JP2001081024A - Milky oil-in-water type emulsification composition and method for producing the same composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition excellent in storage stability, practical characteristics and skin stability by mixing a transparent or translucent emulsification product comprising a specific component with a water-soluble polymer aqueous solution comprising a specific component at a specific ratio. SOLUTION: This emulsification composition is obtained by mixing (A) 5-80 wt.% transparent or translucent emulsified product comprising (i) 5-15 wt.% polyglycerol fatty acid ester (example of fatty acid: lauric acid) and/or sorbitan fatty acid ester (example of fatty acid: isostearic acid), (ii) 30-70 wt.% liquid oily substance, (iii) 0.2-1.5 wt.% N-long chain acyl acidic amino acid salt (e.g. N-stearoyl-L-glutamic acid), (iv) 17-50 wt.% glycerol and/or diglycerol and (v) 5-15 wt.% water with (B) 20-95 wt.% water-soluble polymer aqueous solution comprising (i) 0.2-2.0 wt.% water-soluble polymer (e.g. a carboxyvinyl polymer), (ii) 0-1.4 wt.% basic substance (e.g. a neutralizing agent) and (iii) the balance of water.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a milky oil-in-water emulsion composition which is excellent in storage stability, practical properties and skin safety and is used for cosmetics, pharmaceuticals and the like, and a method for producing the same.

[0002]

2. Description of the Related Art Compositions comprising a polyglycerin fatty acid ester as a main emulsifier component are known.

For example, Japanese Patent Application Laid-Open No. 7-96162 discloses that 0.5 to 12% by weight of polyglycerin fatty acid ester is used.
(Hereinafter, weight% is abbreviated as%) and liquid oily substance 4
0 to 90%, water is 0.5 to 12%, and the weight of water is 4%.
A transparent gel composition comprising 5 to 59% of a polyhydric alcohol which is twice or more times as described in JP-A-6-2199.
No. 23 is characterized in that the polyglycerol higher fatty acid ester and the nonionic surfactant are contained in a total amount of 5 to 40%, an oily component is contained in a content of 3 to 70%, and water is contained in a content of 0.5 to 80%. A clear liquid composition is described.

However, these compositions are transparent gel or transparent liquid compositions, and their dosage forms and properties are limited, and their storage stability is not sufficient.
It was also difficult to apply to cosmetics and pharmaceuticals. In other words, polyglycerin fatty acid esters have attracted attention as active agents with excellent skin safety, but their functions as emulsifier components are limited.

Therefore, in the former, a polyhydric alcohol such as glycerin and a liquid oily substance and a polyglycerin fatty acid ester are combined in a large amount with respect to the amount of water, and in the latter, the polyglycerin fatty acid ester is added to the oily substance. On the other hand, it is blended in a large amount to improve the storage stability as a transparent gel or liquid composition in which the oily substance is dispersed in a solubilized state. Therefore, these compositions have high tackiness, have poor spreadability when applied to the skin, have a problem in practical properties such as having a sticky feeling, and have not been sufficiently improved.

[0006]

SUMMARY OF THE INVENTION An object of the present invention is to provide an emulsified composition comprising a specific polyglycerin fatty acid ester and / or sorbitan fatty acid ester as a main emulsifier component. An object of the present invention is to provide a milky oil-in-water-in-water emulsified composition excellent in practical properties such as low stickiness of a substance, good spreadability when applied to the skin and low stickiness, and excellent skin safety. An object of the present invention is to provide a method for producing the above-mentioned milky oil-in-water emulsion composition.

[0007]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to achieve the above object, and as a result, a specific emulsion and a milky oil-in-water obtained by a production method for redispersing and emulsifying the same are described below. The type emulsion composition was found to be excellent in storage stability, practical characteristics, and skin safety, and completed the present invention.

That is, the present invention provides a translucent to transparent (A) comprising the following components (A-1) and (A-2).
5 to 80% of emulsion and (B) aqueous solution of water-soluble polymer 20 to 9
5% and a milky oil-in-water emulsion composition.

