | Cordance Medical Inc. | Methods and systems for confirming focus of ultrasound beams |
| WO2024047580A1 (en) * | 2022-08-31 | 2024-03-07 | Insightec Ltd. | Enforced tissue residency of payload molecules by acoustic disruption |
| KR102626932B1 (ko) * | 2023-01-03 | 2024-01-23 | 주식회사 뉴머스 | 환자 맞춤형 헬멧 및 이의 제조 방법 |
| CN117018481A (zh) * | 2023-03-31 | 2023-11-10 | 杭州市第一人民医院 | 个性化3d打印导板引导的聚焦超声介导的脑部药物递送系统及其递送方法 |
| US20250152975A1 (en) * | 2023-11-15 | 2025-05-15 | Cordance Medical Inc. | Determining ultrasound-based blood-brain barrier opening or increased permeability using physiologic signals |
| CN118614957B (zh) * | 2024-06-07 | 2025-01-24 | 天津大学 | 一种面向脑瘤切除术的术中结构功能同步成像装置 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004066856A1 (ja) | 2003-01-31 | 2004-08-12 | Hitachi Medical Corporation | 超音波プローブ及び超音波装置 |
| US20060241529A1 (en) | 2005-03-07 | 2006-10-26 | Kullervo Hynynen | Adaptive ultrasound delivery system |
| JP2008284144A (ja) | 2007-05-17 | 2008-11-27 | Hitachi Medical Corp | 超音波治療等におけるリファレンス像表示方法及び超音波装置 |
| JP2010500084A (ja) | 2006-08-11 | 2010-01-07 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 脳血流画像化、及びマイクロバブルを用いた血餅溶解をする超音波システム |
| WO2015092604A1 (en) | 2013-12-18 | 2015-06-25 | Koninklijke Philips N.V. | System and method for ultrasound and computed tomography image registration for sonothrombolysis treatment |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5797849A (en) * | 1995-03-28 | 1998-08-25 | Sonometrics Corporation | Method for carrying out a medical procedure using a three-dimensional tracking and imaging system |
| US6334846B1 (en) * | 1995-03-31 | 2002-01-01 | Kabushiki Kaisha Toshiba | Ultrasound therapeutic apparatus |
| US6612988B2 (en) | 2000-08-29 | 2003-09-02 | Brigham And Women's Hospital, Inc. | Ultrasound therapy |
| US8088067B2 (en) | 2002-12-23 | 2012-01-03 | Insightec Ltd. | Tissue aberration corrections in ultrasound therapy |
| US7699780B2 (en) * | 2004-08-11 | 2010-04-20 | Insightec—Image-Guided Treatment Ltd. | Focused ultrasound system with adaptive anatomical aperture shaping |
| US20060241438A1 (en) * | 2005-03-03 | 2006-10-26 | Chung-Yuo Wu | Method and related system for measuring intracranial pressure |
| US7680307B2 (en) * | 2005-04-05 | 2010-03-16 | Scimed Life Systems, Inc. | Systems and methods for image segmentation with a multi-stage classifier |
| WO2007012068A2 (en) * | 2005-07-20 | 2007-01-25 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Device for movement detection, movement correction and training |
| US7713200B1 (en) * | 2005-09-10 | 2010-05-11 | Sarvazyan Armen P | Wireless beacon for time-reversal acoustics, method of use and instrument containing thereof |
| US9114252B2 (en) * | 2005-12-02 | 2015-08-25 | University Of Rochester | Image-guided therapy delivery and diagnostic needle system |
| JP4807778B2 (ja) * | 2006-01-06 | 2011-11-02 | 国立大学法人大阪大学 | 超音波薬剤装置及び医用画像診断装置 |
| US20080004528A1 (en) | 2006-01-25 | 2008-01-03 | Fitzsimons Thomas P | Ultrasound medical system and methods |
| EP2015846A2 (en) * | 2006-04-24 | 2009-01-21 | Ekos Corporation | Ultrasound therapy system |
| US20100016707A1 (en) * | 2006-08-08 | 2010-01-21 | Keter Medical Ltd | Imaging system |
| WO2008044441A1 (fr) * | 2006-10-10 | 2008-04-17 | Hitachi Medical Corporation | appareil de diagnostic d'images médicales, procédé de mesure d'images médicales et programme de mesure d'images médicales |
| US20080183077A1 (en) | 2006-10-19 | 2008-07-31 | Siemens Corporate Research, Inc. | High intensity focused ultrasound path determination |
| US20100143241A1 (en) * | 2008-10-22 | 2010-06-10 | Johnson G Allan | Method and apparatus for delivery of agents across the blood brain barrier |
| CN101810913B (zh) | 2009-02-25 | 2013-03-27 | 西门子公司 | 一种超声换能器 |
| EP2403602A2 (en) | 2009-03-06 | 2012-01-11 | Mirabilis Medica Inc. | Ultrasound treatment and imaging applicator |
| JP2013503681A (ja) * | 2009-09-03 | 2013-02-04 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 対側アレイベースの経頭蓋超音波収差補正 |
