JP6878299B2 - オーバーサイズアデノ随伴ベクターの産生 - Google Patents

オーバーサイズアデノ随伴ベクターの産生 Download PDF

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JP6878299B2
JP6878299B2 JP2017553005A JP2017553005A JP6878299B2 JP 6878299 B2 JP6878299 B2 JP 6878299B2 JP 2017553005 A JP2017553005 A JP 2017553005A JP 2017553005 A JP2017553005 A JP 2017553005A JP 6878299 B2 JP6878299 B2 JP 6878299B2
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aav
raav
genome
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oversized
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JP2018510648A5 (enExample
JP2018510648A (ja
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シルッカ・キョスティオ−ムーア
デーヴィッド・スーザ
カレン・ヴィンセント
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Genzyme Corp
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

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  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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JP2017553005A 2015-04-08 2016-04-07 オーバーサイズアデノ随伴ベクターの産生 Active JP6878299B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021075526A JP2021118724A (ja) 2015-04-08 2021-04-28 オーバーサイズアデノ随伴ベクターの産生
JP2023097370A JP2023116678A (ja) 2015-04-08 2023-06-14 オーバーサイズアデノ随伴ベクターの産生

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562144862P 2015-04-08 2015-04-08
US62/144,862 2015-04-08
US201562220067P 2015-09-17 2015-09-17
US62/220,067 2015-09-17
PCT/US2016/026486 WO2016164609A2 (en) 2015-04-08 2016-04-07 Production of oversized adeno-associated vectors

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JP2018510648A JP2018510648A (ja) 2018-04-19
JP2018510648A5 JP2018510648A5 (enExample) 2019-05-09
JP6878299B2 true JP6878299B2 (ja) 2021-05-26

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JP2017553005A Active JP6878299B2 (ja) 2015-04-08 2016-04-07 オーバーサイズアデノ随伴ベクターの産生
JP2021075526A Withdrawn JP2021118724A (ja) 2015-04-08 2021-04-28 オーバーサイズアデノ随伴ベクターの産生
JP2023097370A Pending JP2023116678A (ja) 2015-04-08 2023-06-14 オーバーサイズアデノ随伴ベクターの産生

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JP2021075526A Withdrawn JP2021118724A (ja) 2015-04-08 2021-04-28 オーバーサイズアデノ随伴ベクターの産生
JP2023097370A Pending JP2023116678A (ja) 2015-04-08 2023-06-14 オーバーサイズアデノ随伴ベクターの産生

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US (1) US10815497B2 (enExample)
EP (2) EP3280799B1 (enExample)
JP (3) JP6878299B2 (enExample)
KR (2) KR20250126875A (enExample)
CN (1) CN107864657A (enExample)
AU (3) AU2016245806A1 (enExample)
BR (1) BR112017021505A2 (enExample)
CA (1) CA2982123A1 (enExample)
CL (1) CL2017002537A1 (enExample)
CO (1) CO2017011344A2 (enExample)
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EA (1) EA201792236A1 (enExample)
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PE (1) PE20171800A1 (enExample)
PH (1) PH12017501836A1 (enExample)
PL (1) PL3280799T3 (enExample)
SG (3) SG10201912912QA (enExample)
TN (1) TN2017000431A1 (enExample)
TW (1) TWI707951B (enExample)
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Cited By (1)

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JP2021118724A (ja) * 2015-04-08 2021-08-12 ジェンザイム・コーポレーション オーバーサイズアデノ随伴ベクターの産生

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Publication number Priority date Publication date Assignee Title
JP2021118724A (ja) * 2015-04-08 2021-08-12 ジェンザイム・コーポレーション オーバーサイズアデノ随伴ベクターの産生

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BR112017021505A2 (pt) 2018-07-03
CO2017011344A2 (es) 2018-03-28
CL2017002537A1 (es) 2018-05-11
KR20250126875A (ko) 2025-08-25
AU2016245806A1 (en) 2017-11-30
HUE069779T2 (hu) 2025-04-28
PL3280799T3 (pl) 2025-04-14
HK1246339A1 (en) 2018-09-07
NZ737009A (en) 2024-01-26
SG10201909381WA (en) 2019-11-28
SG10201912912QA (en) 2020-02-27
IL254933B (en) 2021-06-30
IL294965A (en) 2022-09-01
ECSP17074016A (es) 2018-02-28
IL283291B (en) 2022-08-01
EP4512429A3 (en) 2025-05-21
KR20170133500A (ko) 2017-12-05
TWI707951B (zh) 2020-10-21
CA2982123A1 (en) 2016-10-13
WO2016164609A2 (en) 2016-10-13
AU2022203942B2 (en) 2023-12-14
US20190048362A1 (en) 2019-02-14
PE20171800A1 (es) 2017-12-28
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IL283291A (en) 2021-07-29
US10815497B2 (en) 2020-10-27
CN107864657A (zh) 2018-03-30
KR102848324B1 (ko) 2025-08-20
DK3280799T3 (da) 2025-01-27
EP3280799A2 (en) 2018-02-14
CR20170505A (es) 2018-01-26
GT201700214A (es) 2018-10-24
JP2018510648A (ja) 2018-04-19
TN2017000431A1 (en) 2019-04-12
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ES3008382T3 (en) 2025-03-24
UY36611A (es) 2016-11-30
NZ774736A (en) 2024-08-30
SG11201708203UA (en) 2017-11-29
JP2021118724A (ja) 2021-08-12
IL254933A0 (en) 2017-12-31
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EP4512429A2 (en) 2025-02-26

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