(A) Emulsion (based on 100% total amount) (A-1) Component (1) Polyglycerin fatty acid ester and / or sorbitan fatty acid ester: 5 to 15% (2) Liquid oily substance: 30 (A-2) component (3) N-long-chain acyl acidic amino acid salt: 0.2 to
1.5% (4) Glycerin and / or diglycerin: 17 to
50% (5) Water: 5 to 15%

(B) Water-soluble polymer aqueous solution (total 100% basis) (1) Water-soluble polymer: 0.2 to 2.0% (2) Basic substance (neutralizing agent): 0 To 1.4% by weight (3) Water: the remaining amount when the total amount of the composition is 100%

In the composition of the present invention, the fatty acid of the polyglycerin fatty acid ester is preferably lauric acid or isostearic acid, and the fatty acid of the sorbitan fatty acid ester is preferably isostearic acid.

In the composition of the present invention, the N-long-chain acyl acidic amino acid salt is N-stearoyl-L-glutamic acid, N-palmitoyl-L-glutamic acid, N-stearoyl-aspartic acid, N-palmitoyl-aspartic acid. It is preferable that at least one of a monosodium salt and a monopotassium salt is used.

In the composition of the present invention, the water-soluble polymer is preferably at least one of a carboxyvinyl polymer, an alkyl-modified carboxyvinyl polymer, and xanthan gum. Next, in the composition of the present invention, 0.5 parts by weight or more of polyglycerin laurate and 100 parts by weight of water in the composition,
It is preferable to contain 4.0 parts by weight of 2-pentanediol.

The present invention relates to a translucent to transparent (A) emulsion 5 obtained by mixing the component (A-1) and the component (A-2) at 40 to 80 ° C. and cooling if necessary. (B) 20 to 95% of a water-soluble polymer aqueous solution which is uniformly dissolved by heating the water-soluble polymer and water as required.
This is a method for producing a milky oil-in-water-in-water emulsified composition which is mixed at 0 ° C and cooled to 30 ° C as needed.

Further, the milky oil-in-water emulsion composition of the present invention preferably comprises the following components. (Ingredient composition) (%) (1) Polyglycerin fatty acid ester 0.5 to 7.5, preferably 0.8 to 7.0 ter and / or sorbitan fatty acid ester (2) Liquid oily substance 2.0 to 56.0 Preferably 3.0 to 50.0 (3) N-long chain acyl acidity 0.025 to 0.8 preferably 0.05 to 0.7 amino acid salt (4) glycerin and / or 1.2 to 20.0 Preferably 1.5 to 15.0 diglycerin (5) water-soluble polymer 0.12 to 1.6 preferably 0.15 to 1.5 (6) basic substance (neutralizing agent) 0 to 1.1 Preferably 0 to 0.9 (7) water remaining amount with the total amount of the water composition being 100%

[0016]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below.

The polyglycerin constituting the polyglycerin fatty acid ester used in the present invention is a polyglycerin having a degree of polymerization of 2 to 11, and generally has an average value of 2,
Diglycerin, tetraglycerin, hexaglycerin and decaglycerin, which are polymers of 4, 6, and 10, are applied. As the fatty acid constituting the polyglycerin fatty acid ester and the sorbitan fatty acid ester, a fatty acid having 12 to 22 carbon atoms is used.

In particular, polyglycerol fatty acid esters in liquid or paste form at room temperature are excellent in redispersion and emulsification properties described later, and lauric acid and isostearic acid are preferred. Further, as for isostearic acid, isostearic acid having a methyl side chain obtained by a method of hydrogenating an unsaturated side chain fatty acid by-produced when producing dimer acid from oleic acid has excellent emulsifying properties and is suitable.

Further, with a saturated fatty acid having 14 to 22 carbon atoms, in order to obtain the translucent to transparent (A) emulsion,
There is a limitation on the amount of the compound. In addition, unsaturated fatty acids such as oleic acid and linoleic acid have poor storage stability of the final composition and cause coloration and odor. Therefore, the amount of the unsaturated fatty acid is similarly limited, but the range of achieving the object of the present invention is also limited. It is also possible to apply with.

In particular, polyglycerin fatty acid esters and sorbitan fatty acid esters have a high monoester content, and polyglycerin fatty acid esters preferably have a content of 30% or more, and sorbitan fatty acid esters have a content of 40% or more. Further, the HLB value, which is an emulsifying property of polyglycerin fatty acid ester, has a wide distribution of polymerization degree of polyglycerin, and mono-, di- and triester may coexist in polyglycerin fatty acid ester having an average polymerization degree of 4 to 10. ,
I. of the liquid oily substance described below. O. By referring to the B value, it is possible to select an emulsifier component suitable for the liquid oily substance, and its blending amount and blending ratio.

