JP7018387B2 - 腫瘍標的療法のためのcxcr6形質導入t細胞 - Google Patents
腫瘍標的療法のためのcxcr6形質導入t細胞 Download PDFInfo
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- JP7018387B2 JP7018387B2 JP2018519323A JP2018519323A JP7018387B2 JP 7018387 B2 JP7018387 B2 JP 7018387B2 JP 2018519323 A JP2018519323 A JP 2018519323A JP 2018519323 A JP2018519323 A JP 2018519323A JP 7018387 B2 JP7018387 B2 JP 7018387B2
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- C—CHEMISTRY; METALLURGY
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- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
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- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4214—Receptors for cytokines
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/70521—CD28, CD152
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
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- C12N2510/00—Genetically modified cells
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Veterinary Medicine (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021162481A JP2022008805A (ja) | 2015-10-16 | 2021-10-01 | 腫瘍標的療法のためのcxcr6形質導入t細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15190179 | 2015-10-16 | ||
| EP15190179.0 | 2015-10-16 | ||
| PCT/EP2016/074644 WO2017064222A1 (en) | 2015-10-16 | 2016-10-14 | Cxcr6-transduced t cells for targeted tumor therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021162481A Division JP2022008805A (ja) | 2015-10-16 | 2021-10-01 | 腫瘍標的療法のためのcxcr6形質導入t細胞 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018531016A JP2018531016A (ja) | 2018-10-25 |
| JP2018531016A6 JP2018531016A6 (ja) | 2018-12-13 |
| JP2018531016A5 JP2018531016A5 (https=) | 2019-11-28 |
| JP7018387B2 true JP7018387B2 (ja) | 2022-02-10 |
Family
ID=54359823
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519323A Active JP7018387B2 (ja) | 2015-10-16 | 2016-10-14 | 腫瘍標的療法のためのcxcr6形質導入t細胞 |
| JP2021162481A Pending JP2022008805A (ja) | 2015-10-16 | 2021-10-01 | 腫瘍標的療法のためのcxcr6形質導入t細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021162481A Pending JP2022008805A (ja) | 2015-10-16 | 2021-10-01 | 腫瘍標的療法のためのcxcr6形質導入t細胞 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11723922B2 (https=) |
| EP (1) | EP3362569B1 (https=) |
| JP (2) | JP7018387B2 (https=) |
| AU (2) | AU2016336868B2 (https=) |
| CA (1) | CA3001507C (https=) |
| DK (1) | DK3362569T3 (https=) |
| ES (1) | ES2895901T3 (https=) |
| WO (1) | WO2017064222A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018223211B2 (en) * | 2017-02-21 | 2025-02-27 | Adelaide university | T cells expressing chemokine receptors for treating cancer |
| BR112019020909A2 (pt) * | 2017-04-05 | 2020-05-12 | Korea Research Institute Of Bioscience And Biotechnology | Proteína de fusão ativadora de célula nk, célula nk e composição farmacêutica incluindo a mesma |
| WO2019113132A1 (en) * | 2017-12-05 | 2019-06-13 | Caribou Biosciences, Inc. | Modified lymphocytes |
| US20210130438A1 (en) * | 2019-10-28 | 2021-05-06 | The Broad Institute, Inc. | Pan-cancer t cell exhaustion genes |
| CN116333995A (zh) * | 2020-07-14 | 2023-06-27 | 广州泛恩生物科技有限公司 | 基于cxcr6阳性t细胞的用于杀伤肿瘤的tcr-t细胞及其制备方法和应用 |
| CN113736740A (zh) * | 2021-07-27 | 2021-12-03 | 天津市肿瘤医院(天津医科大学肿瘤医院) | 胰腺癌稳转细胞系及其构建方法和应用 |
| WO2023158997A2 (en) * | 2022-02-15 | 2023-08-24 | Memorial Sloan-Kettering Cancer Center | Compositions including killer innate-like t cells and uses therof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020076694A1 (en) | 1997-07-17 | 2002-06-20 | Littman Dan R. | G-coupled receptors associated with retroviral entry into cells, and therapeutic uses thereof |
