JP6959248B2 - 癌治療用の４，６−ジヒドロピロロ［３，４−ｃ］ピラゾール−５（１Ｈ）−カルボニトリル誘導体 - Google Patents

癌治療用の４，６−ジヒドロピロロ［３，４−ｃ］ピラゾール−５（１Ｈ）−カルボニトリル誘導体 Download PDF

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JP6959248B2
JP6959248B2 JP2018548677A JP2018548677A JP6959248B2 JP 6959248 B2 JP6959248 B2 JP 6959248B2 JP 2018548677 A JP2018548677 A JP 2018548677A JP 2018548677 A JP2018548677 A JP 2018548677A JP 6959248 B2 JP6959248 B2 JP 6959248B2
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pyrazole
dihydropyrrolo
carbonitrile
phenyl
optionally substituted
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JP2019508462A (ja
JP2019508462A5 (enExample
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ジョーンズ アリソン
イアン ケンプ マーク
リー ストックリー マーティン
ディー．ウッドロー マイケル
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ミッション セラピューティクス リミティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2018548677A 2016-03-18 2017-03-17 癌治療用の４，６−ジヒドロピロロ［３，４−ｃ］ピラゾール−５（１Ｈ）−カルボニトリル誘導体 Active JP6959248B2 (ja)

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GB1604638.5 2016-03-18
GBGB1604638.5A GB201604638D0 (en) 2016-03-18 2016-03-18 Novel compounds
PCT/GB2017/050755 WO2017158381A1 (en) 2016-03-18 2017-03-17 4,6 dihydropyrrolo [3,4-c] pyrazole-5 (1h)-carbonitrile derivates for trating cancer

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JP2019508462A5 JP2019508462A5 (enExample) 2020-03-05
JP6959248B2 true JP6959248B2 (ja) 2021-11-02

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US (1) US11306096B2 (enExample)
EP (1) EP3430012B1 (enExample)
JP (1) JP6959248B2 (enExample)
CN (1) CN108473502B (enExample)
GB (1) GB201604638D0 (enExample)
MA (1) MA43745A (enExample)
WO (1) WO2017158381A1 (enExample)

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KR20230016674A (ko) 2020-05-28 2023-02-02 미션 테라퓨틱스 엘티디 미토콘드리아 기능장애의 치료를 위한 usp30 억제제로서 n-(1-시아노피롤리딘-3-일)-5-(3-(트라이플루오로메틸)페닐)옥사졸-2-카복스아미드 유도체 및 상응하는 옥사다이아졸 유도체
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Publication number Publication date
JP2019508462A (ja) 2019-03-28
WO2017158381A1 (en) 2017-09-21
US11306096B2 (en) 2022-04-19
MA43745A (fr) 2018-11-28
GB201604638D0 (en) 2016-05-04
CN108473502A (zh) 2018-08-31
US20210221813A1 (en) 2021-07-22
WO2017158381A8 (en) 2018-01-11
EP3430012B1 (en) 2021-06-16
CN108473502B (zh) 2022-04-26
EP3430012A1 (en) 2019-01-23

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