JP7051106B2 - メラノコルチン－４受容体経路関連障害の治療方法 - Google Patents
メラノコルチン－４受容体経路関連障害の治療方法 Download PDFInfo
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/04—Anorexiants; Antiobesity agents
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
- C07K14/685—Alpha-melanotropin
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
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| PL3539551T3 (pl) | 2011-12-29 | 2022-02-21 | Rhythm Pharmaceuticals, Inc. | Sposób leczenia zaburzeń związanych z receptorem melanokortyny 4 u heterozygotycznych nosicieli |
| AR113885A1 (es) | 2017-11-15 | 2020-06-24 | Rhythm Pharmaceuticals Inc | Formulaciones de péptidos de liberación sostenida |
| US20210052551A1 (en) | 2018-02-20 | 2021-02-25 | Charite - Universitatsmedizin Berlin | MC4R Agonist Efficacy in Subjects with MC4R Deficiencies and Impaired NFAT Signaling |
| US20210221867A1 (en) | 2018-05-15 | 2021-07-22 | Novo Nordisk A/S | Compounds Capable of Binding to Melanocortin 4 Receptor |
| CN108841932B (zh) * | 2018-07-13 | 2021-03-12 | 东北农业大学 | 一种预示和鉴定鸡腹部脂肪量的分子标记方法及应用 |
| CA3181543A1 (en) * | 2020-05-04 | 2021-11-11 | Regeneron Pharmaceuticals, Inc. | Proprotein convertase subtilisin/kexin type 1 (pcsk1) variants and uses thereof |
| TW202228760A (zh) * | 2020-09-24 | 2022-08-01 | 美商律森製藥股份有限公司 | 治療黑素皮質素-4受體路徑相關病症之方法 |
| WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
| KR20250127061A (ko) * | 2022-11-18 | 2025-08-26 | 리듬 파마슈티컬즈, 인코포레이티드 | Mc4r 작용제를 이용한 비만 치료 방법 |
| WO2024155828A1 (en) * | 2023-01-18 | 2024-07-25 | Loma Linda University Health | Uses of aminopyridines in the management of weight and satiety |
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| PL3539551T3 (pl) * | 2011-12-29 | 2022-02-21 | Rhythm Pharmaceuticals, Inc. | Sposób leczenia zaburzeń związanych z receptorem melanokortyny 4 u heterozygotycznych nosicieli |
| EP2970389B1 (en) | 2013-03-15 | 2020-08-19 | Rhythm Pharmaceuticals, Inc. | Pharmaceutical compositions |
| FI3356386T3 (fi) * | 2015-09-30 | 2024-05-16 | Rhythm Pharmaceuticals Inc | Melanokortiini-4-reseptoripolkuun liittyvien häiriöiden hoitamismenetelmä |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014144260A1 (en) | 2013-03-15 | 2014-09-18 | Rhythm Metabolic, Inc. | Peptide compositions |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023078335A (ja) * | 2015-09-30 | 2023-06-06 | リズム ファーマシューティカルズ， インコーポレイテッド | メラノコルチン－４受容体経路関連障害の治療方法 |
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