KR102219317B1 - A method of producing a cosmetic composition comprising a micelle complex formed by using natural moisturizing factor, and a cosmetic composition formed by the method - Google Patents

Abstract

The present invention provides a method for preparing a cosmetic composition comprising a micelle complex formed by using a natural moisturizing factor and a cosmetic composition comprising a micelle complex prepared therefrom. The method comprises the steps of: adding a mineral component to purified water and dissolving the same by irradiating microwaves; adding a first hydrophilic amino acid to prepare a mineral-hydrophilic amino acid reactant; adding an acrylic polymer; adding a second hydrophilic amino acid to neutralize the acrylic polymer, form a cross-link and bond the acrylic polymer and a mineral-amino acid reactant; preparing a first composition by adding a third hydrophilic amino acid; preparing a second composition including an amphiphilic solvent and a hydrophobic amino acid; preparing a composition including a micelle complex by mixing the first and second compositions.

Description

A method of producing a cosmetic composition comprising a micelle complex formed by using natural moisturizing factor, and a cosmetic composition formed by the method}

The present invention relates to a method for producing a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor and a cosmetic composition prepared therefrom.

As active ingredients showing activity in cosmetic compositions, vitamins and their derivatives, amino acids, plant extracts, flavors, enzymes, microbial extracts, minerals, etc. can be exemplified. When exposed to external factors such as temperature, pH, light, and air Stability is lowered, and accordingly, the skin absorption rate is lowered, and functional effects such as wrinkle improvement, whitening, moisturizing, and UV protection are lowered.

The human skin can create a moisturizing factor called natural moisturizing factor (NMF) by itself. The natural moisturizing factor is a water-soluble low molecule that is soluble in water, and amino acids account for about 40%. The natural moisturizing factor present in the skin is a substance that helps to form a moisture barrier in the epidermis and stratum corneum by absorbing moisture around it. Examples of substances other than amino acids include mineral components as components present in sweat and sebum. Most natural moisturizing factors exist inside the skin, and sweat and sebum are responsible for moisturizing the outside of the skin. The minerals present in sweat and sebum can provide moisture to the dead skin cells. Natural moisturizing factors are substances that play a major role in skin elasticity, moisturizing and anti-wrinkle, and when natural moisturizing factors are insufficient, the skin becomes dry, and in severe cases, the properties of the skin may change due to atopy or extremely dryness. As the content of the factor in the skin decreases, the skin may become dry or cause wrinkles.

In the development of cosmetics, technologies to improve stability by protecting the above-described active ingredients from external factors, technologies to improve the solubility or dispersion efficiency of active ingredients, technologies to efficiently deliver active ingredients to desired areas, and skin of active ingredients. There is a need to develop a technology that promotes absorption, and ultimately, there is a need to develop a stable delivery system that allows the active ingredient to fully exhibit its original function at a desired site.

Surfactants are recognized to be uniquely adsorbed on interfaces such as oil/water interfaces and solid/liquid interfaces, and stabilizers for creating dispersions of particles in a liquid medium (e.g., water) that remain stable against aggregation upon storage. Is used as Because of this adsorption property as a monomolecular layer at the interface, a surfactant in the form of a polymer electrolyte has been used to create a layer of surfactant on a substrate such as solid particles. Surfactants can also be agglomerated into structures containing multiple surfactant molecules in a single aggregate. These aggregates are called micelles. These aggregates are usually spherical in shape, but can have a wide range of shapes and structures. The number of molecules that make up such aggregates is very large, and can often be on the order of hundreds of molecules. The micelle may be composed of a relatively simple surfactant structure, but may also be composed of a block copolymer surfactant having a high molecular weight.

Unexamined Patent Publication No. 2016-0133069

The problem to be solved by the present invention is to provide a method for producing a cosmetic composition including a micelle complex formed using a natural moisturizing factor and a cosmetic composition prepared therefrom.

In order to solve the above problems, the present invention provides a step of dissolving a mineral component in purified water and irradiating microwaves, preparing a mineral-hydrophilic amino acid reactant by introducing a hydrophilic first amino acid, adding an acrylic polymer, and hydrophilicity. The step of neutralizing the acrylic polymer by adding a second amino acid to form a cross link and combining the acrylic polymer and a mineral-amino acid reactant, preparing a first composition by introducing a hydrophilic third amino acid, an amphiphilic solvent and a hydrophobic amino acid Of a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor comprising the step of preparing a second composition including and preparing a composition including the micelle complex by mixing the first and second compositions Provides a manufacturing method.

