KR100539111B1 - Cosmetic composition comprising paramagnetic gold nanoparticles - Google Patents

Abstract

The present invention relates to a cosmetic composition containing paramagnetic gold nanoparticles, and in particular, 3 to 20 ppm of paramagnetic gold nanoparticles are contained, and in addition to the paramagnetic gold nanoparticles described above, a carrier, a softener, a humectant, and a surfactant , Emulsifiers, and bioactive substances are further contained. The cosmetic composition containing paramagnetic gold nanoparticles according to the present invention not only has excellent skin moisturizing ability and skin absorption ability of the active ingredient, but also improves skin trouble, does not make the skin sticky, and softens the skin. It has the advantage of remarkably excellent skin cleansing effect.

Description

Cosmetic composition containing paramagnetic gold nanoparticles

The present invention relates to a cosmetic composition, the active ingredient is well absorbed into the skin, has excellent skin moisturizing properties, improves skin troubles, and has excellent skin feel, and more particularly, to a cosmetic composition containing paramagnetic gold nanoparticles. .

The magnetic properties of materials can be divided into ferromagnetic, weak magnetic and diamagnetic materials. Weak magnetic materials are classified into antiferromagnetic and paramagnetic materials. In the case of paramagnetic, the magnetic effects of electrons, including spin and orbital motions, cancel most of the atoms or ions so that the atoms or ions do not exhibit magnetic properties. This appears in an inert gas such as neon or copper ions constituting copper. However, at some atoms or ions, the magnetic effects of the electrons are not completely canceled out, so that the whole atom has a magnetic dipole moment. When n atoms each having a magnetic dipole moment are placed in a magnetic field, these atomic dipoles try to align side by side in the direction of the magnetic field. This tendency is called paramagnetic. If all are aligned in one direction, the total dipole moment will be nμ. However, the alignment process is hindered by thermal motion. Clogged vibration of atoms causes collisions between atoms and transfers kinetic energy, destroying already aligned states. The importance of thermal motion can be seen by comparing the two types of energy. One of them is the average translational kinetic energy (3/2) kT of atoms at temperature T. The other is 2 μB, the energy difference in two states, parallel and antiparallel to the direction of the magnetic dipole magnetic field. However, the former is considerably larger than the latter at normal temperatures or magnetic fields. Hence, the thermal motion of atoms interferes with the dipole alignment. Although the magnetic moment is generated in the external magnetic field, it is far below the maximum possible nμ. One can think of the magnetic moment per unit volume to indicate the degree of magnetization of a substance. This is called magnetization M.

Materials called diamagnetics do not have their own magnetic dipoles and are not paramagnetic, but magnetic moments can be induced by external magnetic fields. If a sample of such material is placed near a non-uniform, strong magnetic field, a magnetic force will act. In contrast to the electrical case, however, it is pushed to the pole of the magnet without being dragged. This difference between electricity and magnetism is that induced electric dipoles are in the same direction as the external electric field, but induced magnetic dipoles are opposite to the external magnetic field. Diamagnetics apply Faraday's law of induction to electrons in atoms, and classically, the motion of electrons is a very small current ring. The induced magnetic moment is opposite to the direction of the magnetic field, which is the result of Lenz's law on atomic scale.

Diamagnetics are properties that all atoms have. However, if an atom has its own magnetic dipole moment, the diamagnetic effect is masked by stronger paramagnetic or ferromagnetic properties.

On the other hand, gold is a typical diamagnetic material that exhibits magnetic properties in the opposite direction to an external magnetic field, and gold is known to not change its magnetic properties even when its size is nanoscaled. Because of the poor application field, there are limitations. Only gold nanoparticles are applied due to the original gold properties. Gold nanopowders may be applied to nano gold soaps, sports lotions, cosmetics, drinking water, semiconductor light emitting devices, drug carriers, etc. It is only.

The effect of gold with conventional diamagnetic properties is good for preventing skin aging and removing blemishes by promoting blood circulation due to ionic action, and for skin wrinkle prevention and freckle removal by activating skin due to stimulating hormone secretion. Due to wound healing, it is effective in preventing skin inflammation and acne healing, strengthening immune function, regenerating damaged cells in the heart, spleen, pancreas and muscle, and stimulating the pituitary gland to improve nutrient absorption Has the effect of doing

On the other hand, cosmetic products containing gold have recently appeared, and the Republic of Korea Patent Publication No. 10-2004-26472 has been disclosed with respect to a cosmetic preparation method added with gold powder, but has not yet been disclosed with respect to the cosmetic composition. The invention used gold processed within 2000 micro, and cosmetics are characterized in that it is applied to drinking and skin. The cosmetics according to the invention have the advantage of being only convenient to use, but have no effect on the moisture and absorbency of the skin. In addition, commercially available cosmetics containing a diamagnetic gold powder commercially have aesthetic advantages of making the skin color fine and clear and transparent skin, but the effect of skin absorbency and moisturizing is weak.

