AU2017305228B2 - Ultrasound guided opening of blood-brain barrier - Google Patents

Ultrasound guided opening of blood-brain barrier Download PDF

Info

Publication number
AU2017305228B2
AU2017305228B2 AU2017305228A AU2017305228A AU2017305228B2 AU 2017305228 B2 AU2017305228 B2 AU 2017305228B2 AU 2017305228 A AU2017305228 A AU 2017305228A AU 2017305228 A AU2017305228 A AU 2017305228A AU 2017305228 B2 AU2017305228 B2 AU 2017305228B2
Authority
AU
Australia
Prior art keywords
ultrasound
transducer
treatment
image
target region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017305228A
Other languages
English (en)
Other versions
AU2017305228A1 (en
Inventor
Bhaskar Ramamurthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cordance Medical Inc
Original Assignee
Cordance Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cordance Medical Inc filed Critical Cordance Medical Inc
Publication of AU2017305228A1 publication Critical patent/AU2017305228A1/en
Application granted granted Critical
Publication of AU2017305228B2 publication Critical patent/AU2017305228B2/en
Priority to AU2022241580A priority Critical patent/AU2022241580B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0808—Clinical applications for diagnosis of the brain
    • A61B8/0816—Clinical applications for diagnosis of the brain using echo-encephalography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13—Tomography
    • A61B8/14—Echo-tomography
    • A61B8/145—Echo-tomography characterised by scanning multiple planes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/4461—Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/46—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
    • A61B8/461—Displaying means of special interest
    • A61B8/466—Displaying means of special interest adapted to display 3D data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/46—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
    • A61B8/467—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient characterised by special input means
    • A61B8/469—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient characterised by special input means for selection of a region of interest
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5207—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
    • A61B8/5261—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image combining images from different diagnostic modalities, e.g. ultrasound and X-ray
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B9/00—Instruments for examination by percussion; Pleximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046—Tracking techniques
    • A61B2034/2063—Acoustic tracking systems, e.g. using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046—Tracking techniques
    • A61B2034/2065—Tracking using image or pattern recognition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0039—Ultrasound therapy using microbubbles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0052—Ultrasound therapy using the same transducer for therapy and imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0073—Ultrasound therapy using multiple frequencies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Computer Graphics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Surgical Instruments (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
AU2017305228A 2016-08-01 2017-07-31 Ultrasound guided opening of blood-brain barrier Active AU2017305228B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022241580A AU2022241580B2 (en) 2016-08-01 2022-09-30 Ultrasound guided opening of blood-brain barrier

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662369208P 2016-08-01 2016-08-01
US62/369,208 2016-08-01
PCT/US2017/044763 WO2018026738A1 (en) 2016-08-01 2017-07-31 Ultrasound guided opening of blood-brain barrier

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022241580A Division AU2022241580B2 (en) 2016-08-01 2022-09-30 Ultrasound guided opening of blood-brain barrier

Publications (2)

Publication Number Publication Date
AU2017305228A1 AU2017305228A1 (en) 2019-01-31
AU2017305228B2 true AU2017305228B2 (en) 2022-06-30

Family

ID=61073080

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017305228A Active AU2017305228B2 (en) 2016-08-01 2017-07-31 Ultrasound guided opening of blood-brain barrier
AU2022241580A Active AU2022241580B2 (en) 2016-08-01 2022-09-30 Ultrasound guided opening of blood-brain barrier

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022241580A Active AU2022241580B2 (en) 2016-08-01 2022-09-30 Ultrasound guided opening of blood-brain barrier

Country Status (6)

