JP6959942B2 - タンパク質生成のための脂質代謝のモジュレーション - Google Patents

タンパク質生成のための脂質代謝のモジュレーション Download PDF

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JP6959942B2
JP6959942B2 JP2018557851A JP2018557851A JP6959942B2 JP 6959942 B2 JP6959942 B2 JP 6959942B2 JP 2018557851 A JP2018557851 A JP 2018557851A JP 2018557851 A JP2018557851 A JP 2018557851A JP 6959942 B2 JP6959942 B2 JP 6959942B2
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cell
lmm
cells
nucleic acid
product
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JP2019514399A (ja
JP2019514399A5 (OSRAM
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バッジ、ジェームズ
マーク スメールズ、クリストファー
ナイト、タンヤ
ヤング、ロバート
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Lonza AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0097—Oxidoreductases (1.) acting on reduced flavodoxin as donor (1.19)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
    • C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2018557851A 2016-05-03 2017-05-03 タンパク質生成のための脂質代謝のモジュレーション Active JP6959942B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662330973P 2016-05-03 2016-05-03
US62/330,973 2016-05-03
PCT/EP2017/060484 WO2017191165A1 (en) 2016-05-03 2017-05-03 Modulation of lipid metabolism for protein production

Publications (3)

Publication Number Publication Date
JP2019514399A JP2019514399A (ja) 2019-06-06
JP2019514399A5 JP2019514399A5 (OSRAM) 2020-06-18
JP6959942B2 true JP6959942B2 (ja) 2021-11-05

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JP2018557851A Active JP6959942B2 (ja) 2016-05-03 2017-05-03 タンパク質生成のための脂質代謝のモジュレーション

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Country Link
US (3) US10655111B2 (OSRAM)
EP (1) EP3452608B1 (OSRAM)
JP (1) JP6959942B2 (OSRAM)
KR (1) KR102536221B1 (OSRAM)
CN (1) CN109415748A (OSRAM)
AU (1) AU2017259010B2 (OSRAM)
CA (1) CA3023038C (OSRAM)
EA (1) EA201892503A1 (OSRAM)
ES (1) ES2938626T3 (OSRAM)
IL (2) IL262646B (OSRAM)
MX (1) MX2018013499A (OSRAM)
SG (1) SG11201809626PA (OSRAM)
WO (1) WO2017191165A1 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3452608B1 (en) * 2016-05-03 2022-11-30 Lonza Ltd Modulation of lipid metabolism for protein production
US20210324366A1 (en) * 2018-07-11 2021-10-21 Cornell University Supported plant plasma membrane lipid bilayer on-a-chip
KR20210052389A (ko) 2018-08-27 2021-05-10 리제너론 파마슈티칼스 인코포레이티드 다운스트림 정제에서의 라만 분광법의 사용
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
WO2020084528A1 (en) * 2018-10-24 2020-04-30 Selexis Sa Expression systems, recombinant cells and uses thereof
JP7574206B2 (ja) 2019-03-20 2024-10-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ステロール調節エレメント結合転写因子１（ｓｒｅｂｆ１）阻害剤による上昇した脂質レベルの治療
CN110317799A (zh) * 2019-07-18 2019-10-11 江南大学 一种人源岩藻糖转移酶8的原核表达方法及其产品
CN114746554A (zh) 2019-11-14 2022-07-12 隆萨有限公司 细胞选择的方法
CN115029307A (zh) * 2022-07-28 2022-09-09 吉林大学 一种延缓MSCs衰老的方法

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
ATE386802T1 (de) 1997-06-12 2008-03-15 Novartis Int Pharm Ltd Künstliche antikörperpolypeptide
JP2003516124A (ja) 1999-10-15 2003-05-13 ユニバーシティー オブ マサチューセッツ 標的とした遺伝的干渉の手段としてのｒｎａ干渉経路遺伝子
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
AU2001275474A1 (en) 2000-06-12 2001-12-24 Akkadix Corporation Materials and methods for the control of nematodes
WO2002095008A2 (en) * 2001-02-02 2002-11-28 Bayer Corporation Methods of modulating surfactant phospholipid production
US20050106222A1 (en) * 2003-06-11 2005-05-19 Ailor Eric N. Method to increase protein production in culture
AU2005233326B2 (en) 2004-04-16 2010-09-23 Dsm Ip Assets B.V. Fungal promoters for expressing a gene in a fungal cell
ES2864039T3 (es) * 2005-05-20 2021-10-13 Lonza Biologics Plc Expresión de alto nivel de un anticuerpo recombinante en una célula huésped de mamífero
US20080182249A1 (en) * 2006-09-01 2008-07-31 Fox Brian G Expression systems for mammalian and mycobacterial desaturases
WO2009062789A1 (en) * 2007-11-13 2009-05-22 Boehringer Ingelheim Pharma Gmbh & Co Kg Improving the secretory capacity in host cells
WO2010057246A1 (en) * 2008-11-18 2010-05-27 Commonwealth Scientific Industrial Research Organisation Enzymes and methods for producing omega-3 fatty acids
CN105073995A (zh) * 2013-02-01 2015-11-18 瑟莱克斯公司 增强的转基因表达和加工
JP6676526B2 (ja) * 2013-08-06 2020-04-08 ロンザ バイオロジクス ピーエルシー 組換えタンパク質の生産のための哺乳動物生産細胞の生成のための手段及び方法
EP3452608B1 (en) 2016-05-03 2022-11-30 Lonza Ltd Modulation of lipid metabolism for protein production

Also Published As

Publication number Publication date
JP2019514399A (ja) 2019-06-06
ES2938626T3 (es) 2023-04-13
MX2018013499A (es) 2019-09-11
CN109415748A (zh) 2019-03-01
EP3452608A1 (en) 2019-03-13
SG11201809626PA (en) 2018-11-29
BR112018072434A2 (pt) 2019-02-19
US10655111B2 (en) 2020-05-19
US11434474B2 (en) 2022-09-06
KR102536221B1 (ko) 2023-05-23
KR20190003651A (ko) 2019-01-09
US20200231944A1 (en) 2020-07-23
IL294241B2 (en) 2023-10-01
US20170321194A1 (en) 2017-11-09
IL294241B1 (en) 2023-06-01
IL262646A (en) 2018-12-31
IL294241A (en) 2022-08-01
EP3452608B1 (en) 2022-11-30
CA3023038A1 (en) 2017-11-09
US20230047838A1 (en) 2023-02-16
EA201892503A1 (ru) 2019-09-30
AU2017259010A1 (en) 2018-11-22
WO2017191165A1 (en) 2017-11-09
CA3023038C (en) 2023-03-14
AU2017259010B2 (en) 2021-04-22
IL262646B (en) 2022-08-01

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