The HLB values of polyglycerin monofatty acid esters and sorbitan monofatty acid esters generally used in industry are shown below. Polyglycerol monolaurate having an average degree of polymerization of 2 to 10 is 8 to 15, polyglycerin monoisostearate having an average degree of polymerization of 2 to 10 is 6.5 to 13, sorbitan monolaurate is 10, sorbitan monoisostearate. Is 7.5.

In the emulsion (A) of the present invention, the total amount of the polyglycerol fatty acid ester and / or the sorbitan fatty acid ester is 5 to 15%, and is 0% in the milky oil-in-water emulsion composition of the final composition. 0.5 to 7.5%, preferably 0.8 to 7.0%.

The liquid oily substance used in the present invention is at room temperature (2
0 ° C.), for example, liquid paraffin (IOB = 0), squalane (0), polybutene (0), isocetyl myristate (0.10), octyldodecyl myristate (0. 09), palmitic acid 2
-Ethylhexyl (0.13), isopropyl palmitate (0.16), isopropyl diisostearate (0.16), glyceryl tri-2-ethylhexanoate (0.35), glyceryl triisostearate (0.
16) and the like, and most other liquid synthetic ester oils having a low degree of unsaturation are also applied. When blending olive oil, jojoba oil, ester oil of unsaturated fatty acid, etc., the storage stability of the milky oil-in-water emulsion composition of the final composition is excellent,
It is also possible to mix them within a range that achieves the object of the present invention. In addition, I. O. The B value is described in “Chemical Field, Vol. 11, No. 10
No., pp. 719-725, 1957, author Fujita ".

Liquid oily substances I. O. It is preferable to select the emulsifier component and its HLB value using the B value as a guide. In addition, I.I. O. As the B value was closer to 0, a milky water-in-water emulsion composition of the final composition having excellent storage stability was easily obtained, and the types and amounts of the emulsion composition components showed a wider range of application. For example, I. O. It is possible to improve the storage stability by mixing a substance having a high B value and a substance having a low B value. That is, I.I. O. The B value (including the weighted average value) is preferably 0.15 or less, because the storage stability of the final composition is also improved.

The compounding amount of the liquid oily substance is 30 to 70% in the emulsion (A), and 2.0 to 56.0% in the milky oil-in-water emulsion composition of the final composition, preferably 3.0. ~ 5
0.0%.

The long-chain acyl group of the N-long-chain acyl acidic amino acid salt used in the present invention preferably has 14 or more carbon atoms.
-Long-chain acyl-L-glutamic acid monosalt and N-long-chain acyl-aspartic acid monosalt are preferred. For example, N-myristoyl-L-glutamic acid monosalt, N-palmitoyl-L-glutamic acid monosalt, N-stearoyl-L-
Glutamic acid monosalt, N-myristoyl-aspartic acid monosalt, N-palmitoyl-aspartic acid monosalt,
N-stearoyl-aspartic acid monosalt and the like are applied.

The bases of these salts include sodium, potassium, arginine, triethanolamine and the like.
In particular, mono-sodium salts and mono-potassium salts such as N-palmitoyl-L-glutamic acid, N-stearoyl-L-glutamic acid, N-palmitoyl-aspartic acid, and N-stearoyl-aspartic acid having excellent emulsifying properties are preferable. At least one applies. When the N-long-chain acyl-acid amino acid salt is used as a neutralizing agent with a basic substance that forms the N-long-chain acyl-acid amino acid and its salt, the emulsion (A) according to the composition of the present invention is used as the neutralizer. Both may be blended, and it is also possible to blend an N-long-chain acyl-acidic amino acid into the component (A-1) and a basic substance into the component (A-2). In this case, the basic substance is preferably caustic soda or caustic potash.

The N-length of the milky, oil-in-water emulsion composition, which is the final composition of the present invention, is adjusted to a pH value of 5 to 7, preferably 5.5 to 6.5. Chain acyl-acidic amino acid salts are applied. The compounding amount is 0.2 to 1.5% in the emulsion (A) and 0.025 to 0.8%, preferably 0.05 to 0.7% in the final composition.

