JP6931357B2 - デングウイルス複製阻害剤としての置換インドリン誘導体 - Google Patents

デングウイルス複製阻害剤としての置換インドリン誘導体 Download PDF

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Publication number
JP6931357B2
JP6931357B2 JP2018550333A JP2018550333A JP6931357B2 JP 6931357 B2 JP6931357 B2 JP 6931357B2 JP 2018550333 A JP2018550333 A JP 2018550333A JP 2018550333 A JP2018550333 A JP 2018550333A JP 6931357 B2 JP6931357 B2 JP 6931357B2
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mmol
compound
mixture
methoxyphenyl
synthesis
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Japanese (ja)
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JP2019510027A (ja
JP2019510027A5 (enExample
Inventor
アリス マリー−イヴ バルディオ，ドロセー
アリス マリー−イヴ バルディオ，ドロセー
ボンファンティ，ジャン−フランソワ
ルドルフ ロマニー ケステルイン，バート
ルドルフ ロマニー ケステルイン，バート
ディディエ エム マーチャン，アルノー
ディディエ エム マーチャン，アルノー
ジャン−マリー ベルナール ラボワッソン，ピエール
ジャン−マリー ベルナール ラボワッソン，ピエール
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Katholieke Universiteit Leuven
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Katholieke Universiteit Leuven
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2018550333A 2016-03-31 2017-03-31 デングウイルス複製阻害剤としての置換インドリン誘導体 Active JP6931357B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16163281.5 2016-03-31
EP16163281 2016-03-31
PCT/EP2017/057663 WO2017167953A1 (en) 2016-03-31 2017-03-31 Substituted indoline derivatives as dengue viral replication inhibitors

Publications (3)

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JP2019510027A JP2019510027A (ja) 2019-04-11
JP2019510027A5 JP2019510027A5 (enExample) 2019-05-23
JP6931357B2 true JP6931357B2 (ja) 2021-09-01

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Country Link
US (1) US10913716B2 (enExample)
EP (1) EP3436436B1 (enExample)
JP (1) JP6931357B2 (enExample)
KR (1) KR102359735B1 (enExample)
CN (1) CN109195949B (enExample)
AU (1) AU2017240077A1 (enExample)
BR (1) BR112018069601A2 (enExample)
CA (1) CA3013407A1 (enExample)
CL (1) CL2018002718A1 (enExample)
CO (1) CO2018008421A2 (enExample)
CR (1) CR20180496A (enExample)
EA (1) EA201892216A1 (enExample)
EC (1) ECSP18073366A (enExample)
ES (1) ES2923771T3 (enExample)
IL (1) IL261943A (enExample)
MA (1) MA44498A (enExample)
MX (1) MX2018011788A (enExample)
PH (1) PH12018502016A1 (enExample)
SG (1) SG11201808270PA (enExample)
WO (1) WO2017167953A1 (enExample)

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EA201992782A1 (ru) 2017-05-22 2020-03-24 Янссен Фармасьютикалз, Инк. Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
CN109485596A (zh) * 2018-12-19 2019-03-19 山东理工职业学院 一种含吲哚啉的登革病毒抑制剂的制备方法

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Publication number Publication date
US20200339511A1 (en) 2020-10-29
CN109195949A (zh) 2019-01-11
MA44498A (fr) 2019-02-06
CR20180496A (es) 2018-12-06
KR20180132056A (ko) 2018-12-11
PH12018502016A1 (en) 2019-07-15
CL2018002718A1 (es) 2018-12-14
KR102359735B1 (ko) 2022-02-08
MX2018011788A (es) 2019-05-20
CO2018008421A2 (es) 2018-10-22
AU2017240077A1 (en) 2018-08-09
CA3013407A1 (en) 2017-10-05
ECSP18073366A (es) 2018-10-31
BR112018069601A2 (pt) 2019-01-29
WO2017167953A1 (en) 2017-10-05
JP2019510027A (ja) 2019-04-11
EP3436436B1 (en) 2022-05-11
EA201892216A1 (ru) 2019-03-29
ES2923771T3 (es) 2022-09-30
SG11201808270PA (en) 2018-10-30
US10913716B2 (en) 2021-02-09
CN109195949B (zh) 2021-09-17
IL261943A (en) 2018-10-31
EP3436436A1 (en) 2019-02-06

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