CN113081864A

CN113081864A - Method for producing cosmetic composition containing micelle complex formed by natural moisturizing factor, and cosmetic composition

Info

Publication number: CN113081864A
Application number: CN202110432185.3A
Authority: CN
Inventors: 朴多珍; 姜志训; 李青熙
Original assignee: L&p Cosmetic Co ltd
Current assignee: L&p Cosmetic Co ltd
Priority date: 2020-10-06
Filing date: 2021-04-21
Publication date: 2021-07-09
Anticipated expiration: 2041-04-21
Also published as: WO2022075657A1; KR102219317B1; CN113081864B; JP6963137B1; JP2022061451A

Abstract

The present invention provides a method for preparing a cosmetic composition containing a micelle complex formed using a natural moisturizing factor, the method comprising: putting the mineral components into purified water, and irradiating microwaves to dissolve the mineral components; a step of charging a hydrophilic first amino acid to prepare a mineral-hydrophilic amino acid reactant; a step of charging an acrylic polymer; a step of charging a hydrophilic second amino acid, neutralizing the acrylic polymer to form crosslinks, and combining the acrylic polymer and the mineral-amino acid reactant; a step of charging a hydrophilic third amino acid to prepare a first composition; a step of preparing a second composition comprising an amphiphilic solvent and a hydrophobic amino acid; and a step of mixing the first composition and the second composition to prepare a composition containing a micelle complex.

Description

Method for producing cosmetic composition containing micelle complex formed by natural moisturizing factor, and cosmetic composition

Technical Field

The present invention relates to a method for preparing a cosmetic composition containing a micelle complex formed using a natural moisturizing factor, and a cosmetic composition prepared using the same.

Background

As active ingredients exhibiting activity in cosmetic compositions, there are given vitamins and derivatives thereof, amino acids, plant extracts, perfumes, enzymes, microbial extracts, minerals, and the like, and when exposed to external factors such as temperature, pH, light, air, and the like, stability deteriorates, and as a result, skin absorption rate becomes low, which results in a reduction in functional effects of cosmetics such as wrinkle improvement, whitening, moisturizing, and ultraviolet ray prevention.

The human skin may produce Moisturizing factors known as Natural Moisturizing Factors (NMF) by itself. The natural moisturizing factor is water-soluble low molecule dissolved in water, and amino acid accounts for about 40%. The natural moisturizing factor present in the skin is a substance that absorbs surrounding water and helps the epidermis and stratum corneum form a water barrier. As for substances other than amino acids, as components present in sweat and sebum, mineral components are typically mentioned. Most of the natural moisturizing factors are present on the inner side of the skin, and the moisturizing on the outer side of the skin is responsible for sweat and sebum. The mineral components present in sweat and sebum can supply moisture to the cutin. Natural moisturizing factors are substances that play a major role in enhancing skin elasticity, moisturizing skin, and preventing wrinkles, and in the absence of natural moisturizing factors, the skin becomes dry, and in severe cases, the properties of the skin may change due to allergy or extreme dryness, and the more aged the skin, the less the content of the skin, which may cause the skin to become dry or wrinkles.

The development of cosmetics requires the development of: at the end of the above-mentioned problems, there is a need to develop a stable carrier that can sufficiently exert the original function of the active ingredient at a desired site, for example, a technique for protecting the active ingredient from external factors to improve the stability, a technique for improving the solubility or dispersion efficiency of the active ingredient, a technique for efficiently delivering the active ingredient to a desired site, and a technique for promoting the absorption of the active ingredient into the skin.

Surfactants are known to adsorb uniquely at interfaces such as oil-water interfaces and solid-liquid interfaces to act as stabilizers against flocculation on storage to form dispersions of particles that remain stably in a liquid medium (e.g., water). As a monolayer in the interface, a surfactant in the form of a polyelectrolyte is used to form a layer of the surfactant on a substrate such as solid particles due to such adsorption characteristics. Surfactants can also agglomerate into structures containing multiple surfactant molecules in a single floc. The floc is called a micelle. The floc is generally spherical in shape, but can have a wide variety of shapes and structures. The number of molecules constituting the floc is extremely large, often in the order of hundreds of molecules. Micelles can consist of relatively simple surfactant structures and also of high molecular weight block copolymer surfactants.