Furthermore, the present invention is a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor prepared by the above manufacturing method, wherein the micelle includes a head part of a mineral-hydrophilic amino acid conjugate and a tail part of an acrylic polymer, and the micelle It provides a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor that contains a hydrophobic amino acid inside to form a micelle complex.

The method for producing a cosmetic comprising a micelle complex formed using a natural moisturizing factor according to the present invention can significantly improve the solubility rate of minerals, which are functional substances, by increasing the electrical conductivity during initial production by using microwaves. , By easily forming a micelle complex, while carrying a hydrophobic amino acid, it is possible to secure a high degree of dispersion and secure layer separation stability.

In addition, a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor prepared by the above manufacturing method can bring excellent effects on moisturizing power and wrinkle reduction.

1 is a photograph of wrinkles around the eyes before and after use of a test subject using a cosmetic composition according to Example 1 of the present invention.

Hereinafter, various embodiments of the present invention will be described with reference to the accompanying drawings. The present invention is not limited to specific embodiments, and it should be understood that various modifications, equivalents, and/or alternatives of the embodiments of the present invention are included. In connection with the description of the drawings, similar reference numerals may be used for similar elements.

In this document, expressions such as "have", "may have", "include", or "may contain" are the presence of corresponding features (eg, elements such as numbers, functions, actions, or parts). And does not exclude the presence of additional features.

In this document, expressions such as "A or B", "at least one of A or/and B", or "one or more of A or/and B" may include all possible combinations of items listed together. . For example, “A or B”, “at least one of A and B”, or “at least one of A or B” includes (1) at least one A, (2) at least one B, Or (3) it may refer to all cases including both at least one A and at least one B.

The expression "Configured to" used in this document is, for example, "Suitable for", "Having the capacity to" depending on the situation. It can be used interchangeably with ", "Designed to", "Adapted to", "Made to", or "Capable of". The term “configured to (or set) to” does not necessarily mean only “specifically designed to”.

Terms used in this document are only used to describe a specific embodiment, and may not be intended to limit the scope of other embodiments. Singular expressions may include plural expressions unless the context clearly indicates otherwise. Terms used herein, including technical or scientific terms, may have the same meaning as commonly understood by one of ordinary skill in the technical field described in this document. Among the terms used in this document, terms defined in a general dictionary may be interpreted as having the same or similar meaning as the meaning in the context of the related technology, and unless explicitly defined in this document, they may be interpreted in an ideal or excessively formal meaning. It is not interpreted. In some cases, even terms defined in this document cannot be interpreted to exclude embodiments of the present document.

The embodiments disclosed in this document are presented for description and understanding of the disclosed and technical content, and do not limit the scope of the present invention. Therefore, the scope of this document should be construed as including all changes or various other embodiments based on the technical idea of the present invention.

Hereinafter, a preferred embodiment of the present invention will be described in detail. Prior to this, terms or words used in the specification and claims should not be construed as being limited to their usual or dictionary meanings, and the inventors appropriately explain the concept of terms in order to explain their own invention in the best way. Based on the principle that it can be defined, it should be interpreted as a meaning and concept consistent with the technical idea of the present invention.

Therefore, the configurations of the embodiments described in the present specification are only some of the most preferred embodiments of the present invention, and do not represent all the technical spirit of the present invention, and various equivalents and modifications that can replace them at the time of application It should be understood that there may be.

Throughout the specification, when a part "includes" a certain component, it means that other components may be further included rather than excluding other components unless otherwise stated.

Hereinafter, the present invention will be described in detail.

Method for producing a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor

The present invention includes steps of dissolving a mineral component in purified water and irradiating microwaves, preparing a mineral-hydrophilic amino acid reactant by introducing a hydrophilic first amino acid, adding an acrylic polymer, and adding a hydrophilic second amino acid. Neutralizing the acrylic polymer to form a cross-link and combining the acrylic polymer with a mineral-amino acid reactant, preparing a first composition by introducing a hydrophilic third amino acid, and preparing a second composition including an amphiphilic solvent and a hydrophobic amino acid It may include the step of preparing and mixing the first and second compositions to prepare a composition including a micelle complex.

