JP6961684B2 - Ｂｅｔタンパク質分解物質としての縮合１，４−オキサゼピン - Google Patents

Ｂｅｔタンパク質分解物質としての縮合１，４−オキサゼピン Download PDF

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JP6961684B2
JP6961684B2 JP2019513957A JP2019513957A JP6961684B2 JP 6961684 B2 JP6961684 B2 JP 6961684B2 JP 2019513957 A JP2019513957 A JP 2019513957A JP 2019513957 A JP2019513957 A JP 2019513957A JP 6961684 B2 JP6961684 B2 JP 6961684B2
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oxazepine
benzyl
thieno
triazolo
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JP2019526615A (ja
JP2019526615A5 (enExample
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シャオメン ワン
ヤン フー
チョン チン
フーミン スー
ジャンタオ フー
ビン チョウ
チョウ チェン
エステル フェルナンデスーサラス
ロンチュアン バイ
ドナ マケカーン
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ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2019513957A 2016-09-13 2017-09-13 Ｂｅｔタンパク質分解物質としての縮合１，４−オキサゼピン Expired - Fee Related JP6961684B2 (ja)

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US201662393904P 2016-09-13 2016-09-13
US62/393,904 2016-09-13
PCT/US2017/051282 WO2018052945A1 (en) 2016-09-13 2017-09-13 Fused 1,4-oxazepines as bet protein degraders

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JP2019526615A JP2019526615A (ja) 2019-09-19
JP2019526615A5 JP2019526615A5 (enExample) 2020-10-22
JP6961684B2 true JP6961684B2 (ja) 2021-11-05

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US (1) US11466028B2 (enExample)
EP (1) EP3512855B1 (enExample)
JP (1) JP6961684B2 (enExample)
CN (1) CN110062759B (enExample)
AU (1) AU2017326171B2 (enExample)
CA (1) CA3036834A1 (enExample)
WO (1) WO2018052945A1 (enExample)

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EP3512855B1 (en) 2022-07-27
US11466028B2 (en) 2022-10-11
US20210284657A1 (en) 2021-09-16
JP2019526615A (ja) 2019-09-19
CN110062759A (zh) 2019-07-26
AU2017326171B2 (en) 2021-12-09
WO2018052945A1 (en) 2018-03-22
EP3512855A1 (en) 2019-07-24
CA3036834A1 (en) 2018-03-22
CN110062759B (zh) 2022-05-24
AU2017326171A1 (en) 2019-04-04

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