CN108431023B - 治疗黑皮质素-4受体途径相关病症的方法 - Google Patents

治疗黑皮质素-4受体途径相关病症的方法 Download PDF

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Publication number
CN108431023B
CN108431023B CN201680057324.6A CN201680057324A CN108431023B CN 108431023 B CN108431023 B CN 108431023B CN 201680057324 A CN201680057324 A CN 201680057324A CN 108431023 B CN108431023 B CN 108431023B
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CN108431023A (zh
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S.夏尔马
L.H.T.V.D.普勒格
B.亨德森
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RHYTHM METABOLIC Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • C07K14/685—Alpha-melanotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cell Biology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
CN201680057324.6A 2015-09-30 2016-09-29 治疗黑皮质素-4受体途径相关病症的方法 Active CN108431023B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562235003P 2015-09-30 2015-09-30
US62/235,003 2015-09-30
PCT/US2016/054455 WO2017059075A1 (en) 2015-09-30 2016-09-29 Method of treating melanocortin-4 receptor pathway-associated disorders

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CN108431023A CN108431023A (zh) 2018-08-21
CN108431023B true CN108431023B (zh) 2022-11-04

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CN201680064771.4A Pending CN108601816A (zh) 2015-09-30 2016-09-29 治疗黑皮质素-4受体路径相关联病症的方法
CN201680057324.6A Active CN108431023B (zh) 2015-09-30 2016-09-29 治疗黑皮质素-4受体途径相关病症的方法

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EP (4) EP4360704A3 (enExample)
JP (7) JP6940853B2 (enExample)
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CN (2) CN108601816A (enExample)
AU (6) AU2016330772A1 (enExample)
BR (1) BR112018006674A2 (enExample)
CA (2) CA3000673A1 (enExample)
DK (1) DK3356386T3 (enExample)
ES (1) ES2985734T3 (enExample)
FI (1) FI3356386T3 (enExample)
HK (1) HK1259424A1 (enExample)
IL (3) IL299541A (enExample)
MA (2) MA43040A (enExample)
MX (2) MX2018003983A (enExample)
PL (1) PL3356386T3 (enExample)
PT (1) PT3356386T (enExample)
SG (1) SG10202101510XA (enExample)
WO (2) WO2017059075A1 (enExample)
ZA (1) ZA201802704B (enExample)

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US20210052551A1 (en) 2018-02-20 2021-02-25 Charite - Universitatsmedizin Berlin MC4R Agonist Efficacy in Subjects with MC4R Deficiencies and Impaired NFAT Signaling
US20210221867A1 (en) 2018-05-15 2021-07-22 Novo Nordisk A/S Compounds Capable of Binding to Melanocortin 4 Receptor
CN108841932B (zh) * 2018-07-13 2021-03-12 东北农业大学 一种预示和鉴定鸡腹部脂肪量的分子标记方法及应用
AU2021268327A1 (en) * 2020-05-04 2022-12-15 Regeneron Pharmaceuticals, Inc. Proprotein convertase subtilisin/kexin type 1 (PCSK1) variants and uses thereof
AR123603A1 (es) * 2020-09-24 2022-12-21 Rhythm Pharmaceuticals Inc Métodos de tratamiento de los trastornos asociados a la vía del receptor de melanocortina
WO2024083843A1 (en) 2022-10-18 2024-04-25 Confo Therapeutics N.V. Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders
IL320947A (en) * 2022-11-18 2025-07-01 Rhythm Pharmaceuticals Inc Methods for treating obesity with an mc4r agonist
WO2024155828A1 (en) * 2023-01-18 2024-07-25 Loma Linda University Health Uses of aminopyridines in the management of weight and satiety
CN117143183B (zh) * 2023-08-25 2024-08-16 广州益养生物科技有限公司 一种三肽、三肽盐或衍生物及其应用

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EP3355905A1 (en) 2018-08-08
SG10202101510XA (en) 2021-03-30
AU2024278597A1 (en) 2025-01-16
WO2017059075A1 (en) 2017-04-06
BR112018006674A2 (en) 2018-10-09
JP2021088611A (ja) 2021-06-10
FI3356386T3 (fi) 2024-05-16
IL289996B1 (en) 2023-03-01
AU2021201448A1 (en) 2021-03-25
HK1259424A1 (zh) 2019-11-29
IL289996A (en) 2022-03-01
US20180311309A1 (en) 2018-11-01
AU2022279420A1 (en) 2023-01-19
AU2016330773A1 (en) 2018-04-19
JP7051106B2 (ja) 2022-04-11
CA3000673A1 (en) 2017-04-06
EP4029513A1 (en) 2022-07-20
CN108601816A (zh) 2018-09-28
JP2018531937A (ja) 2018-11-01
EP3356386A1 (en) 2018-08-08
US20210169970A1 (en) 2021-06-10
MX2023003358A (es) 2023-03-29
JP7752373B2 (ja) 2025-10-10
IL299541A (en) 2023-02-01
IL289996B2 (en) 2023-07-01
US20250195606A1 (en) 2025-06-19
EP3356386B1 (en) 2024-02-14
US20220226425A1 (en) 2022-07-21
EP4360704A2 (en) 2024-05-01
JP2021102650A (ja) 2021-07-15
ZA201802704B (en) 2024-08-28
JP2022173426A (ja) 2022-11-18
AU2023229494A1 (en) 2023-09-28
PL3356386T3 (pl) 2024-08-05
US12263202B2 (en) 2025-04-01
IL258412A (en) 2018-05-31
IL258412B2 (en) 2023-06-01
AU2016330772A1 (en) 2018-04-19
MX2018003983A (es) 2018-11-09
US10960046B2 (en) 2021-03-30
US20180215790A1 (en) 2018-08-02
ES2985734T3 (es) 2024-11-07
JP6940853B2 (ja) 2021-09-29
JP2025019234A (ja) 2025-02-06
PT3356386T (pt) 2024-05-17
EP4360704A3 (en) 2024-07-24
MA43040A (fr) 2018-08-08
CN108431023A (zh) 2018-08-21
KR20180063221A (ko) 2018-06-11
WO2017059076A1 (en) 2017-04-06
JP2023078335A (ja) 2023-06-06
CA3000670A1 (en) 2017-04-06
JP2018531938A (ja) 2018-11-01
MA43038A (fr) 2018-08-08
DK3356386T3 (da) 2024-05-21
AU2022279420B2 (en) 2024-09-19
WO2017059076A8 (en) 2018-04-26

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