In the step of dissolving the mineral component in purified water by irradiation with microwaves, the mineral component is evenly dispersed in the purified water, and the electron spins of the mineral atoms are formed to form and expand the gap between the minerals through the active movement of the atoms. .

The mineral components are sodium (Na), calcium (Ca), phosphorus (P), magnesium (Mg), potassium (K), sulfur (S), germanium (Ge), zinc (Zn), selenium (Se ) And may be selected from the group consisting of a combination thereof.

Any material containing a high concentration of mineral components may be included in the present specification without limitation. A mineral component or a substance containing a mineral component at a high concentration includes a combination of one or two or more mineral components themselves. For example, the mineral component may refer to the minerals listed above, such as calcium or sodium, or may refer to MgCl2·6H2O itself. According to an embodiment of the present invention, the mineral component may include NaCl, MgCl ₂ , and CaCl ₂ in the form of a salt, and may include Na ⁺ , Mg ²⁺ , and Ca ²⁺ ions in the form of ions. .

As the purified water, purified water or ultrapure purified water commonly used in the art may be used, and preferably ultrapure purified water may be used. General purified water is water commonly used in pharmaceuticals and cosmetics, and has a dissolved solid content of 1.0 to 0.5 ppm indicating purity, and the size of a filter used to remove particulates and microorganisms when preparing purified water is 0.2 to 0.45 μm, and the pH is It varies from weak acid to weak alkali. The ultrapure purified water has a very high purity with a dissolved solid content of 0.03ppm, and the size of the filter used in the manufacture of ultrapure purified water is 0.001µm, which removes 99.99% of microorganisms. In particular, ultrapure purified water not only prevents the automatic oxidation reaction of the composition by removing metal ions, but also prevents polymer agglomeration caused by metal ions, so that the formulation can be evenly applied while being mildly irritating.

The inventors of the present invention believe that in the microwave irradiation, the mineral ions in the aqueous solution carry electric charge, so the mineral component is dissolved in purified water at 50°C to 80°C, and the microwave is irradiated for 3 to 10 minutes, preferably 4 to 6 minutes. It was found that the molecular motion is the most active, the electrical conductivity is high, and the molecular spacing is extended. Here, the frequency of the microwave may be 1,500 to 3,000Mhz. The output of the microwave may be preferably 500 to 1500W, and the output of the microwave is preferably within the above range, in terms of securing the dispersibility of the mineral component and the electrical conductivity of the composition.

It is preferable that the composition has an appropriate range of electrical conductivity to be easily combined with the mineral component hydrophilic first amino acid in the subsequent process. Specifically, it is a condition after mineral component dissolution and microwave irradiation, as a measurement standard at 40°C of 700 μs. In the range of /cm to 900 µs/cm, the molecular motion of the mineral components is most active, so that the spacing between molecules can be effectively expanded without agglomeration.

The step of preparing a mineral-hydrophilic amino acid reactant by adding the hydrophilic first amino acid is a step of forming a hydrophilic head part compound for bonding with an acrylic polymer in subsequent micelle formation.

In the step of preparing a mineral-hydrophilic amino acid reactant by adding the hydrophilic first amino acid, it is preferable to add the hydrophilic first amino acid after cooling to 30° C. to 50° C., wherein the electrical conductivity of the composition is 850 μs/s based on 40° C. In the range of cm to 1100 µs/cm, synthesis of the amino acid and the hydrophilic first amino acid can be most efficiently performed.

Here, the hydrophilic first amino acid may include one or more of serine and threonine.

In the step of introducing the acrylic polymer, the mineral-amino acid reactant formed in the previous step is bonded to the hydrophilic moiety of the amphiphilic acrylic polymer, so that it is introduced as a base material for forming the hydrophilic head portion and the hydrophobic tail portion.

The amphiphilic acrylic polymer is a copolymer of a hydrophilic moiety and a hydrophobic moiety, and for example, a hydrophobic moiety having a reactive end at a complementary reaction site of the hydrophilic polymer may be graft-polymerized. The acrylic polymer is, for example, an amphiphilic polymer derived from (meth)acrylic acid. For example, sodium polyacrylate, acrylate/C10-30 alkyl acrylate crosspolymer (Acrylates/C10-30 Alkyl Acrylate Crosspolymer), acrylate/C12-22 alkyl methacrylate copolymer (Acrylates/C12-22 Alkyl Methacrylate) Copolymer), acrylate/beheneth-25 methacrylate copolymer (Acrylates/Beheneth-25 Methacrylate Copolymer), acrylate/ceteth-20 methacrylate copolymer (Acrylates/Ceteth-20 Methacrylate Copolymer), hydroxyethyl One or more selected from the group consisting of acrylate/sodium acryloyldimethyl taurate copolymer and ammonium acryloyldimethyltaurate/VP copolymer It may be included.

