JP6929837B2 - ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ - Google Patents

ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ Download PDF

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JP6929837B2
JP6929837B2 JP2018517357A JP2018517357A JP6929837B2 JP 6929837 B2 JP6929837 B2 JP 6929837B2 JP 2018517357 A JP2018517357 A JP 2018517357A JP 2018517357 A JP2018517357 A JP 2018517357A JP 6929837 B2 JP6929837 B2 JP 6929837B2
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trc1
cell
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JP2018536390A (ja
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ニコルソン，マイケル，ジー．
スミス，ジェームス，ジェファーソン
ジャンツ，デレック
バートセビッチ，ビクター
マクレオード，ダニエル，ティー．
アントニー，ジェヤラージ
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プレシジョン バイオサイエンシズ，インク．
プレシジョン バイオサイエンシズ，インク．
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    • A—HUMAN NECESSITIES
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    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K47/67—Enzyme prodrug therapy, e.g. gene directed enzyme drug therapy [GDEPT] or VDEPT
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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JP2018517357A 2015-10-05 2016-10-05 ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ Active JP6929837B2 (ja)

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JP2021131109A JP2022000019A (ja) 2015-10-05 2021-08-11 ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ
JP2023133416A JP2023175698A (ja) 2015-10-05 2023-08-18 ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ
JP2025092415A JP2025143265A (ja) 2015-10-05 2025-06-03 ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ

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US201562237382P 2015-10-05 2015-10-05
US62/237,382 2015-10-05
US201662297445P 2016-02-19 2016-02-19
US62/297,445 2016-02-19
PCT/US2016/055472 WO2017062439A1 (en) 2015-10-05 2016-10-05 Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene

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JP2018536390A5 JP2018536390A5 (https=) 2019-11-14
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JP2021131109A Pending JP2022000019A (ja) 2015-10-05 2021-08-11 ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ
JP2023133416A Pending JP2023175698A (ja) 2015-10-05 2023-08-18 ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ
JP2025092415A Pending JP2025143265A (ja) 2015-10-05 2025-06-03 ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ

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JP2023133416A Pending JP2023175698A (ja) 2015-10-05 2023-08-18 ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ
JP2025092415A Pending JP2025143265A (ja) 2015-10-05 2025-06-03 ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ

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US (4) US10799535B2 (https=)
EP (3) EP3359660B1 (https=)
JP (4) JP6929837B2 (https=)
AU (4) AU2016333886B2 (https=)
CA (1) CA3001008A1 (https=)
DK (2) DK3359660T3 (https=)
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JP2022000019A (ja) * 2015-10-05 2022-01-04 プレシジョン バイオサイエンシズ，インク． ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ

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JP2023175698A (ja) * 2015-10-05 2023-12-12 プレシジョン バイオサイエンシズ，インク． ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ
JP2025143265A (ja) * 2015-10-05 2025-10-01 プレシジョン バイオサイエンシズ，インク． ヒトｔ細胞受容体アルファ定常領域遺伝子中に見出される認識配列に対して操作されたメガヌクレアーゼ

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