JP2001010925A - Emulsified composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition excellent in bleaching effect, antimicrobial effect, etc., having sufficient stability and suitable for cosmetics and lotions by including a polymer having an alkyl in the side chain and a resorcinol derivative. SOLUTION: This emulsified composition comprises (A) preferably 0.01-2 wt.% polymer having a 1-30C alkyl in the side chain and having 1,000,000 to 3,000,000 average molecular weight (e.g. acrylic acid-alkyl methacrylate copolymer) and (B) preferably 0.01-10 wt.% resorcinol derivative of formula I (R1 and R2 are H, a 1-4C acyl or the like; R3 is an alkyl or H) (e.g. 4-n- butylresorcinol of formula II). The composition preferably does not use a nonionic surfactant (e.g. polyoxyethylene fatty acid ester). The composition can further comprise an aqueous component, an oily component, an emulsifying agent, etc., and can be formulated in a dosage form of cream, emulsion, ointment, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an emulsion composition useful for cosmetics and pharmaceutical bases.

[0002]

2. Description of the Related Art Resorcinol derivatives have a melanin production-suppressing action and an antibacterial action and are excellent in safety, and thus are useful as active ingredients in skin preparations such as cosmetics and skin preparations. However, percutaneous absorption through the skin of a cosmetic or the like containing a resorcinol derivative was not always sufficient. Therefore, it has been desired to improve percutaneous absorption through the skin by formulating a resorcinol derivative using a compounding system suitable for enhancing the above-mentioned effective effects.

[0003] In the system of the emulsified composition used for cosmetics and pharmaceutical bases, the emulsifying properties are usually stabilized by a nonionic surfactant, but from the viewpoint of safety, a nonionic surfactant is contained. It is preferable to stabilize without performing. Therefore, development of a preparation containing a resorcinol derivative which does not contain a nonionic surfactant and has sufficient stability has been desired. However, it is difficult to obtain a stable emulsified composition by emulsification under the condition that does not contain a nonionic surfactant, and the viscosity of the produced composition becomes high, so that the elongation at the time of use increases. There were also problems in use such as becoming heavy.

On the other hand, a polymer having an average molecular weight of 1 to 3,000,000 having a side chain of an alkyl group having 10 to 30 carbon atoms is commercially available as a thickener having an emulsifying action, and this is emulsified together with a resorcinol derivative. It has not been known that the composition contains a non-ionic surfactant or a stable emulsification system without a nonionic surfactant.

[0005]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and is suitable for a cosmetic or a skin external medicine containing a resorcinol derivative such as 4-n-butylresorcinol. It is an object of the present invention to provide a preparation containing no ionic surfactant and having sufficient stability.

[0006]

DISCLOSURE OF THE INVENTION In view of such circumstances, the present inventors have developed a formulation containing a resorcinol derivative, which is suitable for cosmetics and external medicine for skin and has sufficient stability.
Preferably, as a result of intensive research efforts for a formulation containing no nonionic surfactant, the emulsified composition is characterized by containing a polymer having an alkyl group in a side chain. Heading, the invention was completed.

[0007] That is, the present invention provides a compound having 10 to 30 carbon atoms.
An emulsified composition comprising a polymer having an average molecular weight of 1 to 3,000,000 having an alkyl group as a side chain and a resorcinol derivative represented by the following general formula (I).

[0008]

Embedded image (Wherein, R ₁ and R ₂ each independently represent a hydrogen atom, an acyl group having 1 to 4 carbon atoms, an alkyl group having 1 to 4 carbon atoms,
R ₃ represents an alkyl group or a hydrogen atom; )

Further, the resorcinol derivative is preferably 4-n-butyl resorcinol represented by the following general formula (II) and / or a salt thereof.

[0010]

Embedded image

Examples of the polymer having an alkyl group in the side chain include an acrylic acid / alkyl methacrylate copolymer and / or
Or its salt is preferable.

Further, the present invention provides the above emulsified composition, wherein the composition contains no nonionic surfactant.

