IL299541A - Melanocortin-4 receptor (MC4R) agonists for use in the treatment of disorders associated with melanocortin-4 receptor pathways - Google Patents
Melanocortin-4 receptor (MC4R) agonists for use in the treatment of disorders associated with melanocortin-4 receptor pathwaysInfo
- Publication number
- IL299541A IL299541A IL299541A IL29954122A IL299541A IL 299541 A IL299541 A IL 299541A IL 299541 A IL299541 A IL 299541A IL 29954122 A IL29954122 A IL 29954122A IL 299541 A IL299541 A IL 299541A
- Authority
- IL
- Israel
- Prior art keywords
- subject
- mutation
- arg
- agonist
- gene
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
- C07K14/685—Alpha-melanotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Cell Biology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562235003P | 2015-09-30 | 2015-09-30 | |
| PCT/US2016/054457 WO2017059076A1 (en) | 2015-09-30 | 2016-09-29 | Method of treating melanocortin-4 receptor pathway-associated disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL299541A true IL299541A (en) | 2023-02-01 |
Family
ID=57138146
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL299541A IL299541A (en) | 2015-09-30 | 2016-09-29 | Melanocortin-4 receptor (MC4R) agonists for use in the treatment of disorders associated with melanocortin-4 receptor pathways |
| IL258412A IL258412B2 (en) | 2015-09-30 | 2018-03-27 | Melanocortin-4 receptor (mc4r) agonists for use in the treatment of disorders associated with the melanocortin-4 receptor pathway |
| IL289996A IL289996B2 (en) | 2015-09-30 | 2022-01-20 | Melanocortin-4 receptor (mc4r) agonists for use in the treatment of disorders associated with melanocortin-4 receptor pathways |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL258412A IL258412B2 (en) | 2015-09-30 | 2018-03-27 | Melanocortin-4 receptor (mc4r) agonists for use in the treatment of disorders associated with the melanocortin-4 receptor pathway |
| IL289996A IL289996B2 (en) | 2015-09-30 | 2022-01-20 | Melanocortin-4 receptor (mc4r) agonists for use in the treatment of disorders associated with melanocortin-4 receptor pathways |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US10960046B2 (enExample) |
| EP (4) | EP4360704A3 (enExample) |
| JP (7) | JP7051106B2 (enExample) |
| KR (1) | KR20180063221A (enExample) |
| CN (2) | CN108601816A (enExample) |
| AU (6) | AU2016330773A1 (enExample) |
| BR (1) | BR112018006674A2 (enExample) |
| CA (2) | CA3000673A1 (enExample) |
| DK (1) | DK3356386T3 (enExample) |
| ES (1) | ES2985734T3 (enExample) |
| FI (1) | FI3356386T3 (enExample) |
| HK (1) | HK1259424A1 (enExample) |
| IL (3) | IL299541A (enExample) |
| MA (2) | MA43040A (enExample) |
| MX (2) | MX2018003983A (enExample) |
| PL (1) | PL3356386T3 (enExample) |
| PT (1) | PT3356386T (enExample) |
| SG (1) | SG10202101510XA (enExample) |
| WO (2) | WO2017059075A1 (enExample) |
| ZA (1) | ZA201802704B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3988108A1 (en) | 2011-12-29 | 2022-04-27 | Rhythm Pharmaceuticals, Inc. | Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers |
| US10960046B2 (en) * | 2015-09-30 | 2021-03-30 | Rhythm Pharmaceuticals, Inc. | Method of treating melanocortin-4 receptor pathway-associated disorders |
| TW201922278A (zh) * | 2017-11-15 | 2019-06-16 | 美商律森製藥股份有限公司 | 持續釋放之胜肽調配物 |
| CA3090966A1 (en) | 2018-02-20 | 2019-08-29 | Charite - Universitatsmedizin Berlin | Mc4r agonist efficacy in subjects with mc4r deficiencies and impaired nfat signaling |
| US20210221867A1 (en) | 2018-05-15 | 2021-07-22 | Novo Nordisk A/S | Compounds Capable of Binding to Melanocortin 4 Receptor |
| CN108841932B (zh) * | 2018-07-13 | 2021-03-12 | 东北农业大学 | 一种预示和鉴定鸡腹部脂肪量的分子标记方法及应用 |
| CA3181543A1 (en) * | 2020-05-04 | 2021-11-11 | Regeneron Pharmaceuticals, Inc. | Proprotein convertase subtilisin/kexin type 1 (pcsk1) variants and uses thereof |
| JP2023542985A (ja) * | 2020-09-24 | 2023-10-12 | リズム ファーマシューティカルズ， インコーポレイテッド | メラノコルチン－４受容体経路関連障害の治療方法 |
| WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
| IL320947A (en) * | 2022-11-18 | 2025-07-01 | Rhythm Pharmaceuticals Inc | Methods for treating obesity with an mc4r agonist |
| WO2024155828A1 (en) * | 2023-01-18 | 2024-07-25 | Loma Linda University Health | Uses of aminopyridines in the management of weight and satiety |
| CN117143183B (zh) * | 2023-08-25 | 2024-08-16 | 广州益养生物科技有限公司 | 一种三肽、三肽盐或衍生物及其应用 |
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| EP3988108A1 (en) * | 2011-12-29 | 2022-04-27 | Rhythm Pharmaceuticals, Inc. | Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers |
| TR201815173T4 (tr) * | 2013-03-15 | 2018-11-21 | Rhythm Pharmaceuticals Inc | Peptit bileşimleri. |
| ES2825076T3 (es) * | 2013-03-15 | 2021-05-14 | Rhythm Pharmaceuticals Inc | Composiciones farmacéuticas |
| US10960046B2 (en) | 2015-09-30 | 2021-03-30 | Rhythm Pharmaceuticals, Inc. | Method of treating melanocortin-4 receptor pathway-associated disorders |
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2016
- 2016-09-29 US US15/764,725 patent/US10960046B2/en active Active
- 2016-09-29 FI FIEP16782150.3T patent/FI3356386T3/fi active
- 2016-09-29 JP JP2018517274A patent/JP7051106B2/ja active Active
- 2016-09-29 MA MA043040A patent/MA43040A/fr unknown
- 2016-09-29 US US15/764,730 patent/US20180215790A1/en active Pending
- 2016-09-29 WO PCT/US2016/054455 patent/WO2017059075A1/en not_active Ceased
- 2016-09-29 WO PCT/US2016/054457 patent/WO2017059076A1/en not_active Ceased
- 2016-09-29 PT PT167821503T patent/PT3356386T/pt unknown
- 2016-09-29 EP EP24150717.7A patent/EP4360704A3/en active Pending
- 2016-09-29 SG SG10202101510XA patent/SG10202101510XA/en unknown
- 2016-09-29 ES ES16782150T patent/ES2985734T3/es active Active
- 2016-09-29 CA CA3000673A patent/CA3000673A1/en active Pending
- 2016-09-29 PL PL16782150.3T patent/PL3356386T3/pl unknown
- 2016-09-29 AU AU2016330773A patent/AU2016330773A1/en not_active Abandoned
- 2016-09-29 IL IL299541A patent/IL299541A/en unknown
- 2016-09-29 EP EP21204226.1A patent/EP4029513A1/en active Pending
- 2016-09-29 CN CN201680064771.4A patent/CN108601816A/zh active Pending
- 2016-09-29 BR BR112018006674-5A patent/BR112018006674A2/en active Search and Examination
- 2016-09-29 MA MA043038A patent/MA43038A/fr unknown
- 2016-09-29 CA CA3000670A patent/CA3000670A1/en active Pending
- 2016-09-29 HK HK19101826.7A patent/HK1259424A1/zh unknown
- 2016-09-29 AU AU2016330772A patent/AU2016330772A1/en not_active Abandoned
- 2016-09-29 CN CN201680057324.6A patent/CN108431023B/zh active Active
- 2016-09-29 JP JP2018517270A patent/JP6940853B2/ja active Active
- 2016-09-29 EP EP16782150.3A patent/EP3356386B1/en active Active
- 2016-09-29 MX MX2018003983A patent/MX2018003983A/es unknown
- 2016-09-29 EP EP16782343.4A patent/EP3355905A1/en not_active Withdrawn
- 2016-09-29 DK DK16782150.3T patent/DK3356386T3/da active
- 2016-09-29 KR KR1020187012330A patent/KR20180063221A/ko active Pending
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2018
- 2018-03-27 IL IL258412A patent/IL258412B2/en unknown
- 2018-03-28 MX MX2023003358A patent/MX2023003358A/es unknown
- 2018-04-23 ZA ZA2018/02704A patent/ZA201802704B/en unknown
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2021
- 2021-02-09 US US17/171,563 patent/US12263202B2/en active Active
- 2021-03-05 AU AU2021201448A patent/AU2021201448A1/en not_active Abandoned
- 2021-03-15 JP JP2021041611A patent/JP2021088611A/ja active Pending
- 2021-04-06 JP JP2021064764A patent/JP7752373B2/ja active Active
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2022
- 2022-01-20 IL IL289996A patent/IL289996B2/en unknown
- 2022-04-04 US US17/712,752 patent/US20220226425A1/en active Pending
- 2022-09-28 JP JP2022155051A patent/JP2022173426A/ja active Pending
- 2022-11-29 AU AU2022279420A patent/AU2022279420B2/en active Active
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