MA43745A - Dérivés de 4,6-dihydropyrrolo[3,4-c]pyrazole-5(1h)-carbonitrile pour le traitement du cancer - Google Patents
Dérivés de 4,6-dihydropyrrolo[3,4-c]pyrazole-5(1h)-carbonitrile pour le traitement du cancerInfo
- Publication number
- MA43745A MA43745A MA043745A MA43745A MA43745A MA 43745 A MA43745 A MA 43745A MA 043745 A MA043745 A MA 043745A MA 43745 A MA43745 A MA 43745A MA 43745 A MA43745 A MA 43745A
- Authority
- MA
- Morocco
- Prior art keywords
- dihydropyrrolo
- pyrazole
- cancer
- treatment
- carbonitrile derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1604638.5A GB201604638D0 (en) | 2016-03-18 | 2016-03-18 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43745A true MA43745A (fr) | 2018-11-28 |
Family
ID=55968542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA043745A MA43745A (fr) | 2016-03-18 | 2017-03-17 | Dérivés de 4,6-dihydropyrrolo[3,4-c]pyrazole-5(1h)-carbonitrile pour le traitement du cancer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11306096B2 (fr) |
| EP (1) | EP3430012B1 (fr) |
| JP (1) | JP6959248B2 (fr) |
| CN (1) | CN108473502B (fr) |
| GB (1) | GB201604638D0 (fr) |
| MA (1) | MA43745A (fr) |
| WO (1) | WO2017158381A1 (fr) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3277677T3 (da) | 2015-03-30 | 2021-05-25 | Mission Therapeutics Ltd | 1-cyano-pyrrolidinforbindelser som usp30-hæmmere |
| EP3800186A1 (fr) | 2015-07-14 | 2021-04-07 | Mission Therapeutics Limited | Cyanopyrrolidines en tant qu'inhibiteurs des dub pour le traitement du cancer |
| GB201521109D0 (en) | 2015-11-30 | 2016-01-13 | Mission Therapeutics Ltd | Novel compounds |
| GB201522267D0 (en) | 2015-12-17 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| GB201522768D0 (en) | 2015-12-23 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| GB201602854D0 (en) | 2016-02-18 | 2016-04-06 | Mission Therapeutics Ltd | Novel compounds |
| GB201603779D0 (en) | 2016-03-04 | 2016-04-20 | Mission Therapeutics Ltd | Novel compounds |
| GB201604647D0 (en) | 2016-03-18 | 2016-05-04 | Mission Therapeutics Ltd | Novel compounds |
| EP3433246B1 (fr) | 2016-03-24 | 2022-05-04 | Mission Therapeutics Limited | Dérivés de 1-cyano-pyrrolidine comme des inhibiteurs de dbu |
| EP3519385B1 (fr) | 2016-09-27 | 2020-11-18 | Mission Therapeutics Limited | Dérivés de cyanopyrrolidine ayant une activité en tant qu'inhibiteurs de l'usp 30 |
| GB201616511D0 (en) | 2016-09-29 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| GB201616627D0 (en) | 2016-09-30 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| TWI771327B (zh) | 2016-10-05 | 2022-07-21 | 英商使命醫療公司 | 新穎化合物 |
| GB201617758D0 (en) | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| GB201708652D0 (en) | 2017-05-31 | 2017-07-12 | Mission Therapeutics Ltd | Novel compounds and uses |
| WO2018234775A1 (fr) | 2017-06-20 | 2018-12-27 | Mission Therapeutics Limited | Cyanopyrrolidines substituées présentant une activité en tant qu'inhibiteurs de dub |