| BR112012013691A8 (pt) | 2009-12-10 | 2017-11-07 | Dartmouth College | Método para segmentação automática e sistema |
| WO2011079177A1 (en) | 2009-12-22 | 2011-06-30 | The Trustees Of Columbia University In The City Of New York | A planning system for targeting tissue structures with ultrasound |
| CN101797424B (zh) | 2010-03-26 | 2012-03-21 | 深圳市一体医疗科技股份有限公司 | 用于治疗肿瘤的超声探头及治疗系统 |
| JP5851127B2 (ja) * | 2011-06-24 | 2016-02-03 | オリンパス株式会社 | 超音波照射装置及び超音波照射装置の作動方法 |
| EP2766051B1 (en) * | 2011-10-13 | 2019-12-04 | University Health Network | Porphyrin-phospholipid conjugate microbubbles and their use as contrast agents. |
| US9392992B2 (en) | 2012-02-28 | 2016-07-19 | Siemens Medical Solutions Usa, Inc. | High intensity focused ultrasound registration with imaging |
| EP2841161A1 (en) * | 2012-04-27 | 2015-03-04 | Medtronic Ardian Luxembourg S.à.r.l. | Ultrasound apparatuses, systems, and methods for renal neuromodulation |
| CN103479403B (zh) | 2012-06-08 | 2016-06-22 | 长庚大学 | 以手术导航系统导引聚焦式超声波释放能量的系统及其方法 |
| US11167154B2 (en) * | 2012-08-22 | 2021-11-09 | Medtronic, Inc. | Ultrasound diagnostic and therapy management system and associated method |
| RU2648226C2 (ru) * | 2012-12-17 | 2018-03-22 | Конинклейке Филипс Н.В. | Лучевая терапия с адаптивным расчетом дозы в реальном масштабе времени |
| CN105407969B (zh) * | 2013-06-28 | 2019-04-05 | 皇家飞利浦有限公司 | 用于图像引导超声溶栓的换能器放置和配准 |
| US10028723B2 (en) * | 2013-09-03 | 2018-07-24 | The Trustees Of Columbia University In The City Of New York | Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening |
| US20170065835A1 (en) * | 2014-02-28 | 2017-03-09 | Msp Co., Ltd | Helmet-type low-intensity focused ultrasound stimulation device and system |
| CN105435378B (zh) | 2014-06-13 | 2018-10-23 | 重庆海扶医疗科技股份有限公司 | 一种聚焦超声治疗系统 |
| EP2998932B1 (en) * | 2014-09-16 | 2021-01-27 | Esaote S.p.A. | Method and device for the acquisition of ultrasound images and for the fusion of such images with pre-acquired images |
| JP6384340B2 (ja) * | 2015-01-28 | 2018-09-05 | コニカミノルタ株式会社 | 超音波診断装置 |
| US10285593B2 (en) | 2015-04-24 | 2019-05-14 | Sunnybrook Research Institute | Method for registering pre-operative images of a subject to an ultrasound treatment space |
| CA3015001A1 (en) * | 2016-02-23 | 2017-08-31 | Sunnybrook Research Institute | Patient-specific headset for diagnostic and therapeutic transcranial procedures |
-
2017
- 2017-07-31 CN CN201780047574.6A patent/CN109688934A/zh active Pending
- 2017-07-31 AU AU2017305228A patent/AU2017305228B2/en active Active
- 2017-07-31 EP EP17837489.8A patent/EP3487410B1/en active Active
- 2017-07-31 WO PCT/US2017/044763 patent/WO2018026738A1/en not_active Ceased
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- 2022-09-30 AU AU2022241580A patent/AU2022241580B2/en active Active
- 2022-12-23 US US18/146,028 patent/US11857812B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004066856A1 (ja) | 2003-01-31 | 2004-08-12 | Hitachi Medical Corporation | 超音波プローブ及び超音波装置 |
| US20060241529A1 (en) | 2005-03-07 | 2006-10-26 | Kullervo Hynynen | Adaptive ultrasound delivery system |
| JP2010500084A (ja) | 2006-08-11 | 2010-01-07 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 脳血流画像化、及びマイクロバブルを用いた血餅溶解をする超音波システム |
| JP2008284144A (ja) | 2007-05-17 | 2008-11-27 | Hitachi Medical Corp | 超音波治療等におけるリファレンス像表示方法及び超音波装置 |
| WO2015092604A1 (en) | 2013-12-18 | 2015-06-25 | Koninklijke Philips N.V. | System and method for ultrasound and computed tomography image registration for sonothrombolysis treatment |
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| US11857812B2 (en) | 2024-01-02 |
| AU2022241580A1 (en) | 2022-11-17 |
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| EP3487410B1 (en) | 2025-02-12 |
| EP3487410A4 (en) | 2020-04-08 |
| JP2019524294A (ja) | 2019-09-05 |
| US20230128189A1 (en) | 2023-04-27 |
| US20190184204A1 (en) | 2019-06-20 |
| CN109688934A (zh) | 2019-04-26 |
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