Further, the emulsified composition of the present invention is suitable for use as an external preparation for skin and also suitable for use as a cosmetic.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail focusing on embodiments. The present invention is an emulsified composition comprising a resorcinol derivative and a polymer having an alkyl group in a side chain. First, the resorcinol derivative will be described. (1) Resorcinol derivative The emulsified composition of the present invention contains a resorcinol derivative. The resorcinol derivative referred to in the present invention means a 1,3-dihydroxyphenol derivative represented by the general formula (I) and / or a physiologically acceptable salt thereof, and is preferably an alkylresorcinol and / or a salt thereof. These salts are physiologically acceptable.

[0015]

Embedded image Here, the alkyl group is an alkyl group having a linear, branched or cyclic structure having about 4 to 7 carbon atoms, and the binding site thereof is preferably the 4-position of a benzene ring. Particularly preferred among these alkyl groups are n-butyl groups bonded to the 4-position. That is, 4-n-butyl resorcinol and / or a salt thereof having a structure represented by the following general formula (II). These have an excellent melanin production inhibitory action, that is, a physiologically active action such as a whitening action and an antibacterial action.

[0016]

Embedded image (Wherein, R ₁ and R ₂ each independently represent a hydrogen atom, an acyl group having 1 to 4 carbon atoms, an alkyl group having 1 to 4 carbon atoms,
It represents a mesyl group (methanesulfonyl group) or a tosyl group (p-toluenesulfonyl group), and R ₃ represents an alkyl group or a hydrogen atom. )

The alkylresorcinol represented by the general formula (I) is a known substance, and its production method is also known (see Japanese Patent Application Laid-Open No. 2-49715). That is, resorcinol is prepared, for example, by condensing a saturated carboxylic acid and resorcinol in the presence of zinc chloride, and then reducing the condensate with zinc amalgam / hydrochloric acid (Lille. J. Bi).
tter, LA. Peiner. V, Tr. Nauch-Iasled. Inst.slan
tsev 1969, No. 18, 127) or a method in which resorcinol and the corresponding alkyl alcohol are reacted at a high temperature of 200 to 400 ° C. using an alumina catalyst (see British Patent No. 1,581,428). ) Can be easily obtained.

As the salt, any physiologically acceptable salt can be used without any particular limitation.
Alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium and magnesium; ammonium salts; organic amine salts such as triethanolamine salts and triethylamine salts; basic amino acid salts such as lysine salts and arginine salts; Can be preferably exemplified. Among these,
Particularly preferred are alkali metal salts, of which potassium salts are particularly preferred.

The content of the resorcinol derivative in the emulsified composition of the present invention is preferably from 0.01 to 10% by weight, more preferably from 0.05 to 5% by weight.

(2) Polymer having an alkyl group on the side chain The emulsion composition of the present invention contains a polymer having an alkyl group on the side chain. This is achieved by emulsifying with the polymer in a combination of the above resorcinol derivative and an ether of a polyhydric alcohol and an unsaturated alcohol,
This is because the separation of the cosmetic can be suppressed and the action time can be prolonged. Here, the alkyl group is preferably an alkyl group having many carbon atoms, more preferably having 8 to 34 carbon atoms, and particularly preferably having 10 to 30 carbon atoms. Further, the average molecular weight of the polymer is preferably from 100,000 to 3,000,000, and particularly preferably from 1,000,000 to 3,000,000. Examples of such a polymer include one or more selected from acrylic acid and its alkyl ester, alkyl amide, methacrylic acid and its alkyl ester, alkyl amide, acylated vinyl alcohol and its alkyl ether, styrene and α-alkylstyrene. A polymer (homopolymer) and / or copolymer containing two or more kinds of constituent monomers is preferably exemplified, and among them, an acrylic acid / alkyl methacrylate copolymer and / or a salt thereof is preferably exemplified. Such a polymer is prepared by converting acrylic acid or methacrylic acid to chloride with thionyl chloride or the like according to a conventional method, and then reacting with an alcohol or an alkylamine in the presence of an alkali to form a constituent monomer, which is polymerized. Although it is possible to obtain it, it is also possible to use a commercially available product.

