JP7016321B2 - 房室弁の接合を改善するインプラントおよび方法 - Google Patents

房室弁の接合を改善するインプラントおよび方法 Download PDF

Info

Publication number
JP7016321B2
JP7016321B2 JP2018553328A JP2018553328A JP7016321B2 JP 7016321 B2 JP7016321 B2 JP 7016321B2 JP 2018553328 A JP2018553328 A JP 2018553328A JP 2018553328 A JP2018553328 A JP 2018553328A JP 7016321 B2 JP7016321 B2 JP 7016321B2
Authority
JP
Japan
Prior art keywords
valve
innate
annulus
support element
leaflet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018553328A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019500994A (ja
Inventor
モール、ヴェルナー
Original Assignee
アブヴィー ゲゼルシャフト ミット ベシュレンクテル ハフツンク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アブヴィー ゲゼルシャフト ミット ベシュレンクテル ハフツンク filed Critical アブヴィー ゲゼルシャフト ミット ベシュレンクテル ハフツンク
Publication of JP2019500994A publication Critical patent/JP2019500994A/ja
Application granted granted Critical
Publication of JP7016321B2 publication Critical patent/JP7016321B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466—Delivery devices therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A61F2/2457—Chordae tendineae prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0006—Rounded shapes, e.g. with rounded corners circular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
JP2018553328A 2015-12-30 2016-12-30 房室弁の接合を改善するインプラントおよび方法 Active JP7016321B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/984,456 US10426619B2 (en) 2015-12-30 2015-12-30 Implant and method for improving coaptation of an atrioventricular valve
US14/984,456 2015-12-30
PCT/IB2016/001819 WO2017115123A1 (en) 2015-12-30 2016-12-30 Implant and method for improving coaptation of an atrioventricular valve

Publications (2)

Publication Number Publication Date
JP2019500994A JP2019500994A (ja) 2019-01-17
JP7016321B2 true JP7016321B2 (ja) 2022-02-04

Family

ID=57838426

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018553328A Active JP7016321B2 (ja) 2015-12-30 2016-12-30 房室弁の接合を改善するインプラントおよび方法

Country Status (5)

Country Link
US (2) US10426619B2 (zh)
EP (1) EP3397205B1 (zh)
JP (1) JP7016321B2 (zh)
CN (1) CN108778186B (zh)
WO (1) WO2017115123A1 (zh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US8888843B2 (en) 2011-01-28 2014-11-18 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US11065118B2 (en) * 2013-03-04 2021-07-20 The Medical Research, Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center Cardiac valve commissure brace
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10166098B2 (en) 2013-10-25 2019-01-01 Middle Peak Medical, Inc. Systems and methods for transcatheter treatment of valve regurgitation
JP6714518B2 (ja) 2014-06-18 2020-06-24 ポラレス・メディカル・インコーポレイテッド 弁膜逆流の治療のための僧帽弁インプラント
WO2015200497A1 (en) 2014-06-24 2015-12-30 Middle Peak Medical, Inc. Systems and methods for anchoring an implant
JP7006940B2 (ja) 2016-01-29 2022-01-24 ニオバスク ティアラ インコーポレイテッド 流出の閉塞を回避するための人工弁
US20200146854A1 (en) 2016-05-16 2020-05-14 Elixir Medical Corporation Methods and devices for heart valve repair
CN113893064A (zh) 2016-11-21 2022-01-07 内奥瓦斯克迪亚拉公司 用于快速收回经导管心脏瓣膜递送系统的方法和系统
FR3060292B1 (fr) * 2016-12-15 2019-01-25 Cmi'nov Dispositif pour realiser ou preparer une annuloplastie mitrale par voie transfemorale
US10675017B2 (en) 2017-02-07 2020-06-09 Edwards Lifesciences Corporation Transcatheter heart valve leaflet plication
US10653524B2 (en) 2017-03-13 2020-05-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US10478303B2 (en) 2017-03-13 2019-11-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US11458017B2 (en) 2017-03-27 2022-10-04 Vvital Biomed Ltd. Device and method for transcatheter mitral and tricuspid valve repair
US10842619B2 (en) 2017-05-12 2020-11-24 Edwards Lifesciences Corporation Prosthetic heart valve docking assembly
WO2019036810A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. TRANSCATHETER MITRAL VALVULE PROSTHESIS WITH SEQUENTIAL DEPLOYMENT
US11026791B2 (en) * 2018-03-20 2021-06-08 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
EP3620133A1 (en) * 2018-09-07 2020-03-11 AVVie GmbH Implant for improving coaptation of an artrioventricular valve
JP7260930B2 (ja) 2018-11-08 2023-04-19 ニオバスク ティアラ インコーポレイテッド 経カテーテル僧帽弁人工補綴物の心室展開
US11998447B2 (en) 2019-03-08 2024-06-04 Neovasc Tiara Inc. Retrievable prosthesis delivery system
CN113811265A (zh) 2019-04-01 2021-12-17 内奥瓦斯克迪亚拉公司 能够以可控的方式部署的假体瓣膜
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
CN114025813B (zh) 2019-05-20 2024-05-14 内奥瓦斯克迪亚拉公司 具有止血机构的引入器
JP2022537559A (ja) 2019-06-20 2022-08-26 ニオバスク ティアラ インコーポレイテッド 薄型人工補綴僧帽弁
US20210196462A1 (en) * 2019-12-31 2021-07-01 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
EP3912595B1 (en) 2020-05-19 2023-01-04 AVVie GmbH Implant for improving coaptation of an atrioventricular valve
US20230270549A1 (en) * 2020-07-22 2023-08-31 Mtex Cardio Ag Cardiac leaflet coapters
US11464634B2 (en) 2020-12-16 2022-10-11 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation with secondary anchors
US11759321B2 (en) 2021-06-25 2023-09-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
WO2023058024A1 (en) * 2021-10-06 2023-04-13 Entis Allan C Cardiac valve enhancement appliances

