JP6963137B1 - A method for producing a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, and a cosmetic composition produced by the production method. - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic composition excellent in moisturizing power and reduction of wrinkles, and a method for producing the same. According to the present invention, a step of adding a mineral component to purified water and irradiating it with a microwave to dissolve it, and a step of adding a hydrophilic first amino acid to produce a mineral-hydrophilic amino acid reaction product. , A step of adding an acrylic polymer, a step of adding a hydrophilic second amino acid to neutralize the acrylic polymer to form a crosslink, and a step of binding the acrylic polymer and the mineral-amino acid reactant. A step of adding a hydrophilic third amino acid to produce a first composition, a step of producing a second composition containing an amphipathic solvent and a hydrophobic amino acid, and the first composition and the second composition. A method for producing a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, and a method for producing the same, including a step of mixing with a substance to produce a composition containing the micelle complex. Provided is a cosmetic composition produced by. [Selection diagram] Fig. 1

Description

The present invention relates to a method for producing a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, and a method of producing a cosmetic composition comprising a micelle. It relates to complex formed by using natural moisturizing factor and a cosmetic composition formed by the method).

Examples of active ingredients exhibiting activity in cosmetic compositions include vitamins and their derivatives, amino acids, plant extracts, fragrances, enzymes, microbial extracts, minerals, etc., including temperature, pH, light, air. When exposed to external factors such as, the stability is reduced, which reduces the absorption rate of the skin and reduces the functional effects of cosmetic wrinkle improvement, whitening, moisturizing, UV shielding and the like.

The skin of the human body can create a moisturizing factor called Natural Moisturizing Factor (NMF) by itself. The natural moisturizing factor is a water-soluble small molecule that is soluble in water, and amino acids account for about 40%. Natural moisturizing factors present in the skin are substances that help absorb surrounding water and form a water barrier in the epidermis and stratum corneum. Examples of substances other than amino acids include mineral components as components present in sweat and sebum. Natural moisturizing factors are present on the inside of most skin, and sweat and sebum are responsible for moisturizing the outside of the skin. Mineral components present in sweat and sebum can supply water to the keratin. Natural moisturizing factors are substances that play an important role in skin elasticity, moisturizing and wrinkle prevention, and lack of natural moisturizing factors can change the properties of the skin to dryness and, in severe cases, atopy and extreme dryness. As the skin ages, the content of natural moisturizing factors in the skin decreases, causing dryness and wrinkles on the skin.

In the development of cosmetics, the technology to protect the above-mentioned active ingredient from external factors and improve the stability, the technology to improve the solubility and dispersion efficiency of the active ingredient, the technology to efficiently convey the active ingredient to the desired site, and the effective Development of technology for promoting skin absorption of the ingredient is required, and ultimately, development of a stable transmitter that fully exerts the original function at the site where the active ingredient is desired is required.

Surfactants are known to be uniquely adsorbed to interfaces such as the oil / water interface and the solid / liquid interface, and are stable liquid media (eg, water) that remain stable against aggregation during storage. It is used as a stabilizer to form a dispersion of particles within. Due to these adsorption properties as a monomolecular layer at the interface, surfactants in the form of polyelectrolytes have been used to form layers of surfactant on substrates such as solid particles. In addition, the surfactant can be aggregated in a structure containing a large number of surfactant molecules with a single aggregate. These aggregates are called micelles. Such aggregates usually have a spherical shape, but can have various shapes and structures. The number of molecules that make up such aggregates is very large, often counting about hundreds of molecules. Micelle may be composed of a relatively simple surfactant structure, but may also be composed of a high molecular weight block copolymer surfactant.

Korean Patent Publication No. 2016-0133069

An object to be solved by the present invention is to provide a method for producing a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, and a cosmetic composition produced thereby.

