JP7055802B2 - 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体 - Google Patents
正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体 Download PDFInfo
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- JP7055802B2 JP7055802B2 JP2019523710A JP2019523710A JP7055802B2 JP 7055802 B2 JP7055802 B2 JP 7055802B2 JP 2019523710 A JP2019523710 A JP 2019523710A JP 2019523710 A JP2019523710 A JP 2019523710A JP 7055802 B2 JP7055802 B2 JP 7055802B2
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- 239000004323 potassium nitrate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 238000011519 second-line treatment Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- 239000004317 sodium nitrate Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
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- WSNODXPBBALQOF-VEJSHDCNSA-N tafluprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(F)(F)COC1=CC=CC=C1 WSNODXPBBALQOF-VEJSHDCNSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
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- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
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- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| US62/419,153 | 2016-11-08 | ||
| PCT/EP2017/078486 WO2018087092A1 (en) | 2016-11-08 | 2017-11-07 | Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma |
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| JP2019534296A JP2019534296A (ja) | 2019-11-28 |
| JP2019534296A5 JP2019534296A5 (enExample) | 2020-12-10 |
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| JP6750473B2 (ja) * | 2016-11-22 | 2020-09-02 | 沖電気工業株式会社 | 自動取引装置及び自動取引システム |
| CN117979973A (zh) | 2021-09-20 | 2024-05-03 | 尼科斯股份有限公司 | 作为神经保护剂的释放一氧化氮的前列腺酰胺 |
| CA3195291A1 (en) * | 2022-04-13 | 2023-10-13 | Caravel Therapeutics, Inc. | Preservative-free ophthalmic pharmaceutical emulsion and its application |
| WO2024121867A1 (en) * | 2022-12-09 | 2024-06-13 | Sentiss Pharma Private Limited | Pharmaceutical composition for glaucoma and ocular hypertension |
Citations (1)
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| JP2007518716A (ja) | 2004-01-05 | 2007-07-12 | ニコックス，ソシエテ アノニム | プロスタグランヂンニトロオキシ誘導体 |
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| US4952581A (en) | 1987-04-03 | 1990-08-28 | The Trustees Of Columbia University In The City Of New York | Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure |
| ES2105333T3 (es) | 1992-10-13 | 1997-10-16 | Alcon Lab Inc | Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma. |
| IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| CA2613010A1 (en) | 2005-06-29 | 2007-01-04 | Pfizer Inc. | Fluoroprostaglandins nitroderivatives |
| WO2007000641A2 (en) | 2005-06-29 | 2007-01-04 | Pfizer Inc. | Prostaglandin derivatives |
| AR076731A1 (es) | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2007518716A (ja) | 2004-01-05 | 2007-07-12 | ニコックス，ソシエテ アノニム | プロスタグランヂンニトロオキシ誘導体 |
Non-Patent Citations (1)
| Title |
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| Clinical Ophthalmology，2016年，10，pp.2035-2050 |
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| BR112019009330A2 (pt) | 2019-07-30 |
| US20200179401A1 (en) | 2020-06-11 |
| MX2019005321A (es) | 2019-10-14 |
| KR20190104993A (ko) | 2019-09-11 |
| CA3043000A1 (en) | 2018-05-17 |
| JP2019534296A (ja) | 2019-11-28 |
| WO2018087092A1 (en) | 2018-05-17 |
| US11058691B2 (en) | 2021-07-13 |
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