Preferred among such commercial products are Pemulen TR-1 and Pemulen TR-
Acrylic acid / alkyl methacrylate copolymer sold under the trade name of No. 2 (the alkyl group has 10 to 30 carbon atoms)
And / or a salt thereof. Here, as the salt, any physiologically acceptable salt can be used, for example, an alkali metal salt such as sodium or potassium, an alkaline earth metal salt such as calcium or magnesium, an ammonium salt, Organic amine salts such as triethylamine salt and triethanolamine salt, and basic amino acid salts such as lysine and arginine are preferably exemplified. Most preferred of these are alkali metal salts.

These polymers having an alkyl group in the side chain may be used alone or in combination of two or more. In the emulsion composition of the present invention, these polymers may be used in combination. The preferred content of the polymer having an alkyl group is
0.01 to 2% by weight, and more preferably 0.05 to 2% by weight.
1% by weight. This is because if the amount is too large, the viscosity may be excessively increased, and if the amount is too small, the stabilizing effect may not be obtained.

(3) Emulsion composition of the present invention The emulsified composition of the present invention contains the above-mentioned resorcinol derivative, a polymer having an alkyl group in a side chain and / or a salt thereof. In the emulsified composition of the present invention, in addition to the above, it contains a base component for forming an emulsified composition usually used in the field of application of the emulsified composition of the present invention such as a cosmetic or a topical skin medicine. . The base component contains an aqueous component, an oil component, an emulsifier, and the like. And, as a base component, for example, water and the like as an aqueous component, hydrocarbons such as petrolatum and microcrystalline wax as an oil phase component, esters such as jojoba oil and gay wax, tallow, olive oil and the like Triglycerides, cetanol,
Examples include higher alcohols such as oleyl alcohol, fatty acids such as stearic acid and oleic acid, and polyhydric alcohols such as glycerin and 1,3-butanediol. Various surfactants can be used as the emulsifier without particular limitation. As the surfactant, for example,
Examples include anionic surfactants, nonionic surfactants, and amphoteric surfactants. Among these surfactants, lecithin, sucrose fatty acid ester, casein salt, sphingolipid, glycyrrhizic acid or a salt thereof, elastin hydrolyzate, collagen hydrolyzate, N-acyl glutamate, pectin, xanthan gum, locust Natural surfactants such as bean gum and karaya gum are preferred.

The emulsion composition of the present invention can use a nonionic surfactant, but from the viewpoint of safety, it is preferable not to use a nonionic surfactant. According to the present invention, by containing the polymer having an alkyl group in the side chain and / or a salt thereof, an emulsion composition having excellent stability can be produced without using a nonionic surfactant. In addition, as a nonionic surfactant, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyglycerin fatty acid ester, etc. Can be illustrated. In addition, in the case of a commonly known emulsion composition system, the viscosity of the emulsified composition increases when an emulsified formulation is prepared under conditions that do not contain a nonionic surfactant in order to create a highly safe emulsified formulation. Therefore, the use tends to have a longer spread. However, in the emulsified composition of the present invention, 8000 c. s. Even at a low viscosity (at 5 ° C.) or less, a formulation having excellent stability can be obtained, and thus an emulsion composition having good spreadability and excellent usability can be obtained.

As described above, the emulsified composition of the present invention can form a stable emulsified system even without containing a nonionic surfactant, so that it has high safety and is suitable as a base for cosmetics and external medicines for skin. .

In addition to the above-mentioned components, optional components which are usually blended in cosmetics and topical skin medicines, for example, thickeners such as ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants, pigments and powders And the like. Furthermore, if it is a skin external medicine, antifungal agent, anti-inflammatory agent, steroid,
It can contain active ingredients such as antipruritics, antibiotics and the like. The emulsion composition of the present invention can be produced by treating these components according to a conventional method.

