JP7033549B2 - 細胞に基づくネオ抗原ワクチンおよびその使用 - Google Patents

細胞に基づくネオ抗原ワクチンおよびその使用 Download PDF

Info

Publication number
JP7033549B2
JP7033549B2 JP2018557312A JP2018557312A JP7033549B2 JP 7033549 B2 JP7033549 B2 JP 7033549B2 JP 2018557312 A JP2018557312 A JP 2018557312A JP 2018557312 A JP2018557312 A JP 2018557312A JP 7033549 B2 JP7033549 B2 JP 7033549B2
Authority
JP
Japan
Prior art keywords
cell
cells
cancer
neoantigen
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018557312A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019514393A5 (enExample
JP2019514393A (ja
Inventor
スタンリー アール. リデル,
ジョシュア ヴィーチ,
Original Assignee
フレッド ハッチンソン キャンサー リサーチ センター
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フレッド ハッチンソン キャンサー リサーチ センター filed Critical フレッド ハッチンソン キャンサー リサーチ センター
Publication of JP2019514393A publication Critical patent/JP2019514393A/ja
Publication of JP2019514393A5 publication Critical patent/JP2019514393A5/ja
Priority to JP2022029582A priority Critical patent/JP2022091750A/ja
Application granted granted Critical
Publication of JP7033549B2 publication Critical patent/JP7033549B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/19Dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32T-cell receptors [TCR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4201Neoantigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255Salmonella (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5434IL-12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • A61K2039/55527Interleukins
    • A61K2039/55533IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • A61K2039/55527Interleukins
    • A61K2039/55538IL-12
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2018557312A 2016-05-04 2017-05-04 細胞に基づくネオ抗原ワクチンおよびその使用 Active JP7033549B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022029582A JP2022091750A (ja) 2016-05-04 2022-02-28 細胞に基づくネオ抗原ワクチンおよびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662331906P 2016-05-04 2016-05-04
US62/331,906 2016-05-04
PCT/US2017/031171 WO2017192924A1 (en) 2016-05-04 2017-05-04 Cell-based neoantigen vaccines and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022029582A Division JP2022091750A (ja) 2016-05-04 2022-02-28 細胞に基づくネオ抗原ワクチンおよびその使用

Publications (3)

Publication Number Publication Date
JP2019514393A JP2019514393A (ja) 2019-06-06
JP2019514393A5 JP2019514393A5 (enExample) 2020-06-11
JP7033549B2 true JP7033549B2 (ja) 2022-03-10

Family

ID=58739362

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018557312A Active JP7033549B2 (ja) 2016-05-04 2017-05-04 細胞に基づくネオ抗原ワクチンおよびその使用
JP2022029582A Pending JP2022091750A (ja) 2016-05-04 2022-02-28 細胞に基づくネオ抗原ワクチンおよびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022029582A Pending JP2022091750A (ja) 2016-05-04 2022-02-28 細胞に基づくネオ抗原ワクチンおよびその使用

Country Status (5)