Country Link
US (2) US11534630B2 (enExample)
EP (1) EP3487410B1 (enExample)
JP (2) JP7063882B2 (enExample)
CN (1) CN109688934A (enExample)
AU (2) AU2017305228B2 (enExample)
WO (1) WO2018026738A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3067610B1 (fr) * 2017-06-19 2019-07-26 Assistance Publique Hopitaux De Paris Ensemble pour l'imagerie et/ou le traitement d'un tissu cerebral
WO2019055865A1 (en) * 2017-09-14 2019-03-21 Neural Analytics, Inc. SYSTEMS AND METHODS FOR ALIGNING A HEADSET SYSTEM
EP3719164A4 (en) * 2018-01-31 2020-10-07 JFE Steel Corporation FERRITE BASED STAINLESS STEEL
EP3549529A1 (en) * 2018-04-05 2019-10-09 Koninklijke Philips N.V. Ultrasound imaging system and method
EP3801217A4 (en) 2018-05-30 2022-07-20 Zap Surgical Systems, Inc. RADIOSURGICAL NEUROMODLATION CLOSE TO CRITICAL STRUCTURES
KR102141654B1 (ko) * 2018-11-28 2020-08-05 재단법인 대구경북첨단의료산업진흥재단 송수신 듀얼 모드 집속 초음파 트랜스듀서 및 이를 이용한 미소기포 캐비테이션 이미지 가시화방법
WO2020159888A1 (en) * 2019-01-31 2020-08-06 Synaptec Network, Inc. Systems and methods for using low intensity ultrasonic transducer on the brain
JP7474773B2 (ja) 2019-02-13 2024-04-25 アルフェウス メディカル，インク． 非侵襲的音響化学療法
US11620789B2 (en) * 2019-05-03 2023-04-04 Novocure Gmbh Methods, systems, and apparatuses for managing transducer array placement
US20220226471A1 (en) 2019-05-29 2022-07-21 Sonalasense,Inc. Sonosensitization
CN110215601B (zh) * 2019-06-14 2021-08-31 深圳先进技术研究院 一种血脑屏障开放的监测方法、系统及存储介质
EP3804628A1 (en) * 2019-10-07 2021-04-14 Koninklijke Philips N.V. Ultrasound interface unit and method
US20220392085A1 (en) * 2019-09-24 2022-12-08 Nuvasive, Inc. Systems and methods for updating three-dimensional medical images using two-dimensional information
KR102247568B1 (ko) * 2019-10-11 2021-05-04 재단법인 대구경북첨단의료산업진흥재단 집속초음파 조사 시스템 및 집속초음파를 이용한 혈액뇌장벽 개방 조절 방법
CN111134776B (zh) 2020-01-10 2025-08-08 深圳市奥昇医疗科技有限责任公司 高强度聚焦超声设备与控制方法
EP4096527A4 (en) 2020-01-27 2024-01-24 Cordance Medical Inc. ULTRASONIC TRANSDUCER ASSEMBLY
CN111729188B (zh) * 2020-06-24 2023-07-14 南京超维景生物科技有限公司 超声引导的载药微泡递送方法及装置
CA3185803A1 (en) 2020-08-07 2022-02-10 Vijay Agarwal Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
JP2024520222A (ja) 2020-08-13 2024-05-23 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 画像診断アレイを使用した血液脳関門開放及びキャビテーションイメージングのためのシステム及び方法
US11998393B2 (en) * 2020-10-20 2024-06-04 GE Precision Healthcare LLC System and method of signal processing for ultrasound arrays with mechanically adjustable transducer shapes
CA3202517A1 (en) * 2020-11-13 2022-05-19 Decision Sciences Medical Company, LLC Systems and methods for synthetic aperture ultrasound imaging of an object
IT202100003695A1 (it) * 2021-02-17 2022-08-17 Intelligenza Trasparente S R L Sistema di trattamento ad ultrasuoni per l’encefalo
CN113057734A (zh) * 2021-03-12 2021-07-02 上海微创医疗机器人（集团）股份有限公司 一种手术系统
CN113205542A (zh) * 2021-04-30 2021-08-03 深圳高性能医疗器械国家研究院有限公司 运用机器视觉的三维图像配准方法及血脑屏障开放装置
KR102486573B1 (ko) * 2021-12-08 2023-01-11 (주)아이엠지티 뇌 질환용 초음파 영상 장치 및 이를 이용한 초음파 이미징 방법
KR102486574B1 (ko) * 2021-12-08 2023-01-11 (주)아이엠지티 집속 초음파 장치 및 영상 트랜스듀서 보호 방법
CA3255487A1 (en) * 2022-05-26 2023-11-30 Alpheus Medical Inc ULTRASONIC NETWORKS FOR ENHANCED TISSUE THERAPY
CN119630347A (zh) * 2022-07-07 2025-03-14 医视特有限公司 用于对使用不同成像模式获得的图像配准的系统和方法
US20240042242A1 (en) 2022-07-28 2024-02-08 Cordance Medical Inc. Rapid calculation of parameters for delivering ultrasound energy to selected locations in the brain
US12017093B2 (en) * 2022-07-29 2024-06-25 Cordance Medical Inc. Methods and systems for confirming focus of ultrasound beams
WO2024047580A1 (en) * 2022-08-31 2024-03-07 Insightec Ltd. Enforced tissue residency of payload molecules by acoustic disruption
KR102626932B1 (ko) * 2023-01-03 2024-01-23 주식회사 뉴머스 환자 맞춤형 헬멧 및 이의 제조 방법
CN117018481A (zh) * 2023-03-31 2023-11-10 杭州市第一人民医院 个性化3d打印导板引导的聚焦超声介导的脑部药物递送系统及其递送方法
US20250152975A1 (en) * 2023-11-15 2025-05-15 Cordance Medical Inc. Determining ultrasound-based blood-brain barrier opening or increased permeability using physiologic signals
CN118614957B (zh) * 2024-06-07 2025-01-24 天津大学 一种面向脑瘤切除术的术中结构功能同步成像装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060241529A1 (en) * 2005-03-07 2006-10-26 Kullervo Hynynen Adaptive ultrasound delivery system