In order to solve the above-mentioned problems, the present invention comprises a step of adding a mineral component to purified water and irradiating it with microwaves to dissolve it, and adding a hydrophilic first amino acid to prepare a mineral-hydrophilic amino acid reaction product. The step of producing, the step of adding an acrylic polymer, and the step of adding a hydrophilic second amino acid are added to neutralize the acrylic polymer to form a crosslink, and the acrylic polymer and the mineral-amino acid reactant are bound to each other. A step of producing a first composition by adding a hydrophilic third amino acid, a step of producing a second composition containing an amphipathic solvent and a hydrophobic amino acid, and the first composition. A method for producing a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, which comprises a step of mixing the second composition to produce a composition containing a micelle complex. offer.

Furthermore, the present invention is a cosmetic composition containing a micelle complex formed by utilizing the natural moisturizing factor produced by the production method, wherein the micelle is a head portion of a mineral-hydrophilic amino acid conjugate and a head portion. A cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, which contains a tail portion of an acrylic polymer and contains a hydrophobic amino acid inside the micelle to form a micelle complex. offer.

The method for producing a cosmetic containing a micelle complex formed by utilizing a natural moisturizing factor according to the present invention increases the electrical conductivity at the initial stage of production by utilizing microwaves, and is a functional substance, a mineral. Solubility can be significantly improved, and a micelle complex can be easily formed to support hydrophobic amino acids while ensuring a high degree of dispersion and ensuring layer separation stability. ..

In addition, a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor produced by the above-mentioned production method can achieve an excellent effect of moisturizing power and reducing wrinkles.

It is a photograph of wrinkles around the eyes before and after use of a subject using the cosmetic composition according to Example 1 of the present invention.

Hereinafter, various examples of the present invention will be described with reference to the accompanying drawings. The present invention is not limited to specific examples. It should be understood to include various Modifications, Equivalents and / or Alternatives of the embodiments of the present invention. Similar reference numerals may be used for similar components with respect to the description of the drawings.

In this document, expressions such as "have," "can have," "include," or "can include" of the feature (eg, components such as numbers, functions, actions, or parts). Indicates existence and does not rule out the existence of additional features.

In this document, expressions such as "A or B", "at least one of A and / or B", or "any or more of A and / or B" are possible of the items presented. All combinations can be included. For example, "A or B", "at least one of A and B", or "at least one of A or B" may (1) include at least one A, (2) at least one. When B is included, (3) all cases including at least one A and at least one B are shown.

The expressions used in this document, for example, "Configured to", are "Suitable for", "to", depending on the situation. "Having the capacity to", "Designed to", "Adapted to", "Made to" ) ”, Or“ Capable of ”can be used in other words. The term "configured (or set) to" does not mean only what is "specifically designed to".

The terms used in this document are used solely to describe a particular embodiment and are not intended to limit the scope of other embodiments. A singular expression can include multiple expressions unless it clearly means singular in context. Including technical or scientific terms. The terms used in this document may have the same meaning as commonly understood by those with ordinary knowledge in the technical fields described in this document. Of the terms used in this document, those defined in general dictionaries should be construed with the same or similar meanings in the context of the relevant technology and are clearly defined in this document. Unless done, it will not be interpreted in an ideal or overly formal sense. In some cases, even the terms defined in this document shall not be construed to exclude other embodiments of this document.

The examples disclosed in this document are presented for the purpose of explaining and understanding the disclosed technical contents, and do not limit the scope of the present invention. Therefore, the scope of this document should be construed to include all modifications based on the technical ideas of the present invention and various examples.

Hereinafter, preferred embodiments of the present invention will be described in detail. Prior to this, the terms and words used herein and in the scope of the claims shall not be construed as confined to ordinary or lexical meanings, and the inventor may best use his or her invention. It should be interpreted as a meaning and concept that is consistent with the technical idea of the present invention, based on the principle that the concept of terms can be properly defined.

The configuration of the examples described herein is only part of the most preferred embodiment of the invention and does not represent all the technical ideas of the invention. Therefore, it must be understood that at the time of filing in this case, there may be a variety of equivalents and variants that can replace them.

