JP2006045081A - Skin care preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation containing 4-n-butylresorcinol and stably preservable even under a high-temperature condition. <P>SOLUTION: The skin care preparation contains 4-n-butylresorcinol and/or its salt and a compound having a quaternary amino group. Especially, the amount of the 4-n-butylresorcinol and/or its salt is 0.1-0.5 mass% and that of the compound having a quaternary amino group is 0.01-5 mass% based on the total amount of the skin care preparation. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an external preparation for skin. More specifically, the present invention relates to an external preparation for skin suitable as a quasi-drug that promotes the action of suppressing the production of melanin.

  Various whitening materials have been developed to keep the skin white and keep it forever. Examples include ascorbic acid and its derivatives, placenta extract, arbutin, kojic acid, ellagic acid, tranexamic acid, chamomile extract, 4-n-butylresorcinol and the like. These have been developed as active ingredients of quasi drugs for suppressing melanin production. However, because placenta extract is a problem of BSE (bovine sponge brain syndrome) and kojic acid is suspected to be carcinogenic, use of them as quasi-drugs (including whitening materials) is restricted. Has been. Among the whitening materials that can be used at present, 4-n-butylresorcinol is known as a material that has high safety and is considered to be the most promising (see, for example, Patent Document 1). In addition, 4-n-butylresorcinol is already known also about the manufacturing method (for example, refer nonpatent literature 1).

  While 4-n-butylresorcinol has two phenolic hydroxyl groups, it has extremely high stability under actual use conditions (for example, a state of being contained in a skin external preparation under normal pressure and normal temperature conditions). However, in recent years when logistics has been developed internationally, it has been desired to further improve the stability of an external preparation for skin containing such components under severe conditions, particularly at high temperatures. This is because the external preparation for skin is sometimes stored under high temperature conditions in import and export.

In addition, compounds having a quaternary amino group such as cationized guar gum and polyquaternium are known as compounds that enhance water retention of hair and the like (for example, Patent Document 2, Patent Document 3, Patent Document 4, Patent (Ref. Literature 5, Patent Literature 6, Patent Literature 7, and Patent Literature 8).
However, a skin external preparation containing both a compound having a quaternary amino group and 4-n-butylresorcinol is not known, and the effect of the skin external preparation is not known.

Japanese Patent Laid-Open No. 02-49715 Japanese Patent Laid-Open No. 2003-113037 Special table 2001-522786 gazette JP 2004-107319 A JP 2004-83516 A JP 2001-58937 A JP 2000-34218 A JP 2004-2319 A Lille, J .; Bitter, L. A .; Peiner, V. Trudy-Nauchono-Issledovatelskii Institut Slantsev (1969), No. 18, 127-34

  The present invention has been made under such circumstances, and is a skin external preparation containing 4-n-butylresorcinol, which has further improved stability and can be stably stored even under high temperature conditions. It is an object to provide an external preparation.

In view of the above situation, the present inventors have intensively studied for a means for further improving the storage stability of a skin external preparation containing 4-n-butylresorcinol under high temperature conditions. As a result, it has been found that the storage stability of 4-n-butylresorcinol contained in the external preparation for skin is improved by a compound having a quaternary amino group.
From this finding, when the skin external preparation containing a specific amount of 4-n-butylresorcinol and / or a salt thereof further contains a specific amount of a compound having a quaternary amino group, the skin external preparation is subjected to high temperature conditions. The inventors have found that it can be stably stored even underneath, and have completed the invention. That is, the present invention is as follows.

(1) A skin external preparation containing 4-n-butylresorcinol and / or a salt thereof, and a compound having a quaternary amino group.
(2) The content of 4-n-butylresorcinol and / or a salt thereof is 0.1 to 0.5% by mass with respect to the total amount of the external preparation for skin and the content of a compound having a quaternary amino group The external preparation for skin according to (1), characterized in that is 0.01 to 5% by mass relative to the total amount of external preparation for skin.
(3) The skin external preparation according to (1) or (2), wherein the compound having a quaternary amino group is a polymer compound having a quaternary amino group.
(4) The compound having a quaternary amino group is quaternium, trimethylglycine, a cationic surfactant, or bentonite modified with a cationic surfactant, (1) or (2) The skin external preparation described in 1.
(5) The skin external preparation according to any one of (1) to (4), which is a cosmetic.
(6) The external preparation for skin according to any one of (1) to (5), which is a quasi-drug for suppressing melanin production.
(7) The external preparation for skin according to any one of (1) to (6), characterized by appealing an inhibitory action on melanin production.

  ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation with high storage stability in high temperature conditions can be provided.

(1) 4-n-butylresorcinol or a salt thereof which is an essential component of the external preparation for skin of the present invention, 4-n-butylresorcinol or a salt thereof which is an essential component of the external preparation for skin of the present invention has the following structural formula ( A compound having a structure represented by I) or a salt thereof, which may be synthesized or naturally occurring.

The method for producing 4-n-butylresorcinol contained in the external preparation for skin of the present invention is not particularly limited and can be produced according to a conventional method. For example, 1) condensation of resorcin and butanoic acid in the presence of zinc chloride And a method of reducing with zinc amalgam / hydrochloric acid, 2) a method of condensing resorcin and n-butyl alcohol at a high temperature of 200 to 400 ° C. (for example, see Non-Patent Document 1). .

The salt of 4-n-butylresorcinol is not particularly limited as long as it is physiologically acceptable. For example, alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt Preferred examples include organic amine salts such as ammonium salts, triethanolamine salts and triethylamine salts, and basic amino acid salts such as lysine salts and arginine salts. Among these salts, alkali metal salts are particularly preferable, and sodium salts are particularly preferable.
These salts can be obtained by reacting 4-n-butylresorcinol with a corresponding basic compound. For example, an alkali metal salt or an alkaline earth metal salt can be obtained by mixing 4-n-butylresorcinol with an alkali metal or alkaline earth metal hydroxide at normal temperature and normal pressure. The organic amine salt can be obtained by mixing 4-n-butylresorcinol and a corresponding free organic amine at normal temperature and normal pressure. Furthermore, a basic amino acid salt can be obtained by mixing 4-n-butylresorcinol and a corresponding free basic amino acid at room temperature and normal pressure.

  4-n-Butylresorcinol or a salt thereof has an action of suppressing melanin production. There is no particular limitation on the amount of 4-n-butylresorcinol and / or a salt thereof contained in the external preparation for skin, but the total amount is preferably 0.1 to 0.5% by mass, preferably 0.2 to 0%. More preferably, it is 45 mass%. If the content is less than 0.1% by mass, the melanin production inhibitory action is not sufficiently exhibited.

  The preservation stability of the external preparation for skin containing 4-n-butylresorcinol or a salt thereof at a high temperature can be enhanced by allowing a compound having a quaternary amino group described later to coexist.

(2) Compound having a quaternary amino group which is an essential component of the skin external preparation of the present invention The skin external preparation of the present invention is characterized by containing a compound having a quaternary amino group as an essential component. The compound having a quaternary amino group includes a compound having a positively charged tetravalent nitrogen atom in its chemical structure. Also included are compounds having a so-called pentavalent nitrogen atom, such as amine oxide.

  Such a compound having a quaternary amino group can be used without particular limitation as long as it is used in a skin external preparation such as cosmetics. These can be classified into, for example, [1] polymer compounds, [2] surfactants, [3] and others.

[1] Polymer compounds having a quaternary amino group include, for example, cationized polysaccharides, polymethacryloyloxyethyl phosphorylcholine, allylic ammonium salts (compounds in which an allylic group is substituted on a quaternary amino atom). Examples include polymers and copolymers.
Examples of the cationized polysaccharide include cationized cellulose and cationized guar gum. Cationization is the substitution of a group having a quaternary amino group. Examples of the cationized cellulose include hydroxymethylcellulose partially 3-trimethylamino-2-hydroxypropylated. Examples of the cationized guar gum include “Jaguar C-13S (manufactured by Sanki Pharmaceutical Co., Ltd.)”. The molecular weight and cationization degree of the cationized polysaccharide may be appropriately selected and are not particularly limited.
Preferred examples of the allylic ammonium salt homopolymer or copolymer include polymers of cosmetic raw materials called polyquaternium. Since such a polyquaternium already exists as a cosmetic raw material, it can be purchased and used. Among these, it is preferable to use polyquaternium having a crosslinked structure.