Documents of the prior art

Patent document

Patent document 1: japanese laid-open patent publication No. 2016-0133069

Disclosure of Invention

Problems to be solved

The invention provides a preparation method of a cosmetic composition containing a micelle complex formed by a natural moisturizing factor and the cosmetic composition prepared by the preparation method.

Means for solving the problems

In order to achieve the above object, the present invention provides a method for preparing a cosmetic composition containing a micelle complex formed using a natural moisturizing factor, comprising: putting the mineral components into purified water, and irradiating microwaves to dissolve the mineral components; a step of charging a hydrophilic first amino acid to prepare a mineral-hydrophilic amino acid reactant; a step of charging an acrylic polymer; a step of charging a hydrophilic second amino acid, neutralizing the acrylic polymer to form crosslinks, and combining the acrylic polymer and the mineral-amino acid reactant; a step of charging a hydrophilic third amino acid to prepare a first composition; a step of preparing a second composition comprising an amphiphilic solvent and a hydrophobic amino acid; and a step of mixing the first composition and the second composition to prepare a composition containing a micelle complex.

Further, the present invention provides a cosmetic composition comprising a micelle complex formed by a natural moisturizing factor, the micelle complex comprising a head of a mineral-hydrophilic amino acid conjugate and a tail of an acrylic polymer, and the micelle containing a hydrophobic amino acid therein to form a micelle complex, the micelle complex being formed by the natural moisturizing factor prepared by the above preparation method.

Effects of the invention

The method for preparing a cosmetic containing a micelle complex formed using a natural moisturizing factor according to the present invention improves the conductivity at the initial preparation by using microwaves, greatly improves the solubility of a mineral substance as a functional substance, easily forms a micelle complex, supports a hydrophobic amino acid, ensures a high degree of dispersion, and sufficiently ensures stability.

In addition, the cosmetic composition containing the micelle complex formed using the natural moisturizing factor prepared by the above preparation method can have excellent technical effects in moisturizing power and reducing wrinkles.

Drawings

Fig. 1 is a photograph of canthus wrinkles before and after use of a subject who uses the cosmetic composition of example 1 of the present invention.

Detailed Description

Various embodiments of the present invention are described below with reference to the drawings. It is to be understood that the present invention is not limited to the particular embodiments, but includes various modifications, equivalents and/or alternatives of the embodiments. Similar reference characters will be used to describe similar elements in the accompanying drawings.

Herein, expressions such as "having", "may have", "include" or "may include" indicate the presence of the feature (e.g., a numerical value, a function, an action, or a constituent element of a component, etc.), and do not exclude the presence of additional features.

As used herein, expressions such as "A or B", "at least one of A and/or B" or "one or more of A and/or B", and the like, can include all possible combinations of the items listed together. For example, "a or B," "at least one of a and B," or "at least one of a or B" may indicate all of the following: (1) comprises at least one A; (2) comprises at least one B; or (3) both at least one A and at least one B are included.

The expression "composition" used herein is (or is set to) a (Configured to) "may be replaced as appropriate, and for example, may be replaced with" Suitable for "," Having a capability of "," Designed to "," changed to "," prepared to "," trade to ", or" Capable of "according to the circumstances. The term "consisting of (or set to)" does not necessarily mean "Specifically designed to".

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of other embodiments. Expressions in the singular may include expressions in the plural unless the context clearly dictates otherwise. Including technical or scientific terms, the terms used herein may have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. It will be understood that, among the terms used herein, terms defined in general dictionaries may have the same or similar meaning as is commonly understood in the specification of the relevant art, and should not be interpreted in an idealized or overly formal sense unless expressly so defined herein. Depending on the circumstances, even the terms defined herein should not be construed to exclude the embodiments herein.

The examples described herein are intended to aid in the description and understanding of the technical content described and are not intended to limit the scope of the present invention. Therefore, it should be construed that the scope herein includes all modifications or various other embodiments according to the technical idea of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail. In any case, the terms or words used in the specification and claims should not be construed as limited to general or dictionary meanings, but interpreted only as meanings and concepts conforming to the technical idea of the present invention on the basis of the principle that the inventor appropriately defines the concept of the term to describe his own invention by the best method.

Therefore, the embodiments described in the present specification constitute only a part of the most preferable embodiments of the present invention, and do not represent the entire technical idea of the present invention, and it should be understood that various equivalents and modifications may be substituted therefor at the time of applying the present invention.

