CA2968488C - Method for detecting binding interactions - Google Patents

Method for detecting binding interactions

Info

Publication number
CA2968488C
CA2968488C CA2968488A CA2968488A CA2968488C CA 2968488 C CA2968488 C CA 2968488C CA 2968488 A CA2968488 A CA 2968488A CA 2968488 A CA2968488 A CA 2968488A CA 2968488 C CA2968488 C CA 2968488C
Authority
CA
Canada
Prior art keywords
detecting connection
protein
detecting
connection intersections
interactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2968488A
Other languages
English (en)
French (fr)
Other versions
CA2968488A1 (en
Inventor
Csaba Jeney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GENEVILLAGE KFT
Original Assignee
GENEVILLAGE KFT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GENEVILLAGE KFT filed Critical GENEVILLAGE KFT
Publication of CA2968488A1 publication Critical patent/CA2968488A1/en
Application granted granted Critical
Publication of CA2968488C publication Critical patent/CA2968488C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2968488A 2014-11-24 2015-11-24 Method for detecting binding interactions Active CA2968488C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1420852.4 2014-11-24
GBGB1420852.4A GB201420852D0 (en) 2014-11-24 2014-11-24 Method
PCT/GB2015/053573 WO2016083793A1 (en) 2014-11-24 2015-11-24 Method

Publications (2)

Publication Number Publication Date
CA2968488A1 CA2968488A1 (en) 2016-06-02
CA2968488C true CA2968488C (en) 2024-09-10

Family

ID=52292436

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2968488A Active CA2968488C (en) 2014-11-24 2015-11-24 Method for detecting binding interactions

Country Status (10)

Country Link
US (3) US10605814B2 (enExample)
EP (1) EP3224360B1 (enExample)
JP (1) JP6871168B2 (enExample)
KR (1) KR102422494B1 (enExample)
CN (1) CN107430130B (enExample)
CA (1) CA2968488C (enExample)
ES (1) ES2763563T3 (enExample)
GB (1) GB201420852D0 (enExample)
SG (2) SG11201703689SA (enExample)
WO (1) WO2016083793A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017214211A1 (en) * 2016-06-09 2017-12-14 Igc Bio, Inc. Methods for identifying a high affinity antibody
CA3051714A1 (en) * 2017-01-31 2018-08-09 The Governors Of The University Of Alberta Display of molecules on silently genetically encoded nanoscale carriers for determining synergistic molecular interactions
WO2019085958A1 (zh) * 2017-11-06 2019-05-09 清华大学 检测生物分子间相互作用及其调控因子的成套试剂与应用
KR20210038592A (ko) 2018-07-23 2021-04-07 더 거버너스 오브 더 유니버시티 오브 알버타 유전자 인코딩된 이환형 펩타이드 라이브러리
EP3990919B1 (en) 2019-06-25 2023-09-13 Actome GmbH Method and kit for measuring of analytes in bi-component systems and uses thereof
CN115066434A (zh) 2019-12-03 2022-09-16 阿拉玛生物科学公司 核酸连接的免疫-夹心测定(nulisa)
WO2022229205A1 (en) * 2021-04-26 2022-11-03 Ecole Polytechnique Federale De Lausanne (Epfl) High complexity microcompartment-based interaction screening
EP4242656A1 (en) * 2022-03-10 2023-09-13 Actome GmbH Quantitative detection method and corresponding device
WO2024003114A1 (en) 2022-06-29 2024-01-04 Actome Gmbh Detection of biomolecules in single cells
GB202218453D0 (en) 2022-12-08 2023-01-25 Actome Gmbh Assay system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CA2150262C (en) 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Multivalent and multispecific binding proteins, their manufacture and use
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
GB0422431D0 (en) * 2004-10-08 2004-11-10 Affitech As Method
PT2209893E (pt) * 2007-10-12 2014-02-26 Pronota Nv Uso de aptâmeros em proteómica
GB0903316D0 (en) * 2009-02-26 2009-04-08 Affitech As Method
JP5797642B2 (ja) 2009-05-20 2015-10-21 ノビミューン エスアー 合成ポリペプチドライブラリーおよび天然で多様化されたポリペプチドバリアントを作製するための方法
WO2011005221A1 (en) * 2009-07-07 2011-01-13 Agency For Science, Technology And Research Methods of identifying a pair of binding partners
EP3399035B1 (en) * 2010-09-27 2021-02-17 Vipergen A method for making an enriched library
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card

Also Published As

Publication number Publication date
GB201420852D0 (en) 2015-01-07
CN107430130A (zh) 2017-12-01
KR102422494B1 (ko) 2022-07-19
WO2016083793A1 (en) 2016-06-02
ES2763563T3 (es) 2020-05-29
JP6871168B2 (ja) 2021-05-12
US20210003585A1 (en) 2021-01-07
SG11201703689SA (en) 2017-06-29
EP3224360A1 (en) 2017-10-04
CA2968488A1 (en) 2016-06-02
JP2017536846A (ja) 2017-12-14
US20170269098A1 (en) 2017-09-21
EP3224360B1 (en) 2019-10-09
US11421347B2 (en) 2022-08-23
CN107430130B (zh) 2020-07-24
SG10202008300RA (en) 2020-10-29
US10605814B2 (en) 2020-03-31
KR20170086627A (ko) 2017-07-26
US20230175171A1 (en) 2023-06-08

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