JP2002212049A - Skin cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin cosmetic capable of solving a problem happened when a crosslinked polyacrylic high molecular compound is used as a water-soluble high molecular compound, excellent in pharmaceutical stability, and having an excellent moisturizing effect and good feeling of use. SOLUTION: The crosslinked polyacrylic high molecular compound is neutralized by a basic amino acid, and furthermore one or more kinds selected from an N-acyl acidic amino acid and a salt thereof and one or more kinds of polyalcohol having three or more hydroxyl groups in a molecule are used in combination and included in the skin cosmetic.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic composition having excellent preparation stability, an excellent moisturizing effect, and a good feeling in use.

[0002]

2. Description of the Related Art Conventionally, water-soluble polymer compounds have been used in skin cosmetics for the purpose of thickening, emulsifying, and stabilizing dispersion. Among the water-soluble polymer compounds,
Cross-linked polyacrylic polymer compounds such as carboxyvinyl polymer, which are excellent in thickening, microbial resistance, quality uniformity, aging resistance, and viscosity stability against temperature change, are widely used.

A crosslinked polyacrylic polymer compound is neutralized with a basic substance to increase the viscosity. However, when neutralized with a strong base, there is a problem that light resistance is poor and the viscosity is significantly reduced by ultraviolet rays. Was. In addition, when freeze-thawing was repeated, a phenomenon that the fluidity of the preparation was lost sometimes appeared. Therefore, although a method using a weak base such as L-arginine as a neutralizing agent has been attempted, it is difficult to say that sufficient formulation stability has been obtained.

[0004]

Accordingly, the present invention solves the above-mentioned problems in skin cosmetics using a cross-linked polyacrylic polymer compound as a water-soluble polymer compound, and improves the formulation stability. The purpose of the present invention is to obtain a product having excellent moisture retention and excellent use feeling.

[0005]

As a result of various studies for solving the above problems, in skin cosmetics, a crosslinked polyacrylic polymer compound was neutralized with a basic amino acid,
1 selected from N-acyl acidic amino acids and salts thereof
A good combination of two or more species and one or more selected from the group consisting of polyhydric alcohols, monosaccharides and disaccharides having three or more hydroxyl groups in the molecule is favorable. The present inventors have found that the stability of the preparation, the excellent moisturizing effect and the feeling upon use can be obtained, and the present invention has been completed.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The N-acyl acidic amino acid used in the skin cosmetic composition according to the present invention has 12 to 2 carbon atoms.
D-aspartic acid, L-aspartic acid, DL-aspartic acid, D-glutamic acid, L-glutamic acid or DL-glutamic acid having a saturated or unsaturated acyl group having about 0 linear or branched chains; Preferred as these salts are alkali metal salts such as sodium salts and potassium salts, ammonium salts, triethanolamine salts, basic amino acid salts such as L-arginine salts, L-histidine salts and L-lysine salts. No. Specifically, N-lauroyl-L-aspartic acid, N-lauroyl-DL
-Aspartic acid, N-myristoyl-L-aspartic acid,
N-myristoyl-DL-aspartic acid, N-palmitoyl-L
-Aspartic acid, N-palmitoyl-DL-aspartic acid, N-stearoyl-L-aspartic acid, N-stearoyl-DL-aspartic acid, N-oleoyl-L-aspartic acid, N-oleoyl-DL-aspartic acid N-isostearoyl-L-aspartic acid, N-isostearoyl-DL-aspartic acid, N-coconut fatty acid acyl-L-aspartic acid, N-coconut fatty acid acyl-DL-aspartic acid, N-coconut fatty acid・ Hardened tallow fatty acid acyl-L-aspartic acid, N
-Acyl fatty acid / hardened tallow fatty acid acyl-DL-aspartic acid, N-lauroyl-L-glutamic acid, N-lauroyl-DL
-Glutamic acid, N-myristoyl-L-glutamic acid, N-myristoyl-DL-glutamic acid, N-palmitoyl-L-glutamic acid, N-palmitoyl-DL-glutamic acid, N-stearoyl-L-glutamic acid, N-stearoyl-DL-glutamic acid , N-Oleoyl-L-glutamic acid, N-Oleoyl-DL
-Glutamic acid, N-isostearoyl-L-glutamic acid,
N-isostearoyl-DL-glutamic acid, N-coconut fatty acid acyl-L-glutamic acid, N-coconut fatty acid acyl-DL-glutamic acid, N-coconut fatty acid / hardened tallow fatty acid acyl-L
-Glutamic acid, N-coconut fatty acid / hardened tallow fatty acid acyl-DL-glutamic acid, and their sodium, potassium, ammonium, triethanolamine, L-
Arginine salts, DL-arginine salts and the like are exemplified as preferable ones, and one or more of them are selected and used.