When a component is described as "containing" in the entire specification, the other component may be further included instead of excluding the other component unless otherwise contradictory. It has meaning.

Hereinafter, the present invention will be specifically described.

Method for Producing Cosmetic Composition Containing Micelle Complex Formed Using Natural Moisturizing Factor The present invention comprises a step of adding a mineral component to purified water and irradiating it with microwaves to dissolve it, and a first hydrophilic property. A step of adding an amino acid to produce a mineral-hydrophilic amino acid reaction product, a step of adding an acrylic polymer, and a step of adding a hydrophilic second amino acid to neutralize the acrylic polymer to form a crosslink. A step of forming and binding an acrylic polymer to a mineral-amino acid reactant, a step of adding a hydrophilic third amino acid to prepare a first composition, and a second containing an amphipathic solvent and a hydrophobic amino acid. A step of producing a composition and a step of mixing the first composition and the second composition to produce a composition containing a micelle complex can be included.

The step of putting the mineral component into purified water and irradiating it with microwaves to dissolve it is a step of evenly dispersing the mineral component in purified water. Through the steps, spins can be formed on the electrons of the mineral atoms dispersed in purified water, which can increase the motility of the mineral atoms and widen the gap between the respective mineral atoms.

The mineral components include sodium (Na) in the form of salt, calcium (Ca), phosphorus (P), magnesium (Mg), potassium (K), sulfur (S), and germanium (Ge). , Zinc (Zn), selenium (Se), and any combination thereof.

Any substance containing a high concentration of mineral components can be included without limitation as described herein. A high concentration of mineral components or a substance containing a mineral component can include a combination of one or more mineral components. For example, mineral components of the may be a pure atoms such as calcium (Ca) and sodium (Na), may be a hydrate such as MgCl ₂ · 6H ₂ O. Alternatively, the mineral component may include salt forms such as NaCl, MgCl ₂ , CaCl _{2 and the} like, and may also include ionic forms such as Na ⁺ , Mg ²⁺ , Ca ²⁺ .

As the purified water, purified water generally used in the art, ultrapure water, can be used, and ultrapure water is preferably used. General purified water is water generally used for pharmaceuticals, cosmetics, etc., and has a dissolved solid content of 1.0 to 0.5 ppm, which indicates purity, and is used for removing fine particles and microorganisms in the production of purified water. The pore size of the filter varies from 0.2 to 0.45 μm and the pH varies from weak acid to weak alkali. The ultrapure water has a dissolved solid content of about 0.03 ppm and a very high purity, and the pore size of the filter used in the production of ultrapure water is 0.001 μm. It was 99% removed. In particular, in ultrapure water, metal ions are removed, so that the autoxidation reaction of the composition can be prevented, and the polymer aggregation phenomenon due to metal ions can be prevented, so that the formulation can be prepared while suppressing irritation. Make sure it is applied evenly.

As a result of the study of the example, the present inventors dissolved the mineral component in purified water at 50 ° C. to 80 ° C. and microwaved for 3 to 10 minutes because the mineral ions in the aqueous solution carried the electric charge in the microwave irradiation. It has been found that when irradiated for preferably 4 to 6 minutes, the movement of the molecules becomes the most active, the electrical conductivity increases, and the spacing between the molecules increases. Therefore, the frequency of the microwave is 1,500 to 3,000 MHz. The microwave output is preferably 500 to 1500 W. It is desirable that the microwave output is within the above range from the viewpoint of ensuring the dispersibility of the mineral component and the electrical conductivity of the composition.

It is preferable that the composition has an electric conductivity in an appropriate range for easy bonding between the mineral component and the hydrophilic first amino acid in the subsequent steps. Specifically, the molecular motion of the mineral component is most active and does not aggregate at 700 to 900 μS / cm in an environment measured at 40 ° C. after dissolution of the mineral component and irradiation with microwaves. The molecular spacing can be effectively extended.

The step of adding the hydrophilic first amino acid to produce a mineral-hydrophilic amino acid reaction product is a step of forming a hydrophilic head portion compound for binding to an acrylic polymer in micelle formation described later.

