JP6997462B2 - がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 - Google Patents
がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 Download PDFInfo
- Publication number
- JP6997462B2 JP6997462B2 JP2018562701A JP2018562701A JP6997462B2 JP 6997462 B2 JP6997462 B2 JP 6997462B2 JP 2018562701 A JP2018562701 A JP 2018562701A JP 2018562701 A JP2018562701 A JP 2018562701A JP 6997462 B2 JP6997462 B2 JP 6997462B2
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- pyridin
- methylmorpholine
- methyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 *C(COCC1*)N1C(C=C(*)N1*)=CC1=O Chemical compound *C(COCC1*)N1C(C=C(*)N1*)=CC1=O 0.000 description 17
- KJRRQXYWFQKJIP-UHFFFAOYSA-N Cc1c[o]cc1 Chemical compound Cc1c[o]cc1 KJRRQXYWFQKJIP-UHFFFAOYSA-N 0.000 description 2
- TWGNOYAGHYUFFR-UHFFFAOYSA-N Cc1cncnc1 Chemical compound Cc1cncnc1 TWGNOYAGHYUFFR-UHFFFAOYSA-N 0.000 description 2
- LYBKZXJPARFTAV-UHFFFAOYSA-N CC(COCC1)N1C(C=C(c1c(C)ccnc1)N1)=CC1=O Chemical compound CC(COCC1)N1C(C=C(c1c(C)ccnc1)N1)=CC1=O LYBKZXJPARFTAV-UHFFFAOYSA-N 0.000 description 1
- VURLBOASIVOCCE-UHFFFAOYSA-N CC1(C)OB(c(cc2)ccc2-c2ccn[nH]2)OC1(C)C Chemical compound CC1(C)OB(c(cc2)ccc2-c2ccn[nH]2)OC1(C)C VURLBOASIVOCCE-UHFFFAOYSA-N 0.000 description 1
- NLODRXAIDDLFIJ-CQSZACIVSA-N C[C@H](COCC1)N1C(C=C(c1c(C)ccc2c1cccn2)N1)=CC1=O Chemical compound C[C@H](COCC1)N1C(C=C(c1c(C)ccc2c1cccn2)N1)=CC1=O NLODRXAIDDLFIJ-CQSZACIVSA-N 0.000 description 1
- JSBLNGVJMUICFQ-SNVBAGLBSA-N C[C@H](COCC1)N1C(C=C(c1c[o]cc1)N1)=CC1=O Chemical compound C[C@H](COCC1)N1C(C=C(c1c[o]cc1)N1)=CC1=O JSBLNGVJMUICFQ-SNVBAGLBSA-N 0.000 description 1
- SOHNHMPRMJKRJT-SSDOTTSWSA-N C[C@H](COCC1)N1c1cc(Cl)nc(Cl)c1 Chemical compound C[C@H](COCC1)N1c1cc(Cl)nc(Cl)c1 SOHNHMPRMJKRJT-SSDOTTSWSA-N 0.000 description 1
- AVFKEUHJKWTBAC-UHFFFAOYSA-N Cc1c[s]cc1S Chemical compound Cc1c[s]cc1S AVFKEUHJKWTBAC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021199161A JP7389504B2 (ja) | 2016-02-19 | 2021-12-08 | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
| JP2023192216A JP2024016225A (ja) | 2016-02-19 | 2023-11-10 | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16156530.4 | 2016-02-19 | ||
| EP16156530 | 2016-02-19 | ||
| PCT/EP2017/053612 WO2017140841A1 (en) | 2016-02-19 | 2017-02-17 | 6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021199161A Division JP7389504B2 (ja) | 2016-02-19 | 2021-12-08 | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505594A JP2019505594A (ja) | 2019-02-28 |
| JP2019505594A5 JP2019505594A5 (enExample) | 2020-03-26 |
| JP6997462B2 true JP6997462B2 (ja) | 2022-01-17 |
Family
ID=55404645
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018562701A Active JP6997462B2 (ja) | 2016-02-19 | 2017-02-17 | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
| JP2021199161A Active JP7389504B2 (ja) | 2016-02-19 | 2021-12-08 | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