Country Link
US (1) US11723962B2 (enExample)
EP (1) EP3452082A1 (enExample)
JP (2) JP7033549B2 (enExample)
CA (1) CA3022267A1 (enExample)
WO (1) WO2017192924A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11278570B2 (en) 2016-12-16 2022-03-22 B-Mogen Biotechnologies, Inc. Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
KR102523318B1 (ko) 2016-12-16 2023-04-18 비-모젠 바이오테크놀로지스, 인크. 증진된 hAT 패밀리 트랜스포존 매개 유전자 전달 및 연관된 조성물, 시스템, 및 방법
EP3612632A2 (en) 2017-04-18 2020-02-26 Yale University A platform for t lymphocyte genome engineering and in vivo high-throughput screening thereof
CA3062591A1 (en) 2017-05-08 2018-11-15 Gritstone Oncology, Inc. Alphavirus neoantigen vectors
WO2019086711A1 (en) * 2017-11-06 2019-05-09 Ludwig Institute For Cancer Research Ltd Method for expansion of lymphocytes
EP3706770A4 (en) * 2017-11-07 2021-10-27 Nektar Therapeutics IMMUNOTHERAPEUTIC COMBINATION FOR THE TREATMENT OF CANCER
EP3743083A4 (en) * 2018-01-23 2021-11-03 Vanderbilt University SELF-ANTIGEN SPECIFIC T-LYMPHOCYTES AS VACCINES TO INCREASE ENGINEERING AND STABILITY OF AUTOLOGOUS TRANSFER
WO2019173441A1 (en) * 2018-03-06 2019-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of preparing populations of cells and retroviral reagents for adoptive cell immunotherapy
EP3781678A4 (en) * 2018-04-18 2022-06-01 Yale University Compositions and methods for multiplexed tumor vaccination with endogenous gene activation
WO2020036646A2 (en) * 2018-04-25 2020-02-20 The Methodist Hospital System Cancer neoantigens and their utilities in cancer vaccines and tcr-based cancer immunotherapy
TW202000906A (zh) * 2018-05-23 2020-01-01 美商葛利史東腫瘤科技公司 免疫檢查點抑制劑共表現載體
MX2020012649A (es) * 2018-05-25 2021-07-02 The Wistar Inst Neoantígenos especificos de tumor y métodos de uso de estos.
EP3810764A2 (en) 2018-06-21 2021-04-28 B-Mogen Biotechnologies, Inc. Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods
JP2021534752A (ja) 2018-08-22 2021-12-16 フレッド ハッチンソン キャンサー リサーチ センター Kras抗原またはher2抗原を標的とする免疫療法
WO2020097530A2 (en) 2018-11-09 2020-05-14 Fred Hutchinson Cancer Research Center Immunotherapy targeting mesothelin
WO2020123716A1 (en) 2018-12-11 2020-06-18 Obsidian Therapeutics, Inc. Membrane bound il12 compositions and methods for tunable regulation
CN113164578B (zh) * 2019-01-03 2024-04-30 南京传奇生物科技有限公司 表达鞭毛蛋白多肽的经修饰的免疫细胞
CN111454358A (zh) * 2019-01-18 2020-07-28 四川科伦博泰生物医药股份有限公司 一种嵌合抗原受体及其应用
GB2596461B (en) 2019-02-20 2023-09-27 Fred Hutchinson Cancer Center Binding proteins specific for RAS neoantigens and uses thereof
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
WO2020252404A1 (en) 2019-06-12 2020-12-17 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
WO2021043804A1 (en) * 2019-09-02 2021-03-11 Institut Curie Immunotherapy targeting tumor neoantigenic peptides
CN110804594B (zh) * 2019-11-21 2020-11-20 启辰生生物科技(珠海)有限公司 工程化抗原递呈细胞及其在用于活化cd3+免疫细胞中的应用
AU2021253641A1 (en) * 2020-04-07 2022-10-27 Evaxion Biotech A/S Neoepitope immunotherapy with APC targeting unit
GB202006254D0 (en) * 2020-04-28 2020-06-10 Institute Of Cancer Res Anti-cancer vaccines and related therapy
CN111690609B (zh) * 2020-06-30 2022-04-05 深圳裕泰抗原科技有限公司 一种新生抗原免疫原性的测试方法
CA3187258A1 (en) 2020-08-06 2022-02-10 Karin Jooss Multiepitope vaccine cassettes
WO2022067038A1 (en) * 2020-09-25 2022-03-31 President And Fellows Of Harvard College Immunotherapeutic virus for the treatment of cancer
AR124826A1 (es) * 2021-02-08 2023-05-10 Hutchinson Fred Cancer Res Sistema y métodos para vincular la señalización de cd40 a la unión del antígeno
WO2023173116A1 (en) * 2022-03-10 2023-09-14 City Of Hope Membrane-bound il-12 for cellular immunotherapy
WO2024118634A2 (en) * 2022-11-28 2024-06-06 The Trustees Of The University Of Pennsylvania In vivo expansion of car t cells and delivery of car target antigen to tumors using mrna lipid nanoparticles
CN117338914B (zh) * 2023-10-27 2024-09-06 中山市珈钰生物医药有限公司 一种同种异体树突细胞肿瘤疫苗及其制备方法和应用
WO2025101584A1 (en) * 2023-11-06 2025-05-15 Immunitybio, Inc. Virally educated t cells
CN119823283B (zh) * 2025-01-08 2025-08-26 国科明耀(山东)医学科技有限公司 一种il-12-cd137嵌合蛋白、一种功能增强型工程化nk细胞、其制备及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007535924A (ja) 2004-05-07 2007-12-13 − グスタフ ユングレン、ハンス ワクチン用アジュバントとしてのフラジェリンの使用
JP2008539751A (ja) 2005-05-10 2008-11-20 アヴァリス・アーベー 新規組成物およびその使用
WO2016040900A1 (en) 2014-09-14 2016-03-17 Washington University Personalized cancer vaccines and methods therefor
WO2016054555A2 (en) 2014-10-03 2016-04-07 Novartis Ag Combination therapies