Specifically, polyquaternium 1 (Onamar M; manufactured by Stepan), polyquaternium 2 (Mirapol A15; manufactured by Rhône Poulen), polyquaternium 4 (Selcoat LOR; manufactured by Uniquema), polyquaternium 5 (Helco Flock 849: manufactured by Hercres) ), Polyquaternium 6 (Alcofix 182: manufactured by Sumitomo Three Bond Co., Ltd.), polyquaternium 7 (Mercoat 550: manufactured by NALCO), polyquaternium 10 (Leoguard P; manufactured by Lion Corporation), polyquaternium 11 (rubicoat PQ11; manufactured by BASF), Polyquaternium 14 (J-Flock; manufactured by Vulcan Chemicals), Polyquaternium 15 (Aron Flock C325: manufactured by Toa Gosei Co., Ltd.), Polyquaternium 16 (Rubicort SC370; BASF) ), Polyquaternium 17 (Mirapol AD; manufactured by Rhône-Poulenc), Polyquaternium 18 (Mirapol AZ; manufactured by Rhône Poulenc), Polyquaternium 20 (Alaton PQ225; manufactured by Unikema), Polyquaternium 22 (Mercoat 295; manufactured by NALCO) Polyquaternium 24 (Amercor LM200; manufactured by Dow Chemical Co., Ltd.), Polyquaternium 27 (Mirapol 95; manufactured by Rhône Poulen), Polyquaternium 28 (Guffcoat HS-100; manufactured by ISP), Polyquaternium 29 (Lexcoat CH; manufactured by Inorex Corporation) ), Polyquaternium 30 (Mexomail PX; manufactured by CIMEX), Polyquaternium 31 (Hipan QT-100; manufactured by Lipochemical), Polyquaternium 32 (Salcare SC) 2; manufactured by Ciba Specialties), polyquaternium 33 (Salcare SC93; manufactured by Ciba Specialties), polyquaternium 34 (Mexomer PAK; manufactured by CHIMEX), polyquaternium 35 (plex 3074L; manufactured by Rohm), polyquaternium 36 (plex) 4739L; manufactured by Rohm Co., Ltd.), polyquaternium 37 (syntalen CR; manufactured by 3V Sigma), polyquaternium 39 (Mercoat Plus 3330; manufactured by NALCO), polyquaternium 42 (Almobrene NPX; manufactured by Lion Corporation), polyquaternium 43 (Bozcoat 4000; Clariant) S.A.), Polyquaternium 44 (Rubicort Ultracare; manufactured by BASF), Polyquaternium 45 (Plex 3073L; manufactured by Rohm), PO Liquonium 46 (ruby coat hold; manufactured by BASF), Polyquaternium 47 (Mercoat 2001; manufactured by NALCO), Polyquaternium 48 (Plastasize L-450; manufactured by Kaohaku Chemical Co., Ltd.), Polyquaternium 49 (Plastic size L-440; Interactive chemical) Co., Ltd.), Polyquaternium 50 (Plast Size L-401; manufactured by Kyoyo Chemical Co., Ltd.), Polyquaternium 51 (Lipidure PMB; manufactured by Nippon Oil & Fats Co., Ltd.), Polyquaternium 53 (Mercoat 2003; manufactured by NALCO), Polyquaternium 54 (Kilty High; Mitsui Chemicals Co., Ltd.), Polyquaternium 55 (Stylize W20; manufactured by ISP), Polyquaternium 56 (Hair Roll UC-4; Sanyo Chemical Co., Ltd.), Polyquaternium 57 (Zenigros Q-SE; Zenite ), Polyquaternium 58 (Levenor; Lebenstein), Polyquaternium 59 (Crodasolve UV-HPP; Kuroda), Polyquaternium 60 (Polylipid PPI-RC; Arzo), Polyquaternium 61 (Lipidure S; Japan) Manufactured by Yushi Co., Ltd.), polyquaternium 62 (Nanoaquasome; manufactured by Pacific Co.), polyquaternium 63 (OF-308; manufactured by WSP Chemical & Technology Co., Ltd.), polyquaternium 64 (Lipidure-C; manufactured by Nippon Yushi Co., Ltd.), polyquaternium 65 (Lipidure) -A; manufactured by Nippon Oil & Fats Co., Ltd.) is preferable.
Of these, polyquaternium 7, polyquaternium 9, polyquaternium 14, polyquaternium 32, polyquaternium 37, polyquaternium 39, polyquaternium 51, polyquaternium 55, and polyquaternium 61 are particularly preferred.