Throughout the specification, when a part is referred to as "comprising" a component, it is meant that other components may be included without excluding other components, unless there is a particular statement to the contrary.

The present invention will be specifically described below.

Method for preparing cosmetic composition containing micelle complex formed by natural moisturizing factor

The present invention may include: putting the mineral components into purified water, and irradiating microwaves to dissolve the mineral components; a step of charging a hydrophilic first amino acid to prepare a mineral-hydrophilic amino acid reactant; a step of charging an acrylic polymer; a step of charging a hydrophilic second amino acid, neutralizing the acrylic polymer to form crosslinks, and combining the acrylic polymer and the mineral-amino acid reactant; a step of charging a hydrophilic third amino acid to prepare a first composition; a step of preparing a second composition comprising an amphiphilic solvent and a hydrophobic amino acid; and a step of mixing the first composition and the second composition to prepare a composition containing a micelle complex.

The step of dissolving the mineral components by irradiating the purified water with microwaves is a step of dispersing the mineral components uniformly in the purified water to form spins of electrons of mineral atoms and form and expand the spaces between the minerals by vigorous movement of the mineral atoms.

The mineral component may be selected from: sodium (Na), calcium (Ca), phosphorus (P), magnesium (Mg), potassium (K), sulfur (S), germanium (Ge), zinc (Zn), selenium (Se) in salt form, and combinations thereof.

The present specification may include, without limitation, any substance containing a high concentration of mineral components. A substance containing a high concentration of a mineral component or mineral components includes one or more of the mineral component combinations themselves. For example, the mineral component may mean the minerals listed above such as calcium and sodium, and may mean MgCl₂·6H₂O itself. According to an embodiment of the invention, the mineral component may comprise NaCl, MgCl as salt form₂、CaCl₂(ii) a Na may also be included as an ionic form⁺、Mg²⁺、Ca²⁺Ions.

The purified water may be purified water, ultrapure purified water, which is generally used in the art, and preferably, ultrapure purified water may be used. Generally, purified water is water which is commonly used in pharmaceuticals, cosmetics, etc., and has a dissolved solid content of 1.0 to 0.5ppm showing purity, and a filter for removing particles and microorganisms has a size of 0.2 to 0.45 μm and a pH in various forms ranging from weak acids to weak bases when preparing purified water. The ultrapure purified water had a dissolved solid content of 0.03ppm and an extremely high purity, and the size of the filter used for preparing the ultrapure purified water was 0.001 μm, and 99.99% of microorganisms could be removed by this filter. In particular, the ultrapure purified water can remove metal ions, and therefore, not only can the autoxidation reaction of the composition be prevented, but also the aggregation phenomenon of the polymer caused by the metal ions can be prevented, and the formulation can be uniformly coated with less irritation.

The inventor finds that: the microwave irradiation can make mineral ions in the aqueous solution transport charges, so that the mineral components are dissolved in the purified water at 50 ℃ to 80 ℃, and when the microwave irradiation is performed for 3 minutes to 10 minutes, preferably for 4 minutes to 6 minutes, molecular motion is most active, electrical conductivity is high, and the inter-molecular distance is expanded. Wherein the frequency of the microwave may be 1,500 to 3,000 Mhz. The power of the microwave is preferably 500 to 1500W, and is preferably within the above range from the viewpoint of dispersibility of the mineral component and securing the conductivity of the composition.

From the viewpoint of easy binding to the hydrophilic first amino acid of the mineral component in the subsequent step, it is preferable that the composition has an electrical conductivity in an appropriate range, and specifically, when the temperature condition after dissolving the mineral component and irradiating the microwave is 40 ℃ and 700. mu.s/cm to 900. mu.s/cm is used as the detection standard, the molecular motion of the mineral component is most active, flocculation does not occur, and the distance between molecules can be effectively expanded.

The step of dosing the hydrophilic first amino acid to produce the mineral-hydrophilic amino acid reactant described above is a step of forming a hydrophilic head compound for binding with the acrylic polymer in a later micelle formation process.

In the above step of dosing the hydrophilic first amino acid to produce the mineral-hydrophilic amino acid reactant, preferably after cooling to 30 ℃ to 50 ℃, the hydrophilic first amino acid is dosed, wherein the amino acid and the hydrophilic first amino acid are most efficiently synthesized when the composition has a conductivity of 850. mu.s/cm to 1100. mu.s/cm based on 40 ℃.