This is because even though the silver and gold powder having a normalized diamagnetism has a nanoscaled size, although the volumetric characteristics are reduced, the surface of the nanoparticles is accumulated in an oxide layer, so that no specific characteristic on the surface is observed and the diamagnetic properties are maintained. It seems to be due.

The inventors of the present invention developed a gold nanoparticle having a paramagnetic property which is not conventionally possessed by gold nanoparticles and filed with Korean Patent Application No. 2004-68246. As a result of research on product development using the applied gold nanoparticles, The addition of paramagnetic gold nanoparticles according to the invention to the cosmetic composition has a unique effect of increasing the activity of various active ingredients included in the cosmetic composition, enhances skin moisturizing effect, improves skin troubles, and makes the skin sticky The present invention has been completed by discovering that it does not soothe, softens the skin and cleanses the skin.

Accordingly, an object of the present invention is to increase the activity of the cosmetic composition, excellent skin absorption of the active ingredient, excellent skin moisturizing, excellent skin feel, cosmetic composition containing paramagnetic gold nanoparticles without skin problems To provide.

The present invention relates to a cosmetic composition containing paramagnetic gold nanoparticles, and in particular, paramagnetic gold nanoparticles containing 3 to 20 ppm of paramagnetic gold nanoparticles having specific characteristics that do not appear. Nanoparticles are paramagnetic in all temperature ranges, but especially paramagnetic at absolute temperatures above 20K.

The size of the paramagnetic gold nanoparticles is not limited, but may contain 40 μm or less.

Hereinafter, the present invention will be described in detail.

The cosmetic composition of the present invention is characterized by further containing paramagnetic gold nanoparticles in addition to the usual cosmetic composition. The cosmetic composition according to the present invention has parasitic gold nanoparticles, which have a unique effect that cannot be seen in conventional diamagnetic gold nanoparticles, that is, a unique effect of increasing the activity of various active ingredients than when adding gold particles having conventional diamagnetic properties. It has excellent skin absorption of the active ingredient, excellent skin moisturizing properties, excellent skin feel, and has no skin trouble. Moreover, even if paramagnetic gold nanoparticles are added, they are not cohesive and excellent in dispersibility.

The paramagnetic gold nanoparticles included in the cosmetic composition of the present invention are paramagnetic at all temperatures, which means that they have the same direction as the external magnetic field, that is, a positive susceptibility at all temperatures. In particular, the paramagnetic properties of these gold nanoparticles can be more clearly identified at 20K or higher absolute temperature. The paramagnetic gold nanoparticles according to the present invention exhibit extremely small coercive force, and do not have a surface oxide layer, are stable at room temperature, have no cohesiveness, and have high dispersibility. That is, the conventional diamagnetic gold nanoparticles have a problem that the specific characteristics of the surface of the nanoparticles are not sufficiently exhibited because the surface of the nanoparticles is wrapped in an oxide layer even though volume characteristics are reduced through nanoization.

The paramagnetic gold nanoparticles used in the cosmetic composition according to the present invention have different slopes of susceptibility curves depending on the size of the powder. The smaller the size, the remarkably the paramagnetic characteristics are, and the hollow particles of the hollow structure are not filled inside the powder. In addition, the paramagnetic properties of the gold particles, the susceptibility curves vary depending on the temperature, but the paramagnetic properties appear in all temperature ranges below room temperature, and the coercivity of the gold nanoparticles according to the present invention is 5 gauss in the range below room temperature. The following characteristics are shown, and in particular, at room temperature, it has an extremely small coercive force of 2 gauss or less.

The paramagnetic gold nanoparticles used in the cosmetic composition according to the present invention is not particularly limited in size, and is suitable if the size of the paramagnetic gold nanoparticles is used in the cosmetic composition according to the present invention. Since the size of the silver powder is clearly shown in the range of 40 μm or less, the size of the gold nanoparticles is preferably 40 μm or less, and the slope of the susceptibility curve varies depending on the size of the gold nanoparticles. Is remarkable, in particular 1-20 nm in size. As the size of the gold nanoparticles is smaller, the paramagnetic properties are clearer, so that the effect according to the present invention can be more large.However, in the case of small particles, not only the production cost is increased but also the effect of the invention due to the paramagnetic properties in the size degree Since is expressed sufficiently, it is not necessary to use the thing below the said size.