The amount of glycerin and / or diglycerin used in the present invention is 17 to 50 in the emulsion (A).
%, 1.2 to 20.0%, preferably 1.5 to 15.0% in the final composition. Here, glycerin and / or
Or, instead of diglycerin, other polyhydric alcohols, propylene glycol, dipropylene glycol,
1,3-butylene glycol, isoprene glycol,
When 1,2 pentanediol or the like is used, the object of the present invention cannot be achieved, but a part thereof can be changed within a range that achieves the object of the present invention.

As the water-soluble polymer used in the present invention, at least one of carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, xanthan gum and the like is applied.
arbopol 980, 981, ETD 2050,
BFG, which is an alkyl-modified carboxyvinyl polymer
oodrich PEMULEN TR-1, TR-
2 is used. The compounding amount is 0.2 to 2.0% in the aqueous solution of the water-soluble polymer (B), and 0.1 to 2.0 in the final composition.
It is 12 to 1.6%, preferably 0.15 to 1.5%.

When a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer is used, a neutralizing agent such as caustic soda, caustic potash, triethanolamine, arginine or the like is added to 0.05 part of the water-soluble polymer per 1 part. It is applied that the liquid composition of the milky oil-in-water emulsion composition as the final composition has a pH of 5 to 7, preferably 5.5 to 6.5. . Also,
In particular, the alkyl-modified carboxy polymer may be dispersed and dissolved in the component (A-1) of the emulsion (A) according to the composition of the present invention, and the basic substance may be the component (B) in the aqueous solution of a water-soluble polymer. Or after mixing (A) the emulsion and (B) the water-soluble polymer aqueous solution. here,
When xanthan gum is used as the water-soluble polymer, as described above, when it is not necessary to use it as a neutralizing agent that generates a salt of an N-long-chain acyl acidic amino acid, and when it is not necessary to use it as a pH adjuster of the final composition, 0% of basic substance
It is what becomes.

As the water, purified water such as ion-exchanged water or distilled water is used. The amount of the water is 5 to 15% for the emulsion (A) according to the composition of the present invention, and the other for (B) the aqueous solution of the water-soluble polymer. The remaining amount including the total amount of the composition including the components, basic substances, additional components, and the like as 100% is applied.

The production method according to the composition of the present invention will be described. (A) Production of Emulsion (A) Each of the different components of (A-1) and (A-2) is preferably heated to 40 to 80 ° C. to dissolve uniformly,
1) Add (A-2) to (A-2) or (A-1) to (A-2), and mix (B) the components of (A-1) and (A-2) in a dissolution tank. In a method of sequentially dissolving and mixing while maintaining the temperature at 40 to 80 ° C., first, an N-long-chain acyl acidic amino acid salt is added to water, then glycerin and / or diglycerin, and then polyglycerin fatty acid ester and / or Alternatively, a sorbitan fatty acid ester is sequentially dissolved and mixed to obtain an emulsion. Either method may be used to produce a translucent to transparent (A) emulsion.

(B) Preparation of aqueous solution of water-soluble polymer: Water is heated to 40 to 80 ° C to dissolve the water-soluble polymer uniformly. Here, when the water-soluble polymer is a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer, the temperature is preferably adjusted to 30 to 60 ° C. after neutralization.

(Preparation of milky oil-in-water-in-water emulsion composition) Next, the emulsion (A) and the aqueous solution (B) of a water-soluble polymer may be mixed. For the modified carboxyvinyl polymer, each is at 30 to 60 ° C, and for the xanthan gum, each is at 30 to 60 ° C.
The mixture was adjusted to a temperature of 80 ° C., and (A) the aqueous polymer solution (B) or the aqueous solution (B) was uniformly mixed with the aqueous polymer solution (B) while stirring. Also,
(A) Emulsion and (B) water-soluble polymer aqueous solution are simultaneously mixed in a desired ratio. Furthermore, it cools to 30 degreeC, stirring as needed, and produces the milky white oil-in-water emulsion composition of this invention.