| EA202090871A1 (ru) | 2017-10-06 | 2020-07-03 | Форма Терапьютикс, Инк. | Ингибирование убиквитин-специфической пептидазы 30 |
| IL310857A (en) | 2018-04-25 | 2024-04-01 | Bayer Ag | Heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides |
| US11572374B2 (en) | 2018-08-14 | 2023-02-07 | Amgen Inc. | N-cyano-7-azanorbornane derivatives and uses thereof |
| MX2021002981A (es) | 2018-10-05 | 2021-05-14 | Forma Therapeutics Inc | Pirrolinas fusionadas que actuan como inhibidores de la proteasa 30 especifica de la ubiquitina (usp30). |
| CN113453679A (zh) | 2018-12-20 | 2021-09-28 | C4医药公司 | 靶向蛋白降解 |
| GB201905375D0 (en) | 2019-04-16 | 2019-05-29 | Mission Therapeutics Ltd | Novel compounds |
| GB201905371D0 (en) | 2019-04-16 | 2019-05-29 | Mission Therapeutics Ltd | Novel compounds |
| GB201912674D0 (en) | 2019-09-04 | 2019-10-16 | Mission Therapeutics Ltd | Novel compounds |
| CR20220316A (es) | 2019-12-06 | 2022-10-07 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio |
| WO2021155264A1 (fr) * | 2020-01-29 | 2021-08-05 | Foghorn Therapeutics Inc. | Composés et leurs utilisations |
| GB202001980D0 (en) | 2020-02-13 | 2020-04-01 | Almac Discovery Ltd | Therapeutic mentods |
| WO2021204856A1 (fr) | 2020-04-08 | 2021-10-14 | Mission Therapeutics Limited | N-cyanopyrrolidines ayant une activité en tant qu'inhibiteurs de l'usp30 |
| CN115667252A (zh) | 2020-05-28 | 2023-01-31 | 特殊治疗有限公司 | 用于治疗线粒体功能障碍的作为usp30抑制剂的n-(1-氰基-吡咯烷-3-基)-5-(3-(三氟甲基)苯基)噁唑-2-甲酰胺衍生物和对应噁二唑衍生物 |
| US20230303547A1 (en) | 2020-06-04 | 2023-09-28 | Mission Therapeutics Limited | N-cyanopyrrolidines with activity as usp30 inhibitors |
| US20230312580A1 (en) | 2020-06-08 | 2023-10-05 | Mission Therapeutics Limited | 1-(5-(2-cyanopyridin-4-yl)oxazole-2-carbonyl)-4-methylhexahydropyrrolo[3,4-b]pyr role-5(1h)-carbonitrile as usp30 inhibitor for use in the treatment of mitochondrial dysfunction, cancer and fibrosis |
| GB202016800D0 (en) | 2020-10-22 | 2020-12-09 | Mission Therapeutics Ltd | Novel compounds |
| WO2022256622A1 (fr) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques |
| WO2023099561A1 (fr) | 2021-12-01 | 2023-06-08 | Mission Therapeutics Limited | N-cyanopyrrolidines substituées ayant une activité en tant qu'inhibiteurs de l'usp30 |
| GB202200753D0 (en) | 2022-01-21 | 2022-03-09 | Almac Discovery Ltd | Pharmaceutical compounds |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6835727B2 (en) | 2000-04-06 | 2004-12-28 | Merck Frosst Canada & Co. | Cathepsin cysteine protease inhibitors |
| EP2516430B1 (fr) | 2009-12-22 | 2014-11-05 | Merck Sharp & Dohme Corp. | Composés tricycliques fusionnés et leurs méthodes d'utilisation pour le traitement de maladies virales |
| AU2011305315A1 (en) * | 2010-09-24 | 2013-03-28 | The Regents Of The University Of Michigan | Deubiquitinase inhibitors and methods for use of the same |
| US9315518B2 (en) | 2011-06-16 | 2016-04-19 | Merck Sharp & Dohme Corp. | Imidazopyridin-2-one derivatives |