According to an embodiment of the present invention, the acrylic polymer may include sodium polyacrylate and acrylate/C10-30 Alkyl Acrylate Crosspolymer (Acrylates/C10-30 Alkyl Acrylate Crosspolymer), and these are alkyl acrylate crosspolymers. As a weight ratio based on the polymer (Acrylates/C10-30 Alkyl Acrylate Crosspolymer), 1: 20 to 40 may be included in the cosmetic composition. If it is less than the above range, after the formation of micelles, the effect of wrinkle care may be insufficient in that the hydrophobic amino acid cannot be easily supported therein, and if it exceeds the above range, it is difficult to secure an appropriate pH (weak acidity) and the moisturizing power may be insufficient. It is not preferable in terms of formulation stability, such as opaqueness in the formulation, precipitation problems at low temperatures, and separation into thin spaces at high temperatures.

Further, based on the temperature of the composition at 40° C., when the acrylic polymer is dissolved, the electrical conductivity is preferably 600 μs/cm to 850 μs/cm in terms of securing transparency, and the pH is preferably 4 to 7.

The step of neutralizing the acrylic polymer by adding a hydrophilic second amino acid to form a cross-link and combining the acrylic polymer and the mineral-amino acid reactant emulsifies the structure of the entangled acrylic polymer, thereby inducing the polymer to become linear, After being hydrated with purified water, the acrylic polymer may be neutralized by a hydrophilic second amino acid to be transformed into a straight chain.

The hydrophilic second amino acid is a basic amino acid, and may include at least one selected from the group consisting of lysine, arginine, and histidine.

The step of preparing the first composition by adding the hydrophilic third amino acid is a step of providing a buffer for securing an appropriate pH and stabilizing the solution, and the hydrophilic third amino acid may be an acidic amino acid, specifically, glutamic acid and aspartic acid. It may include one or more selected from the group consisting of.

The first composition formed by the above-described process may have an electrical conductivity of 700 µs/cm to 850 µs/cm at 40° C., and a pH of 4.5 to 6.0, which may be weakly acidic. By securing such pH and electrical conductivity, a weakly acidic formulation suitable for the skin can be implemented when the cosmetic composition according to an embodiment of the present invention is applied.

The step of preparing the second composition containing the amphiphilic solvent and the hydrophobic amino acid is a two-component step for a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor, and dissolving the amphiphilic solvent and the hydrophobic amino acid in a separate container. Thus, it is to allow the hydrophobic amino acid to be easily included in the micelle when the micelle complex is formed. The second composition may optionally further include purified water.

The amphiphilic solvent is one selected from the group consisting of glycerin, dipropylene glycol, methyl propanediol, propylene glycol, and butylene glycol. It may include the above.

The hydrophobic amino acid may include at least one selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine, and proline.

The step of preparing a composition including the micelle complex by mixing the first and second compositions is a two-component reaction, preferably the first composition and the second composition are prepared in a weight ratio of 1: 0.15 to 0.35. Can be.

If it is less than the above range, since it is a water-in-oil (W/O) type and an acrylic polymer is added, it has a structure that specifically binds moisture (purified water) in a W/P type (Water in Polymer) formulation, so it is hydrophobic. Due to the lack of (Polymer) part, micelles may or may not be formed insufficiently, and if it exceeds the above range, layer separation may occur and transparency of the final cosmetic composition may be insufficient.

The content of each component of the cosmetic composition including the micelle complex of the present invention is as follows. The content is based on each of the first composition and the second composition, and each component may be dissolved in a solvent within the following content range and added.

In the first composition, based on 100 parts by weight of the purified water, 0.01 to 0.05 parts by weight of a mineral component, 0.005 to 0.015 parts by weight of a hydrophilic first amino acid, 0.01 to 0.15 parts by weight of an acrylic polymer, 0.001 to 0.010 parts by weight of a hydrophilic second amino acid, and The hydrophilic third amino acid may be included in an amount of 0.005 to 0.015 parts by weight.