Next, preferred examples of the crosslinked polyacrylic polymer compound used in the skin cosmetic according to the present invention include carboxyvinyl polymer and acrylic acid / alkyl methacrylate copolymer. Carbopol 1342,
Carbopol 934, Carbopol 940, Carbopol 94
1. Commercial products such as Carbopol 981 (above manufactured by BF Goodrich), Hibiswako 104 and Hibiswako 105 (both manufactured by Wako Pure Chemical Industries, Ltd.) can be used. As the acrylic acid / alkyl methacrylate copolymer, PEMU is used.
LEN TR-1 and PEMULEN TR-2 (BF Goo
Commercial products such as Drich Co.) can be used. In the present invention, one or more of these are selected and used.

In the skin cosmetic according to the present invention, the basic amino acids used for neutralizing the crosslinked polyacrylic polymer compound include arginine, lysine, hydroxylysine, histidine and ornithine. L-
Both body and DL-body can be used. In the present invention, one or more of these are selected and used.

Further, polyhydric alcohols having three or more hydroxyl groups in a molecule contained in the skin cosmetic according to the present invention include glycerin, erythritol, D-arabitol, xylitol, D-ribitol, galactitol, D-
Sugar alcohols such as glucitol, D-mannitol, maltitol and the like can be mentioned. Examples of monosaccharides include tetroses such as D-erythrulose, D-erythrose, and D-threose, and aldpentoses such as D-arabinose, L-arabinose, D-xylose, D-lyxose, L-lyxose, and D-ribose. , D-xylulose, L-xylulose, D-
Ketopentoses such as ribulose and L-ribulose, aldohexoses such as D-galactose, L-galactose, D-glucose, D-talose and D-mannose, L-sorbose, D-tagatose, D-psicose and D-fructose And the like, and branched sugars such as D-apiose and D-hammellose. Examples of disaccharides include xylobiose, agarobiose, carabiose, maltose, isomaltose, sophorose, cellobiose, trehalose, neotrehalose, and isotrehalose. , Inulobiose, bisianose, isoprimeverose, sambubiose, primeverose, sorabiose, melibiose,
Lactose, lycobiose, epicellobiose, sucrose, turanose, maltulose, lactulose, epigentiose, robinobiose, silanobiose, rutinose and the like. In the present invention, one or more selected from the group consisting of these are used.

The skin cosmetic according to the present invention can be provided in various preparation forms such as viscous liquid, emulsion, jelly, gel, cream and the like. Accordingly, one or more selected from N-acyl acidic amino acids and salts thereof, one or more cross-linked polyacrylic polymer compounds, and one or more basic amino acids in the skin cosmetic according to the present invention.
One or more selected from the group consisting of polyhydric alcohols, monosaccharides and disaccharides having three or more hydroxyl groups in the molecule, or two or more species, and the compounding amount of the cosmetic is determined by the dosage form of the cosmetic. Is appropriately determined according to the N-acyl acidic amino acid and one or more selected from N-acyl acidic amino acids and salts thereof, and one or two or more of the cross-linked polyacrylic polymer compound is 0.01 to 0.01, respectively. 5.0% by weight and 0.01 to 1.0
It is appropriate that the basic amount of the amino acid is one or more of the basic amino acids. In addition, the content of one or more selected from the group consisting of polyhydric alcohols, monosaccharides, and disaccharides having three or more hydroxyl groups in the molecule is about 3.0 to 20.0% by weight. Is preferred from the viewpoint of moisturizing effect and feeling of use.

The emulsified cosmetic composition for skin according to the present invention contains fats and oils, fatty acids, alcohols, esters, hydrocarbon oils, other surfactants, and the like, as long as the characteristics of the present invention are not impaired. General cosmetic raw materials such as other thickeners, humectants, antioxidants, ultraviolet absorbers, fungicides and fungicides, pigments, fragrances and the like can be further contained.

[0012]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples.

Example 1 Moisturizing Gel (1) Sodium N-stearoyl-L-glutamate 0.30 (% by weight) (2) Carboxyvinyl polymer 30.00 (1.0% by weight aqueous solution) (3) L- Arginine (10.0% by weight aqueous solution) 5.00 (4) Glycerin 15.00 (5) Sodium hyaluronate 0.01 (6) Purified water 46.44 (7) Ethanol 3.00 (8) Methyl paraoxybenzoate 0.15 (9) Fragrance 0.10 Production method: (1) to (5) are sequentially added to (6), mixed and dissolved, and (7) to (9) are previously mixed, dissolved and added. , Mix evenly.