| EP2565186A1 (fr) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Inhibiteurs sélectifs et réversibles de la protéase 7 spécifique de l'ubiquitine |
| JP5833764B2 (ja) * | 2011-09-30 | 2015-12-16 | 山東軒竹医薬科技有限公司 | 縮合環を有するオキサゾリドン（ｏｘａｚｏｌｉｄｏｎｅ）類の抗菌物質 |
| JP2016504365A (ja) * | 2012-12-28 | 2016-02-12 | アメリカ合衆国 | Ｕｓｐ１／ｕａｆ１デユビキチナーゼ複合体阻害剤及びその使用 |
| AU2015240535A1 (en) | 2014-04-04 | 2016-10-20 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| EP3137168B1 (fr) * | 2014-04-30 | 2022-01-05 | The Trustees of Columbia University in the City of New York | 4-phénylepipéridines substituées, leur préparation et utilisation |
| GB201416754D0 (en) | 2014-09-23 | 2014-11-05 | Mission Therapeutics Ltd | Novel compounds |
| DK3277677T3 (da) | 2015-03-30 | 2021-05-25 | Mission Therapeutics Ltd | 1-cyano-pyrrolidinforbindelser som usp30-hæmmere |
| EP3800186A1 (fr) | 2015-07-14 | 2021-04-07 | Mission Therapeutics Limited | Cyanopyrrolidines en tant qu'inhibiteurs des dub pour le traitement du cancer |
| GB201521109D0 (en) | 2015-11-30 | 2016-01-13 | Mission Therapeutics Ltd | Novel compounds |
| GB201522267D0 (en) | 2015-12-17 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| GB201522768D0 (en) | 2015-12-23 | 2016-02-03 | Mission Therapeutics Ltd | Novel compounds |
| GB201602854D0 (en) | 2016-02-18 | 2016-04-06 | Mission Therapeutics Ltd | Novel compounds |
| GB201603779D0 (en) | 2016-03-04 | 2016-04-20 | Mission Therapeutics Ltd | Novel compounds |
| GB201604647D0 (en) | 2016-03-18 | 2016-05-04 | Mission Therapeutics Ltd | Novel compounds |
| EP3433246B1 (fr) | 2016-03-24 | 2022-05-04 | Mission Therapeutics Limited | Dérivés de 1-cyano-pyrrolidine comme des inhibiteurs de dbu |
| EP3519385B1 (fr) | 2016-09-27 | 2020-11-18 | Mission Therapeutics Limited | Dérivés de cyanopyrrolidine ayant une activité en tant qu'inhibiteurs de l'usp 30 |
| GB201616511D0 (en) | 2016-09-29 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| GB201616627D0 (en) | 2016-09-30 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| TWI771327B (zh) | 2016-10-05 | 2022-07-21 | 英商使命醫療公司 | 新穎化合物 |
-
2016
- 2016-03-18 GB GBGB1604638.5A patent/GB201604638D0/en not_active Ceased
-
2017
- 2017-03-17 MA MA043745A patent/MA43745A/fr unknown
- 2017-03-17 EP EP17713402.0A patent/EP3430012B1/fr active Active
- 2017-03-17 US US16/080,229 patent/US11306096B2/en active Active
- 2017-03-17 CN CN201780007893.4A patent/CN108473502B/zh active Active
- 2017-03-17 WO PCT/GB2017/050755 patent/WO2017158381A1/fr active Application Filing
- 2017-03-17 JP JP2018548677A patent/JP6959248B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3430012B1 (fr) | 2021-06-16 |
| CN108473502B (zh) | 2022-04-26 |
| JP2019508462A (ja) | 2019-03-28 |
| US11306096B2 (en) | 2022-04-19 |
| EP3430012A1 (fr) | 2019-01-23 |
| WO2017158381A1 (fr) | 2017-09-21 |
| US20210221813A1 (en) | 2021-07-22 |
| WO2017158381A8 (fr) | 2018-01-11 |
| JP6959248B2 (ja) | 2021-11-02 |
| GB201604638D0 (en) | 2016-05-04 |
| CN108473502A (zh) | 2018-08-31 |
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