If the mineral component is less than the above content range, it is not preferable in that the hydrophilic head portion of the micelle complex cannot be easily formed, and when the content exceeds the above content range, the cross link of the polymer by the mineral component is lowered, resulting in a decrease in the formulation viscosity over time. Hypertransparency can be affected, and when the mineral content is more than a certain amount, moisture from the skin through osmosis is released to the outside rather than to the inside, thereby maximizing dryness.

If the hydrophilic first amino acid is less than the above content range, it is not preferable in that the hydrophilic head portion of the micelle complex cannot be easily formed, and if it exceeds the content range, the size of the hydrophilic head portion becomes excessively large, thus increasing the water binding force, but surface tension, That is, the tension at the interface between the hydrophilic amino acids increases, and the tendency to aggregate between the hydrophilic amino acids appears, which is not preferable in terms of formulation stability.

If the acrylic polymer is less than the above content range, it is not possible to implement a micelle complex due to its low viscosity and content, and it is not preferable in that it cannot carry a hydrophobic amino acid inside the micelle, and if it exceeds the above content range, the formulation is slippery and absorbency is poor Transparency can be affected.

If the content of the hydrophilic second amino acid is less than the above content range, the neutralizing action of the acrylic polyol is insufficient, and the dispersing power is lowered due to the failure to form a crosslink, thereby adversely affecting the formation of the micelle complex. It is not preferable in terms of deteriorating the skin barrier, deteriorating dryness of the skin through loss of moisture, and causing irritation of the skin.

If the hydrophilic third amino acid is less than the above content range, the final cosmetic composition formulation stability and pH cannot be weakly acidic. Therefore, it is not preferable in that the effect of moisturizing power and wrinkle improvement, which are the inherent effects of the present invention, is insufficient, and exceeds the content range. In this case, the pH is lowered, which is not preferable in terms of formulation due to stability problems.

In the second composition, 0.01 to 0.10 parts by weight of a hydrophobic amino acid and 20 to 50 parts by weight of purified water may be included based on 100 parts by weight of the amphiphilic solvent.

If the hydrophobic amino acid is less than the above content range, the total amount of hydrophobic amino acids carried in the micelle complex decreases, which is not preferable in that the effect of moisturizing and wrinkle improvement, which is the inherent effect of the present invention, is insufficient. If it exceeds the range that can be suspended, delamination may occur, which is not preferable in terms of stability of the formulation.

Cosmetic composition containing micelle complex formed using natural moisturizing factor

In the cosmetic composition comprising the micelle complex prepared by the above-described manufacturing method, the micelle formed using the above-described natural moisturizing factor includes a head part of a mineral-hydrophilic amino acid conjugate and a tail part of an acrylic polymer, and a hydrophobic amino acid inside the micelle Is included to form a micelle complex, and may be appropriately dispersed in a cosmetic composition containing purified water as a solvent.

In particular, the hydrophobic amino acid may include a micelle complex comprising at least one selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine, and proline.

The micelle complex may be contained in an amount of 0.01 to 0.05% by weight in 100% by weight of the total composition, and when applied to the skin, the hydrophobic amino acids inside the micelles support the intercellular lipids in the stratum corneum cells and the skin By combining with moisture, it can effectively maintain skin moisture and block moisture evaporation, while securing layer separation stability and transparency of the formulation.

The cosmetic composition containing the micelle complex has an electrical conductivity of 750 µs/cm to 850 µs/cm, based on a temperature of 40° C. of the composition, in terms of securing wrinkle relief and skin moisturizing power, which are the above-described effects of the present invention. It is preferably 5.0 to 6.0

The cosmetic composition according to an embodiment of the present invention is a water-in-oil (W/O) type, and specifically, by using an acrylic polymer, the oil component may include a polymer. . Therefore, the present inventors refer to this as a W/P (Water In Polymer) type, and any formulation satisfying this may be used without limitation. For example, basic cosmetic formulation, skin, lotion, eye cream, soothing gel, ointment, mask pack formulation, body wash formulation, peeling gel, oil-in-water makeup base, water-in-oil makeup base, foundation, skin cover, lipstick, lip gloss, It may be any one selected from a color cosmetic formulation consisting of face powder, two-way cake, eye sado, and cheek color eyebrow pencil, sun cream, BB cream, and scalp formulation.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for explaining the present invention in more detail, and that the scope of the present invention is not limited by these examples according to the gist of the present invention to those of ordinary skill in the art. It will be self-evident.