The amount of paramagnetic gold nanoparticles contained in the cosmetic composition of the present invention may vary depending on the paramagnetic properties of the gold, but the paramagnetic gold nanoparticles may be used based on a size of 40 μm or less and having a coercive force of 5 gauss or less. The content of the nanoparticles is preferably 3 to 20 ppm based on the total composition. When the amount of the gold nanoparticles is less than 3 ppm, the desired addition effect is lowered. When the amount of the gold nanoparticles is more than 20 ppm, the addition effect of the paramagnetic gold nanoparticles is no longer increased, which may be economically disadvantageous.

Toxicity test of paramagnetic gold nanoparticles used in the present invention As a result of oral administration of a dispersion solution of paramagnetic gold nanoparticles concentration of 60 ppm to oral administration limit 20 ml / kg BW to SD rats did not find any toxic symptoms at all No histologic lesions were observed.

Detailed characteristics and manufacturing method of the paramagnetic gold nanoparticles used in the cosmetic composition of the present invention are described in detail in Korean Patent Application No. 2004-68246, which is an application of the present invention on 'gold or silver powder having paramagnetic'. Bar, manufacturing or confirming the properties based on this is easily understood and practiced by those skilled in the art for preparing nanoparticles, so detailed description thereof will be omitted.

The cosmetic composition according to the present invention may contain one or more selected from diluents, softeners, moisturizers, emulsifiers, surfactants, bioactive substances and purified water which are commonly contained in cosmetic compositions in addition to the paramagnetic gold nanoparticles.

The diluent serves to dilute and uniformly dissolve the cosmetic composition to a suitable concentration. As the diluent used in the present invention, a hydrophilic diluent is preferably used. Hydrophilic diluents include water, C1-C4 monohydric alcohols and propylene glycol, polyethylene glycol, polypropylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerol, butylene glycol, 1,2,4-butanetriol, sorbitol esters Preference is given to low molecular weight glycols and polyols such as 1,2,6-hexanetriol, ethanol, iso-propanol, sorbitol esters, ethoxylated ethers, propoxylated ethers and the like. The diluent used in the present invention may be any diluent commonly used. The content of the diluent used is 5 to 30% by weight.

The emollients act to soften the skin, increase the softness and suppleness of the skin, prevent or eliminate drying of the skin, or protect the skin. Emollients are usually used oils or beeswax substances that cannot be mixed with water. It is preferable to use at least one mixture selected from vegetable oils or hydrogenated vegetable oils, animal fats or oils, alkyl ethers, carboxylic acid ethers, isocetyl alcohol, castor oil or tocopherol acetate and mixtures thereof. . More preferably, at least one is selected from isocetyl alcohol, castor oil and tocopherol acetate. The content of the softener used is preferably 3 to 15% by weight.

The moisturizer serves to improve the moisturizing properties of the skin. Moisturizers used include propylene glycol, dipropylene glycol, butylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, erythritol, threitol, pentaethitol, xylitol ( xylitol, glucitol, mannitol, mannitol, hexylene glycol, glycerin, concentrated glycerin, sodium hyaluronate, sodium hyaluronate or dimethicone may be used, and preferably hyaluro Sodium acid, sodium hyaluronate or dimethicone is preferable. The amount of moisturizer used is 10 to 20% by weight. If the amount is less than the amount is used, the moisturizing effect is insignificant, when the amount is exceeded, there is a problem that almost no increase effect of the moisturizing power.

The surfactant serves to disperse and suspend the discontinuous phase in the continuous phase. If the selected agent is chemically and physically compatible with the components of the composition and provides the required properties, conventionally used surfactants may be used. Preferred surfactants include ester oils, isohexatecan, cetanol, stearyl alcohol, oleyl alcohol, lauric acid, myristic acid, palmitic acid or dimethyloctanoic acid. It is preferable that the content of the surfactant is used in an amount of 1 to about 10% by weight, and when the content is less than the content, the oil content is too small, which may weaken the soft feeling. There is.

The emulsifier may be PEG-10 hydrogenate castor oil, PEG-100 hydrogenate castor oil, mineral oil, sorbitan cisquinolate, propylene glycol dicaprylate, stearic acid, triethanolamine, castor oil, and the like. The content of the emulsifier of the present invention is used 1 to 10% by weight.

The bioactive substance used in the present invention is a water-soluble vitamin including vitamin B group and vitamin C group, vitamins such as vitamin A group such as retinol, palmitate retinol, vitamin D group, vitamin E group, and fat-soluble vitamins such as vitamin F group. Commonly used natural extracts such as leucine and arbutin and ginseng extract are used. The content of the bioactive substance is preferably 2 to 10% by weight.

In addition to the composition, one or more selected from among the viscosity adjusting agent, the neutralizing agent, the chelating agent, the astringent, the preservative, and the decontaminant may be contained.

The viscosity modifier is to function to adjust the viscosity of the cosmetic component after emulsification, and commonly used polyglyceryl methacrylate, carboxyl vinyl poly, hydroxyethyl cellulose or carbomer may be used. The content of the thickener may be adjusted to appropriately reduce the viscosity according to the formulation of the cosmetic ingredient.

