JP7038712B2 - ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤のｅ３リガーゼリガンドとのコンジュゲーションによるｂｔｋの分解および使用法 - Google Patents

ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤のｅ３リガーゼリガンドとのコンジュゲーションによるｂｔｋの分解および使用法 Download PDF

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JP7038712B2
JP7038712B2 JP2019527335A JP2019527335A JP7038712B2 JP 7038712 B2 JP7038712 B2 JP 7038712B2 JP 2019527335 A JP2019527335 A JP 2019527335A JP 2019527335 A JP2019527335 A JP 2019527335A JP 7038712 B2 JP7038712 B2 JP 7038712B2
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ナサナエル エス． グレイ
デニス ドブロボルスキー
ハイ－ツァン ファン
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デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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JP2019527335A 2016-11-22 2017-11-22 ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤のｅ３リガーゼリガンドとのコンジュゲーションによるｂｔｋの分解および使用法 Active JP7038712B2 (ja)

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US201662425204P 2016-11-22 2016-11-22
US62/425,204 2016-11-22
PCT/US2017/063011 WO2018098275A1 (en) 2016-11-22 2017-11-22 Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use

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JP2019535744A5 JP2019535744A5 (enExample) 2020-12-24
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AU (1) AU2017363252B2 (enExample)
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JP2021512059A (ja) * 2018-01-29 2021-05-13 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤のｅ３リガーゼリガンドとのコンジュゲーションによるｂｔｋの分解および使用方法

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AU2017363252A1 (en) 2019-05-16
US20190262458A1 (en) 2019-08-29
EP3544975B1 (en) 2022-01-05
WO2018098275A1 (en) 2018-05-31
AU2017363252B2 (en) 2021-08-19
JP2019535744A (ja) 2019-12-12
KR102566109B1 (ko) 2023-08-10
EP3544975A1 (en) 2019-10-02
KR20190077595A (ko) 2019-07-03
US10842878B2 (en) 2020-11-24
EP3544975A4 (en) 2020-07-01

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