Manufacturing example

Manufacturing Example 1

As the first composition, after mixing 0.025 of NaCl, 0.00025 _{g of MgCl 2, and 0.0002 g of CaCl 2} to 0.5 g of purified water at 75°C, the US-made microwave device of CEM was set at 2,400-2,500 MHz, 1000 W.

Irradiation was performed for 15 minutes (S1). After cooling the composition to 40° C., 0.5 g of purified water, 0.005 g of serine, and 0.0015 g of threonine were added to react with the mineral component (S2). Then, 74 g of purified water, 0.045 g of sodium polyacrylate, 0.0017 g of acrylate/C10-30 Alkyl Acrylate Crosspolymer (Acrylates/C10-30 Alkyl Acrylate Crosspolymer) were mixed, and then put into a container (S3). 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine were mixed and then added to the container (S4). 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid were mixed and then put into a container (S5).

As a second composition, 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed in a separate container (S6).

Thereafter, the first composition and the second composition were mixed to prepare a final composition (S7).

Manufacturing Example 2

After mixing 0.025 g of NaCl, 0.00025 _{g of MgCl 2, and 0.0002 g of CaCl 2} in 0.5 g of purified water at 75° C., a microwave apparatus made in the US of CEM was irradiated for 15 minutes with an intensity of 2,400-2,500 MHz and 1000 W (S1*). After cooling the composition to 40° C., 0.5 g of purified water, 0.005 g of serine, and 0.0015 g of threonine were added to react with the mineral component (S2*). Thereafter, 74 g of purified water, 0.045 g of sodium polyacrylate, 0.0017 g of acrylate/C10-30 Alkyl Acrylate Crosspolymer (Acrylates/C10-30 Alkyl Acrylate Crosspolymer) were mixed, and then put into a container (S3*). 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine were mixed and then added to the container (S4*). 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid were mixed and then put into a container (S5*). 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed and added to a container to prepare a final composition (S6*).

Manufacturing Example 3

As a first composition, after mixing 0.025 of NaCl, 0.00025 _{g of MgCl 2, and 0.0002 g of CaCl 2 in} 0.5 g of purified water at 75°C, a microwave apparatus made in the US of CEM was irradiated for 15 minutes with an intensity of 2,400-2,500 MHz and 1000 W ( S1**). After cooling the composition to 40° C., 0.5 g of purified water, 0.005 g of serine, and 0.0015 g of threonine were added to react with the mineral component (S2**). Thereafter, 74 g of purified water and 0.056 g of hydroxyethyl cellulose were mixed, and then put into a container (S3**). 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine were mixed and then added to the container (S4**). 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid were mixed and then added to the container (S5**).

As a second composition, 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed in a separate container (S6**).

Thereafter, the first composition and the second composition were mixed to prepare a final composition (S7**).

Manufacturing Example 4

As the first composition, 0.025 g of NaCl, 0.00025 _{g of MgCl 2, and 0.0002 g of CaCl 2} were mixed in 0.5 g of purified water at 75°C (S1***). After cooling the composition to 40° C., 0.5 g of purified water, 0.005 g of serine, and 0.0015 g of threonine were added to react with the mineral component (S2***). Thereafter, 74 g of purified water, 0.045 g of sodium polyacrylate, 0.0017 g of acrylate/C10-30 Alkyl Acrylate Crosspolymer (Acrylates/C10-30 Alkyl Acrylate Crosspolymer) were mixed, and then put into a container (S4***). 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine were mixed and then added to the container (S5***). 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid were mixed and then added to the container (S6***).

As a second composition, 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed in a separate container (S6***).

Thereafter, the first composition and the second composition were mixed to prepare a final composition (S7***).

Examples and Comparative Examples

Example 1

The cosmetic composition prepared by the process of Preparation Example 1 was used as Example 1.