[0027] The dosage form of the cosmetic of the present invention is not particularly limited. Specifically, creams, emulsions,
Examples include oils, lotions, ointments, packs, aqueous gels, oil gels, bath preparations, and the like. Considering the transdermal absorbability, creams, emulsions, oils and the like are preferred dosage forms. Similarly, skin external medicines can be widely used in the form of ointments, creams and the like.

[0028]

The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited only to these examples.

<Example 1> Cosmetic 1 (emulsion), which is an emulsified composition of the present invention, was produced according to the formulation shown in Table 2 below. That is, the components (a) and (b) are each heated to 80 ° C.
The mixture was gradually added to (1) while stirring to emulsify the mixture, and the emulsion particles were homogenized with a homogenizer, followed by cooling to obtain an emulsion composition.

As Comparative Example 1, an attempt was made to produce an emulsion in which Pemulen TR-2 was replaced with a carboxyvinyl polymer, but emulsification was not possible. The emulsion of Comparative Example 2 produced by substituting 1 part by weight of Pemulen TR-2, potassium hydroxide and water with polyoxyethylene (20) stearyl ether was separated within 24 hours after emulsification at room temperature.

After emulsifying Cosmetic 1 and leaving it at room temperature for 24 hours, it was filled in a storage bottle and stored for 24 hours under the following temperature conditions. The viscosity measured was 5 ° C .;
° C; 2800, 40 ° C; 2000 (unit is each cs)
Met. This cosmetic 2 was stable even when stored under the harsh condition of 50 ° C. for 10 days. Thus, in the emulsified composition of the present invention, when a combination of an ether of a polyhydric alcohol and an unsaturated higher alcohol and a polymer having an alkyl group in a side chain is used, the viscosity is low and the stability is excellent. It can be seen that a polymer having an alkyl group in the side chain is a preferable component.

When the whitening effect of this cosmetic 1 and the emulsion of Comparative Example 2 was evaluated by the evaluation method shown in Table 1 below, Comparative Example 2 was +, whereas Cosmetic 1 was ++. It has been found that the use of such a system emulsified with a polymer having an alkyl group in the side chain without using a nonionic surfactant further enhances the whitening effect of the present invention.

[0033]

[Table 1]

That is, a part 4 of a human forearm 2 cm × 2 cm
Finally, a turning model was created by irradiating ultraviolet light (light source: SE lamp manufactured by Toshiba) 0.5 times the MED obtained in advance once a day for three days. Cosmetic 1 of the present invention was used in one of the four sites turned, the cosmetic of Comparative Example 1 was used in one site, and the cosmetic of Comparative Example 1 was used in one site in an amount of 0.01 ml /.
24 hours after the last administration, the remaining one site was observed at 24 hours after the last administration without any treatment (untreated). The whitening effect of the site was determined based on the criteria shown in Table 1 above.

[0035]

[Table 2]

[0036] Cosmetic 1 was used as a sample on an agar plate medium.
After 0.1 ml was spread, various bacteria were inoculated with a platinum loop, and an antibacterial test was performed to check the growth status. Seven days after the inoculation of the bacteria, colonization was not observed when any of Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans was inoculated.

Example 2 According to the formulation shown in Table 3 below, cosmetic 2 (emulsion), which is an emulsified composition of the present invention, was produced. That is, the components (a) and (b) are each heated to 80 ° C.
The mixture was gradually added to (1) while stirring to emulsify the mixture, and the emulsion particles were homogenized with a homogenizer, followed by cooling to obtain an emulsion composition.

As Comparative Example 3, an attempt was made to produce an emulsion in which Pemulen TR-2 was replaced by a carboxyvinyl polymer, but emulsification was not possible. Further, the emulsion of Comparative Example 4 produced by substituting 1 part by weight of Pemulen TR-2, potassium hydroxide and water with polyoxyethylene (20) stearyl ether was separated within 24 hours after emulsification at room temperature.