Wherein the hydrophilic first amino acid may include one or more of serine and threonine.

In the above step of administering the acrylic polymer, the mineral-amino acid reactant generated in the previous step is bonded to the hydrophilic residue of the amphiphilic acrylic polymer, and the acrylic polymer capable of forming a hydrophilic head and a hydrophobic tail is administered to be used as a base material.

The amphiphilic acrylic polymer is a copolymer of a hydrophilic residue and a hydrophobic residue, and may be obtained by graft-polymerizing a hydrophobic residue having a reactive terminal to a complementary reactive site of a hydrophilic polymer, for example. The acrylic polymer is, for example, an amphiphilic polymer derived from (meth) acrylic acid. For example, one or more selected from the group consisting of: sodium polyacrylate, acrylic/C10-30 alkanol Acrylate Crosspolymer (Acrylates/C10-30 Alkyl Acrylate Copolymer), acrylic/C12-22 alkanol Methacrylate Copolymer (Acrylates/C12-22 Alkyl Methacrylate Copolymer), acrylic/behenyl polyether-25 Methacrylate Copolymer (Acrylates/leather-25 Methacrylate Copolymer), acrylic/cetyl polyether-20 Methacrylate Copolymer (Acrylates/Ceteth-20 Methacrylate Copolymer), hydroxyethyl Acrylate/sodium acryloyldimethyl taurate Copolymer (hydroxyethyl Acrylate/sodium acryloyldimethyl Methacrylate Copolymer), and Ammonium dimethacrylate/VP Copolymer (Ammonium Acrylate/vinyl acetate/VP Copolymer).

In one embodiment of the present invention, the acrylic polymer may include sodium polyacrylate and acrylic/C10-30 alkanol Acrylate Crosspolymer (acrylics/C10-30 acryl Acrylate Crosspolymer) which is included in the cosmetic composition in a weight ratio of 1:20 to 40 based on the Alkyl Acrylate Crosspolymer (acrylics/C10-30 acryl Acrylate Crosspolymer). When the above range is not reached, the hydrophobic amino acid cannot be easily supported inside after the micelle is formed, so that the anti-wrinkle effect is not obvious; when the pH value is out of the above range, it is difficult to secure a suitable pH value (weak acidity), so that the moisturizing ability is not remarkable, and problems in the stability of the dosage form such as opaqueness of the dosage form, precipitation at low temperature, separation into thin interlayers at high temperature, etc. are caused, so that it is not preferable.

Further, when the composition dissolves the acrylic polymer at a temperature of 40 ℃ as a standard, the conductivity is preferably 600. mu.s/cm to 850. mu.s/cm, and the pH is preferably 4 to 7, from the viewpoint of ensuring transparency.

In the step of charging a hydrophilic second amino acid, neutralizing the acrylic polymer to form crosslinks, and combining the acrylic polymer and the mineral-amino acid reactant, the structure of the emulsified and flocculated acrylic polymer is guided to be linear, so that the acrylic polymer is hydrated (hydration) by purified water, and then neutralized (neutralization) by the hydrophilic second amino acid to be deformed into linear.

The hydrophilic second amino acid as a basic amino acid may include: one or more selected from the group consisting of lysine, arginine, and histidine.

The above-mentioned step of charging a hydrophilic third amino acid for preparing the first composition is a step of providing a buffer for ensuring an appropriate pH and stabilizing the solution, and the hydrophilic third amino acid may be an acidic amino acid, and specifically, may include: one or more selected from the group consisting of glutamic acid and aspartic acid.

The first composition formed by the above process may have a conductivity of 700 to 850. mu.s/cm and a pH of 4.5 to 6.0 at 40 ℃ in a weakly acidic state. By ensuring the pH and conductivity, a weakly acidic formulation suitable for the skin may be exhibited when the cosmetic composition of an embodiment of the present invention is applied.

The above-mentioned step of preparing the second composition comprising the amphiphilic solvent and the hydrophobic amino acid is a two-liquid type step for forming a cosmetic composition containing a micelle complex formed using a natural moisturizing factor, and is carried out with the aim of dissolving the amphiphilic solvent and the hydrophobic amino acid with a separate container so that the hydrophobic amino acid is easily included in the inside of the micelle when the micelle complex is formed. The second composition may optionally further comprise purified water.