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5797849A (en) * 1995-03-28 1998-08-25 Sonometrics Corporation Method for carrying out a medical procedure using a three-dimensional tracking and imaging system
US6334846B1 (en) * 1995-03-31 2002-01-01 Kabushiki Kaisha Toshiba Ultrasound therapeutic apparatus
US6612988B2 (en) 2000-08-29 2003-09-02 Brigham And Women's Hospital, Inc. Ultrasound therapy
US8088067B2 (en) 2002-12-23 2012-01-03 Insightec Ltd. Tissue aberration corrections in ultrasound therapy
JP4543430B2 (ja) 2003-01-31 2010-09-15 株式会社日立メディコ 超音波プローブ及び超音波装置
US7699780B2 (en) * 2004-08-11 2010-04-20 Insightec—Image-Guided Treatment Ltd. Focused ultrasound system with adaptive anatomical aperture shaping
US20060241438A1 (en) * 2005-03-03 2006-10-26 Chung-Yuo Wu Method and related system for measuring intracranial pressure
US7680307B2 (en) * 2005-04-05 2010-03-16 Scimed Life Systems, Inc. Systems and methods for image segmentation with a multi-stage classifier
WO2007012068A2 (en) * 2005-07-20 2007-01-25 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Device for movement detection, movement correction and training
US7713200B1 (en) * 2005-09-10 2010-05-11 Sarvazyan Armen P Wireless beacon for time-reversal acoustics, method of use and instrument containing thereof
US9114252B2 (en) * 2005-12-02 2015-08-25 University Of Rochester Image-guided therapy delivery and diagnostic needle system
JP4807778B2 (ja) * 2006-01-06 2011-11-02 国立大学法人大阪大学 超音波薬剤装置及び医用画像診断装置
US20080004528A1 (en) 2006-01-25 2008-01-03 Fitzsimons Thomas P Ultrasound medical system and methods
EP2015846A2 (en) * 2006-04-24 2009-01-21 Ekos Corporation Ultrasound therapy system
US20100016707A1 (en) * 2006-08-08 2010-01-21 Keter Medical Ltd Imaging system
EP2051777B1 (en) * 2006-08-11 2019-01-16 Koninklijke Philips N.V. Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis
WO2008044441A1 (fr) * 2006-10-10 2008-04-17 Hitachi Medical Corporation appareil de diagnostic d'images médicales, procédé de mesure d'images médicales et programme de mesure d'images médicales
US20080183077A1 (en) 2006-10-19 2008-07-31 Siemens Corporate Research, Inc. High intensity focused ultrasound path determination
JP5273945B2 (ja) 2007-05-17 2013-08-28 株式会社日立メディコ 超音波治療等におけるリファレンス像表示方法及び超音波装置
US20100143241A1 (en) * 2008-10-22 2010-06-10 Johnson G Allan Method and apparatus for delivery of agents across the blood brain barrier
CN101810913B (zh) 2009-02-25 2013-03-27 西门子公司 一种超声换能器
EP2403602A2 (en) 2009-03-06 2012-01-11 Mirabilis Medica Inc. Ultrasound treatment and imaging applicator
JP2013503681A (ja) * 2009-09-03 2013-02-04 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 対側アレイベースの経頭蓋超音波収差補正
BR112012013691A8 (pt) 2009-12-10 2017-11-07 Dartmouth College Método para segmentação automática e sistema
WO2011079177A1 (en) 2009-12-22 2011-06-30 The Trustees Of Columbia University In The City Of New York A planning system for targeting tissue structures with ultrasound
CN101797424B (zh) 2010-03-26 2012-03-21 深圳市一体医疗科技股份有限公司 用于治疗肿瘤的超声探头及治疗系统
JP5851127B2 (ja) * 2011-06-24 2016-02-03 オリンパス株式会社 超音波照射装置及び超音波照射装置の作動方法
EP2766051B1 (en) * 2011-10-13 2019-12-04 University Health Network Porphyrin-phospholipid conjugate microbubbles and their use as contrast agents.
US9392992B2 (en) 2012-02-28 2016-07-19 Siemens Medical Solutions Usa, Inc. High intensity focused ultrasound registration with imaging
EP2841161A1 (en) * 2012-04-27 2015-03-04 Medtronic Ardian Luxembourg S.à.r.l. Ultrasound apparatuses, systems, and methods for renal neuromodulation
CN103479403B (zh) 2012-06-08 2016-06-22 长庚大学 以手术导航系统导引聚焦式超声波释放能量的系统及其方法
US11167154B2 (en) * 2012-08-22 2021-11-09 Medtronic, Inc. Ultrasound diagnostic and therapy management system and associated method
RU2648226C2 (ru) * 2012-12-17 2018-03-22 Конинклейке Филипс Н.В. Лучевая терапия с адаптивным расчетом дозы в реальном масштабе времени
CN105407969B (zh) * 2013-06-28 2019-04-05 皇家飞利浦有限公司 用于图像引导超声溶栓的换能器放置和配准
US10028723B2 (en) * 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
WO2015092604A1 (en) * 2013-12-18 2015-06-25 Koninklijke Philips N.V. System and method for ultrasound and computed tomography image registration for sonothrombolysis treatment
US20170065835A1 (en) * 2014-02-28 2017-03-09 Msp Co., Ltd Helmet-type low-intensity focused ultrasound stimulation device and system
CN105435378B (zh) 2014-06-13 2018-10-23 重庆海扶医疗科技股份有限公司 一种聚焦超声治疗系统
EP2998932B1 (en) * 2014-09-16 2021-01-27 Esaote S.p.A. Method and device for the acquisition of ultrasound images and for the fusion of such images with pre-acquired images
JP6384340B2 (ja) * 2015-01-28 2018-09-05 コニカミノルタ株式会社 超音波診断装置
US10285593B2 (en) 2015-04-24 2019-05-14 Sunnybrook Research Institute Method for registering pre-operative images of a subject to an ultrasound treatment space
CA3015001A1 (en) * 2016-02-23 2017-08-31 Sunnybrook Research Institute Patient-specific headset for diagnostic and therapeutic transcranial procedures