After emulsifying the cosmetic 2, the emulsion was allowed to stand at room temperature for 24 hours, then filled in a storage bottle, and stored for 24 hours under the following temperature conditions, and the viscosity measured was 5 ° C .;
° C; 2910, 40 ° C; 2000 (unit is each cs)
Met. This cosmetic 2 was stable even when stored under the harsh condition of 50 ° C. for 10 days. Thus, when a polymer having an alkyl group in the side chain is used in the emulsified composition of the present invention, the effects of low viscosity and excellent stability can be obtained.

[0040]

[Table 3]

<Example 3> Cosmetic 3 (emulsion), which is an emulsified composition of the present invention, was produced according to the formulation shown in Table 4 below. That is, the components (a) and (b) are each heated to 80 ° C.
The mixture was gradually added to (1) while stirring to emulsify the mixture, and the emulsion particles were homogenized with a homogenizer, followed by cooling to obtain an emulsion composition. Incidentally, as Comparative Example 5, an attempt was made to produce an emulsion by substituting Pemlen TR-2 with a carboxyvinyl polymer, but emulsification was not possible. The emulsion of Comparative Example 6 produced by substituting 1 part by weight of Pemulen TR-2, potassium hydroxide and water with polyoxyethylene (20) stearyl ether was separated within 24 hours after emulsification at room temperature.

After emulsifying the cosmetic 3, the cosmetic was left at room temperature for 24 hours, filled in a storage bottle, and stored at 20 ° C. for 24 hours. The viscosity measured was 1960 (unit: each cs). Was. This cosmetic 4 was stable even when stored under the severe conditions of 50 ° C. for 10 days. Thus, when a polymer having an alkyl group in the side chain is used in the emulsion composition of the present invention, the effects of low viscosity and excellent stability can be obtained.

[0043]

[Table 4]

<Example 4> Cosmetic 4 (emulsion), which is an emulsified composition of the present invention, was produced according to the formulation shown in Table 5 below. That is, the components (a) and (b) are each heated to 80 ° C.
The mixture was gradually added to (1) with stirring to emulsify the mixture, homogenized the emulsified particles with a homogenizer, and then cooled to obtain an emulsified composition. In addition, as Comparative Example 7, an attempt was made to produce an emulsion in which Pemulen TR-1 was replaced with a carboxyvinyl polymer, but emulsification was not possible. The emulsion of Comparative Example 8 produced by substituting 1 part by weight of Pemulen TR-2, potassium hydroxide and water with polyoxyethylene (20) stearyl ether was separated within 24 hours after emulsification at room temperature.

This cosmetic 4 was stable when stored under severe conditions of 50 ° C. for 10 days. Than this,
It can be seen that in the emulsion composition of the present invention, when a polymer having an alkyl group in the side chain is used, an effect of excellent stability can be obtained.

[0046]

[Table 5]

Example 5 According to the formulation shown in Table 6 below, cosmetic 5 (emulsion), which is an emulsified composition of the present invention, was produced. That is, the components (a) and (b) are each heated to 80 ° C.
The mixture was gradually added to (1) while stirring to emulsify the mixture, and the emulsion particles were homogenized with a homogenizer, followed by cooling to obtain an emulsion composition. In addition, as Comparative Example 9, an attempt was made to produce an emulsion in which Pemulen TR-2 was substituted with a carboxyvinyl polymer, but the emulsion could not be emulsified. The emulsion of Comparative Example 10 produced by replacing 2 parts by weight of Pemulen TR-2, potassium hydroxide and water with polyoxyethylene (60) hydrogenated castor oil separated within 24 hours after emulsification at room temperature. .

This cosmetic 5 was stable even when stored under severe conditions of 50 ° C. for 10 days. This shows that, in the emulsion of the present invention, when a polymer having an alkyl group in the side chain is used, an effect of excellent stability can be obtained.

