JP6918279B2 - 癌および感染症の治療のために骨髄由来抑制細胞分化を誘導する方法および組成物 - Google Patents

癌および感染症の治療のために骨髄由来抑制細胞分化を誘導する方法および組成物 Download PDF

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JP6918279B2
JP6918279B2 JP2017520986A JP2017520986A JP6918279B2 JP 6918279 B2 JP6918279 B2 JP 6918279B2 JP 2017520986 A JP2017520986 A JP 2017520986A JP 2017520986 A JP2017520986 A JP 2017520986A JP 6918279 B2 JP6918279 B2 JP 6918279B2
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sirpa
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ポワリエ、ニコラ
ヴァンホーブ、ベルナール
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オーエスイー イムノセラピューティクス
オーエスイー イムノセラピューティクス
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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JP2017520986A 2014-10-24 2015-10-21 癌および感染症の治療のために骨髄由来抑制細胞分化を誘導する方法および組成物 Active JP6918279B2 (ja)

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JP2021102148A JP7253008B2 (ja) 2014-10-24 2021-06-21 癌および感染症の治療のために骨髄由来抑制細胞分化を誘導する方法および組成物
JP2023047480A JP2023078398A (ja) 2014-10-24 2023-03-24 癌および感染症の治療のために骨髄由来抑制細胞分化を誘導する方法および組成物

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EP14190370.8A EP3012271A1 (en) 2014-10-24 2014-10-24 Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
EP14190370.8 2014-10-24
PCT/IB2015/058124 WO2016063233A1 (en) 2014-10-24 2015-10-21 Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases

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JP2021102148A Active JP7253008B2 (ja) 2014-10-24 2021-06-21 癌および感染症の治療のために骨髄由来抑制細胞分化を誘導する方法および組成物
JP2023047480A Pending JP2023078398A (ja) 2014-10-24 2023-03-24 癌および感染症の治療のために骨髄由来抑制細胞分化を誘導する方法および組成物

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JP2023047480A Pending JP2023078398A (ja) 2014-10-24 2023-03-24 癌および感染症の治療のために骨髄由来抑制細胞分化を誘導する方法および組成物