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060241529A1 (en) * 2005-03-07 2006-10-26 Kullervo Hynynen Adaptive ultrasound delivery system

Also Published As

Publication number Publication date
EP3487410A1 (en) 2019-05-29
US11857812B2 (en) 2024-01-02
AU2022241580A1 (en) 2022-11-17
AU2017305228A1 (en) 2019-01-31
US11534630B2 (en) 2022-12-27
WO2018026738A1 (en) 2018-02-08
WO2018026738A8 (en) 2018-05-03
JP2022097547A (ja) 2022-06-30
EP3487410C0 (en) 2025-02-12
JP7063882B2 (ja) 2022-05-09
JP7531542B2 (ja) 2024-08-09
AU2022241580B2 (en) 2024-05-09
EP3487410B1 (en) 2025-02-12
EP3487410A4 (en) 2020-04-08
JP2019524294A (ja) 2019-09-05
US20230128189A1 (en) 2023-04-27
US20190184204A1 (en) 2019-06-20
CN109688934A (zh) 2019-04-26

Similar Documents

Publication Publication Date Title
AU2022241580B2 (en) Ultrasound guided opening of blood-brain barrier
US20250057506A1 (en) Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
US6846290B2 (en) Ultrasound method and system
US8287471B2 (en) Medical treatment using an ultrasound phased array
CN105407969B (zh) 用于图像引导超声溶栓的换能器放置和配准
US11730452B2 (en) Systems and methods for regulating microbubbles in ultrasound procedures
US20110144544A1 (en) Ultrasound transducer assembly and methods of using
CN105828876A (zh) 用于超声溶栓处置的超声图像和计算机断层摄影图像配准的系统和方法
EP2509686A1 (en) Devices and methods for adipose tissue reduction and skin contour irregularity smoothing
JP6657266B2 (ja) 超音波誘導放射線治療システム
US20190329075A1 (en) Ultrasonic sonothrombolysis treatment planning
CN111920446B (zh) 使用超声增强医学治疗的系统
JP5117051B2 (ja) 超音波診断システム及びその方法
EP3200699B1 (en) Ultrasonic image guidance of radiation therapy procedures
JP4394945B2 (ja) 三次元組織移動計測装置及び超音波診断装置
JP4264543B2 (ja) 放射線治療システム
KR102244287B1 (ko) 신경을 감지하여 에너지를 조사하는 시술장치
WO2025141545A1 (en) Controller with pid logic for spectrogram-based control of blood-brain barrier opening

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)