As described above, a feature of the production method of the present invention is that the translucent to transparent (A) emulsion is an emulsion or a solubilized liquid or paste composed of fine particles of an oily substance. By mixing (A) the emulsion and (B) the aqueous solution of a water-soluble polymer, it is possible to prevent excessive aggregation or coalescence of particles, and a milky oil-in-water emulsion composition having excellent storage stability. To get things. In addition, it can be produced at a low temperature of 30 to 60 ° C. by this production method, and a component or an additive component having poor heat resistance, for example, an unsaturated liquid oily component, a vitamin, a pigment, a fragrance, an animal or plant extract, etc. It is possible to obtain a milky oil-in-water type emulsion composition which prevents deterioration and has excellent storage stability.

The additional components of the present invention, for example, preservatives, pH
A regulator, an ultraviolet absorber, a chelating agent, a pigment, a fragrance, an antioxidant, a humectant, a skin nutrient, and the like are contained in the emulsion (A) in the case of an oily component, and (B) in the case of a water-soluble component. It may be mixed in a water-soluble polymer aqueous solution, and if necessary, after mixing (A) the emulsion and (B) the water-soluble polymer aqueous solution, in a step of cooling the composition. In particular, the combined use of polyglycerin laurate and 1,2-pentanediol enhances the antibacterial activity and antiseptic activity of the composition of the present invention, and has an antiseptic and bactericidal activity against various general bacteria, yeasts and fungi. Was. For example, as a test bacterium, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, brewer's yeast, black mold, inoculate the sample, and then observe the change in the number of bacteria over the course of one month by smearing. An antiseptic test was performed. In the milky oil-in-water emulsion composition of the present invention, 0.5 parts by weight or more of polyglycerin laurate and 4,2-pentanediol are used in an amount of 100 parts by weight of water in the composition. By containing 0 parts by weight or more, the preservative power required for ordinary cosmetics and pharmaceuticals was recognized.

The milky oil-in-water emulsion composition of the present invention comprises skin gel, skin milk, body lotion, skin cream, hand cream, hair cream, hair treatment, cleansing cream, massage cream,
Applied to ointment bases and the like.

[0039]

EXAMPLES The present invention will be described below in more detail with reference to examples, but the present invention is not limited to these examples.

Examples 1 to 12 were prepared using the compositions shown in Tables 1 to 4.
Comparative Examples 1-1 to 6-1 and 12-1 were prepared, and storage stability, practical characteristics, and skin safety were evaluated by the following evaluation methods. The evaluation results are shown in the lower columns of Tables 1 to 4. In addition, 2-phenoxyethanol which is a preservative is blended in an amount of 0.2% to 0.98% with respect to the total amount of the final compositions of Examples and Comparative Examples, and in Examples 11, 12 and Comparative Example 12-1, And polyglycerol laurate as a preservative and 1,2
Pentanediol was applied.

The names of the raw material components used in Examples and Comparative Examples are abbreviated as follows. (Abbreviations and names of raw material components) PGL-61: hexaglyceryl monolaurate PGL-101: decaglyceryl monolaurate PGIS-21: diglyceryl monoisostearate PGIS-61: hexaglyceryl monoisostearate PGIS-101: decaglyceryl monoisostearate SOBMIS: sorbitan monoisostearate MIC: isocetyl myristate TOG: glyceryl tri-2-ethylhexanoate DISG: propylene glycol diisostearate N-StNa: sodium N-stearoyl glutamate N-PtK: potassium N-palmitoyl glutamate CP-980 980 CP-2050: Carbopol ETD2050 TR-2: PEMULEN TR-2 PGO-21: Noorein diglyceryl PGO-101: decaglyceryl monooleate Phet: 2-phenoxyethanol 1, 2-PD: 1,2-pentanediol KOH: potassium hydroxide NaOH: sodium hydroxide TEA: Triethanolamine

(Evaluation method) <1> Storage stability The examples and comparative examples were placed in a constant temperature room at 45 ° C., and the emulsified state and appearance after standing for 3 months were observed. The evaluation result was evaluated as good when no abnormality was observed (when the emulsified state was uniform and a homogeneous emulsion was formed), and was indicated by "O". When an abnormality was observed (when oil separated, the particles were coarse). , Etc.) were regarded as defective and indicated by “x”.

