JP6865585B2 - 成長分化因子１５（ｇｄｆ−１５）に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用 - Google Patents

成長分化因子１５（ｇｄｆ−１５）に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用 Download PDF

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JP6865585B2
JP6865585B2 JP2016559286A JP2016559286A JP6865585B2 JP 6865585 B2 JP6865585 B2 JP 6865585B2 JP 2016559286 A JP2016559286 A JP 2016559286A JP 2016559286 A JP2016559286 A JP 2016559286A JP 6865585 B2 JP6865585 B2 JP 6865585B2
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antigen
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JP2017508475A5 (enExample
JP2017508475A (ja
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ヴィシュフーセン，ヨルク
ユンケル，マルクス
シェファー，ティナ
ピュリンガー，ディルク
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University of Würzburg
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C12N15/09—Recombinant DNA-technology
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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JP2016559286A 2014-03-26 2015-03-26 成長分化因子１５（ｇｄｆ−１５）に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用 Active JP6865585B2 (ja)

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GB1405477.9 2014-03-26
GB1405475.3A GB2524552B (en) 2014-03-26 2014-03-26 Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and use thereof for treating cancer
GB1405475.3 2014-03-26
GB1405477.9A GB2524553C (en) 2014-03-26 2014-03-26 Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia
PCT/EP2015/056654 WO2015144855A1 (en) 2014-03-26 2015-03-26 Monoclonal antibodies to growth and differentiation factor 15 (gdf-15), and uses thereof for treating cancer cachexia and cancer

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JP2021064572A Active JP7607498B2 (ja) 2014-03-26 2021-04-06 成長分化因子１５（ｇｄｆ－１５）に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用
JP2023062338A Withdrawn JP2023098966A (ja) 2014-03-26 2023-04-06 成長分化因子１５（ｇｄｆ－１５）に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用

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JP2023062338A Withdrawn JP2023098966A (ja) 2014-03-26 2023-04-06 成長分化因子１５（ｇｄｆ－１５）に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用

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US20260008841A1 (en) 2026-01-08
US11760795B2 (en) 2023-09-19
EP3653644B1 (en) 2023-11-15
US20200308264A1 (en) 2020-10-01
SI3122775T1 (sl) 2020-02-28
HRP20231514T1 (hr) 2024-03-01
HUE047398T2 (hu) 2020-04-28
FI3653644T3 (fi) 2023-12-12
EP3653644A1 (en) 2020-05-20
KR102520978B1 (ko) 2023-04-11
EP4316596A2 (en) 2024-02-07
BR112016022013A2 (pt) 2017-10-31
DK3653644T5 (da) 2024-08-26
IL276405A (en) 2020-09-30
BR122023027559A2 (pt) 2024-01-30
AU2020260440A1 (en) 2020-11-26
JP2023098966A (ja) 2023-07-11
US20230382987A1 (en) 2023-11-30
IL248038B (en) 2020-08-31
US20200308265A1 (en) 2020-10-01
US20170204174A1 (en) 2017-07-20
AU2015238264A1 (en) 2016-10-20
US20180298091A1 (en) 2018-10-18
WO2015144855A1 (en) 2015-10-01
US11634482B2 (en) 2023-04-25
DK3122775T3 (da) 2020-02-03
KR20160139005A (ko) 2016-12-06
LT3122775T (lt) 2020-02-10
PL3653644T3 (pl) 2024-03-04
EP3122775B1 (en) 2019-11-13
CY1122456T1 (el) 2021-01-27
IL276405B (en) 2021-07-29
JP2021119138A (ja) 2021-08-12
DK3653644T3 (da) 2023-12-18
NZ724649A (en) 2022-07-01
AU2015238264B2 (en) 2020-09-03
CN106536553A (zh) 2017-03-22
EP3122775A1 (en) 2017-02-01
US10604565B2 (en) 2020-03-31
JP7607498B2 (ja) 2024-12-27
PL3122775T3 (pl) 2020-05-18
IL248038A0 (en) 2016-11-30
HUE064573T2 (hu) 2024-03-28
EP4316596A3 (en) 2024-04-17
HRP20200034T1 (hr) 2020-03-20
AU2020260440B2 (en) 2024-03-21
ES2965626T3 (es) 2024-04-16
PT3122775T (pt) 2019-12-26
LT3653644T (lt) 2024-01-25
RS59700B1 (sr) 2020-01-31
CA2943694A1 (en) 2015-10-01
SMT202000064T1 (it) 2020-03-13
PT3653644T (pt) 2023-12-19
JP2017508475A (ja) 2017-03-30
CN106536553B (zh) 2021-03-12
ES2763859T3 (es) 2020-06-01

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