KR102520978B1 - 성장 및 분화 인자 15 (gdf-15)에 대한 모노클로날 항체, 및 암 악액질 및 암을 치료하기 위한 그의 용도 - Google Patents

성장 및 분화 인자 15 (gdf-15)에 대한 모노클로날 항체, 및 암 악액질 및 암을 치료하기 위한 그의 용도 Download PDF

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KR102520978B1
KR102520978B1 KR1020167029710A KR20167029710A KR102520978B1 KR 102520978 B1 KR102520978 B1 KR 102520978B1 KR 1020167029710 A KR1020167029710 A KR 1020167029710A KR 20167029710 A KR20167029710 A KR 20167029710A KR 102520978 B1 KR102520978 B1 KR 102520978B1
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amino acid
ser
acid sequence
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외르크 비쉬후젠
마르쿠스 윤커
티나 섀퍼
디르크 퓌링거
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율리우스-막시밀리안스 우니버지태트 뷔르츠부르크
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material

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  • Life Sciences & Earth Sciences (AREA)
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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
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KR1020167029710A 2014-03-26 2015-03-26 성장 및 분화 인자 15 (gdf-15)에 대한 모노클로날 항체, 및 암 악액질 및 암을 치료하기 위한 그의 용도 Active KR102520978B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1405477.9 2014-03-26
GB1405475.3A GB2524552B (en) 2014-03-26 2014-03-26 Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and use thereof for treating cancer
GB1405477.9A GB2524553C (en) 2014-03-26 2014-03-26 Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia
GB1405475.3 2014-03-26
PCT/EP2015/056654 WO2015144855A1 (en) 2014-03-26 2015-03-26 Monoclonal antibodies to growth and differentiation factor 15 (gdf-15), and uses thereof for treating cancer cachexia and cancer

Publications (2)

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KR20160139005A KR20160139005A (ko) 2016-12-06
KR102520978B1 true KR102520978B1 (ko) 2023-04-11

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KR1020167029710A Active KR102520978B1 (ko) 2014-03-26 2015-03-26 성장 및 분화 인자 15 (gdf-15)에 대한 모노클로날 항체, 및 암 악액질 및 암을 치료하기 위한 그의 용도

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US (5) US20170204174A1 (enExample)
EP (3) EP3653644B1 (enExample)
JP (3) JP6865585B2 (enExample)
KR (1) KR102520978B1 (enExample)
CN (1) CN106536553B (enExample)
AU (2) AU2015238264B2 (enExample)
BR (1) BR122023027559A2 (enExample)
CY (1) CY1122456T1 (enExample)
DK (2) DK3653644T5 (enExample)
ES (2) ES2965626T3 (enExample)
FI (1) FI3653644T3 (enExample)
HR (2) HRP20231514T1 (enExample)
HU (2) HUE064573T2 (enExample)
IL (2) IL248038B (enExample)
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NZ (1) NZ724649A (enExample)
PL (2) PL3653644T3 (enExample)
PT (2) PT3653644T (enExample)
RS (1) RS59700B1 (enExample)
SI (1) SI3122775T1 (enExample)
SM (1) SMT202000064T1 (enExample)
WO (1) WO2015144855A1 (enExample)

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LT3653644T (lt) 2014-03-26 2024-01-25 Julius-Maximilians-Universität Würzburg Monokloniniai antikūnai prieš augimo ir diferenciacijos faktorių 15 (gdf- 15), ir jų panaudojimas taikant vėžio kacheksijos ir vėžio gydymą
EP3197493B1 (en) 2014-09-25 2021-03-10 Aveo Pharmaceuticals Inc. Methods of reversing cachexia and prolonging survival comprising administering a gdf15 modulator and an anti-cancer agent
BR112018006218A2 (pt) * 2015-10-02 2018-10-09 Univ Wuerzburg J Maximilians iinibidores de hgdf-15, seus usos, composição, kit, combinações e método in vitro para determinar se uma substância de interesse é um inibidor de hgdf-15
GB201517528D0 (en) * 2015-10-02 2015-11-18 Julius Maximillians Universitãt Würzburg GDF-15 as a diagnosis marker for melanoma
FI3356827T3 (fi) 2015-10-02 2024-01-03 Univ Wuerzburg J Maximilians GDF-15 diagnostisena markkerina immuunivasteen vapauttajilla annetun hoidon hoitovasteen ennustamiseksi
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EP3526346A1 (en) * 2016-10-12 2019-08-21 Janssen Biotech, Inc. Methods for screening for modulators of gdf15-like biological activity
AU2017371382A1 (en) * 2016-12-06 2019-06-13 St Vincent's Hospital Sydney Limited Treatment of obesity and eating disorders
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WO2023122213A1 (en) 2021-12-22 2023-06-29 Byomass Inc. Targeting gdf15-gfral pathway cross-reference to related applications
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CN118878677A (zh) * 2024-09-29 2024-11-01 江苏凯基生物技术股份有限公司 一种IgM亚型单克隆抗体及其制备方法和应用

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JP2010536717A (ja) * 2007-08-16 2010-12-02 セントビンセンツ ホスピタル シドニー リミテッド マクロファージ阻害性サイトカイン（ｍｉｃ−１）活性を調節するための作用物質及び方法
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US10604565B2 (en) 2020-03-31
EP3122775A1 (en) 2017-02-01
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US20230382987A1 (en) 2023-11-30
NZ724649A (en) 2022-07-01
AU2020260440B2 (en) 2024-03-21
US20200308264A1 (en) 2020-10-01
DK3122775T3 (da) 2020-02-03
PT3653644T (pt) 2023-12-19
EP4316596A2 (en) 2024-02-07
EP3653644B1 (en) 2023-11-15
CY1122456T1 (el) 2021-01-27
FI3653644T3 (fi) 2023-12-12
EP3653644A1 (en) 2020-05-20
HRP20231514T1 (hr) 2024-03-01
KR20160139005A (ko) 2016-12-06
JP2023098966A (ja) 2023-07-11
JP6865585B2 (ja) 2021-04-28
JP2021119138A (ja) 2021-08-12
IL248038B (en) 2020-08-31
HRP20200034T1 (hr) 2020-03-20
PL3653644T3 (pl) 2024-03-04
BR122023027559A2 (pt) 2024-01-30
WO2015144855A1 (en) 2015-10-01
CA2943694A1 (en) 2015-10-01
EP3122775B1 (en) 2019-11-13
US20170204174A1 (en) 2017-07-20
IL276405B (en) 2021-07-29
LT3122775T (lt) 2020-02-10
PT3122775T (pt) 2019-12-26
BR112016022013A2 (pt) 2017-10-31
DK3653644T5 (da) 2024-08-26
US20200308265A1 (en) 2020-10-01
SI3122775T1 (sl) 2020-02-28
ES2965626T3 (es) 2024-04-16
JP7607498B2 (ja) 2024-12-27
US20180298091A1 (en) 2018-10-18
US11760795B2 (en) 2023-09-19
PL3122775T3 (pl) 2020-05-18
HUE064573T2 (hu) 2024-03-28
CN106536553B (zh) 2021-03-12
AU2015238264A1 (en) 2016-10-20
LT3653644T (lt) 2024-01-25
AU2015238264B2 (en) 2020-09-03
CN106536553A (zh) 2017-03-22
IL276405A (en) 2020-09-30
DK3653644T3 (da) 2023-12-18
RS59700B1 (sr) 2020-01-31
AU2020260440A1 (en) 2020-11-26
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ES2763859T3 (es) 2020-06-01
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IL248038A0 (en) 2016-11-30
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