Example 2 Emulsion (1) Squalane 3.0 (% by weight) (2) Stearic acid 1.0 (3) Beeswax 0.5 (4) Coconut oil fatty acid triglyceride 0.5 (5) Jojoba oil 1.0 (6) Cetanol 0.6 (7) N-stearoyl-L-sodium glutamate 0.3 (8) Carboxyvinyl polymer 10.0 (1.0% by weight aqueous solution) (9) L-arginine 0.3 (10) Glycerin 4.0 (11) Purified water 74.6 (12) Ethanol 4.0 (13) Methyl paraoxybenzoate 0.1 (14) Fragrance 0.1 Production method: oils of (1) to (6) The phase components are mixed and dissolved by heating to 85
° C. On the other hand, the aqueous phase components (7) to (11) were mixed and dissolved, heated to 85 ° C., and the oil phase was added thereto with stirring to pre-emulsify, then homogenized with a homomixer, and then cooled. Then, (12) to (14) are added and mixed at 40 ° C.

Example 3 Cleansing Gel (1) Sodium N-lauroyl-L-glutamate 0.5 (% by weight) (2) Carboxyvinyl polymer 50.0 (1.0% by weight aqueous solution) (3) L- Arginine (10.0% by weight aqueous solution) 6.0 (4) Glycerin 3.0 (5) 1,3-butylene glycol 3.0 (6) Polyoxyethylene (20E.O.) Sorbitan 8.0 Monolaurate (7) Methyl paraoxybenzoate 0.1 (8) Purified water 29.4 Production method: (1) to (7) are sequentially added to (8), and uniformly mixed and dissolved.

Example 4 Emollient Cream (1) Stearyl alcohol 6.0 (% by weight) (2) Stearic acid 2.0 (3) Beeswax 4.0 (4) Squalane 16.0 (5) Jojoba oil 3 0.0 (6) Glyceryl monostearate 2.0 (7) N-myristoyl-DL-sodium glutamate 3.0 (8) Acrylic acid / alkyl methacrylate copolymer 0.1 (9) L-lysine 2 (10) Glycerin 5.0 (11) Xylitol 2.0 (12) Methyl paraoxybenzoate 0.1 (13) Purified water 56.5 (14) Fragrance 0.1 Manufacturing method: (1) to (6) The oil phase components were mixed and dissolved by heating.
° C. On the other hand, the aqueous phase components (7) to (13) were mixed and dissolved, heated to 70 ° C., and the oil phase was added thereto with stirring to carry out preliminary emulsification, then homogenized with a homomixer, and then cooled. (14) is added and mixed at 40 ° C.

Example 5 Massage Cream (1) Squalane 35.50 (% by weight) (2) Jojoba oil 5.00 (3) Coconut oil fatty acid triglyceride 3.00 (4) Stearic acid 1.00 (5) Beeswax 0.15 (6) potassium N-coconut fatty acid acyl-L-glutamate 1.00 (7) hexaglyceryl monostearate 3.00 (8) sucrose monolaurate 0.50 (9) sucrose mono Stearic acid ester 1.00 (10) D-glucitol 7.50 (11) D-glucose 1.50 (12) carboxyvinyl polymer 0.15 (13) methyl paraoxybenzoate 0.10 (14) purified water 38. 50 (15) Hydroxy-L-lysine (10.0% by weight aqueous solution) 2.00 (16) Fragrance 0.10 Production method: Mix and dissolve oil phase components (1) to (5) , 80 ° C
And On the other hand, the aqueous phase components (6) to (14) were mixed and dissolved and heated to 80 ° C., and the oil phase was gradually added thereto for pre-emulsification, homogenized with a homomixer, and then cooled. , 40 ° C
Then, (15) and (16) are added and further cooled.

Example 6 Cleansing Cream (1) Squalane 50.00 (% by weight) (2) Behenyl alcohol 1.50 (3) Stearic acid 1.00 (4) Hardened castor oil 0.50 (5) Beeswax 0 .10 (6) Glyceryl monostearate 1.50 (7) Sodium N-stearoyl-L-aspartate 1.00 (8) Decaglyceryl monolaurate 3.00 (9) Maltitol 7.00 (10) Acrylic acid / alkyl methacrylate copolymer 0.15 (11) Methyl paraoxybenzoate 0.10 (12) Purified water 32.05 (13) DL-ornithine (10.0% by weight aqueous solution) 2.00 (14) Fragrance 0.10 Production method: Mix and heat-dissolve oil phase components (1) to (6),
And On the other hand, the aqueous phase components (7) to (12) were mixed and dissolved, heated to 80 ° C., gradually added to the oil phase, pre-emulsified, homogenized with a homomixer, and cooled. At ° C
(13) and (14) are added and further cooled.