The amphiphilic solvent may include one or more selected from the group consisting of: glycerol (glycerol), Dipropylene Glycol (Dipropylene Glycol), Methyl Propylene Glycol (Methyl Propanediol), Propylene Glycol (Propylene Glycol), and Butylene Glycol (Butylene Glycol).

The hydrophobic amino acids may include: one or more selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine and proline.

The two-liquid type reaction may occur in the step of mixing the first and second compositions to prepare the micelle complex-containing composition, and preferably, the first composition and the second composition may be prepared in a weight ratio of 1:0.15 to 0.35.

If the amount is less than the above range, the acrylic Polymer is added in the form of Water-in-oil (W/O), and specifically, the acrylic Polymer has a structure in which Water (purified Water) is held in a W/P type (Water in Polymer) formulation, so that the hydrophobic (Polymer) region is insufficient, and the formation of micelles may be insufficient or not formed; when the range is exceeded, a delamination phenomenon may occur, resulting in failure to secure transparency of the final cosmetic composition.

In the present invention, the content of each component of the micelle complex-containing cosmetic composition is as follows: the content of each component is determined by the first composition and the second composition, and the components can be dissolved in the solvent and added within the following content range.

The first composition may include, based on 100 parts by weight of the purified water: 0.01 to 0.05 parts by weight of a mineral component, 0.005 to 0.015 parts by weight of a hydrophilic first amino acid, 0.01 to 0.15 parts by weight of an acrylic polymer, 0.001 to 0.010 parts by weight of a hydrophilic second amino acid, and 0.005 to 0.015 parts by weight of a hydrophilic third amino acid.

When the mineral component does not reach the content range, the hydrophilic head of the micelle complex is not easily formed, so that it is not preferable; beyond this range, crosslinking of the polymer may be reduced by the mineral component, which over time may also reduce the viscosity of the dosage form, affecting clarity; when the content of the mineral components exceeds a certain amount, the skin moisture discharged to the outside of the body is more than the skin moisture transferred to the inside of the body due to the permeation phenomenon, and the dryness is improved to the maximum.

When the hydrophilic first amino acid does not reach the content range, the hydrophilic head of the micelle complex is not easily formed, which is not preferable; when the amount is outside the above range, the hydrophilic head becomes too large, and the ability to lock water can be enhanced, but surface tension, that is, interfacial tension of hydrophilic amino acids becomes large, and flocculation tendency between hydrophilic amino acids occurs, and therefore, it is not preferable in view of stability of the dosage form.

When the acrylic polymer does not reach the content range, the acrylic polymer is not preferable because the viscosity and the content are low, a micelle complex cannot be formed, and the hydrophobic amino acid cannot be supported in the micelle; when the content is outside the above range, the dosage form is sticky and slippery, the absorption is poor, and the transparency is also affected.

When the content of the hydrophilic second amino acid is less than the content range, the neutralization effect of the acrylic polyol is not obvious, and crosslinking cannot be formed, so that the dispersing force is reduced, and the formation of a micelle complex is negatively influenced; when the content exceeds the above range, the skin barrier is damaged due to the influence of the increase in pH, and the dryness of the skin is increased by the loss of water, and the skin is irritated, which is not preferable.

When the content of the hydrophilic third amino acid is less than the content range, the stability of the final cosmetic composition formulation cannot be ensured and the pH is weakly acidic, and the effect is not obvious in terms of the specific moisturizing ability and wrinkle improvement of the present invention, so that the present invention is not preferable; when the content is outside the above range, the pH becomes low and there is a defect in stability, so that it is not preferable.

The second composition may include, based on 100 parts by weight of the amphiphilic solvent: 0.01 to 0.10 parts by weight of hydrophobic amino acid and 20 to 50 parts by weight of purified water.

When the hydrophobic amino acid does not reach the content range, the total amount of the hydrophobic amino acid carried in the micelle complex is reduced, and the effects on the specific moisturizing ability and wrinkle improvement of the present invention are not obvious, so that the present invention is not preferable; when the content is outside the range, if the polymer is outside the range in which it can be suspended, delamination occurs, and therefore, it is not desirable in view of the stability of the dosage form.

