CA3036834A1 - Fused 1,4-oxazepines as bet protein degraders - Google Patents

Fused 1,4-oxazepines as bet protein degraders Download PDF

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Publication number
CA3036834A1
CA3036834A1 CA3036834A CA3036834A CA3036834A1 CA 3036834 A1 CA3036834 A1 CA 3036834A1 CA 3036834 A CA3036834 A CA 3036834A CA 3036834 A CA3036834 A CA 3036834A CA 3036834 A1 CA3036834 A1 CA 3036834A1
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CA
Canada
Prior art keywords
optionally substituted
group
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3036834A
Other languages
English (en)
French (fr)
Inventor
Shaomeng Wang
Yang Hu
Chong QIN
Fuming XU
Jiantao HU
Bing Zhou
Zhou CHEN
Ester Fernandez-Salas
Longchuan Bai
Donna Mceachern
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University of Michigan System
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University of Michigan System
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Application filed by University of Michigan System filed Critical University of Michigan System
Publication of CA3036834A1 publication Critical patent/CA3036834A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA3036834A 2016-09-13 2017-09-13 Fused 1,4-oxazepines as bet protein degraders Pending CA3036834A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662393904P 2016-09-13 2016-09-13
US62/393,904 2016-09-13
PCT/US2017/051282 WO2018052945A1 (en) 2016-09-13 2017-09-13 Fused 1,4-oxazepines as bet protein degraders

Publications (1)

Publication Number Publication Date
CA3036834A1 true CA3036834A1 (en) 2018-03-22

Family

ID=59955689

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3036834A Pending CA3036834A1 (en) 2016-09-13 2017-09-13 Fused 1,4-oxazepines as bet protein degraders

Country Status (7)

Country Link
US (1) US11466028B2 (enExample)
EP (1) EP3512855B1 (enExample)
JP (1) JP6961684B2 (enExample)
CN (1) CN110062759B (enExample)
AU (1) AU2017326171B2 (enExample)
CA (1) CA3036834A1 (enExample)
WO (1) WO2018052945A1 (enExample)

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Also Published As

Publication number Publication date
AU2017326171B2 (en) 2021-12-09
JP6961684B2 (ja) 2021-11-05
CN110062759A (zh) 2019-07-26
JP2019526615A (ja) 2019-09-19
US20210284657A1 (en) 2021-09-16
EP3512855A1 (en) 2019-07-24
US11466028B2 (en) 2022-10-11
AU2017326171A1 (en) 2019-04-04
EP3512855B1 (en) 2022-07-27
WO2018052945A1 (en) 2018-03-22
CN110062759B (zh) 2022-05-24

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