[2] Surfactants having a quaternary amino group include cationic surfactants and amphoteric surfactants, and more preferred are cationic surfactants.
Examples of the cationic surfactant include dimethyl distearyl ammonium chloride and stearyl trimethyl ammonium chloride.
Examples of amphoteric surfactants include imidazoliniums.

  [3] Other compounds having a quaternary amino group include quaternium, betaines, bentonite modified with a cationic surfactant, and the like. Examples of such betaines include trimethylglycine.

The above-mentioned quaternium is a low molecular weight substituted quaternary ammonium salt, and is a cosmetic raw material registered in the international standard cosmetic raw material (INCI). Some of these are also cationic surfactants. Specifically, the following are exemplified.
That is, quaternium 14 (lauryldimethylethylbenzylammonium chloride; McCourt MQ2525M; manufactured by Masson), quaternium 15 (N- (3-chloroallyl) hexanium chloride; Dauisil 200; manufactured by Dow Corning), quaternium 18 (dimethyl chloride (hydrogen chloride) Taro) ammonium; Valisoft 442 100P; manufactured by Degassa Specialty), quaternium 22 (γ-gluconamidopropyl dimethyl 2-hydroxyethylammonium chloride; Serafil 60; manufactured by International Specialties), quaternium 24 (decyldimethyl chloride) Octyl ammonium; McCoat 4050; manufactured by Masson Co., Ltd .; Lido; Incrocoat 26; manufactured by Kuroda Co., Ltd .; Quotanium 27 (4,5-dihydro-1-methyl-2-nortaloualkyl-1- (2-tallowamidoethyl) imidazolium methyl sulfate; AEC Quotanium 27; A & E Connock ), Quaternium 33 (N (N ′ lanolin fatty acid amidopropyl) N-ethyl-N, N-dimethylammonium ethyl sulfate; Nikkor Lanocoat DES-50; manufactured by Nikko Chemicals Co., Ltd.), quaternium 43 (cocamidopropyldimethyla) Cetamide ammonium chloride; Simexan CK: manufactured by Simex Co., Ltd.), quaternium 45 (LUMEX; manufactured by Ikeda Bussan Co., Ltd.), and quaternium 52 (POE (octadecylnitrilorio) tri-2,1-ethanediyl) trishydroxyphosphate G, DEHICOAT SP; manufactured by Cognis Co., Ltd.), quaternium 53 (Incrosoft T-90, manufactured by Kuroda Co., Ltd.), quaternium 60 (lanolin, isostearamidopropylethyldimethylammonium etosulphate; lanocoat 1751A, manufactured by Cognis Co., Ltd.), Dimer acid bis (amidopropyl-N, N-dimethyl-N-ethylammonium ethosulphate; shell coat DAS; manufactured by Shell), quaternium 70 (stearamidopropyldimethyl (myristyl acetate) ammonium chloride; Cerafil 70: International Specialties), Quotanium 72 (Incrosoft CFI75; Kuroda), Quotanium 73 (Photosensitive Element 201; Photosensitive Element Co., Ltd.), Quotanium 75 (Lowenorco) Dioner C727; made by Levenstein), quaternium 76 collagen complex (Lexaine QX-3000; made by Inolex), quaternium 77 (fin soft HCM-100; made by Finetics), quaternium 79 (Mac Pro NLP; McKin Tile Co., Ltd.), quaternium 80 (Covafix 123; manufactured by LCW Co.), quaternium 82 (Stepan Coat DC1; manufactured by Stepan Co., Ltd.), quaternium 84 (Mackernium NLE; manufactured by McKintile Co.), quaternium 85 (2-hydroxy-3) -((2-hydroxyethyl) (2-((1-oxotetradecyl (amino) ethyl) amino) -N, N, N-trimethyl-1-propaneaminium chloride; amino cation S-36; Kao Corporation ), Quaternium 6 (Pecosyl SWQ-40; manufactured by Phoenix), Quaterium 87 (Varisoft W575PG; manufactured by Degassa), Quaterium 88 (Necoat DAS-D; manufactured by Arzo), Quaternium 89 (Fincoat CT-P; manufactured by Finetech) ), Quantum 91 (Kuroda Soft DBQ; manufactured by Kuroda) and the like can be preferably exemplified.
Of these, more preferred are quaternium 33, quaternium 45, quaternium 73, quaternium 80 and quaternium 85.