In the step of adding the hydrophilic first amino acid to produce a mineral-hydrophilic amino acid reaction product, it is preferable to add the hydrophilic first amino acid after cooling to 30 to 50 ° C. Here, when the electrical conductivity of the composition is 850 to 1100 μS / cm based on 40 ° C., the synthesis of the amino acid and the hydrophilic first amino acid can proceed most efficiently.

Here, the hydrophilic first amino acid contains either serine or threonine.

The step of adding the acrylic polymer binds the mineral-amino acid reactant formed in the previous step to the hydrophilic residue of the amphipathic acrylic polymer, and has a hydrophilic head portion and a hydrophobic tail portion. Acrylic polymer is used as a base material.

The amphoteric acrylic polymer is a copolymer of a hydrophilic residue and a hydrophobic residue. For example, a hydrophobic residue having a reactive end at a complementary reaction site of the hydrophilic polymer is graft-polymerized (graft). It may be a polymerization). As the acrylic polymer, for example, an amphipathic polymer derived from (meth) acrylic acid is used. For example, sodium polyacrylate, acrylate / C10-30 Alkyl Acrylate Crosspolymer, and acrylate / C12-22 Alkyl Methacrylate Copolymer. , Acrylate / Beheneth-25 Methacrylate Copolymer, Acrylates / Ceteth-20 Methacrylate Copolymer, and hydroxyethyl acrylate / acryloyldimethyltaurine. It can contain one or more selected from the group consisting of Na copolymer (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer) and Ammonium Acryloyldimethyltaurate / VP Copolymer.

According to one embodiment of the present invention, the acrylic polymer can include sodium polyacrylate and acrylate / C10-30 Alkyl Acrylate Crosspolymer. These can be included in the cosmetic composition at a weight ratio of 1:20 to 1:40 based on Acrylates / C10-30 Alkyl Acrylate Crosspolymer. If it is less than the above range, hydrophobic amino acids cannot be easily carried inside after micelle formation, so that the effect of wrinkle care is reduced, and if it exceeds the above range, an appropriate pH (weakly acidic). ) Is difficult to secure, the moisturizing power is reduced, the dosage form becomes opaque, the problem of precipitation at low temperature, and separation in the form of a thin band at high temperature, which is not preferable from the aspect of dosage form stability. ..

When the temperature of the composition is 40 ° C., the electrical conductivity is preferably 600 to 850 μS / cm when the acrylic polymer is dissolved, and the pH is preferably from the viewpoint of ensuring the transparency of the dosage form. It is preferably 4 to 7.

The step of adding a hydrophilic second amino acid to neutralize the acrylic polymer, forming a crosslink and binding the acrylic polymer to the mineral-amino acid reactant emulsifies the structure of the entwined acrylic polymer. , Induce the polymer to be linear. The acrylic polymer is hydrated with purified water and then neutralized with a hydrophilic second amino acid to be linearly deformed.

The hydrophilic second amino acid is a basic amino acid and can include one or more selected from the group consisting of lysine, arginine, and histidine.

The step of adding the hydrophilic third amino acid to prepare the first composition is a step of providing a buffer for ensuring an appropriate pH and stabilizing the solution. The hydrophilic third amino acid is an acidic amino acid. Specifically, it can include one or more selected from the group consisting of glutamic acid and aspartic acid.

The first composition formed through the above-mentioned process had an electrical conductivity of 700 to 850 μS / cm at 40 ° C. and a weak acidity at a pH of 4.5 to 6.0. By ensuring such pH and electrical conductivity, it is possible to provide a weakly acidic dosage form suitable for the skin when applied to the cosmetic composition according to the embodiment of the present invention.

The step of producing the second composition containing the amphipathic solvent and the hydrophobic amino acid is a two-component step for a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor. .. This step is to dissolve the amphipathic solvent and the hydrophobic amino acids in a separate container so that the hydrophobic amino acids are easily contained inside the micelles during the formation of the micelle complex. .. The second composition may further contain purified water, if necessary.