[0049]

[Table 6]

Example 6 Cosmetic 6 (emulsion), which is an emulsified composition of the present invention, was prepared according to the formulation shown in Table 7 below. That is, the components (a) and (b) are each heated to 80 ° C.
The mixture was gradually added to (1) with stirring to emulsify the mixture, homogenized the emulsified particles with a homogenizer, and then cooled to obtain an emulsified composition. In addition, as Comparative Example 11, an attempt was made to produce an emulsion in which Pemulen TR-2 was replaced with a carboxyvinyl polymer, but emulsification was not possible. Also, 2 parts by weight of Pemulen TR-2, potassium hydroxide, and water were used as polyoxyethylene (45).
The emulsion of Comparative Example 12 prepared by substituting the stearic acid ester was separated within 24 hours after emulsification at room temperature.

This cosmetic 6 was stable even when stored under severe conditions of 50 ° C. for 10 days. From this, it can be seen that when a polymer having an alkyl group in the side chain is used in the emulsion composition of the present invention, an effect of excellent stability can be obtained.

[0052]

[Table 7]

<Example 7> Cosmetic 7 (emulsion), which is an emulsified composition of the present invention, was prepared according to the formulation shown in Table 8 below. That is, the components (a) and (b) are each heated to 80 ° C.
The mixture was gradually added to (1) while stirring to emulsify the mixture, and the emulsion particles were homogenized with a homogenizer, followed by cooling to obtain an emulsion composition. In addition, as Comparative Example 13, an attempt was made to produce an emulsion in which Pemulen TR-2 was replaced with a carboxyvinyl polymer, but emulsification was not possible. Also, 2 parts by weight of Pemulen TR-2, potassium hydroxide, and water were used as polyoxyethylene (20).
The emulsion of Comparative Example 14 prepared by substituting oleyl ether was separated within 24 hours after emulsification at room temperature.

This cosmetic 7 was stable even when stored under the severe conditions of 50 ° C. for 10 days. From this, it can be seen that when a polymer having an alkyl group in the side chain is used in the emulsion composition of the present invention, an effect of excellent stability can be obtained.

[0055]

[Table 8]

Example 8 Cosmetic 8 (emulsion), which is an emulsified composition of the present invention, was prepared according to the formulation shown in Table 9 below. That is, the components (a) and (b) are each heated to 80 ° C.
The mixture was gradually added to (1) while stirring to emulsify the mixture, and the emulsion particles were homogenized with a homogenizer, followed by cooling to obtain an emulsion composition. Incidentally, as Comparative Example 15, an attempt was made to produce an emulsion in which Pemulen TR-2 was replaced with a carboxyvinyl polymer, but emulsification was not possible. In addition, 1 part by weight of Pemulen TR-2, potassium hydroxide and water was used as polyoxyethylene (20).
The emulsion of Comparative Example 16 prepared by substituting behenyl ether was separated within 24 hours after emulsification at room temperature.

This cosmetic 8 was stable even when stored under severe conditions of 50 ° C. for 10 days. From this, it can be seen that when a polymer having an alkyl group in the side chain is used in the emulsion composition of the present invention, an effect of excellent stability can be obtained.

[0058]

[Table 9]

<Example 9> The usability of the cosmetics of Examples 1 to 8 at 5 ° C was examined using a specialized paneler. Usability was evaluated based on evaluation criteria shown in Table 10 below for evaluation items of good spreadability, close contact feeling, and good skin familiarity.

[0060]

[Table 10]

Table 11 shows the results. This shows that the cosmetic of the present invention has a low viscosity even at a low temperature, so that it spreads well and has extremely good usability such as a feeling of close contact with skin and conformability.

[0062]

[Table 11]

Example 10 The cosmetics of Examples 1 to 8 were examined for safety using a guinea pig damaged skin model (5 animals per group). The guinea pigs were shaved on their backs, stripped with gum tape and closed for 48 hours. After removal of the patch, the skin response was evaluated according to the so-called Draise criteria shown in Table 12 below.

[0064]

[Table 12]

The results were no reaction (-) with any of the animals, demonstrating that the cosmetic of the present invention has high safety.