Cosmetic composition containing micelle complex formed by natural moisturizing factor

The micelle formed by the natural moisturizing factor comprises the following components: the cosmetic composition comprises a head part comprising a mineral-hydrophilic amino acid conjugate and a tail part comprising an acrylic polymer, wherein the micelle contains a hydrophobic amino acid therein to form a micelle complex, and the micelle complex can be dispersed in a cosmetic composition using purified water as a solvent.

In particular, micellar complexes of hydrophobic amino acids may be included, which may include: one or more selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine and proline.

The micelle complex may be contained in an amount of 0.01 to 0.05 wt% in 100 wt% of the entire composition, and is included in the cosmetic composition in the range so that, when applied to the skin, intercellular lipids within keratinocytes of the stratum corneum are supported by hydrophobic amino acids inside the micelles, combine with skin moisture, effectively retain skin moisture and block evaporation of moisture, while ensuring delamination stability and dosage form transparency.

Regarding the cosmetic composition containing the micelle complex, from the viewpoint of ensuring the wrinkle-and skin-moisturizing effect of the present invention, the electrical conductivity is preferably 750. mu.s/cm to 850. mu.s/cm, and the pH is preferably 5.0 to 6.0, based on the temperature of the composition of 40 ℃.

The cosmetic composition according to an embodiment of the present invention is a Water-In-Oil (W/O, Water In Oil) type, and specifically, an acrylic Polymer may be used, and the Oil (Oil) component contains a Polymer (Polymer). Therefore, the present inventors refer to it as W/P (Water In Polymer) type, and it can be used without limitation as long as it is a formulation conforming to it. For example, it may be one selected from the following dosage forms: a makeup cosmetic formulation consisting of basic cosmetic formulation, skin lotion, eye cream, soothing gel, ointment, mask formulation, bath cream formulation, exfoliating gel, oil-in-water type barrier cream, water-in-oil type barrier cream, foundation cream, covering cream, lipstick, lip gloss, foundation, double-effect foundation, eye shadow, eyebrow color eyebrow pencil (Chinese color eye brow pencil), sunscreen cream, BB cream and hair care product.

The present invention will be described in further detail below with reference to examples. These examples are intended to illustrate the present invention more specifically, and it is obvious that those skilled in the art to which the present invention pertains will understand that the scope of the present invention is not limited by the examples thereof according to the gist of the present invention.

Preparation example

Preparation example 1

As a first composition, 0.025g of NaCl and MgCl were mixed with 0.5g of purified water at 75 ℃ to prepare a mixture₂ 0.00025g、CaCl₂After 0.0002g, the mixture was irradiated with 2,400MHz to 2,500MHz and 1000W power for 15 minutes using a microwave apparatus manufactured in U.S. of CEM (S1). After the composition was cooled to 40 ℃, 0.5g of purified water, 0.005g of serine, and 0.0015g of threonine were put in and reacted with the mineral component (S2). Then, 74g of purified water, 0.045g of sodium polyacrylate, and 0.0017g of acrylic acid/C10-30 alkanol Acrylate crosslinked polymer (acryl/C10-30 acryl crosslinker) were mixed and charged into a container (S3). 0.5g of purified water, 0.0013g of arginine, and 0.005g of histidine were mixed and then put into a container (S4). 5g of purified water, 0.006g of glutamic acid and 0.003g of aspartic acid were mixed and then put into a container (S5).

As a second composition, 14g of glycerin, 0.0015g of alanine, 0.0014g of proline, 0.009g of glycine, and 5g of purified water were mixed in a separate container (S6).

Then, the first composition and the second composition are mixed to prepare a final composition (S7).

Preparation example 2

0.025g of NaCl and 0.025g of MgCl were mixed with 0.5g of purified water at 75 ℃₂ 0.00025g、CaCl₂After 0.0002g, adoptThe irradiation was carried out for 15 minutes using a microwave instrument from CEM at a power of 2,400MHz to 2,500MHz and 1000W (S1). After cooling the composition to 40 ℃, 0.5g of purified water, 0.005g of serine and 0.0015g of threonine were put in and reacted with the mineral component (S2). Then, 74g of purified water, 0.045g of sodium polyacrylate, and 0.0017g of acrylic acid/C10-30 (Acrylate/C10-30 (Alkyl Acrylate Crosspolymer)) crosslinked polymer were mixed and put into a container (S3). 0.5g of purified water, 0.0013g of arginine, and 0.005g of histidine were mixed and then put into a container (S4). 5g of purified water, 0.006g of glutamic acid, and 0.003g of aspartic acid were mixed and then put into a container (S5). After mixing 14g of glycerin, 0.0015g of alanine, 0.0014g of proline, 0.009g of glycine, and 5g of purified water, the mixture was put into a container to prepare a final composition (S6).