The amphoteric solvent is a group consisting of Glycerin, Dipropylene Glycol, Methyl Propanediol, Propylene Glycol, and Butylene Glycol. Can include one or more selected from.

The hydrophobic amino acid can include one or more selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine and proline.

The step of mixing the first composition and the second composition to produce a composition containing a micelle complex is a two-component reaction. The step is preferably a step of producing the first composition and the second composition in a two-component form at a weight ratio of 1: 0.15 to 1: 0.35.

If it is less than the above range, an acrylic polymer is added even though it is a water in oil type, so specifically, a W / P type (Water in Polymer) type is used. Due to the structure binding the water (purified water), the hydrophobic moiety (Polymer) may be deficient and micelles may or may not be formed inadequately. If it exceeds the above range, a phenomenon that the layers are separated may occur, and the transparency of the final cosmetic composition may be deteriorated.

The contents of each of the constituents of the cosmetic composition containing the micelle complex of the present invention are as follows. Regarding the standard of the content, each of the first composition and the second composition is used as a standard. Each component is charged into a solvent and dissolved within the range of the following contents.

In the first composition, based on 100 parts by weight of purified water, the mineral component is 0.01 to 0.05 parts by weight, the hydrophilic first amino acid is 0.005 to 0.015 parts by weight, and the acrylic polymer is 0. It can contain 0.01 to 0.15 parts by weight, 0.001 to 0.010 parts by weight of the hydrophilic second amino acid, and 0.005 to 0.015 parts by weight of the hydrophilic third amino acid.

If the content of the mineral component is less than the above range, the hydrophilic head portion of the micelle complex is not easily formed, which is not preferable. If the content exceeds the above range, the cross-linking of the polymer due to the mineral component may be reduced, which may affect the decrease in the viscosity of the dosage form and the transparency over time. In addition, a mineral component having a content of a predetermined value or more causes water to flow out rather than being supplied to the inside of the skin due to an osmotic phenomenon, which may maximize the feeling of dryness.

If the content of the first hydrophilic amino acid is less than the above range, the hydrophilic head portion of the micelle complex is not easily formed, which is not preferable. If the content exceeds the above range, the size of the hydrophilic head portion becomes excessively large and the water binding force increases, but the surface tension, that is, the tension at the interface of the hydrophilic amino acid becomes large, and the hydrophilicity becomes hydrophilic. There is a tendency for amino acids to aggregate with each other, which is not preferable from the viewpoint of stability of the dosage form.

If the content of the acrylic polymer is less than the above range, the micellar complex cannot be formed due to its low viscosity and content. Further, it is not preferable because it is difficult to support the hydrophobic amino acid inside the micelle. If the content exceeds the range, the dosage form becomes slimy, the water absorption is poor, and the transparency may be affected.

When the content of the hydrophilic second amino acid is less than the above range, the neutralizing action of the acrylic polyol is insufficiently generated, cross-link cannot be formed, the dispersion force is lowered, and the micelle complex is formed. May adversely affect formation. If the content exceeds the above range, it is not desirable from the viewpoint of weakening the skin barrier, causing water loss, worsening the dryness of the skin, and irritating the skin due to the influence of the increase in pH.

When the content of the hydrophilic third amino acid is less than the above range, it affects to ensure the stability of the dosage form of the cosmetic composition. Further, it becomes difficult to adjust the pH to weak acidity, which is not preferable from the viewpoint that the effect of improving the moisturizing power and the effect of improving wrinkles, which are the inherent effects of the present invention, is reduced. If the content exceeds the above range, the pH becomes low, which is not preferable from the viewpoint of stability and dosage form.

The second composition may contain 0.01 to 0.10 parts by weight of hydrophobic amino acids and 20 to 50 parts by weight of purified water based on 100 parts by weight of the amphipathic solvent.

