JP7005007B2 - 固体形態 - Google Patents

固体形態 Download PDF

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JP7005007B2
JP7005007B2 JP2017557899A JP2017557899A JP7005007B2 JP 7005007 B2 JP7005007 B2 JP 7005007B2 JP 2017557899 A JP2017557899 A JP 2017557899A JP 2017557899 A JP2017557899 A JP 2017557899A JP 7005007 B2 JP7005007 B2 JP 7005007B2
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xrpd
diffraction pattern
compound
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formula
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JP2018516883A (ja
JP2018516883A5 (https=
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ラルフ ディオドネ，
ウルス シュヴィッター，
レネ トルッサルディ，
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オリソン ヘノミクス エセ． アー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/78—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton from carbonyl compounds, e.g. from formaldehyde, and amines having amino groups bound to carbon atoms of six-membered aromatic rings, with formation of methylene-diarylamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017557899A 2015-05-06 2016-05-02 固体形態 Active JP7005007B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021060013A JP2021119136A (ja) 2015-05-06 2021-03-31 固体形態

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166641.9 2015-05-06
EP15166641.9A EP3090998A1 (en) 2015-05-06 2015-05-06 Solid forms
PCT/EP2016/059726 WO2016177656A1 (en) 2015-05-06 2016-05-02 Solid forms

Related Child Applications (1)

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JP2021060013A Division JP2021119136A (ja) 2015-05-06 2021-03-31 固体形態

Publications (3)

Publication Number Publication Date
JP2018516883A JP2018516883A (ja) 2018-06-28
JP2018516883A5 JP2018516883A5 (https=) 2019-06-06
JP7005007B2 true JP7005007B2 (ja) 2022-02-04

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JP2017557899A Active JP7005007B2 (ja) 2015-05-06 2016-05-02 固体形態
JP2021060013A Pending JP2021119136A (ja) 2015-05-06 2021-03-31 固体形態

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US (1) US10221125B2 (https=)
EP (2) EP3090998A1 (https=)
JP (2) JP7005007B2 (https=)
KR (1) KR102666390B1 (https=)
CN (1) CN107735394B (https=)
AR (1) AR104505A1 (https=)
AU (1) AU2016259054B2 (https=)
BR (1) BR112017023740B1 (https=)
CA (1) CA2984203C (https=)
ES (1) ES2969970T3 (https=)
HU (1) HUE065558T2 (https=)
IL (1) IL255194B (https=)
MX (1) MX378732B (https=)
PL (1) PL3292100T3 (https=)
WO (1) WO2016177656A1 (https=)

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MX356344B (es) 2011-10-20 2018-05-23 Oryzon Genomics Sa Compuestos de (hetero)arilciclopropilamina como inhibidores de lsd1.
EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
ES3057783T3 (en) 2016-03-15 2026-03-04 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
CN109462980B (zh) 2016-03-15 2022-02-08 奥莱松基因组股份有限公司 用于治疗血液恶性肿瘤的lsd1抑制剂的组合
WO2017158136A1 (en) 2016-03-16 2017-09-21 Oryzon Genomics, S.A. Methods to determine kdm1a target engagement and chemoprobes useful therefor
RS58951B1 (sr) 2016-06-10 2019-08-30 Oryzon Genomics Sa Lečenje multiple skleroze
MX2020001323A (es) 2017-08-03 2020-03-20 Oryzon Genomics Sa Metodos para tratar alteraciones del comportamiento.
SG11202010124SA (en) * 2018-05-04 2020-11-27 Oryzon Genomics Sa Stable pharmaceutical formulation
SG11202109159VA (en) 2019-03-20 2021-10-28 Oryzon Genomics Sa Methods of treating borderline personality disorder
ES3053813T3 (en) 2019-03-20 2026-01-26 Oryzon Genomics Sa Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
CA3132473A1 (en) * 2019-03-25 2020-10-01 Oryzon Genomics, S.A. Combinations of iadademstat for cancer therapy
CN114341366A (zh) 2019-07-05 2022-04-12 奥莱松基因组股份有限公司 用于使用kdm1a抑制剂个体化治疗小细胞肺癌的生物标志物和方法
JP2024513260A (ja) 2021-04-08 2024-03-22 オリゾン ジェノミックス ソシエダッド アノニマ 骨髄癌処置のためのｌｓｄ１阻害剤の組み合わせ
JP2025516648A (ja) 2022-05-09 2025-05-30 オリゾン・ゲノミクス・ソシエダッド・アノニマ Ｌｓｄ１阻害薬を用いるｎｆ１変異腫瘍の治療法
CN119546292A (zh) 2022-05-09 2025-02-28 奥莱松基因组股份有限公司 使用lsd1抑制剂治疗恶性周围神经鞘瘤(mpnst)的方法
CN120529900A (zh) 2022-11-24 2025-08-22 奥莱松基因组股份有限公司 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合

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Ｍｉｎｏ Ｒ．Ｃａｉｒａ，Ｃｒｙｓｔａｌｌｉｎｅ Ｐｏｌｙｍｏｒｐｈｉｓｍ ｏｆ Ｏｒｇａｎｉｃ Ｃｏｍｐｏｕｎｄｓ，Ｔｏｐｉｃｓ ｉｎ Ｃｕｒｒｅｎｔ Ｃｈｅｍｉｓｔｒｙ，ドイツ，Ｓｐｒｉｎｇｅｒ，１９９８年，Ｖｏｌ．１９８，ｐｐ．１６３－２０８，ＵＲＬ，ｈｔｔｐｓ：／／ｌｉｎｋ．ｓｐｒｉｎｇｅｒ．ｃｏｍ／ｃｈａｐｔｅｒ／１０．１００７／３－５４０－６９１７８－２＿５

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Publication number Publication date
CA2984203C (en) 2024-07-02
EP3090998A1 (en) 2016-11-09
EP3292100C0 (en) 2023-11-15
ES2969970T3 (es) 2024-05-23
US20180086692A1 (en) 2018-03-29
AU2016259054B2 (en) 2020-08-13
KR102666390B1 (ko) 2024-05-21
EP3292100A1 (en) 2018-03-14
HUE065558T2 (hu) 2024-06-28
JP2018516883A (ja) 2018-06-28
JP2021119136A (ja) 2021-08-12
HK1245235A1 (zh) 2018-08-24
CA2984203A1 (en) 2016-11-10
MX378732B (es) 2025-03-11
BR112017023740A2 (pt) 2018-07-17
PL3292100T3 (pl) 2024-04-22
CN107735394A (zh) 2018-02-23
CN107735394B (zh) 2021-11-02
EP3292100B1 (en) 2023-11-15
IL255194B (en) 2021-03-25
BR112017023740B1 (pt) 2023-11-07
MX2017014035A (es) 2018-03-01
AR104505A1 (es) 2017-07-26
AU2016259054A1 (en) 2017-11-16
HK1252089A1 (en) 2019-05-17
WO2016177656A1 (en) 2016-11-10
KR20180022660A (ko) 2018-03-06
IL255194A0 (en) 2017-12-31
US10221125B2 (en) 2019-03-05

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