JP6883987B2 - 化学修飾されたオリゴヌクレオチドを利用する創傷治癒の処置のための方法 - Google Patents

化学修飾されたオリゴヌクレオチドを利用する創傷治癒の処置のための方法 Download PDF

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JP6883987B2
JP6883987B2 JP2016536865A JP2016536865A JP6883987B2 JP 6883987 B2 JP6883987 B2 JP 6883987B2 JP 2016536865 A JP2016536865 A JP 2016536865A JP 2016536865 A JP2016536865 A JP 2016536865A JP 6883987 B2 JP6883987 B2 JP 6883987B2
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nucleic acid
acid molecule
modified
nucleotides
oligonucleotide
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JP2016540778A (ja
JP2016540778A5 (https=
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コーウェンバーグ，ジェラード
パヴコ，パメラ，エー．
リバティーン，リン
ブロック，カレン，ジー．
カルディア，ジェームス
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Phio Pharmaceuticals Corp
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JP2016536865A 2013-12-04 2014-12-04 化学修飾されたオリゴヌクレオチドを利用する創傷治癒の処置のための方法 Expired - Fee Related JP6883987B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361911993P 2013-12-04 2013-12-04
US201361911991P 2013-12-04 2013-12-04
US61/911,993 2013-12-04
US61/911,991 2013-12-04
US201462049299P 2014-09-11 2014-09-11
US62/049,299 2014-09-11
PCT/US2014/068654 WO2015085113A1 (en) 2013-12-04 2014-12-04 Methods for treatment of wound healing utilizing chemically modified oligonucleotides

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JP2019179885A Division JP2020033350A (ja) 2013-12-04 2019-09-30 化学修飾されたオリゴヌクレオチドを利用する創傷治癒の処置のための方法

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JP2016540778A JP2016540778A (ja) 2016-12-28
JP2016540778A5 JP2016540778A5 (https=) 2018-01-18
JP6883987B2 true JP6883987B2 (ja) 2021-06-09

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JP2019179885A Pending JP2020033350A (ja) 2013-12-04 2019-09-30 化学修飾されたオリゴヌクレオチドを利用する創傷治癒の処置のための方法

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US (1) US20160304875A1 (https=)
EP (1) EP3077050B1 (https=)
JP (2) JP6883987B2 (https=)
KR (1) KR20160110370A (https=)
CN (1) CN105960265A (https=)
CA (1) CA2932753A1 (https=)
WO (1) WO2015085113A1 (https=)

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WO2010059226A2 (en) 2008-11-19 2010-05-27 Rxi Pharmaceuticals Corporation Inhibition of map4k4 through rnai
WO2010078536A1 (en) 2009-01-05 2010-07-08 Rxi Pharmaceuticals Corporation Inhibition of pcsk9 through rnai
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
EP3494790A1 (en) 2010-03-02 2019-06-12 Phio Pharmaceuticals Corp. Effective sensitizing dose of a gelled immunomodulating topical composition
RU2615143C2 (ru) 2010-03-24 2017-04-04 Адвирна Самодоставляющие PHKi соединения уменьшенного размера
CN103200945B (zh) 2010-03-24 2016-07-06 雷克西制药公司 眼部症候中的rna干扰
EP3560503B1 (en) 2010-03-24 2021-11-17 Phio Pharmaceuticals Corp. Rna interference in dermal and fibrotic indications
CN106061488B (zh) 2013-12-02 2021-04-09 菲奥医药公司 癌症的免疫治疗
WO2015168108A2 (en) 2014-04-28 2015-11-05 Rxi Pharmaceuticals Corporation Methods for treating cancer using nucleic targeting mdm2 or mycn
US10900039B2 (en) 2014-09-05 2021-01-26 Phio Pharmaceuticals Corp. Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
EP3862005A1 (en) 2015-07-06 2021-08-11 Phio Pharmaceuticals Corp. Nucleic acid molecules targeting superoxide dismutase 1 (sod1)
US10808247B2 (en) 2015-07-06 2020-10-20 Phio Pharmaceuticals Corp. Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
US20210052631A1 (en) * 2015-09-25 2021-02-25 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
WO2017070151A1 (en) 2015-10-19 2017-04-27 Rxi Pharmaceuticals Corporation Reduced size self-delivering nucleic acid compounds targeting long non-coding rna
US12544344B2 (en) 2017-04-19 2026-02-10 Phio Pharmaceuticals Corp. Topical delivery of nucleic acid compounds
CN111773392B (zh) * 2020-05-25 2023-04-07 河南省生物工程技术研究中心 一种人血白蛋白/寡核苷酸纳米颗粒及其制备方法和用途
CN111557913B (zh) * 2020-07-07 2022-05-31 中国科学院空天信息创新研究院 靶向癫痫细胞的纳米光敏复合物及调控检测系统
CN113092461B (zh) * 2021-04-09 2023-08-22 四川大学华西医院 一种均相二维可视化/荧光分析方法及应用
CN113842496B (zh) * 2021-09-28 2022-07-29 五峰赤诚生物科技股份有限公司 一种创面液体敷料及其制备方法

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