When the content of the hydrophobic amino acid is less than the above range, the total amount of the hydrophobic amino acid carried inside the micelle complex is reduced, and the moisturizing power and the effect of improving wrinkles, which are the inherent effects of the present invention, are obtained. It is not preferable from the aspect of lowering. If the content exceeds the range in which the polymer can be suspended, layer separation may occur, which is not preferable from the viewpoint of dosage form stability.

Cosmetic Composition Containing Micelle Complex Formed Using Natural Moisturizing Factors Micelles formed using natural moisturizing factors as described above have a head portion containing a mineral-hydrophilic amino acid conjugate and an acrylic type. Includes tail containing polymer. Hydrophobic amino acids are contained inside the micelles. The micelle complex contains the micelle and the hydrophobic amino acid contained in the micelle, and the micelle complex is appropriately dispersed in a cosmetic composition using purified water as a solvent.

In particular, the hydrophobic amino acid can include one or more selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine and proline.

The micelle complex can be contained in an amount of 0.01 to 0.05% by weight based on 100% by weight of the composition. By including the micelle complex in the cosmetic composition in the above range, when applied to the skin, the hydrophobic amino acids inside the micelle support the intercellular lipids in the corneocytes of the stratum corneum and bind to the water content of the skin. do. As a result, it is possible to effectively retain the moisture of the skin and prevent the evaporation of the moisture. At the same time, stability regarding layer separation and transparency of the dosage form can be ensured.

The cosmetic composition containing the micelle complex conducts electricity when the temperature of the composition is 40 ° C. from the viewpoint of alleviating wrinkles and ensuring the moisturizing power of the skin, which are the above-mentioned effects of the present invention. The cosmetic composition according to one embodiment of the present invention, which preferably has a ratio of 750 to 850 μS / cm and a pH of 5.0 to 6.0, is a water-in-oil (W / O) type. .. Specifically, by using an acrylic polymer, the oil component can include a polymer. Therefore, the present inventors refer to this as a W / P (Water In Polymer) type. Any dosage form that satisfies this can be used without limitation. For example, basic cosmetic formulations, skins, lotions, eye creams, soothing gels, ointments, mask pack formulations, body wash formulations, peeling gels, oil-in-water make-up bases, water in oil. Mold Makeup base, foundation, skin cover, lipstick, lip gloss, face powder, 2-way cake powder, eye shadow, chic color eyebrow pencil It may be any one selected from the color-tone cosmetic preparations, sunscreens, BB creams, and scalp preparations consisting of the same types.

Hereinafter, the present invention will be described in more detail through examples. These examples are for more specific explanation of the present invention, and the fact that the scope of the present invention is not limited by these examples is a person who has ordinary knowledge in the technical field to which the present invention belongs. It is clear in.

Manufacturing example
Manufacturing example 1
As a first composition, and NaCl0.025g purified water 0.5g of 75 ° _C., and MgCl 2 _0.00025, after mixing the CaCl 2 0.0002 g, microwaves using a CEM Corporation USA microwave devices Was irradiated at 2,400 to 2,500 MHz and 1000 W for 15 minutes (S1). After cooling the composition to 40 ° C., 0.5 g of purified water, 0.005 g of serine and 0.0015 g of threonine were added and reacted with a mineral component (S2). Then, 74 g of purified water, 0.045 g of sodium polyacrylate, and 0.0017 g of acrylate / C10-30 Alkyl Acrylate Crosspolymer were mixed and then charged into a container (S3). ). After mixing 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine, the mixture was placed in a container (S4). After mixing 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid, the mixture was placed in a container (S5).

As the second composition, 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed in a separate container (S6).

Then, the first composition and the second composition were mixed to produce a final composition (S7).