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009537187A (ja) 2006-05-15 2009-10-29 エドワーズ・ライフサイエンシス・アーゲー 心臓の幾何学的形状を変更するシステムおよび方法
US20140067054A1 (en) 2012-09-06 2014-03-06 Edwards Lifesciences Corporation Heart Valve Sealing Devices
US20150039083A1 (en) 2011-09-22 2015-02-05 Mehr Medical Llc Devices, systems and methods for repairing lumenal systems
WO2015052570A1 (en) 2013-10-07 2015-04-16 Medizinische Universität Wien Implant and method for improving coaptation of an atrioventricular valve

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050070999A1 (en) 2000-02-02 2005-03-31 Spence Paul A. Heart valve repair apparatus and methods
US9072603B2 (en) 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US20150100116A1 (en) * 2013-10-07 2015-04-09 Medizinische Universitat Wien Implant and method for improving coaptation of an atrioventricular valve
US20160030176A1 (en) * 2014-08-04 2016-02-04 Medizinische Universität Wien Implant and method for improving coaptation of an atrioventricular valve
WO2015123597A1 (en) 2014-02-14 2015-08-20 Edwards Lifesciences Corporation Percutaneous leaflet augmentation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009537187A (ja) 2006-05-15 2009-10-29 エドワーズ・ライフサイエンシス・アーゲー 心臓の幾何学的形状を変更するシステムおよび方法
US20150039083A1 (en) 2011-09-22 2015-02-05 Mehr Medical Llc Devices, systems and methods for repairing lumenal systems
US20140067054A1 (en) 2012-09-06 2014-03-06 Edwards Lifesciences Corporation Heart Valve Sealing Devices
WO2015052570A1 (en) 2013-10-07 2015-04-16 Medizinische Universität Wien Implant and method for improving coaptation of an atrioventricular valve

Also Published As

Publication number Publication date
EP3397205B1 (en) 2019-11-27
US20170189186A1 (en) 2017-07-06
US11076957B2 (en) 2021-08-03
CN108778186B (zh) 2021-01-15
WO2017115123A1 (en) 2017-07-06
CN108778186A (zh) 2018-11-09
EP3397205A1 (en) 2018-11-07
US20190290433A1 (en) 2019-09-26
US10426619B2 (en) 2019-10-01
JP2019500994A (ja) 2019-01-17

Similar Documents

Publication Publication Date Title
JP7016321B2 (ja) 房室弁の接合を改善するインプラントおよび方法
US20220110750A1 (en) Mitral valve prosthesis implantation
CN110678149B (zh) 包括对接元件的用于治疗病变二尖瓣的设备
US9895220B2 (en) Mitral bileaflet valve
EP3846740B1 (en) Implant for improving coaptation of an artrioventricular valve
JP6473682B2 (ja) 心臓弁逆流を治療するための埋め込み型デバイス
EP2271284B1 (en) Transvalvular intraannular band for valve repair
JP2020531189A (ja) 僧帽弁逆流を治療するための径カテーテルデバイス
US20150100116A1 (en) Implant and method for improving coaptation of an atrioventricular valve
US20160030176A1 (en) Implant and method for improving coaptation of an atrioventricular valve
EP3184082B1 (en) Stent for a surgical valve
WO2015052570A1 (en) Implant and method for improving coaptation of an atrioventricular valve
CN112912035B (zh) 用于改进房室瓣的接合的植入物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180704

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20190108

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20190108

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191016

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200918

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200929

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210104

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210608

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210907

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220120

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220125