<2> Practical Characteristics Ten subjects, 10 males and 10 females, were applied to the skin for 10 days and then "adhesive, spread when applied to the skin", "stickiness", " A sensory test was conducted on three evaluation items of "offensive odor or skin irritation". The evaluation score was indicated by the total number of the respondents who answered that "good spreadability", "less stickiness", and "do not feel off-odor or irritation after use" are good for each item. The evaluation of a good thing is 60 at the maximum (3 items × 20 persons → 60 points), and the evaluation of a bad thing is 0 at the minimum. The evaluation points of the practical characteristics aimed at by the present invention were set to 50 to 60, and "O", and the evaluation points were 40 to 49.
Is indicated by “△”, and the evaluation points 0 to 39 are indicated by “×”.

<3> Skin Safety A circular patch having a lint cloth with a diameter of 1.0 cm and 0.05 g of a sample applied to the skin of the flexed side of the forearm of a total of 20 males and 10 females. Obstruction is applied for 24 hours using a test bandage. The skin condition of the 20 test subjects 1 hour and 24 hours after the bandage removal is determined and evaluated according to the following evaluation criteria. For the evaluation, the one with the strongest reaction between 1 hour and 24 hours after the bandage removal was adopted, and (-)
Is “○” when 20 are present, “△” when (±) is 1-2, and “×” when (±) is 3 or more or (+) to (+++) is 1 or more. ".

(Evaluation criteria) (Skin condition) (Evaluation) Erythema, edema, blister: (++) Erythema, edema: (++) Erythema: (+) Minor erythema: (±) No erythema, no edema: (−) )

(Examples 1 to 6, 11, and 12 Comparative Example 1
-1 to 6-1 and 12-1) As described in Tables 1, 3 and 4, each of the different components (A-1) and (A-2) was heated to 80 ° C. Then, (A-2) was added to (A-1) and mixed to obtain an emulsion (A). Next, in Examples 1, 2, 4, 5, 6, and 12, water was heated to 60 ° C.
Then, a basic substance as a neutralizing agent was added to uniformly dissolve the water-soluble polymer to obtain (B) a water-soluble polymer aqueous solution.
Each was adjusted to 60 ° C., and the emulsion (A) was mixed with the aqueous solution of the water-soluble polymer (B) while stirring, and further cooled to 30 ° C. to produce the compositions of Examples and Comparative Examples. In Examples 3 and 11, and Comparative Examples 3-1 and 3-2, the amount of the basic substance was 0% because xanthan gum was used.
Met. Adjust each to 80 ° C to (A) emulsion (B)
An aqueous solution of a water-soluble polymer was mixed with stirring, and the compositions of Examples and Comparative Examples were produced in the same manner as in Example 1 below. In Comparative Example 6-1, the PGIS used in Example 6 was used.
-21 to PGO-21, PGIS-101 to PGO-
No. 101 was prepared by replacing TOG with olive oil.

(Production Method of Examples 7 to 10) The hand creams and body lotions of the examples were produced using the ingredients shown in Table 2. Each was heated to 80 ° C and uniformly dissolved (A-
The component (A-2) was added to the component (1) and mixed to obtain an emulsion (A). In Examples 7 to 9, (A) the emulsion and (B) the aqueous solution of the water-soluble polymer were each adjusted to a temperature of 60 ° C. In Example 10, (A) the emulsion and the aqueous solution of the (B) water-soluble polymer were adjusted. Were adjusted to 30 ° C., respectively. Next, in Examples 7 to 9,
(A) Emulsion was uniformly mixed in (B) water-soluble polymer aqueous solution, and in Example 10, (B) water-soluble polymer aqueous solution was uniformly mixed in (A) emulsion. 3 each as needed
It cooled to 0 degreeC, and manufactured the milky white oil-in-water emulsion composition of an Example. In Example 8, the water-soluble polymer T
R-2 is uniformly dispersed and dissolved in the component (A-1), and in Example 9, N-stearoyl-L-glutamic acid is neutralized with caustic soda to form sodium N-stearoyl-L-glutamate. Using. The compositions of Examples 7 to 9 were similar compositions.