| US20140271635A1 (en) | 2013-03-16 | 2014-09-18 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using humanized anti-cd19 chimeric antigen receptor |
| WO2015028444A1 (en) | 2013-08-26 | 2015-03-05 | Universität Zu Köln | Anti cd30 chimeric antigen receptor and its use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19822115B4 (de) | 1998-05-08 | 2004-04-08 | Heinrich-Pette-Institut | Retrovirale Gentransfervektoren |
| CN101287831B (zh) | 2005-09-13 | 2013-05-15 | 国立大学法人三重大学 | T细胞受体和编码该受体的核酸 |
| US20110280894A1 (en) | 2008-07-31 | 2011-11-17 | Angela Krackhardt | Her2/neu specific t cell receptors |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2694549B1 (en) | 2011-04-08 | 2018-08-15 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| WO2013059593A1 (en) | 2011-10-20 | 2013-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd22 chimeric antigen receptors |
| US9359447B2 (en) | 2012-03-23 | 2016-06-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin chimeric antigen receptors |
| EA033110B1 (ru) | 2012-04-11 | 2019-08-30 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерный рецептор антигена, направленный на антиген созревания b-клеток, кодирующая его нуклеиновая кислота, соответствующие экспрессионный вектор, клетка-хозяин, применения и способы |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
-
2016
- 2016-10-14 AU AU2016336868A patent/AU2016336868B2/en active Active
- 2016-10-14 CA CA3001507A patent/CA3001507C/en active Active
- 2016-10-14 US US15/768,301 patent/US11723922B2/en active Active
- 2016-10-14 DK DK16793764.8T patent/DK3362569T3/da active
- 2016-10-14 WO PCT/EP2016/074644 patent/WO2017064222A1/en not_active Ceased
- 2016-10-14 JP JP2018519323A patent/JP7018387B2/ja active Active
- 2016-10-14 EP EP16793764.8A patent/EP3362569B1/en active Active
- 2016-10-14 ES ES16793764T patent/ES2895901T3/es active Active
-
2021
- 2021-10-01 JP JP2021162481A patent/JP2022008805A/ja active Pending
-
2022
- 2022-07-14 AU AU2022205240A patent/AU2022205240A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020076694A1 (en) | 1997-07-17 | 2002-06-20 | Littman Dan R. | G-coupled receptors associated with retroviral entry into cells, and therapeutic uses thereof |
| US20140271635A1 (en) | 2013-03-16 | 2014-09-18 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using humanized anti-cd19 chimeric antigen receptor |
| WO2015028444A1 (en) | 2013-08-26 | 2015-03-05 | Universität Zu Köln | Anti cd30 chimeric antigen receptor and its use |
Non-Patent Citations (4)
| Title |
|---|
| Journal of Immunology (2008), Vol.181, pp.3099-3107 |
| Journal of Virology (2005), Vol.79, No.3, pp.1686-1700 |
| Nature (1997), Vol.388, pp.296-300 |
| Oncotarget (Mar.29, 2015), Vol.6, No.16, pp.14165-14178 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3362569A1 (en) | 2018-08-22 |
| AU2016336868A1 (en) | 2018-03-15 |
| JP2022008805A (ja) | 2022-01-14 |
| CA3001507A1 (en) | 2017-04-20 |
| US11723922B2 (en) | 2023-08-15 |
| WO2017064222A1 (en) | 2017-04-20 |
| DK3362569T3 (da) | 2021-10-18 |
| AU2016336868B2 (en) | 2022-04-14 |
| US20180256645A1 (en) | 2018-09-13 |
| AU2022205240A1 (en) | 2022-09-29 |
| ES2895901T3 (es) | 2022-02-23 |
| JP2018531016A (ja) | 2018-10-25 |
| CA3001507C (en) | 2023-09-19 |
| EP3362569B1 (en) | 2021-09-01 |
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