CA3000673A1 - Method of treating melanocortin-4 receptor pathway-associated disorders - Google Patents

Method of treating melanocortin-4 receptor pathway-associated disorders Download PDF

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Publication number
CA3000673A1
CA3000673A1 CA3000673A CA3000673A CA3000673A1 CA 3000673 A1 CA3000673 A1 CA 3000673A1 CA 3000673 A CA3000673 A CA 3000673A CA 3000673 A CA3000673 A CA 3000673A CA 3000673 A1 CA3000673 A1 CA 3000673A1
Authority
CA
Canada
Prior art keywords
subject
mutation
arg
agonist
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3000673A
Other languages
English (en)
French (fr)
Inventor
Leonardus H.T. Van Der Ploeg
Bart Henderson
Peter KUHNEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Charite Universitaetsmedizin Berlin
Rhythm Pharmaceuticals Inc
Original Assignee
Charite Universitaetsmedizin Berlin
Rhythm Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charite Universitaetsmedizin Berlin, Rhythm Pharmaceuticals Inc filed Critical Charite Universitaetsmedizin Berlin
Publication of CA3000673A1 publication Critical patent/CA3000673A1/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68Melanocyte-stimulating hormone [MSH]
    • C07K14/685Alpha-melanotropin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3000673A 2015-09-30 2016-09-29 Method of treating melanocortin-4 receptor pathway-associated disorders Pending CA3000673A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562235003P 2015-09-30 2015-09-30
US62/235,003 2015-09-30
PCT/US2016/054457 WO2017059076A1 (en) 2015-09-30 2016-09-29 Method of treating melanocortin-4 receptor pathway-associated disorders

Publications (1)

Publication Number Publication Date
CA3000673A1 true CA3000673A1 (en) 2017-04-06

Family

ID=57138146

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3000673A Pending CA3000673A1 (en) 2015-09-30 2016-09-29 Method of treating melanocortin-4 receptor pathway-associated disorders
CA3000670A Pending CA3000670A1 (en) 2015-09-30 2016-09-29 Method of treating melanocortin-4 receptor pathway-associated disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3000670A Pending CA3000670A1 (en) 2015-09-30 2016-09-29 Method of treating melanocortin-4 receptor pathway-associated disorders

Country Status (20)

Country Link
US (5) US10960046B2 (enExample)
EP (4) EP3356386B1 (enExample)
JP (7) JP7051106B2 (enExample)
KR (1) KR20180063221A (enExample)
CN (2) CN108601816A (enExample)
AU (6) AU2016330772A1 (enExample)
BR (1) BR112018006674A2 (enExample)
CA (2) CA3000673A1 (enExample)
DK (1) DK3356386T3 (enExample)
ES (1) ES2985734T3 (enExample)
FI (1) FI3356386T3 (enExample)
HK (1) HK1259424A1 (enExample)
IL (3) IL299541A (enExample)
MA (2) MA43038A (enExample)
MX (2) MX2018003983A (enExample)
PL (1) PL3356386T3 (enExample)
PT (1) PT3356386T (enExample)
SG (1) SG10202101510XA (enExample)
WO (2) WO2017059075A1 (enExample)
ZA (1) ZA201802704B (enExample)

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DK3356386T3 (da) * 2015-09-30 2024-05-21 Rhythm Pharmaceuticals Inc Fremgangsmåde til behandling af melanocortin-4 receptorbane-associerede lidelser
SG11202004373RA (en) * 2017-11-15 2020-06-29 Rhythm Pharmaceuticals Inc Sustained release peptide formulations
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CN108841932B (zh) * 2018-07-13 2021-03-12 东北农业大学 一种预示和鉴定鸡腹部脂肪量的分子标记方法及应用
CA3181543A1 (en) * 2020-05-04 2021-11-11 Regeneron Pharmaceuticals, Inc. Proprotein convertase subtilisin/kexin type 1 (pcsk1) variants and uses thereof
KR20230095956A (ko) * 2020-09-24 2023-06-29 리듬 파마슈티컬즈, 인코포레이티드 멜라노코르틴-4 수용체 경로 관련 장애를 치료하는 방법
WO2024083843A1 (en) 2022-10-18 2024-04-25 Confo Therapeutics N.V. Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders
KR20250127061A (ko) * 2022-11-18 2025-08-26 리듬 파마슈티컬즈, 인코포레이티드 Mc4r 작용제를 이용한 비만 치료 방법
WO2024155828A1 (en) * 2023-01-18 2024-07-25 Loma Linda University Health Uses of aminopyridines in the management of weight and satiety
CN117143183B (zh) * 2023-08-25 2024-08-16 广州益养生物科技有限公司 一种三肽、三肽盐或衍生物及其应用

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Also Published As

Publication number Publication date
IL299541A (en) 2023-02-01
IL289996B1 (en) 2023-03-01
MX2018003983A (es) 2018-11-09
US20210169970A1 (en) 2021-06-10
AU2022279420A1 (en) 2023-01-19
PL3356386T3 (pl) 2024-08-05
EP4029513A1 (en) 2022-07-20
ZA201802704B (en) 2024-08-28
US20180215790A1 (en) 2018-08-02
EP3356386B1 (en) 2024-02-14
CN108601816A (zh) 2018-09-28
EP4360704A3 (en) 2024-07-24
CN108431023A (zh) 2018-08-21
US10960046B2 (en) 2021-03-30
AU2016330772A1 (en) 2018-04-19
WO2017059076A8 (en) 2018-04-26
JP2022173426A (ja) 2022-11-18
US20220226425A1 (en) 2022-07-21
DK3356386T3 (da) 2024-05-21
KR20180063221A (ko) 2018-06-11
WO2017059076A1 (en) 2017-04-06
JP2021088611A (ja) 2021-06-10
JP2018531937A (ja) 2018-11-01
AU2023229494A1 (en) 2023-09-28
EP3356386A1 (en) 2018-08-08
JP6940853B2 (ja) 2021-09-29
ES2985734T3 (es) 2024-11-07
IL258412B2 (en) 2023-06-01
WO2017059075A1 (en) 2017-04-06
BR112018006674A2 (en) 2018-10-09
JP2025019234A (ja) 2025-02-06
IL289996B2 (en) 2023-07-01
US12263202B2 (en) 2025-04-01
FI3356386T3 (fi) 2024-05-16
JP2021102650A (ja) 2021-07-15
AU2016330773A1 (en) 2018-04-19
AU2021201448A1 (en) 2021-03-25
AU2022279420B2 (en) 2024-09-19
SG10202101510XA (en) 2021-03-30
JP2023078335A (ja) 2023-06-06
IL258412A (en) 2018-05-31
CN108431023B (zh) 2022-11-04
MA43040A (fr) 2018-08-08
JP2018531938A (ja) 2018-11-01
CA3000670A1 (en) 2017-04-06
AU2024278597A1 (en) 2025-01-16
EP3355905A1 (en) 2018-08-08
IL289996A (en) 2022-03-01
PT3356386T (pt) 2024-05-17
EP4360704A2 (en) 2024-05-01
JP7752373B2 (ja) 2025-10-10
MA43038A (fr) 2018-08-08
MX2023003358A (es) 2023-03-29
HK1259424A1 (zh) 2019-11-29
JP7051106B2 (ja) 2022-04-11
US20180311309A1 (en) 2018-11-01
US20250195606A1 (en) 2025-06-19

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