JP7005007B2 - 固体形態 - Google Patents

固体形態 Download PDF

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Publication number
JP7005007B2
JP7005007B2 JP2017557899A JP2017557899A JP7005007B2 JP 7005007 B2 JP7005007 B2 JP 7005007B2 JP 2017557899 A JP2017557899 A JP 2017557899A JP 2017557899 A JP2017557899 A JP 2017557899A JP 7005007 B2 JP7005007 B2 JP 7005007B2
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xrpd
diffraction pattern
compound
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formula
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JP2018516883A5 (enExample
JP2018516883A (ja
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ラルフ ディオドネ，
ウルス シュヴィッター，
レネ トルッサルディ，
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オリソン ヘノミクス エセ． アー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/78—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton from carbonyl compounds, e.g. from formaldehyde, and amines having amino groups bound to carbon atoms of six-membered aromatic rings, with formation of methylene-diarylamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017557899A 2015-05-06 2016-05-02 固体形態 Active JP7005007B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021060013A JP2021119136A (ja) 2015-05-06 2021-03-31 固体形態

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15166641.9A EP3090998A1 (en) 2015-05-06 2015-05-06 Solid forms
EP15166641.9 2015-05-06
PCT/EP2016/059726 WO2016177656A1 (en) 2015-05-06 2016-05-02 Solid forms

Related Child Applications (1)

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JP2021060013A Division JP2021119136A (ja) 2015-05-06 2021-03-31 固体形態

Publications (3)

Publication Number Publication Date
JP2018516883A JP2018516883A (ja) 2018-06-28
JP2018516883A5 JP2018516883A5 (enExample) 2019-06-06
JP7005007B2 true JP7005007B2 (ja) 2022-02-04

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JP2017557899A Active JP7005007B2 (ja) 2015-05-06 2016-05-02 固体形態
JP2021060013A Pending JP2021119136A (ja) 2015-05-06 2021-03-31 固体形態

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US (1) US10221125B2 (enExample)
EP (2) EP3090998A1 (enExample)
JP (2) JP7005007B2 (enExample)
KR (1) KR102666390B1 (enExample)
CN (1) CN107735394B (enExample)
AR (1) AR104505A1 (enExample)
AU (1) AU2016259054B2 (enExample)
BR (1) BR112017023740B1 (enExample)
CA (1) CA2984203C (enExample)
ES (1) ES2969970T3 (enExample)
HU (1) HUE065558T2 (enExample)
IL (1) IL255194B (enExample)
MX (1) MX378732B (enExample)
PL (1) PL3292100T3 (enExample)
WO (1) WO2016177656A1 (enExample)

Families Citing this family (17)

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AU2012324803B9 (en) 2011-10-20 2017-08-24 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
SG10201913290QA (en) 2016-03-15 2020-03-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for the treatment of hematological malignancies
CN120661674A (zh) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
JP2019512546A (ja) 2016-03-16 2019-05-16 オリゾン・ゲノミクス・ソシエダッド・アノニマ Ｋｄｍ１ａ標的会合を決定するための方法、およびそれに有用な化学プローブ
SI3307267T1 (sl) 2016-06-10 2019-08-30 Oryzon Genomics, S.A. Zdravljenje multiple skleroze
AU2018309372B2 (en) 2017-08-03 2024-08-15 Oryzon Genomics, S.A. Methods of treating behavior alterations
WO2019211491A1 (en) * 2018-05-04 2019-11-07 Oryzon Genomics, S.A. Stable pharmaceutical formulation
HRP20251471T1 (hr) 2019-03-20 2026-01-02 Oryzon Genomics, S.A. Postupci liječenja poremećaja hiperaktivnosti s deficitom pažnje korištenjem inhibitora kdm1a kao što je spoj vafidemstat
SI3941466T1 (sl) 2019-03-20 2026-04-30 Oryzon Genomics, S.A. Vafidemstat za zdravljenje neagresivnih simptomov mejne osebnostne motnje
EP3946295B1 (en) * 2019-03-25 2026-08-05 Oryzon Genomics, S.A. Combinations of iadademstat for cancer therapy
CN114341366A (zh) 2019-07-05 2022-04-12 奥莱松基因组股份有限公司 用于使用kdm1a抑制剂个体化治疗小细胞肺癌的生物标志物和方法
CA3231846A1 (en) 2021-04-08 2022-10-13 Tamara Maes Combinations of lsd1 inhibitors for treating myeloid cancers
US20250275969A1 (en) 2022-05-09 2025-09-04 Oryzon Genomics, S.A. Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
US20250295660A1 (en) 2022-05-09 2025-09-25 Oryzon Genomics, S.A. Methods of treating nf1-mutant tumors using lsd1 inhibitors
US20260151399A1 (en) 2022-11-24 2026-06-04 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors and menin inhibitors for treating cancer
CN116718625A (zh) * 2023-06-13 2023-09-08 烟台大学 一种红霉素口服固体制剂中红霉素a晶型的检测方法