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CA (1) CA2964203C (https=)
DK (2) DK3209691T3 (https=)
ES (2) ES3060595T3 (https=)
HU (1) HUE050318T2 (https=)
PL (2) PL3783027T3 (https=)
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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
WO2017027422A1 (en) 2015-08-07 2017-02-16 Alexo Therapeutics Inc. Constructs having a sirp-alpha domain or variant thereof
EP3341015B2 (en) 2015-08-26 2023-12-27 The Board of Trustees of the Leland Stanford Junior University Enhanced depletion of targeted cells with cd47 blockade and an immune costimulatory agonist
JP7078533B2 (ja) * 2015-10-21 2022-05-31 オーエスイー イムノセラピューティクス 炎症促進性細胞へのマクロファージ分極を改変して癌を治療するための抗ＳＩＲＰａ化合物
RS66062B1 (sr) 2016-04-14 2024-11-29 Ose Immunotherapeutics Nova anti-sirpa antitela i njihove terapijske primene
KR102379464B1 (ko) 2016-06-20 2022-03-29 키맵 리미티드 항-pd-l1 항체
US20190153095A1 (en) * 2016-07-05 2019-05-23 National University Corporation Kobe University Antitumor Agent
JOP20190009A1 (ar) * 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
CN118027200A (zh) 2016-12-09 2024-05-14 艾利妥 抗SIRPα抗体及其使用方法
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof
LT3565579T (lt) 2017-01-05 2023-09-11 Kahr Medical Ltd. Pd1-41bbl sulietas baltymas ir jo panaudojimo būdai
PT3565828T (pt) 2017-01-05 2022-02-08 Kahr Medical Ltd Proteína de fusão sirp1 alfa-41bbl e seus métodos de utilização
WO2018127918A1 (en) 2017-01-05 2018-07-12 Kahr Medical Ltd. A sirp alpha-cd70 fusion protein and methods of use thereof
WO2018136659A1 (en) * 2017-01-18 2018-07-26 Nant Holdings Ip, Llc Modulation of tumor cell susceptibility
US20200306300A1 (en) * 2017-02-15 2020-10-01 The Regents Of The University Of California Compositions and methods for activating nk cells
JP7262440B2 (ja) 2017-08-02 2023-04-21 フェインズ セラピューティクス，インコーポレーテッド 抗ｃｄ４７抗体及びその使用
JP7395471B2 (ja) 2017-10-13 2023-12-11 オーセ イミュノセラピューティクス 改変抗ＳＩＲＰａ抗体及びその使用
AU2019233577A1 (en) 2018-03-13 2020-09-03 Ose Immunotherapeutics Use of anti-human SIRPa v1 antibodies and method for producing anti-SIRPa v1 antibodies
MX2020009774A (es) 2018-03-21 2020-10-08 Alx Oncology Inc Anticuerpos contra proteína alfa reguladora de señal y métodos de uso.
EP3802602A1 (en) 2018-05-25 2021-04-14 Alector LLC Anti-sirpa antibodies and methods of use thereof
US11759485B2 (en) 2018-06-14 2023-09-19 Meiji Co., Ltd. Composition for enhancing immune checkpoint blockade therapy
US12134638B2 (en) 2018-07-11 2024-11-05 Kahr Medical Ltd. SIRPalpha-4-1BBL variant fusion protein and methods of use thereof
KR20210044221A (ko) 2018-07-11 2021-04-22 카 메디컬 리미티드 Pd1-4-1bbl 변이체 융합 단백질 및 이의 사용 방법
US11591390B2 (en) 2018-09-27 2023-02-28 Celgene Corporation SIRP-α binding proteins and methods of use thereof
SG11202102851XA (en) 2018-09-27 2021-04-29 Celgene Corp SIRPa BINDING PROTEINS AND METHODS OF USE THEREOF
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
BR112021007286A2 (pt) * 2018-10-19 2021-07-27 Ohio State Innovation Foundation células furtivas terapêuticas nanoprojetadas
BR112021024003A2 (pt) 2019-05-31 2022-04-19 Alx Oncology Inc Métodos de tratamento de câncer com fusão sirp alfa-fc em combinação com um inibidor de checkpoint imunológico
CN114206912B (zh) 2019-06-07 2025-02-11 Alx肿瘤生物技术公司 用于在血清学测定中减少结合cd47的药物的干扰的方法和试剂
AU2020394204A1 (en) 2019-11-27 2022-06-02 ALX Oncology Inc. Combination therapies for treating cancer
US12343377B2 (en) 2020-06-01 2025-07-01 ALX Oncology Inc. Combination therapies comprising a hypomethylation agent for treating cancer
CN111808800B (zh) * 2020-07-20 2022-08-26 中南大学湘雅二医院 一种体外诱导免疫抑制性髓系抑制细胞及其制备和应用
WO2022120286A1 (en) 2020-12-06 2022-06-09 ALX Oncology Inc. Multimers for reducing the interference of drugs that bind cd47 in serological assays
JP2024520902A (ja) 2021-05-13 2024-05-27 エーエルエックス オンコロジー インコーポレイテッド がんを治療するための併用療法
WO2023020459A1 (zh) 2021-08-17 2023-02-23 杭州九源基因工程有限公司 靶向SIRPα的单克隆抗体及其用途
JP2025523369A (ja) 2022-06-01 2025-07-23 エーエルエックス オンコロジー インコーポレイテッド 尿路上皮癌腫を治療するための併用療法
EP4619435A1 (en) 2022-11-16 2025-09-24 Boehringer Ingelheim International GmbH Predictive efficacy biomarkers for anti-sirpa antibodies
CN115896015B (zh) * 2023-02-08 2023-09-29 上海诚益生物科技有限公司 一种髓系来源抑制性细胞的体外培养方法
CN117054649A (zh) * 2023-08-04 2023-11-14 广州中医药大学第一附属医院 一种慢性萎缩性胃炎向胃癌转化标志物及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1048299A1 (en) 1999-04-28 2000-11-02 Faculteit der Geneeskunde van de Vrije Universiteit Method for inhibiting cell functioning for use in anti-inflammatory and anti-tumour therapies
JP3936673B2 (ja) 2003-06-02 2007-06-27 国立大学法人群馬大学 Ｃｄ４７部分ペプチドと抗ｓｈｐｓ−１モノクロナール抗体
EP2630966B1 (en) * 2007-10-12 2017-04-19 Massachusetts Institute of Technology Vaccine nanotechnology
AU2009205665B2 (en) * 2008-01-15 2013-12-05 The Board Of Trustees Of The Leland Stanford Junior University Methods for manipulating phagocytosis mediated by CD47
EP2111869A1 (en) 2008-04-23 2009-10-28 Stichting Sanquin Bloedvoorziening Compositions and methods to enhance the immune system
PL2995315T3 (pl) 2009-05-15 2024-04-22 University Health Network Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie sirp alfa-cd47
GB201015765D0 (en) * 2010-09-21 2010-10-27 Immatics Biotechnologies Gmbh Use of myeloid cell biomarkers for the diagnosis of cancer
EP3682896A1 (en) * 2011-04-28 2020-07-22 University of Southern California Human myeloid derived suppressor cell cancer markers
WO2013056352A1 (en) * 2011-10-19 2013-04-25 University Health Network Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers
SI2804617T1 (sl) 2012-01-17 2020-10-30 The Board Of Trustees Of The Leland Stanford Junior University Visokoafinitetni SIRP-alfa reagenti
CN105101997B (zh) * 2013-02-06 2018-11-09 印希彼有限合伙公司 不减少血小板和不减少血红细胞的cd47抗体及其使用方法
AU2015229448B2 (en) 2014-03-11 2020-09-03 The Board Of Trustees Of The Leland Stanford Junior University Anti SIRP-alpha antibodies and Bi-specific Macrophage Enhancing antibodies

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EP4691569A3 (en) 2026-04-15
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CA2964203C (en) 2023-08-22
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JP2017538669A (ja) 2017-12-28
HK1243428A1 (en) 2018-07-13
EP3209691B1 (en) 2020-07-15
PL3783027T3 (pl) 2026-04-20
WO2016063233A1 (en) 2016-04-28
EP3783027B1 (en) 2025-12-03
ES2817074T3 (es) 2021-04-06
CA2964203A1 (en) 2016-04-28
EP3783027A1 (en) 2021-02-24
US20220281993A1 (en) 2022-09-08
JP2021155432A (ja) 2021-10-07
JP7253008B2 (ja) 2023-04-05
JP2023078398A (ja) 2023-06-06
DK3209691T3 (da) 2020-08-24
EP3209691A1 (en) 2017-08-30
ES3060595T3 (en) 2026-03-27
DK3783027T3 (da) 2026-02-02
US20240294659A1 (en) 2024-09-05
EP4691569A2 (en) 2026-02-11

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