Bentonite modified with a cationic surfactant is, for example, a mixture of bentonite dispersed in an aqueous carrier and an aqueous solution of a cationic surfactant, and an anionic portion of bentonite and a cationic surfactant. A paired ion complex is formed with the part. Examples of the cationic surfactant used for modifying bentonite include dimethyl distearyl ammonium chloride and stearyl trimethyl ammonium chloride.
Specific examples of bentonite modified with a cationic surfactant include “Benton 38V (manufactured by Elementis)” and “Thixogel VSP1438-V (manufactured by Sud Hemy United Catalysis)” (trade name). It is done.

  Counter anions of compounds having a quaternary amino group include chloride anions, sulfate anions, nitrate anions, phosphate anions, carbonate anions, mineral acid anions, citrate anions, oxalate anions, acetic acid anions and other organic acid anions. It can be illustrated.

Any component having such a quaternary amino group is a component widely used in external preparations for skin such as cosmetics, and there are commercially available products that are readily available.
The skin external preparation of the present invention can contain only one kind of a compound having a quaternary amino group, or can contain two or more kinds in combination. The preferable content of the compound having a quaternary amino group in the external preparation for skin of the present invention is a total amount, and is preferably 0.01 to 5% by mass with respect to the total amount of external preparation for skin, 0.05 to It is especially preferable that it is 3 mass%. This improves the storage stability of the aforementioned 4-n-butylresorcinol and / or its salt under high temperature conditions when the content of such compound is less than 0.01% by mass relative to the total amount of the external preparation for skin. This is because it may be difficult to achieve this, and if it exceeds 5% by mass, the effect reaches its peak and the feeling of use may be impaired.

(3) Skin external preparation of this invention The skin external preparation of this invention contains 1) 4-n-butyl resorcinol and / or its salt, and 2) the compound which has a quaternary amino group.
Furthermore, the skin external preparation of the present invention preferably contains 4-n-butylresorcinol and / or a salt thereof in an amount of 0.1 to 0.5% by mass based on the skin external preparation, and has a quaternary amino group. It is preferable to contain 0.01-5 mass% of compounds with respect to a skin external preparation.

  The skin external preparation of this invention can contain the arbitrary components normally used with a skin external preparation other than the said essential component. Such components include oils / waxes, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils, oil agents, surfactants, polyhydric alcohols, moisturizing ingredients, thickeners, Examples thereof include powders, inorganic pigments, organic dyes, organic powders, ultraviolet absorbers, lower alcohols, vitamins, and polymers having a biologically similar structure.

Examples of oils and waxes include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hardened coconut oil, hardened Oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, etc.
Examples of the hydrocarbons include liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, and microcrystalline wax.

Examples of higher fatty acids include oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, etc.
Examples of higher alcohols include cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol, and the like.
Synthetic ester oils include, for example, cetyl isooctanoate, isopropyl myristate, hexyl decyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diisostearyl malate, ethylene di-2-ethylhexanoate Glycol, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, tetra-2-ethylhexane Acid pentane erythritol, etc.
Examples of oils include chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and diphenylpolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane, and amino-modified polysiloxanes. Examples thereof include silicone oils such as siloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, and modified polysiloxane such as fluorine-modified polysiloxane.

Surfactants may be either anionic surfactants or nonionic surfactants.
Examples of anionic surfactants include fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, alkyl sulfate triethanolamine ether, and the like.
Nonionic surfactants include, for example, sorbitan fatty acid esters (such as sorbitan monostearate and sorbitan sesquioleate), glycerin fatty acids (such as glyceryl monostearate), and propylene glycol fatty acid esters (such as propylene glycol monostearate). ), Hardened castor oil derivative, glycerin alkyl ether, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin Fatty acid esters (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl Ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid ester, alkyl glucoside and the like can be mentioned.

Examples of polyhydric alcohols include polyethylene glycol, glycerin, 1,3-butanediol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2 , 4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol, etc.
Examples of moisturizing ingredients include sodium pyrrolidonecarboxylate, lactic acid, sodium lactate and the like,
Examples of thickeners include guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, methyl hydroxypropyl cellulose, chondroitin sulfate, dermatan sulfate, glycogen , Heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, dextran, kerato sulfate, locust bean gum, succinoglucan, carolinic acid, chitin,
Examples include chitosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxy vinyl polymer, sodium polyacrylate, polyethylene glycol, bentonite and the like.