[0048]

[Table 1]

[0049]

[Table 2]

[0050]

[Table 3]

[0051]

[Table 4]

As is clear from the results of Tables 1 to 4, Examples 1 to 12 are superior to Comparative Examples 1-1 to 6-1 and 12-1 in all of storage stability, practical characteristics and skin safety. The results are shown, and the milky oil-in-water emulsion composition which is the object of the present invention was obtained. Comparative Examples 1-1, 1-2, 2-1, 3-1 and 3-2,
5-1 is poor in storage stability, 4-1 is sticky, 6
-1 had an unpleasant odor, and the practical characteristics were poor. In addition, bacteria of 12-1 proliferated by daily observation, showed no preservative power, and had poor storage stability. The differences between the comparative example and the example are described below. Comparative Example 1-1 [(A) Emulsion 2.0%], 1-2 [N-
StGNa: 0%], 2-1 [water-soluble polymer: 0%],
3-1 [(A) water of emulsion: 20%], 3-2 [NS
tGNa: 2.0%], 4-1 [(B) CP-980 of a water-soluble polymer aqueous solution: 2.5%, strong adhesion], 4-
2 [Liquid oily substance 25%], 5-1 [(A) emulsion:
(B) water-soluble polymer aqueous solution = 85: 15], 6-1 [P
GIS-21 to PGO-21, PGIS-101 to P
Off-flavor generation by changing GO-101 and TOG to olive oil], 12-1 [1,2-pentanediol: 2.5%, bacterial growth confirmed]

[0053]

The present invention provides a milky oil-in-water-in-water emulsion composition excellent in storage stability, practical properties and skin safety, and a process for producing the same.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/06 A61K 7/06 7/50 7/50 9/107 9/107 47/10 47/10 47 / 14 47/14 47/16 47/16 47/30 47/30 47/32 47/32 47/34 47/34 47/36 47/36 B01J 13/00 B01J 13/00 A // B01F 17/42 B01F 17/42

Claims (6)

[Claims] 1. A translucent or transparent (A) emulsion comprising the following components (A-1) and (A-2): 5 to 80% by weight and (B) a water-soluble polymer aqueous solution of 20 to 95% by weight. % Of a milky white oil-in-water emulsion composition. (A) Emulsified product (based on a total amount of 100% by weight) (A-1) Component (1) Polyglycerin fatty acid ester and / or sorbitan fatty acid ester: 5 to 15% by weight (2) Liquid oily substance: 30 to 70% by weight (A-2) Component (3) N-long-chain acyl acidic amino acid salt: 0.2 to
1.5% by weight (4) Glycerin and / or diglycerin: 17 to
50% by weight (5) Water: 5 to 15% by weight (B) Water-soluble polymer aqueous solution (based on a total amount of 100% by weight) (1) Water-soluble polymer: 0.2 to 2.0% by weight ( 2) Basic substance (neutralizing agent): 0 to 1.4% by weight (3) Water: The remaining amount when the total amount is 100% by weight 2. The milky white oil-in-water emulsion composition according to claim 1, wherein the fatty acid of the polyglycerin fatty acid ester is lauric acid or isostearic acid, and the fatty acid of the sorbitan fatty acid ester is isostearic acid. 3. An N-long-chain acyl acidic amino acid salt comprising N-stearoyl-L-glutamic acid or N-palmitoyl-L
-Glutamic acid, N-stearoyl-aspartic acid,
2. The composition according to claim 1, which is at least one of a monosodium salt and a monopotassium salt of N-palmitoyl-aspartic acid.
Or the milky white oil-in-water emulsion composition according to claim 2. 4. The milky oil-in-water emulsion composition according to claim 1, wherein the water-soluble polymer is at least one of a carboxyvinyl polymer, an alkyl-modified carboxyvinyl polymer, and xanthan gum. 5. A composition comprising at least 0.5 parts by weight of polyglycerin laurate and at least 4.0 parts by weight of 1,2-pentanediol based on 100 parts by weight of water in the composition. The milky white oil-in-water emulsion composition according to any one of claims 1 to 4. 6. The combination of the component (A-1) and the component (A-2)
The mixture is mixed at 0 to 80 ° C., and if necessary, cooled to obtain a translucent to transparent (A) emulsion of 5 to 80% by weight, and the water-soluble polymer and water are heated as necessary to obtain a uniform mixture. Dissolved (B)
20-95% by weight of a water-soluble polymer aqueous solution at 30-80 ° C
The method for producing an oil-in-water oil-in-water emulsion composition according to claim 1, wherein the composition is cooled to 30 ° C as needed.