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AU2012324803B9 (en) 2011-10-20 2017-08-24 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
KR20180011331A (ko) 2015-06-12 2018-01-31 오리존 지노믹스 에스.에이. Lsd1 억제제와 관련된 바이오마커 및 그의 용도
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SG10201913290QA (en) 2016-03-15 2020-03-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for the treatment of hematological malignancies
JP2019512546A (ja) 2016-03-16 2019-05-16 オリゾン・ゲノミクス・ソシエダッド・アノニマ Ｋｄｍ１ａ標的会合を決定するための方法、およびそれに有用な化学プローブ
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Ｍｉｎｏ Ｒ．Ｃａｉｒａ，Ｃｒｙｓｔａｌｌｉｎｅ Ｐｏｌｙｍｏｒｐｈｉｓｍ ｏｆ Ｏｒｇａｎｉｃ Ｃｏｍｐｏｕｎｄｓ，Ｔｏｐｉｃｓ ｉｎ Ｃｕｒｒｅｎｔ Ｃｈｅｍｉｓｔｒｙ，ドイツ，Ｓｐｒｉｎｇｅｒ，１９９８年，Ｖｏｌ．１９８，ｐｐ．１６３－２０８，ＵＲＬ，ｈｔｔｐｓ：／／ｌｉｎｋ．ｓｐｒｉｎｇｅｒ．ｃｏｍ／ｃｈａｐｔｅｒ／１０．１００７／３－５４０－６９１７８－２＿５

Also Published As

Publication number Publication date
KR102666390B1 (ko) 2024-05-21
EP3292100B1 (en) 2023-11-15
PL3292100T3 (pl) 2024-04-22
US10221125B2 (en) 2019-03-05
AU2016259054A1 (en) 2017-11-16
US20180086692A1 (en) 2018-03-29
WO2016177656A1 (en) 2016-11-10
EP3292100A1 (en) 2018-03-14
ES2969970T3 (es) 2024-05-23
CN107735394B (zh) 2021-11-02
CA2984203A1 (en) 2016-11-10
AU2016259054B2 (en) 2020-08-13
MX2017014035A (es) 2018-03-01
HUE065558T2 (hu) 2024-06-28
CN107735394A (zh) 2018-02-23
EP3292100C0 (en) 2023-11-15
HK1245235A1 (zh) 2018-08-24
IL255194B (en) 2021-03-25
MX378732B (es) 2025-03-11
BR112017023740B1 (pt) 2023-11-07
AR104505A1 (es) 2017-07-26
CA2984203C (en) 2024-07-02
EP3090998A1 (en) 2016-11-09
KR20180022660A (ko) 2018-03-06
BR112017023740A2 (pt) 2018-07-17
JP2018516883A (ja) 2018-06-28
HK1252089A1 (en) 2019-05-17
IL255194A0 (en) 2017-12-31
JP2021119136A (ja) 2021-08-12

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