With respect to Examples 1 to 6, the stability of the preparation, the moisturizing effect and the feeling upon use were evaluated. that time,
The glycerin was purified in Comparative Examples 1, Comparative Example 3, Comparative Example 5, Comparative Example 7, Examples 1 and 2 by replacing the N-acyl acidic amino acid salt with purified water in Examples 1 to 4. Comparative Example 2 and Comparative Example 4 in which water was substituted, Comparative Example 6 in which glycerin was substituted for propylene glycol in Example 3, and Comparative Example 8 in which glycerin and xylitol were substituted for propylene glycol in Example 4. , At the same time.

The stability of the preparations was determined for each of the Examples and Comparative Examples at 25 ° C. for 3 months, 50 ° C. for 1 month, −5 ° C.
After storage under the conditions of one month while changing the temperature at 40 ° C., observe the presence or absence of a change in state such as phase separation, precipitation of contained components, and change in viscosity or hardness. Not possible ","△; slight change in state "," X: noticeable change in state "
It was shown to.

As for the moisturizing effect and feeling of use,
Evaluation was made by a use test in which 20 female panelists in their 0s to 50s were grouped as one group. That is, each of the examples and the comparative examples was blindly used by each group, and the moisturizing effect felt after use, the elongation at the time of use, the conformity with the skin, and the presence or absence of stickiness were sensory evaluated according to the evaluation criteria shown in Table 2. The average value of the 20 subjects was calculated, and the results are shown in Table 3.

[0022]

[Table 1]

[0023]

[Table 2]

[0024]

[Table 3]

As is evident from Table 1, no change was observed in the working examples of the present invention under any of the storage conditions. On the other hand, Comparative Example 1, Comparative Example 3, Comparative Example 5, and Comparative Example 7, which do not contain the N-acyl acidic amino acid salt, particularly at 50 ° C. for one month or at −5 ° C. to 50 ° C. for one month In Comparative Examples 2 and 4, which have poor stability under storage conditions and do not contain any polyhydric alcohol or the like, a slight change in state was observed under the storage conditions.

As is clear from Table 3, high moisturizing effects were observed in all of the examples of the present invention. In addition, elongation during use and conformability with the skin were evaluated to be good, and no sticky feeling that was a problem was felt. On the other hand, Comparative Example 1, Comparative Example 3, Comparative Example 5, and Comparative Example 7, which did not contain the N-acyl acidic amino acid salt, had a low evaluation particularly on the familiarity with the skin. Further, Comparative Example 2, Comparative Example 4, which did not contain a polyhydric alcohol having three or more hydroxyl groups in the molecule.
About Comparative Example 6 and Comparative Example 8, the evaluation of the moisturizing effect was low, and Comparative Examples 2 and 4 were further evaluated.
Except for the examples, the stickiness was felt stronger than the corresponding examples.

[0027]

As described above in detail, according to the present invention, the problems in the case of using a crosslinked polyacrylic polymer compound as the water-soluble polymer compound are solved, the preparation stability is excellent, and excellent moisture retention is achieved. A skin cosmetic having an effect and a good feeling in use could be obtained.

Continued on the front page (72) Inventor Masumi Takei 112-1 Nogami, Okada-cho, Yoka City, Shiga Prefecture F-term in Noevir Shiga Central Research Laboratory Co., Ltd. 4C083 AA082 AA122 AC022 AC062 AC102 AC111 AC122 AC132 AC242 AC422 AC442 AC482 AC582 AC661 AC662 AD091 AD092 AD202 AD222 AD332 CC02 CC05 EE12

Claims (2)

[Claims] 1. One or more kinds selected from N-acyl acidic amino acids and salts thereof, one or more kinds of crosslinked polyacrylic polymer compounds, one or more kinds of basic amino acids, And a skin cosmetic comprising one or more selected from the group consisting of polyhydric alcohols having three or more hydroxyl groups in the molecule, monosaccharides and disaccharides. 2. A crosslinked polyacrylic polymer compound 1
The skin cosmetic according to claim 1, wherein the species or two or more species are selected from a carboxyvinyl polymer and an acrylic acid / alkyl methacrylate copolymer.