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
GB9518220D0 (en) 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
US5853719A (en) 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
US20020155093A1 (en) 1997-02-18 2002-10-24 Houghton Alan N. Method for stimulation of an immune response to a differentiation antigen stimulated by an altered antigen
GB0224442D0 (en) 2002-10-21 2002-11-27 Molmed Spa A delivery system
JP2006506072A (ja) * 2002-11-12 2006-02-23 デイッセロース,アルバート,ビー アデノウイルスベクターワクチン
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
WO2006076678A2 (en) 2005-01-13 2006-07-20 The Johns Hopkins University Prostate stem cell antigen vaccines and uses thereof
US20090324630A1 (en) 2008-04-21 2009-12-31 Jensen Michael C Fusion multiviral chimeric antigen
EP2258719A1 (en) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
KR101976882B1 (ko) 2011-03-23 2019-05-09 프레드 헛친슨 켄서 리서치 센터 세포 면역요법용 방법 및 조성물
CN103502439B (zh) 2011-04-13 2016-10-12 因缪尼卡姆股份公司 用于抗原特异性t细胞增殖的方法
JP6117515B2 (ja) 2011-11-01 2017-04-19 国立大学法人名古屋大学 髄膜腫治療用医薬組成物
KR20210108497A (ko) 2013-02-26 2021-09-02 메모리얼 슬로안 케터링 캔서 센터 면역치료용 조성물 및 방법
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
DK2981607T3 (da) 2013-04-03 2020-11-16 Memorial Sloan Kettering Cancer Center Effektiv generering af tumormålrettede t-celler afledt af pluripotente stamceller
CA2908434C (en) 2013-04-07 2021-12-28 The Broad Institute, Inc. Compositions and methods for personalized neoplasia vaccines
AU2015231461B2 (en) 2014-03-17 2021-09-09 Tapimmune Inc. Nucleic acid molecule vaccine compositions and uses thereof
JP2017531427A (ja) 2014-10-03 2017-10-26 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド グルココルチコイド誘導腫瘍壊死因子受容体(gitr)抗体およびその使用法
CN107106611B (zh) 2014-10-27 2021-11-23 弗雷德哈钦森癌症研究中心 用于提高过继细胞免疫疗法效力的组合物和方法
US20170268071A1 (en) 2014-10-28 2017-09-21 Thomas Jefferson University COMPOSITIONS AND METHODS OF USING TRANSFER RNAS (tRNAs)
EP3294896A1 (en) 2015-05-11 2018-03-21 Editas Medicine, Inc. Optimized crispr/cas9 systems and methods for gene editing in stem cells
EP4578480A3 (en) 2015-10-01 2025-08-27 QXMedical, LLC Catheter structure with improved support
JP6923219B2 (ja) 2015-11-03 2021-08-18 ホーホシューレ ダルムシュタット 選択的hdac8阻害剤およびこれらの使用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007535924A (ja) 2004-05-07 2007-12-13 − グスタフ ユングレン、ハンス ワクチン用アジュバントとしてのフラジェリンの使用
JP2008539751A (ja) 2005-05-10 2008-11-20 アヴァリス・アーベー 新規組成物およびその使用
WO2016040900A1 (en) 2014-09-14 2016-03-17 Washington University Personalized cancer vaccines and methods therefor
WO2016054555A2 (en) 2014-10-03 2016-04-07 Novartis Ag Combination therapies

