JP6865585B2 - 成長分化因子15(gdf−15)に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用 - Google Patents

成長分化因子15(gdf−15)に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用 Download PDF

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JP6865585B2
JP6865585B2 JP2016559286A JP2016559286A JP6865585B2 JP 6865585 B2 JP6865585 B2 JP 6865585B2 JP 2016559286 A JP2016559286 A JP 2016559286A JP 2016559286 A JP2016559286 A JP 2016559286A JP 6865585 B2 JP6865585 B2 JP 6865585B2
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antibody
amino acid
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acid sequence
antigen
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JP2017508475A5 (enExample
JP2017508475A (ja
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ヴィシュフーセン,ヨルク
ユンケル,マルクス
シェファー,ティナ
ピュリンガー,ディルク
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Julius Maximilians Universitaet Wuerzburg
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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JP2016559286A 2014-03-26 2015-03-26 成長分化因子15(gdf−15)に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用 Active JP6865585B2 (ja)

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JP2021064572A JP7607498B2 (ja) 2014-03-26 2021-04-06 成長分化因子15(gdf-15)に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用

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Application Number Priority Date Filing Date Title
GB1405475.3A GB2524552B (en) 2014-03-26 2014-03-26 Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and use thereof for treating cancer
GB1405477.9A GB2524553C (en) 2014-03-26 2014-03-26 Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia
GB1405477.9 2014-03-26
GB1405475.3 2014-03-26
PCT/EP2015/056654 WO2015144855A1 (en) 2014-03-26 2015-03-26 Monoclonal antibodies to growth and differentiation factor 15 (gdf-15), and uses thereof for treating cancer cachexia and cancer

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JP2017508475A5 JP2017508475A5 (enExample) 2018-05-17
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JP2021064572A Active JP7607498B2 (ja) 2014-03-26 2021-04-06 成長分化因子15(gdf-15)に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用
JP2023062338A Withdrawn JP2023098966A (ja) 2014-03-26 2023-04-06 成長分化因子15(gdf-15)に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用

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JP2023062338A Withdrawn JP2023098966A (ja) 2014-03-26 2023-04-06 成長分化因子15(gdf-15)に対するモノクローナル抗体およびがん悪液質およびがんを処置するためのその使用

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DK3653644T5 (da) 2024-08-26
PL3122775T3 (pl) 2020-05-18
KR102520978B1 (ko) 2023-04-11
IL248038A0 (en) 2016-11-30
US11760795B2 (en) 2023-09-19
EP3122775A1 (en) 2017-02-01
CN106536553B (zh) 2021-03-12
JP7607498B2 (ja) 2024-12-27
ES2965626T3 (es) 2024-04-16
EP3653644B1 (en) 2023-11-15
LT3653644T (lt) 2024-01-25
EP4316596A2 (en) 2024-02-07
PT3653644T (pt) 2023-12-19
AU2015238264A1 (en) 2016-10-20
EP4316596A3 (en) 2024-04-17
IL276405B (en) 2021-07-29
FI3653644T3 (fi) 2023-12-12
US20200308264A1 (en) 2020-10-01
IL248038B (en) 2020-08-31
JP2017508475A (ja) 2017-03-30
LT3122775T (lt) 2020-02-10
HRP20231514T1 (hr) 2024-03-01
AU2020260440A1 (en) 2020-11-26
AU2020260440B2 (en) 2024-03-21
PL3653644T3 (pl) 2024-03-04
ES2763859T3 (es) 2020-06-01
SMT202000064T1 (it) 2020-03-13
US11634482B2 (en) 2023-04-25
PT3122775T (pt) 2019-12-26
CY1122456T1 (el) 2021-01-27
WO2015144855A1 (en) 2015-10-01
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US20180298091A1 (en) 2018-10-18
EP3122775B1 (en) 2019-11-13
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CN106536553A (zh) 2017-03-22
HRP20200034T1 (hr) 2020-03-20
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DK3122775T3 (da) 2020-02-03
NZ724649A (en) 2022-07-01
DK3653644T3 (da) 2023-12-18
SI3122775T1 (sl) 2020-02-28
KR20160139005A (ko) 2016-12-06
HUE064573T2 (hu) 2024-03-28
IL276405A (en) 2020-09-30
JP2023098966A (ja) 2023-07-11
US20170204174A1 (en) 2017-07-20
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