| JP2023192216A Pending JP2024016225A (ja) | 2016-02-19 | 2023-11-10 | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021199161A Active JP7389504B2 (ja) | 2016-02-19 | 2021-12-08 | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
| JP2023192216A Pending JP2024016225A (ja) | 2016-02-19 | 2023-11-10 | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11077113B2 (enExample) |
| EP (1) | EP3416945B1 (enExample) |
| JP (3) | JP6997462B2 (enExample) |
| CN (3) | CN113754581A (enExample) |
| AU (3) | AU2017219846B2 (enExample) |
| CY (1) | CY1123285T1 (enExample) |
| DK (1) | DK3416945T3 (enExample) |
| ES (1) | ES2816376T3 (enExample) |
| HR (1) | HRP20201400T1 (enExample) |
| HU (1) | HUE050863T2 (enExample) |
| LT (1) | LT3416945T (enExample) |
| PL (1) | PL3416945T3 (enExample) |
| PT (1) | PT3416945T (enExample) |
| RS (1) | RS60898B1 (enExample) |
| RU (1) | RU2754664C2 (enExample) |
| SI (1) | SI3416945T1 (enExample) |
| SM (1) | SMT202000523T1 (enExample) |
| TW (1) | TWI721104B (enExample) |
| WO (1) | WO2017140841A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022022368A (ja) * | 2016-02-19 | 2022-02-03 | スプリント バイオサイエンス アクティエボラーグ | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3416957T (pt) * | 2016-02-19 | 2020-09-25 | Sprint Bioscience Ab | Compostos 6-heterociclil-4-morfolin-4-ilpiridin-2-ona úteis para o tratamento do cancro e da diabetes |
| HRP20220497T1 (hr) * | 2017-08-23 | 2022-05-27 | Sprint Bioscience Ab | Spoj morfolinilpiridona |
| IL302356A (en) * | 2017-08-23 | 2023-06-01 | Sprint Bioscience Ab | Pyridylpyridone compounds |
| PL3672948T3 (pl) * | 2017-08-23 | 2022-12-05 | Sprint Bioscience Ab | Związki pirydynoamino-pirydonu i pirymidynoamino-pirydonu |
| IL302355A (en) | 2017-08-23 | 2023-06-01 | Sprint Bioscience Ab | Azaindolylpyridone and diazaindolylpyridone compounds |
| WO2020008046A1 (en) | 2018-07-06 | 2020-01-09 | Sprint Bioscience Ab | Biomarker |
| US12540115B2 (en) * | 2019-08-21 | 2026-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibitors of phospholipid synthesis and methods of use |
| JP2023550638A (ja) | 2020-11-25 | 2023-12-04 | デシフェラ・ファーマシューティカルズ，エルエルシー | ウイルス感染症の処置に使用するための、ｖｓｐ３４阻害剤としてのモルホリノ誘導体 |
| WO2022115549A1 (en) | 2020-11-25 | 2022-06-02 | Deciphera Pharmaceuticals, Llc | Anti-viral activity of vps34 inhibitors |
| CN117083064A (zh) | 2020-11-25 | 2023-11-17 | 德西费拉制药有限责任公司 | 作为vps34抑制剂用于治疗病毒感染的吡啶基吡啶酮衍生物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014151616A1 (en) | 2013-03-14 | 2014-09-25 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| WO2015030057A1 (ja) | 2013-08-29 | 2015-03-05 | 富士フイルム株式会社 | 新規なモルホリン誘導体またはその塩 |
| JP2015525236A (ja) | 2012-06-22 | 2015-09-03 | サノフイ | 置換モルホリンを含む新規な２，３−ジヒドロ−１Ｈ−イミダゾ｛１，２−ａ｝ピリミジン−５−オンおよびこの１，２，３，４−テトラヒドロピリミド｛１，２−ａ｝ピリミジン−６−オン誘導体、その調製およびその製薬学的使用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2316831T3 (da) | 2002-11-21 | 2013-06-10 | Novartis Ag | 2-(Morpholin-4-yl)pyrimidiner som phosphotidylinositol (PI)-3-kinaseinhibitorer samt deres anvendelse ved behandling af cancer |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| PL2448940T3 (pl) | 2009-07-02 | 2014-10-31 | Sanofi Sa | Pochodne 6,7,8,9-tetrahydro-pirymido{1,2-a} pirymidyn-4-onu, ich wytwarzanie i zastosowanie farmaceutyczne |