Examples of powders include mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc., whose surface may be treated.
As the inorganic pigments, for example, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide, etc., whose surface may be treated, are mentioned,
As organic pigments, the surface may be treated, pearl agents such as titanium mica, fish phosphorus foil, bismuth oxychloride, red 202, red 228, red 226, which may be raked, Yellow No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple 201 No., red No. 204, etc.
Examples of organic powders include polyethylene powder, polymethyl methacrylate, nylon powder, and organopolysiloxane elastomer.

Examples of the UV absorbers include paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane and the like,
Examples of lower alcohols include ethanol, isopropanol, phenoxyethanol, and the like.
Examples of vitamins include vitamin A or a derivative thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or a derivative thereof, vitamin B such as vitamin B12, vitamin B15 or a derivative thereof, and α-tocopherol , Β-tocopherol, γ-tocopherol, vitamin E such as vitamin E acetate, vitamin D, vitamin H, pantothenic acid, pantethine, pyrroloquinoline quinone and the like can be preferably exemplified.
Examples of the polymer having a bio-similar structure include polymethacryloyl lysine and polyglycosyl ethyl methacrylate.

Among these optional components, antibacterial polyhydric alcohols such as isoprene glycol, 1,2-pentanediol, 1,2-hexanediol, 2,4-hexylene glycol and 1,2-octanediol are used in the skin of the present invention. It is preferable to make it contain in an external preparation.
This is because by containing such antibacterial polyhydric alcohol, it is possible to reduce or eliminate the content of a substance that may induce a transient stimulus such as paraben to be blended for antiseptic purposes. In order to exert such an effect, the content of the antibacterial polyhydric alcohol is preferably 1 to 10% by mass, and 2 to 7% by mass with respect to the total amount of the external preparation for skin. Is more preferable. The antibacterial polyhydric alcohol may contain only one species or may contain two or more species in combination.

The external preparation for skin of the present invention can be produced by treating the above-mentioned essential components and optional components according to a conventional method.
The dosage form of the external preparation for skin of the present invention is not particularly limited as long as it can be applied to the skin, and examples thereof include a solubilized lotion dosage form, a thickening essence dosage form, and an emulsifier form.

The skin external preparation of the present invention has a melanin production inhibitory action (may be an effect by 4-n-butylresorcinol), and when applied to the skin, suppresses the increase in melanin production at the application site, Suppresses the deterioration of pigmentation and improves pigmentation. By this action, a whitening effect is exhibited. Therefore, it is preferable that the skin external preparation of this invention appeals the effect | action which suppresses melanin production. For example, it is preferable that an indication of having an action of suppressing melanin production is described on the package of the external preparation, or an instruction to that effect is attached to the external preparation. Or it can also tell in an advertisement or an advertisement that the skin external preparation of this invention has a melanin production inhibitory effect.

  The use of the external preparation for skin of the present invention is not particularly limited as long as it is intended to be applied to the skin for external use, and examples thereof include applications such as cosmetics, external preparations for skin, and external goods for skin. Of these, cosmetics are more preferable. In particular, the external preparation for skin of the present invention is preferably a quasi-drug cosmetic. Here, a quasi-drug means a quasi-drug defined by the Pharmaceutical Affairs Law.

The external preparation for skin of the present invention, which is a quasi-drug, preferably has a label based on the Pharmaceutical Affairs Law. For example, a display indicating that it has an action of suppressing the production of melanin that is increased by ultraviolet rays or the like, and a display of a suitable usage for suppressing the production of melanin are given.
The indication of suitable usage includes, for example, that an appropriate amount of the cosmetic of the present invention should be applied once or several times a day to a site where production of melanin is enhanced, and by the application, A display indicating that the application should be stopped immediately and a dermatologist should be consulted can be suitably exemplified when a tingling sensation is felt. Such a display may be posted on the back surface of the container filled with the cosmetic or the back surface of the package. It is also possible to write it down and attach it.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the scope of the present invention is not limited by these examples.

<Example 1>
A cosmetic (skin lotion) was prepared according to the formulation shown below. That is, a lotion was obtained by heating a mixture of the following formulation components to 80 ° C., stirring, solubilizing, and cooling with stirring. This skin lotion is designated as cosmetic 1.