Preparation example 3

As a first composition, 0.025g of NaCl and MgCl were mixed with 0.5g of purified water at 75 ℃ to prepare a mixture₂0.00025g、CaCl₂After 0.0002g, the cells were irradiated for 15 minutes at a power of 2,400MHz to 2,500MHz and 1000W using a microwave-producing instrument from CEM (S1). After cooling the composition to 40 ℃, 0.5g of purified water, 0.005g of serine and 0.0015g of threonine were put in and reacted with the mineral component (S2). Then, 74g of purified water and 0.056g of hydroxyethyl cellulose were mixed and put into a container (S3). After mixing 0.5g of purified water, 0.0013g of arginine, and 0.005g of histidine, the mixture was put into a container (S4). 5g of purified water, 0.006g of glutamic acid and 0.003g of aspartic acid were mixed and then put into a container (S5).

As a second composition, 14g of glycerin, 0.0015g of alanine, 0.0014g of proline, 0.009g of glycine, and 5g of purified water (S6 ×) were mixed with another container.

Then, the first composition and the second composition were mixed to prepare a final composition (S7).

Preparation example 4

As a first composition, 0.025g of NaCl and MgCl were mixed with 0.5g of purified water at 75 ℃ to prepare a mixture₂0.00025g、CaCl₂0.0002g (S1). After cooling the composition to 40 ℃, 0.5g of purified water, 0.005g of serine and 0.0015g of threonine were put in and reacted with the mineral component (S2 ×). Then, 74g of purified water, 0.045g of sodium polyacrylate, and 0.0017g of acrylic acid/C10-30 alkanol Acrylate crosslinked polymer (acryl/C10-30 Alkyl Acrylate crosslinker) were mixed and put into a container (S3). After mixing 0.5g of purified water, 0.0013g of arginine, and 0.005g of histidine, the mixture was put into a container (S4). After mixing 5g of purified water, 0.006g of glutamic acid and 0.003g of aspartic acid, the mixture was put into a container (S5).

Examples and comparative examples

Example 1

The cosmetic composition prepared by the procedure of preparation example 1 was taken as example 1.

Examples 2 to 7

The preparation procedure was the same as in preparation example 1, and cosmetic compositions prepared by adjusting the contents of the ingredients according to the following table were used as examples 2 to 7.

[ TABLE 1 ]

Comparative example 1

The cosmetic composition prepared by the procedure of preparation example 2 was taken as comparative example 1.

Comparative example 2

The cosmetic composition prepared by the procedure of preparation example 3 was taken as comparative example 2.

Comparative example 3

The cosmetic composition prepared by the procedure of preparation example 4 was taken as comparative example 3.

Test example 1: confirmation of temperature and pH of Each step

The results of temperature, pH and conductivity measurements in the preparation steps of preparation examples 1 to 4 are shown in the following table. The conductivity was measured using the Cond probe InLab 720 product from METTER TOLEDO corporation (-indicating no measurement).

[ TABLE 2 ]

Test example 2: increasing skin moisture

As the cosmetic compositions prepared in the examples and comparative examples, 50 women of 20 to 40 years old age with poor skin condition were screened, applied twice daily to the face or neck, etc., and persisted for one month. At that time, before the application was started, the skin dryness was measured in advance under constant temperature and humidity conditions (temperature: 24 ℃ C., humidity: 40%) using a moisture meter (CM 820 moisture Khazaka electronic GmbH, Germany) as an initial value, and after 1 week, 2 weeks, and 4 weeks, respectively, the skin moisture content was measured to objectively evaluate the effect, and the results are shown in Table 3 below.

[ TABLE 3 ]

Test example 3: observation of stability with time after preparation (Observation of stability in layers)

The compositions prepared in the examples and comparative examples were allowed to stand at normal temperature for 12 months or more, at high temperature of 45 ℃ for 1 month or more, and at low temperature of-4 ℃ for 1 month or more, respectively, and the stability with time was observed, and the results are shown in table 4 below.