The neutralizing agent is added after the addition of the thickener to adjust the pH of the product, diethanolamine, triethanolamine, arginine and the like are used.

The chelating agent acts as a protection against environmental factors that can lead to UV radiation and skin damage causing excessive scale rings or tissue changes in the stratum corneum. Tetraacetic acid, furyldioxime or sodium tetraacetic acid may be used as the chelating agent. Suitable amounts are from 0.01 to 1.0% by weight.

The astringent acts to temporarily contract pores, and zinc oxide, zinc sulfate, allantoan, hydroxyaluminum, citric acid, lactic acid, aluminum sulfate, aluminum chloride, zinc stearate, or bagwood extract are used.

The preservatives include methyl paraben, ethyl paraben, propyl paraben, butyl paraben, isobutyl paraben, phenoxyethanol and the like. Suitable content is 0.01 to 1.0% by weight.

The decontaminant serves to cleanly remove contaminants remaining on the skin, and sodium tetraacetic acid is used.

Hereinafter, the present invention will be described in more detail with reference to the following examples, which are intended only for understanding the configuration and effects of the present invention and are not intended to limit the scope of the present invention.

Paramagnetic gold nanoparticles added were prepared by the reaction conditions described in Preparation Example 5 described in detail in Korean Patent Application No. 2004-68246.

Example 1 and Example 2

To prepare a cosmetic composition according to the composition shown in Table 1.

TABLE 1

Comparative Example 1 and Comparative Example 2

The composition of Comparative Example 1 was prepared in the same manner as in Example 1 and Example 2 except that the paramagnetic gold nanoparticles were not used, and the composition of Comparative Example 2 was prepared according to the composition shown in Table 2 below.

TABLE 2

[Test Example 1]

Moisturizing Effect Experiment

After applying the cosmetic composition containing the paramagnetic gold nanoparticles of Examples 1 and 2 and the cosmetic composition containing no paramagnetic gold nanoparticles of Comparative Examples 1 and 2 to the skin, the skin moisturizing effect meter (corneometer) ) Was used to evaluate skin moisture retention.

In the test method, a constant amount was applied to the inside of Habakku 20 subjects in a constant temperature and humidity room of 22 ° C. and a relative humidity of 50%, and then rubbed well, and the moisture content of the skin over time was measured and the results are shown in Table 3 below. .

TABLE 3

As shown in Table 3, it can be seen that the cosmetic compositions of Examples 1 and 2 containing paramagnetic gold nanoparticles had a much better moisturizing effect than the cosmetic compositions of Comparative Examples 1 and 2 containing no gold nanoparticles. have.

[Test Example 2]

Skin absorption and skin texture effect test

The cosmetic compositions of Examples 1, 2, Comparative Example 1 and Comparative Example 2 were provided to 30 subjects on a blind basis. Each subject was evaluated for skin absorption and skin feel properties for four compositions. Property (1) is a fast skin absorption, and property (2) is a non-sticky, soft texture. The ratings are very good, excellent, fair and poor, with 1 to 4, respectively. The results are shown in Table 4 below.

TABLE 4

In Table 4, in Examples 1 and 2, which are cosmetic compositions containing paramagnetic gold nanoparticles according to the present invention, all the subjects showed a response that the skin absorbency and the feel were excellent. On the other hand, in Comparative Example 1 and Comparative Example 2, which does not contain paramagnetic gold nanoparticles, about half of the subjects responded that the skin absorbency and feel were normal or poor. Therefore, it can be seen that the cosmetic composition containing paramagnetic gold nanoparticles according to the present invention has excellent skin absorption and feel effect.

The cosmetic composition containing paramagnetic gold nanoparticles according to the present invention is excellent in the skin absorption of the active ingredient, remarkably excellent skin moisturizing effect, excellent skin feel, by using paramagnetic gold nanoparticles and improving skin troubles and Excellent skin cleansing effect.

Claims (6)

delete Cosmetic composition, characterized in that the paramagnetic gold nanoparticles are contained in an amount of 3 to 20 ppm. The method of claim 2, The paramagnetic gold nanoparticles have a paramagnetic property at an absolute temperature of 20 K or more. The method of claim 2, The paramagnetic gold nanoparticles is a cosmetic composition, characterized in that 40 ㎛ or less. The method according to claim 3 or 4, Cosmetic composition, characterized in that it contains at least one from diluents, emollients, moisturizers, surfactants, emulsifiers, bioactive substances and purified water. The method of claim 5, Cosmetic composition, characterized in that it further contains one or more selected from viscosity modifiers, neutralizing agents, chelating agents, astringents, preservatives, decontaminants.