1,2-hexanediol 3% by mass
1,3-butanediol 5% by mass
Glycerin 2% by mass
Phenoxyethanol 0.5% by mass
Polyoxyethylene hydrogenated castor oil 0.1% by mass
Ethanol 5% by mass
4-n-butylresorcinol 0.3% by mass
Polymethacryloyl lysine 0.1% by mass
Polyquaternium 39 0.1% by mass
Polyglycosyl ethyl methacrylate 0.1% by mass
83.8% by weight of water

<Comparative Examples 1-3>
Comparative cosmetic 1 which is a skin lotion in which polyquaternium 39 which is a prescription component of cosmetic 1 is replaced with water, and comparative cosmetic 2 which is a skin lotion in which polyquaternium 39 which is a prescription component of cosmetic 1 is replaced with sodium polyacrylate Comparative cosmetic 3 was prepared in the same manner as in Example 1, except that 4-n-butylresorcinol, which is a formulation component of cosmetic 1, was replaced with water.

<Test Example 1>
The high temperature preservation test of cosmetic 1 and comparative cosmetics 1 to 3 was performed. In the high temperature storage test, it was stored at 50 ° C. for 3 weeks. As control samples, the same samples as cosmetic 1 and comparative cosmetics 1 to 3, respectively, were stored at 5 ° C. After completion of storage, the color difference between each sample and the stored product at 5 ° C. was measured with an optical measuring instrument (“Color Difference Meter Minolta CR-300” manufactured by Minolta Co., Ltd.). These results are shown in Table 1.

From Table 1, the comparative cosmetics 1 and 2 (containing 4-n-butylresorcinol) after the test had a color difference from the control compared to the comparative cosmetic 3 (containing no 4-n-butylresorcinol). You can see that it ’s big.
On the other hand, although the cosmetic 1 after the test contains 4-n-butylresorcinol, the color difference from the control is small. Therefore, it can be seen that the polyquaternium 39 improves the stability of 4-n-butylresorcinol, thereby enhancing the storage stability of the cosmetic.

<Example 2>
Cosmetics 2 to 16 (lotion) were prepared in the same manner as in Example 1 according to the formulation shown below.

1,2-hexanediol 3% by mass
1,3-butanediol 5% by mass
Glycerin 2% by mass
Phenoxyethanol 0.5% by mass
Polyoxyethylene hydrogenated castor oil 0.1% by mass
Ethanol 5% by mass
4-n-butylresorcinol 0.3% by mass
Polymethacryloyl lysine 0.1% by mass
Compound having a quaternary amino group (described in Table 2) 0.1% by mass
Polyglycosyl ethyl methacrylate 0.1% by mass
83.8% by weight of water

<Test Example 2>
About the obtained cosmetics 2-16, when the same storage test as Test Example 1 was carried out, the results shown in Table 2 were obtained.

  From Table 2, it can be seen that compounds having various quaternary amino groups have the effect of enhancing the storage stability of cosmetics.

The present invention relates to a skin external preparation (particularly a quasi-drug cosmetic) having a melanin production inhibitory action, and may be stored under severe conditions (for example, conditions preserved upon import / export). It can be applied to external preparations.
Thereby, it is possible to prevent the quality of the external preparation from being impaired during storage, or it is possible to easily store the external preparation without strictly controlling storage conditions.

Claims (7)

  A skin external preparation containing 4-n-butylresorcinol and / or a salt thereof, and a compound having a quaternary amino group.   The content of 4-n-butylresorcinol and / or a salt thereof is 0.1 to 0.5% by mass with respect to the total amount of the external preparation for skin, and the content of the compound having a quaternary amino group is for external use on the skin. The skin external preparation according to claim 1, wherein the amount is 0.01 to 5 mass% with respect to the total amount of the preparation.   The skin external preparation according to claim 1 or 2, wherein the compound having a quaternary amino group is a polymer compound having a quaternary amino group.   The skin external preparation according to claim 1 or 2, wherein the compound having a quaternary amino group is quaternium, trimethylglycine, a cationic surfactant, or bentonite modified with a cationic surfactant. .   It is a cosmetic, The skin external preparation as described in any one of Claims 1-4 characterized by the above-mentioned.   The external preparation for skin according to any one of claims 1 to 5, which is a quasi-drug for suppressing melanin production.   The external preparation for skin according to any one of claims 1 to 6, wherein the preparation for promoting melanin production is promoted.