Manufacturing example 2
And NaCl0.025g purified water 0.5g of 75 ° _C., and MgCl 2 _0.00025, after mixing the CaCl 2 0.0002 g, microwaves using a CEM Corporation USA microwave equipment 2,400～2 Irradiation was performed for 15 minutes at an output of 500 MHz and 1000 W (S1 *). After cooling the composition to 40 ° C., 0.5 g of purified water, 0.005 g of serine and 0.0015 g of threonine were added and reacted with a mineral component (S2 *). Then, 74 g of purified water, 0.045 g of sodium polyacrylate, and 0.0017 g of acrylate / C10-30 Alkyl Acrylate Crosspolymer were mixed and then charged into a container (S3). *). After mixing 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine, the mixture was placed in a container (S4 *). After mixing 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid, the mixture was placed in a container (S5 *). After mixing 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water, the mixture was put into a container to prepare a final composition (S6 *).

Manufacturing example 3
As a first composition, and NaCl0.025g purified water 0.5g of 75 ° _C., and MgCl 2 _0.00025, after mixing the CaCl 2 0.0002 g, microwaves using a CEM Corporation USA microwave devices Was irradiated for 15 minutes at an output of 2,400 to 2,500 MHz and 1000 W (S1 **). After cooling the composition to 40 ° C., 0.5 g of purified water, 0.005 g of serine and 0.0015 g of threonine were added and reacted with a mineral component (S2 **). Then, 74 g of purified water and 0.056 g of hydroxy-ethylcellulose were mixed and then put into a container (S3 **). After mixing 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine, the mixture was placed in a container (S4 **). After mixing 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid, the mixture was placed in a container (S5 **).

As the second composition, 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed in a separate container (S6 **).

Then, the first composition and the second composition were mixed to produce a final composition (S7 **).

Manufacturing example 4
As the first composition, 0.025 g of NaCl, 0.00025 g of MgCl ₂ and _{0.0002 g of CaCl 2} were mixed in 0.5 g of purified water at 75 ° C. (S1 ***). After cooling the composition to 40 ° C., 0.5 g of purified water, 0.005 g of serine and 0.0015 g of threonine were added and reacted with a mineral component (S2 ***). Then, 74 g of purified water, 0.045 g of sodium polyacrylate, and 0.0017 g of acrylate / C10-30 Alkyl Acrylate Crosspolymer were mixed and then charged into a container (S3). ***). After mixing 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine, the mixture was placed in a container (S4 ***). After mixing 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid, the mixture was placed in a container (S5 ***).

As the second composition, 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed in a separate container (S6 ***).

Then, the first composition and the second composition were mixed to produce a final composition (S7 ***).

Examples and Comparative Examples
Example 1
The cosmetic composition produced by the process of Production Example 1 was designated as Example 1.

Examples 2-7
It is manufactured in the same manner as in the process of Production Example 1. However, the cosmetic compositions produced by adjusting the content of the constituent components as follows were used in Examples 2 to 7.

Comparative Example 1
The cosmetic composition produced by the process of Production Example 2 was designated as Comparative Example 1.

Comparative Example 2
The cosmetic composition produced by the process of Production Example 3 was designated as Comparative Example 2.

Comparative Example 3
The cosmetic composition produced by the process of Production Example 4 was designated as Comparative Example 3.

Experimental Example 1: Checking the temperature and pH at each step The temperature, pH, and electrical conductivity at each manufacturing step of Production Examples 1 to 4 were measured as shown in the table below. In the case of electrical conductivity, METTER TOLEDO Cond probe InLab 720 product was used. (The notation of "-" indicates that the measurement has not been performed.)

Experimental Example 2: Increase in skin moisture The inventors selected 50 women aged 20 to 40 years with poor skin, and applied the cosmetic composition produced by the above Examples and Comparative Examples twice daily for 1 month. I applied it to my face and neck for a while. The basic value is measured by measuring the dryness of the skin using a moisture measuring device (Corneometer, CM820 courage Khazaka electronic GmbH, Germany) in an environment where constant temperature and humidity conditions (24 ° C, humidity 40%) are satisfied prior to the start of application. Was regarded as. The moisturizing amount of the skin after the lapses of the 1st week, the 2nd week, and the 4th week, respectively, was measured to evaluate the objective effect. The results are shown in [Table 3].