Example 11 According to the formulation shown in Table 13 below, a skin external medicine 1 (emulsion) as an emulsified composition of the present invention was produced. That is, each of the components (a) and (b) is
Then, the mixture was gradually added to the mixture while stirring, and the mixture was emulsified. After homogenizing the emulsified particles with a homogenizer, the mixture was cooled to obtain an emulsion composition. It was an excellent pharmaceutical base because it spreads very well and has little detachment from the skin. Undesirable effects (physical irritation) due to application were also suppressed on damaged skin using anti-inflammatory agents. Further, the antibacterial action of the resorcinol derivative was stable against microorganisms.

[0067]

[Table 13]

Example 12 According to the formulation shown in Table 14 below, a skin external medicine 2 (emulsion), which is an emulsified composition of the present invention, was produced. That is, each of the components (a) and (b) is
Then, the mixture was gradually added to the mixture while stirring, and the mixture was emulsified. After homogenizing the emulsified particles with a homogenizer, the mixture was cooled to obtain an emulsion composition. It was an excellent pharmaceutical base because it spreads very well and has little detachment from the skin. Undesired effects of application (physical irritation) were also suppressed on viran skin using antifungal agents. Further, no pigmentation was observed on the skin after the recovery of virane due to the action of the resorcinol derivative.

[0069]

[Table 14]

[0070]

The emulsified composition of the present invention is excellent in resorcinol derivatives, such as whitening effect and antibacterial effect. The emulsion composition of the present invention has excellent stability without using the nonionic surfactant. Further, in the emulsified composition of the present invention, even a low-viscosity composition can produce a preparation having excellent stability,
An emulsion composition having good spreadability and excellent usability can be provided. According to the present invention, suitable for cosmetics and external medicines for skin, suitable for cosmetics and external medicines containing resorcinol derivatives, preparations that do not use nonionic surfactants, and preparations that have sufficient stability Can be provided.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification code FI Theme coat ゛ (Reference) A61K 31/00 617 A61K 31/00 617 631 631C 31/045 601 31/045 601 47/10 47/10 ( 72) Inventor Yasuhiro Fukuda 27-1, Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa Prefecture Inside the Yokohama Research Laboratory, Polar Chemical Industry Co., Ltd. (72) Inventor Masahiro Torihara 2-28, Kurashiki-cho, Nakajo-cho, Kitakanbara-gun, Niigata Prefecture 72) Inventor Hiromichi Tamai 2-28 Kurashiki-cho, Nakajo-cho, Kitakanbara-gun, Niigata F-term in Kuraray Co., Ltd. AC472 AC482 AD091 AD092 AD152 CC01 CC02 CC05 DD31 EE01 FF05 4C206 AA01 AA02 CA17 CA19 MA01 MA83 NA11 ZA89

Claims (6)

[Claims] 1. A polymer having a side chain of an alkyl group having 10 to 30 carbon atoms and having an average molecular weight of 1 to 3,000,000, and a resorcinol derivative represented by the following general formula (I). Emulsified composition. Embedded image (Wherein, R ₁ and R ₂ each independently represent a hydrogen atom, an acyl group having 1 to 4 carbon atoms, an alkyl group having 1 to 4 carbon atoms,
R ₃ represents an alkyl group or a hydrogen atom; ) 2. The emulsion composition according to claim 1, wherein the resorcinol derivative is 4-n-butyl resorcinol represented by the following general formula (II) and / or a salt thereof. Embedded image 3. The polymer having an alkyl group as a side chain,
The emulsion composition according to claim 1, which is an acrylic acid / alkyl methacrylate copolymer and / or a salt thereof. 4. The emulsion composition according to claim 1, wherein the emulsion composition does not contain a nonionic surfactant. 5. The emulsified composition according to claim 1, which is an external preparation for skin. 6. The cosmetic according to claim 1, which is a cosmetic.
The emulsified composition according to any one of claims 1 to 5.