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ADHAM S BEAR; CONRAD R CRUZ; AARON E FOSTER,T CELLS AS VEHICLES FOR CANCER VACCINATION,JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,米国,2011年,VOL:2011,PAGE(S):1 - 7,http://dx.doi.org/10.1155/2011/417403
CARRENO BEATRIZ M; ET AL,CANCER IMMUNOTHERAPY. A DENDRITIC CELL VACCINE INCREASES THE BREADTH AND DIVERSITY 以下備考,SCIENCE,2015年05月15日,VOL:348, NR:6236,PAGE(S):803 - 808,http://dx.doi.org/10.1126/science.aaa3828,OF MELANOMA NEOANTIGEN-SPECIFIC T CELLS
J. Immunol., 1998, 160(3):1139-1147
Molecular Therapy, 2012, 20(5):927-937
SONG-NAN ZHANG; IL-KYU CHOI; JING-HUA HUANG; ET AL,OPTIMIZING DC VACCINATION BY COMBINATION WITH ONCOLYTIC ADENOVIRUS COEXPRESSING IL-12 AND GM-CSF,MOLECULAR THERAPY,2011年08月,VOL:19, NR:8,PAGE(S):1558 - 1568,http://dx.doi.org/10.1038/mt.2011.29
YOZO NAKAZAWA; LESLIE E HUYE; GIANPIETRO DOTTI; ET AL,OPTIMIZATION OF THE PIGGYBAC TRANSPOSON SYSTEM FOR THE SUSTAINED GENETIC MODIFICATION 以下備考,J.IMMUNOTHER.,2009年10月,VOL:32 ,NR:8,PAGE(S):1-18,http://dx.doi.org/10.1097/CJI.0b013e3181ad762b,OF HUMAN T LYMPHOCYTES

Also Published As

Publication number Publication date
WO2017192924A1 (en) 2017-11-09
US11723962B2 (en) 2023-08-15
US20190224236A1 (en) 2019-07-25
EP3452082A1 (en) 2019-03-13
CA3022267A1 (en) 2017-11-09
JP2019514393A (ja) 2019-06-06
JP2022091750A (ja) 2022-06-21

Similar Documents

Publication Publication Date Title
JP7033549B2 (ja) 細胞に基づくネオ抗原ワクチンおよびその使用
US20250034217A1 (en) Nucleic acid constructs for co-expression of chimeric antigen receptor and transcription factor, cells containing and therapeutic use thereof
US20240083968A1 (en) Treatment of cancer using chimeric cd3 receptor proteins
TWI787599B (zh) 嵌合抗原和t細胞受體及使用方法
JP2023109921A (ja) 改変された多能性幹細胞並びに製造方法及び使用方法
US20200360431A1 (en) Bcma-targeting chimeric antigen receptor, cd19-targeting chimeric antigen receptor, and combination therapies
US20190375815A1 (en) Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
US20200061113A1 (en) Chimeric antigen receptor therapy characterization assays and uses thereof
US20230074800A1 (en) Car-t cell therapies with enhanced efficacy
JP2021500894A (ja) キメラ抗原受容体発現細胞を作製する方法
JP2021509009A (ja) Bcmaターゲティングキメラ抗原受容体及びその使用
JP2023515211A (ja) キメラ抗原受容体発現細胞を作製する方法
JP2018519842A (ja) 免疫細胞の有効性および増大を改善する方法
JP2018516592A (ja) キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法
KR20140127816A (ko) 암의 치료에 유용한 t 세포의 지속성 집단을 생성시키기 위한 조성물 및 방법
AU2021326504B2 (en) Improving immune cell function
JP7690597B2 (ja) 免疫細胞機能の改善
WO2018111340A1 (en) Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells
CN118055944A (zh) 调节Bcl-2增强嵌合抗原受体癌症免疫疗法功效

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200427

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200427

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210319

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210329

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210625

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210825

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210929

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20210929

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220127

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220228

R150 Certificate of patent or registration of utility model

Ref document number: 7033549

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313111

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250