Examples 2 to 7

It was prepared in the same manner as in Preparation Example 1, but the cosmetic compositions prepared by adjusting the content of the constituents as follows were used as Examples 2 to 7.

step ingredient Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 First composition Purified water 80.5 80.5 80.5 80.5 80.5 80.5 NaCl 0.025 0.025 0.025 0.025 0.025 0.025 MgCl ₂ 0.00025 0.00025 0.00025 0.00025 0.00025 0.00025 CaCl ₂ 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 Serine 0.005 0.005 0.005 0.005 0.005 0.005 Threonine 0.0015 0.0015 0.0015 0.0015 0.0015 0.0015 Sodium polyacrylate 0.045 0.045 0.045 0.040 0.030 0.075 Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 Arginine 0.0013 0.0013 0.0013 0.0013 0.0013 0.0013 Histidine 0.005 0.005 0.005 0.005 0.005 0.005 Glutamic acid 0.006 0.006 0.006 0.006 0.006 0.006 Aspartic acid 0.003 0.003 0.003 0.003 0.003 0.003 Second composition glycerin 17 9 22 14 14 14 Alanine 0.0030 0.001 0.0035 0.0015 0.0015 0.0015 Proline 0.0035 0.001 0.0030 0.0014 0.0014 0.0014 Glycine 0.0015 0.0045 0.020 0.009 0.009 0.009 Purified water 8 2 10 5 5 5

Comparative Example 1

The cosmetic composition prepared by the process of Preparation Example 2 was used as Comparative Example 1.

Comparative Example 2

The cosmetic composition prepared by the process of Preparation Example 3 was used as Comparative Example 2.

Comparative Example 3

The cosmetic composition prepared in the process of Preparation Example 4 was used as Comparative Example 3.

Experimental Example 1: Check the temperature and pH at each step

Temperature, pH and electrical conductivity in the manufacturing steps of Preparation Examples 1 to 4 were measured as follows. In the case of electrical conductivity, METTER TOLEDO's Cond probe InLab 720 product was used. (- In case, it indicates that it was not measured.)

Remark step Temperature(℃) pH
(Measurement temperature 40℃) Electrical conductivity ㎲/cm
(Measurement temperature 40℃) Manufacturing Example 1 S1 70 5.68 1,060 S2 40 5.87 884.5 S3 40 5.68 699.1 S4 40 6.37 710 S5 40 5.12 780 S6 70 5.35 810.5 S7 40 5.35 810.5 Manufacturing Example 2 S1* 70 5.46 1,060 S2* 40 5.69 735.9 S3* 40 5.45 574.1 S4* 40 6.28 576 S5* 40 4.65 643 S6* 70 4.65 643 Manufacturing Example 3 S1** 70 5.43 1,060 S2** 40 5.64 710.7 S3** 40 5.48 681.2 S4** 40 7.35 713.9 S5** 40 3.98 745.3 S6** 70 4.23 773.2 S7** 40 4.23 773.2 Manufacturing Example 4 S1*** 70 5.48 870 S2*** 40 5.59 610.7 S3*** 40 5.46 564.7 S4*** 40 6.28 582.5 S5*** 40 4.61 620.5 S6*** 70 4.7 631.4 S7*** 40 4.7 631.4

Experimental Example 2: Increased skin moisture

As the cosmetic composition prepared in the above Examples and Comparative Examples, 50 women aged 20 to 40 years old with poor skin were selected and applied twice a day to the face and the first half for 1 month. At this time, before starting the application, measure the skin dryness by using a moisture meter (corneometer, CM820 courage Khazaka electronic GmbH, Germany) under constant temperature and humidity conditions (24 ℃, humidity 40%) and set it as a default value, and take each one week , After 2 weeks and 4 weeks, the skin moisturizing amount was measured to evaluate the objective effect. The results are shown in Table 3 below.

division
Skin moisturizing amount (A.U) 1 week elapsed 2 weeks elapsed After 4 weeks Example 1 65 69 74 Example 2 64 70 73 Example 3 56 59 60 Example 4 62 67 70 Example 5 63 68 73 Example 6 61 65 65 Example 7 59 63 66 Comparative Example 1 63 65 69 Comparative Example 2 57 55 57 Comparative Example 3 61 64 67

Experimental Example 3: Observation of stability over time after manufacture (observation of layer separation stability)

The compositions prepared in Examples and Comparative Examples were placed at room temperature for 12 months or more, 45°C for 1 month or more, and -4°C for 1 month or more, respectively, and stability over time was observed. The results are shown in Table 5.

