JP6871168B2 - 方法 - Google Patents

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Publication number
JP6871168B2
JP6871168B2 JP2017546051A JP2017546051A JP6871168B2 JP 6871168 B2 JP6871168 B2 JP 6871168B2 JP 2017546051 A JP2017546051 A JP 2017546051A JP 2017546051 A JP2017546051 A JP 2017546051A JP 6871168 B2 JP6871168 B2 JP 6871168B2
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Japan
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protein
binder
library
binding
target
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Japanese (ja)
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JP2017536846A (ja
JP2017536846A5 (enExample
Inventor
ジェニー,チャバ
Original Assignee
ジーンビレッジ コルラートルト フェレレーシェシェーギュー タールシャシャーグ
ジーンビレッジ コルラートルト フェレレーシェシェーギュー タールシャシャーグ
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/10Oligonucleotides as tagging agents for labelling antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2017546051A 2014-11-24 2015-11-24 方法 Active JP6871168B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1420852.4 2014-11-24
GBGB1420852.4A GB201420852D0 (en) 2014-11-24 2014-11-24 Method
PCT/GB2015/053573 WO2016083793A1 (en) 2014-11-24 2015-11-24 Method

Publications (3)

Publication Number Publication Date
JP2017536846A JP2017536846A (ja) 2017-12-14
JP2017536846A5 JP2017536846A5 (enExample) 2018-12-27
JP6871168B2 true JP6871168B2 (ja) 2021-05-12

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Family Applications (1)

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JP2017546051A Active JP6871168B2 (ja) 2014-11-24 2015-11-24 方法

Country Status (10)

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US (3) US10605814B2 (enExample)
EP (1) EP3224360B1 (enExample)
JP (1) JP6871168B2 (enExample)
KR (1) KR102422494B1 (enExample)
CN (1) CN107430130B (enExample)
CA (1) CA2968488C (enExample)
ES (1) ES2763563T3 (enExample)
GB (1) GB201420852D0 (enExample)
SG (2) SG11201703689SA (enExample)
WO (1) WO2016083793A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017214211A1 (en) * 2016-06-09 2017-12-14 Igc Bio, Inc. Methods for identifying a high affinity antibody
CA3051714A1 (en) * 2017-01-31 2018-08-09 The Governors Of The University Of Alberta Display of molecules on silently genetically encoded nanoscale carriers for determining synergistic molecular interactions
WO2019085958A1 (zh) * 2017-11-06 2019-05-09 清华大学 检测生物分子间相互作用及其调控因子的成套试剂与应用
KR20210038592A (ko) 2018-07-23 2021-04-07 더 거버너스 오브 더 유니버시티 오브 알버타 유전자 인코딩된 이환형 펩타이드 라이브러리
EP3990919B1 (en) 2019-06-25 2023-09-13 Actome GmbH Method and kit for measuring of analytes in bi-component systems and uses thereof
CN115066434A (zh) 2019-12-03 2022-09-16 阿拉玛生物科学公司 核酸连接的免疫-夹心测定(nulisa)
WO2022229205A1 (en) * 2021-04-26 2022-11-03 Ecole Polytechnique Federale De Lausanne (Epfl) High complexity microcompartment-based interaction screening
EP4242656A1 (en) * 2022-03-10 2023-09-13 Actome GmbH Quantitative detection method and corresponding device
WO2024003114A1 (en) 2022-06-29 2024-01-04 Actome Gmbh Detection of biomolecules in single cells
GB202218453D0 (en) 2022-12-08 2023-01-25 Actome Gmbh Assay system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CA2150262C (en) 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Multivalent and multispecific binding proteins, their manufacture and use
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
GB0422431D0 (en) * 2004-10-08 2004-11-10 Affitech As Method
PT2209893E (pt) * 2007-10-12 2014-02-26 Pronota Nv Uso de aptâmeros em proteómica
GB0903316D0 (en) * 2009-02-26 2009-04-08 Affitech As Method
JP5797642B2 (ja) 2009-05-20 2015-10-21 ノビミューン エスアー 合成ポリペプチドライブラリーおよび天然で多様化されたポリペプチドバリアントを作製するための方法
WO2011005221A1 (en) * 2009-07-07 2011-01-13 Agency For Science, Technology And Research Methods of identifying a pair of binding partners
EP3399035B1 (en) * 2010-09-27 2021-02-17 Vipergen A method for making an enriched library
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card

Also Published As

Publication number Publication date
GB201420852D0 (en) 2015-01-07
CN107430130A (zh) 2017-12-01
KR102422494B1 (ko) 2022-07-19
CA2968488C (en) 2024-09-10
WO2016083793A1 (en) 2016-06-02
ES2763563T3 (es) 2020-05-29
US20210003585A1 (en) 2021-01-07
SG11201703689SA (en) 2017-06-29
EP3224360A1 (en) 2017-10-04
CA2968488A1 (en) 2016-06-02
JP2017536846A (ja) 2017-12-14
US20170269098A1 (en) 2017-09-21
EP3224360B1 (en) 2019-10-09
US11421347B2 (en) 2022-08-23
CN107430130B (zh) 2020-07-24
SG10202008300RA (en) 2020-10-29
US10605814B2 (en) 2020-03-31
KR20170086627A (ko) 2017-07-26
US20230175171A1 (en) 2023-06-08

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