Experimental Example 3: Observe the stability over time after production (observe the layer separation stability)
The compositions produced by the above Examples and Comparative Examples were used for 12 months or more under normal temperature conditions, 1 month or more under high temperature conditions of 45 ° C., and 1 month or more under low temperature conditions of -4 ° C. It was exposed to the environment and its stability over time was observed. The results are shown in [Table 4].

◯: Good (no change in appearance, transparent), Δ: Change (opaque appearance), ×: Defective (separation of layers occurs)

Experimental example 4: Measurement of wrinkle improvement Twenty healthy women aged 25 to 55 (average age: 40.30 years) were selected under constant temperature and humidity conditions of room temperature and humidity of 40 to 60%, and every experiment day. In each case, wrinkles around the eyes and skin viscoelasticity measurements (Cutometer MPA 580 (C + K, Germany)) were performed immediately before the subject used the cosmetic composition of the example. The results are shown in [Table 5].

Skin viscoelasticity value = skin change pattern region (Uv) / skin recovery pattern region (Ue)
The lower the skin viscoelasticity value, the better the elasticity.

One subject was selected, and wrinkles around the eyes before and after use (at the time of 4 weeks) of the cosmetic composition according to Example 1 of the present invention were used using a wrinkle measurement imaging device (aram ASM-300). Was taken. The result is shown in FIG. Since the area of wrinkles after use decreased, it can be seen that the wrinkles were significantly improved.

Claims (6)

With the step of adding mineral components to purified water and irradiating with microwaves to dissolve them;
With the step of adding a hydrophilic first amino acid to produce a mineral-hydrophilic amino acid reactant;
With the step of adding an acrylic polymer;
With the step of adding a hydrophilic second amino acid to neutralize the acrylic polymer to form a crosslink and binding the acrylic polymer to the mineral-amino acid reactant;
With the step of producing the first composition by adding the hydrophilic third amino acid;
With the step of making a second composition containing an amphipathic solvent and a hydrophobic amino acid;
Look including a; and mixing the second composition and the first composition, the step of preparing a composition comprising a micellar complex
The hydrophilic first amino acid contains either serine or threonine.
The acrylic polymers include sodium polyacrylate, acrylate / C10-30 Alkyl Acrylate Crosspolymer, and acrylate / C12-22 Alkyl methacrylate copolymer (Acrylates / C12-22 Alkyl). Methacrylate Copolymer), acrylate / Beheneth-25 Methacrylate Copolymer, Acrylates / Ceteth-20 Methacrylate Copolymer, and hydroxyethyl acrylate. / Includes one or more selected from the group consisting of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer and Ammonium Acryloyldimethyltaurate / VP Copolymer.
The hydrophilic second amino acid comprises one or more selected from the group consisting of lysine, arginine, and histidine.
A method for producing a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, wherein the hydrophilic third amino acid contains at least one selected from the group consisting of glutamic acid and aspartic acid. The method for producing a cosmetic composition containing a micelle complex formed by utilizing the natural moisturizing factor according to claim 1, wherein the microwave is irradiated with an output of 500 W to 1500 W. The first composition and the second composition are micelle complexes formed by utilizing the natural moisturizing factor according to claim 1, which have a weight ratio of 1: 0.15 to 1: 0.35. A method for producing a cosmetic composition containing. The amphoteric solvent is a group consisting of Glycerin, Dipropylene Glycol, Methyl Propanediol, Propylene Glycol, and Butylene Glycol. A method for producing a cosmetic composition containing a micelle complex formed by utilizing the natural moisturizing factor according to claim 1, which comprises one or more selected from. Before SL micelles Mineral - head of a hydrophilic amino acid complex and includes a tail portion of the acrylic polymer,
The method for producing a cosmetic composition according to any one of claims 1 to 4, wherein the inside of the micelle contains a hydrophobic amino acid to form a micelle complex. The hydrophobic amino acid includes at least one selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine, and proline, according to claim 5 . The method for producing a cosmetic composition according to the above.

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