○ Good (no change in appearance, transparent), △ changeable (exterior is opaque), Х: poor (layer separation occurs)

Test items and
Condition Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative Example 1 Comparative Example 2 Comparative Example 3 25℃ 12 months ○ ○ △ ○ ○ ○ ○ △ △ ○ -4℃ 1 month ○ ○ Х △ ○ △ Х Х △ Х 40℃ 1 month ○ ○ ○ Х ○ ○ ○ △ △ ○

Experimental Example 4: Wrinkle improvement measurement

20 healthy women aged 25 to 55 years old (average age 40.30 years old) were selected under constant temperature and humidity conditions at room temperature and humidity of 40 to 60%, and the test subjects measured the wrinkles and skin viscoelasticity ( Cutometer MPA 580 (C+K, Germany)) was performed, and the results are shown in Table 5.

Skin viscoelasticity value = skin change pattern area (Uv)/skin recovery pattern area (Ue). The lower the value, the better the elasticity.

One test subject was selected, and wrinkles around the eyes were photographed before and after (after 4 weeks) use of the cosmetic composition of Example 1 of the present invention using a wrinkle measurement photographing apparatus (aram ASM-300). The results are shown in FIG. 1. It can be seen that the wrinkle improvement was significantly improved as the area of the wrinkles after use was reduced.

Remark Skin viscoelasticity (Uv/Ue) first 1 week 2 weeks 4 weeks Example 1 0.93 0.90 0.85 0.72 Example 2 0.94 0.90 0.87 0.76 Example 3 0.93 0.91 0.88 0.86 Example 4 0.94 0.92 0.89 0.86 Example 5 0.93 0.90 0.88 0.77 Example 6 0.93 0.91 0.88 0.82 Example 7 0.93 0.93 0.89 0.83 Comparative Example 1 0.94 0.91 0.87 0.82 Comparative Example 2 0.93 0.92 0.88 0.85 Comparative Example 3 0.93 0.92 0.89 0.80

Claims (8)

Adding a mineral component to purified water and dissolving it by irradiating microwaves;
Preparing a mineral-hydrophilic amino acid reactant by introducing a hydrophilic first amino acid;
Introducing an acrylic polymer;
Neutralizing the acrylic polymer by introducing a hydrophilic second amino acid to form a cross link, and combining the acrylic polymer with a mineral-amino acid reactant;
Preparing a first composition by adding a hydrophilic third amino acid;
Preparing a second composition comprising an amphiphilic solvent and a hydrophobic amino acid, and
A method for producing a cosmetic composition comprising a micelle composite formed using a natural moisturizing factor comprising the step of preparing a composition comprising a micelle composite by mixing the first and second compositions.
The method according to claim 1,
The second hydrophilic amino acid is a basic amino acid, and the third hydrophilic amino acid is an acidic amino acid. A method for producing a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor.
The method according to claim 1,
The acrylic polymer is sodium polyacrylate, acrylate/C10-30 alkyl acrylate crosspolymer (Acrylates/C10-30 Alkyl Acrylate Crosspolymer), acrylate/C12-22 alkyl methacrylate copolymer (Acrylates/C12-22 Alkyl Methacrylate) Copolymer), acrylate/beheneth-25 methacrylate copolymer (Acrylates/Beheneth-25 Methacrylate Copolymer), acrylate/ceteth-20 methacrylate copolymer (Acrylates/Ceteth-20 Methacrylate Copolymer), hydroxyethyl One or more selected from the group consisting of acrylate/sodium acryloyldimethyl taurate copolymer and ammonium acryloyldimethyltaurate/VP copolymer A method for producing a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor that includes.
The method according to claim 1,
The method for producing a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor that the microwave is irradiated with an intensity of 500W to 1500W.
The method according to claim 1,
The first composition and the second composition as a weight ratio, 1: 0.15 to 0.35 ratio of the method for producing a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor.
The method according to claim 1,
The amphiphilic solvent is one selected from the group consisting of glycerin, dipropylene glycol, methyl propanediol, propylene glycol, and butylene glycol. A method for producing a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor comprising the above.
As a cosmetic composition comprising a micelle complex prepared by the manufacturing method of any one of claims 1 to 6,
The micelle includes a head portion of a mineral-hydrophilic amino acid conjugate and a tail portion of an acrylic polymer,
A cosmetic composition comprising a micelle complex formed by using a natural moisturizing factor that contains a hydrophobic amino acid inside the micelle to form a micelle complex.
The method of claim 7,
The hydrophobic amino acid is glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine, and a cosmetic composition comprising a micelle complex formed using a natural moisturizing factor that contains at least one selected from the group consisting of proline .

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