KR20190104993A - 정상 안압 녹내장을 치료하기 위한 산화질소 방출 프로스타글란딘 유도체 - Google Patents
정상 안압 녹내장을 치료하기 위한 산화질소 방출 프로스타글란딘 유도체 Download PDFInfo
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- KR20190104993A KR20190104993A KR1020197016230A KR20197016230A KR20190104993A KR 20190104993 A KR20190104993 A KR 20190104993A KR 1020197016230 A KR1020197016230 A KR 1020197016230A KR 20197016230 A KR20197016230 A KR 20197016230A KR 20190104993 A KR20190104993 A KR 20190104993A
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- Prior art keywords
- compound
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- glaucoma
- pharmaceutically acceptable
- iop
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- Ceased
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
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| US201662419153P | 2016-11-08 | 2016-11-08 | |
| US62/419,153 | 2016-11-08 | ||
| PCT/EP2017/078486 WO2018087092A1 (en) | 2016-11-08 | 2017-11-07 | Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190104993A true KR20190104993A (ko) | 2019-09-11 |
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| JP (1) | JP7055802B2 (enExample) |
| KR (1) | KR20190104993A (enExample) |
| BR (1) | BR112019009330A2 (enExample) |
| CA (1) | CA3043000A1 (enExample) |
| MX (1) | MX2019005321A (enExample) |
| WO (1) | WO2018087092A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6750473B2 (ja) * | 2016-11-22 | 2020-09-02 | 沖電気工業株式会社 | 自動取引装置及び自動取引システム |
| CN117979973A (zh) | 2021-09-20 | 2024-05-03 | 尼科斯股份有限公司 | 作为神经保护剂的释放一氧化氮的前列腺酰胺 |
| CA3195291A1 (en) * | 2022-04-13 | 2023-10-13 | Caravel Therapeutics, Inc. | Preservative-free ophthalmic pharmaceutical emulsion and its application |
| WO2024121867A1 (en) * | 2022-12-09 | 2024-06-13 | Sentiss Pharma Private Limited | Pharmaceutical composition for glaucoma and ocular hypertension |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4952581A (en) | 1987-04-03 | 1990-08-28 | The Trustees Of Columbia University In The City Of New York | Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure |
| ES2105333T3 (es) | 1992-10-13 | 1997-10-16 | Alcon Lab Inc | Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma. |
| IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| KR100850133B1 (ko) * | 2004-01-05 | 2008-08-04 | 니콕스 에스. 에이. | 프로스타글란딘 나이트로옥시 유도체 |
| CA2613010A1 (en) | 2005-06-29 | 2007-01-04 | Pfizer Inc. | Fluoroprostaglandins nitroderivatives |
| WO2007000641A2 (en) | 2005-06-29 | 2007-01-04 | Pfizer Inc. | Prostaglandin derivatives |
| AR076731A1 (es) | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
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2017
- 2017-11-07 US US16/343,323 patent/US11058691B2/en active Active
- 2017-11-07 WO PCT/EP2017/078486 patent/WO2018087092A1/en not_active Ceased
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- 2017-11-07 CA CA3043000A patent/CA3043000A1/en active Pending
- 2017-11-07 MX MX2019005321A patent/MX2019005321A/es unknown
- 2017-11-07 KR KR1020197016230A patent/KR20190104993A/ko not_active Ceased
- 2017-11-07 BR BR112019009330A patent/BR112019009330A2/pt not_active Application Discontinuation
Also Published As
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| BR112019009330A2 (pt) | 2019-07-30 |
| US20200179401A1 (en) | 2020-06-11 |
| MX2019005321A (es) | 2019-10-14 |
| CA3043000A1 (en) | 2018-05-17 |
| JP2019534296A (ja) | 2019-11-28 |
| WO2018087092A1 (en) | 2018-05-17 |
| US11058691B2 (en) | 2021-07-13 |
| JP7055802B2 (ja) | 2022-04-18 |
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