O: good (no appearance change, transparent); and (delta): variation (opaque appearance); x: failure (occurrence of delamination)

[ TABLE 4 ]

Test example 4: detecting wrinkle improvement

20 women aged 25 to 55 years (average age of 40.30 years) were screened for good health under constant temperature and humidity conditions of normal temperature and humidity of 40 to 60%, and before the cosmetic compositions of examples were used by subjects, wrinkles in the canthus and skin viscoelasticity (Cutomer MPA 580(C + K, Germany)) were measured, and the results are shown in Table 5 below.

The skin viscoelasticity value is defined as skin change pattern region (Uv)/skin recovery pattern region (Ue), and the smaller the value, the better the elasticity.

The results of photographing the canthus wrinkles before and after use (after 4 weeks) of the cosmetic composition of example 1 of the present invention with a wrinkle detection photographing device (aram ASM-300) of 1 subject are shown in fig. 1. After use, the wrinkle area decreased, indicating that the wrinkles were significantly improved.

[ TABLE 5 ]

Claims

1. A method for preparing a cosmetic composition containing a micelle complex formed using a natural moisturizing factor, comprising:

putting the mineral components into purified water, and irradiating microwaves to dissolve the mineral components;

a step of charging a hydrophilic first amino acid to prepare a mineral-hydrophilic amino acid reactant;

a step of charging an acrylic polymer;

a step of charging a hydrophilic second amino acid, neutralizing the acrylic polymer to form crosslinks, and combining the acrylic polymer and the mineral-amino acid reactant;

a step of charging a hydrophilic third amino acid to prepare a first composition;

a step of preparing a second composition comprising an amphiphilic solvent and a hydrophobic amino acid; and

and a step of mixing the first composition and the second composition to prepare a composition containing a micelle complex.

2. The method for producing a cosmetic composition containing a micelle complex formed using a natural moisturizing factor according to claim 1, wherein the hydrophilic second amino acid is a basic amino acid, and the hydrophilic third amino acid is an acidic amino acid.

3. The method for preparing a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor according to claim 1, wherein the acrylic polymer comprises one or more selected from the group consisting of: sodium polyacrylate, acrylic/C10-30 alkanol Acrylate Crosspolymer (Acrylates/C10-30 Alkyl Acrylate Copolymer), acrylic/C12-22 alkanol Methacrylate Copolymer (Acrylates/C12-22 Alkyl Methacrylate Copolymer), acrylic/behenyl polyether-25 Methacrylate Copolymer (Acrylates/leather-25 Methacrylate Copolymer), acrylic/cetyl polyether-20 Methacrylate Copolymer (Acrylates/leather-20 Methacrylate Copolymer), hydroxyethyl Acrylate/sodium acryloyldimethyl taurate Copolymer (hydroxyethyl Acrylate/sodium acryloyldimethyl Methacrylate Copolymer), and Ammonium dimethacrylate/VP Copolymer (Ammonium Acrylate/vinyl acetate/VP Copolymer).

4. The method for preparing a cosmetic composition comprising the micelle complex formed using the natural moisturizing factor according to claim 1, wherein the microwave is irradiated at a power of 500W to 1500W.

5. The method for preparing a cosmetic composition comprising the micelle complex formed using a natural moisturizing factor according to claim 1, wherein the weight ratio of the first composition to the second composition is 1:0.15 to 0.35.

6. The method for preparing a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor according to claim 1, wherein the amphiphilic solvent comprises one or more selected from the group consisting of: glycerol (glycerol), Dipropylene Glycol (Dipropylene Glycol), Methyl Propylene Glycol (Methyl Propanediol), Propylene Glycol (Propylene Glycol), and Butylene Glycol (Butylene Glycol).

7. A cosmetic composition comprising a micelle complex formed by using a natural moisturizing factor, which comprises the micelle complex prepared by the preparation method according to any one of claims 1 to 6,

the micelle includes a head of a mineral-hydrophilic amino acid conjugate and a tail of an acrylic polymer, and the micelle contains a hydrophobic amino acid therein to form a micelle complex.

8. The cosmetic composition comprising the micelle complex formed using natural moisturizing factors according to claim 7, wherein the hydrophobic amino acids comprise: one or more selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine and proline.