| EA201390917A1 (ru) * | 2010-12-21 | 2013-12-30 | Новартис Аг | Дигетероарильные соединения в качестве ингибиторов vps34 |
| PT2655375E (pt) * | 2010-12-23 | 2015-03-02 | Sanofi Sa | Derivados de pirimidinona, sua preparação e sua utilização farmacêutica |
| GB201120317D0 (en) | 2011-11-24 | 2012-01-04 | Queen Mary & Westfield College | Screening method |
| WO2014145512A2 (en) * | 2013-03-15 | 2014-09-18 | President And Fellows Of Harvard College | Potent small molecule inhibitors of autophagy, and methods of use thereof |
| TN2016000270A1 (en) | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
| WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| MA39823A (fr) | 2014-04-03 | 2018-01-09 | Janssen Pharmaceutica Nv | Dérivés de pyridine macrocyclique |
| JP2017528486A (ja) * | 2014-09-17 | 2017-09-28 | ヴァーセオン コーポレイション | セリンプロテアーゼ阻害剤としてのピラゾリル置換ピリドン化合物 |
| PL3416945T3 (pl) * | 2016-02-19 | 2020-12-28 | Sprint Bioscience Ab | Związki 6-arylo-4-(morfolin-4-ylo)-1h-pirydyn-2-onu przydatne w leczeniu nowotworu i cukrzycy |
-
2017
- 2017-02-17 PL PL17705878T patent/PL3416945T3/pl unknown
- 2017-02-17 SI SI201730395T patent/SI3416945T1/sl unknown
- 2017-02-17 US US15/999,530 patent/US11077113B2/en active Active
- 2017-02-17 TW TW106105179A patent/TWI721104B/zh not_active IP Right Cessation
- 2017-02-17 EP EP17705878.1A patent/EP3416945B1/en active Active
- 2017-02-17 HU HUE17705878A patent/HUE050863T2/hu unknown
- 2017-02-17 AU AU2017219846A patent/AU2017219846B2/en active Active
- 2017-02-17 WO PCT/EP2017/053612 patent/WO2017140841A1/en not_active Ceased
- 2017-02-17 DK DK17705878.1T patent/DK3416945T3/da active
- 2017-02-17 LT LTEP17705878.1T patent/LT3416945T/lt unknown
- 2017-02-17 CN CN202111121825.5A patent/CN113754581A/zh active Pending
- 2017-02-17 CN CN202111123598.XA patent/CN113845472A/zh active Pending
- 2017-02-17 JP JP2018562701A patent/JP6997462B2/ja active Active
- 2017-02-17 RU RU2018131775A patent/RU2754664C2/ru active
- 2017-02-17 HR HRP20201400TT patent/HRP20201400T1/hr unknown
- 2017-02-17 PT PT177058781T patent/PT3416945T/pt unknown
- 2017-02-17 CN CN201780013738.3A patent/CN108698996B/zh active Active
- 2017-02-17 RS RS20201057A patent/RS60898B1/sr unknown
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022022368A (ja) * | 2016-02-19 | 2022-02-03 | スプリント バイオサイエンス アクティエボラーグ | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
| JP7389504B2 (ja) | 2016-02-19 | 2023-11-30 | スプリント バイオサイエンス アクティエボラーグ | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
| JP2024016225A (ja) * | 2016-02-19 | 2024-02-06 | スプリント バイオサイエンス アクティエボラーグ | がんおよび糖尿病の治療に有用な６－アリール－４－モルホリン－１－イルピリドン化合物 |
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