JP6824041B2 - ３つのタンパク質を補体成分に結合するための核酸化合物 - Google Patents

３つのタンパク質を補体成分に結合するための核酸化合物 Download PDF

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JP6824041B2
JP6824041B2 JP2016569420A JP2016569420A JP6824041B2 JP 6824041 B2 JP6824041 B2 JP 6824041B2 JP 2016569420 A JP2016569420 A JP 2016569420A JP 2016569420 A JP2016569420 A JP 2016569420A JP 6824041 B2 JP6824041 B2 JP 6824041B2
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deoxyuridine
methyluridine
fluorouridine
naphthylmethylcarboxyamide
aptamer
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JP2017517261A (ja
JP2017517261A5 (https=
Inventor
ダニエル ダブリュー． ドロレ
ダニエル ダブリュー． ドロレ
チー チャン
チー チャン
ダニエル ジェイ． オコンネル
ダニエル ジェイ． オコンネル
シャシ グプタ
シャシ グプタ
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Somalogic Inc
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Somalogic Inc
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JP2016569420A 2014-05-30 2015-05-29 ３つのタンパク質を補体成分に結合するための核酸化合物 Expired - Fee Related JP6824041B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462005300P 2014-05-30 2014-05-30
US62/005,300 2014-05-30
PCT/US2015/033355 WO2015184372A1 (en) 2014-05-30 2015-05-29 Nucleic acid compounds for binding to complement component 3 protein

Publications (3)

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JP2017517261A JP2017517261A (ja) 2017-06-29
JP2017517261A5 JP2017517261A5 (https=) 2019-03-14
JP6824041B2 true JP6824041B2 (ja) 2021-02-03

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JP2016569420A Expired - Fee Related JP6824041B2 (ja) 2014-05-30 2015-05-29 ３つのタンパク質を補体成分に結合するための核酸化合物

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Country Link
US (2) US11466275B2 (https=)
EP (1) EP3149173B1 (https=)
JP (1) JP6824041B2 (https=)
CN (2) CN106459979B (https=)
CA (1) CA2949246C (https=)
ES (1) ES2664179T3 (https=)
NO (1) NO2718257T3 (https=)
WO (1) WO2015184372A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI770036B (zh) 2016-07-01 2022-07-11 美商私募蛋白質體操作有限公司 包含經修飾核苷之寡核苷酸
EP4047004B1 (en) * 2019-10-18 2024-03-06 FUJIFILM Wako Pure Chemical Corporation Phosphoramidite activator

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140490A (en) * 1996-02-01 2000-10-31 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of complement system proteins
US6395888B1 (en) 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
WO1997042317A1 (en) * 1996-05-07 1997-11-13 T Cell Sciences, Inc. APTAMERS FOR COMPLEMENT PROTEIN C3b
US20020082227A1 (en) * 1999-09-30 2002-06-27 Scott Henry Use of oligonucleotides for inhibition of complement activation
US20030219801A1 (en) * 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
WO2007084886A2 (en) * 2006-01-17 2007-07-26 Somalogic, Incorporated Multiplexed analyses of test samples
US8975026B2 (en) * 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) * 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8927509B2 (en) * 2008-05-20 2015-01-06 The Research Foundation Of State University Of New York Aptamer modulators of complement protein C3 and biologically active proteolytic products thereof
EP3345915B1 (en) * 2010-04-12 2021-11-24 Somalogic, Inc. 5-position modified pyrimidines and their use
AU2012225273B2 (en) * 2011-03-10 2016-10-13 Somalogic, Inc. Aptamers for Clostridium difficile diagnostics
US9243060B2 (en) * 2012-04-03 2016-01-26 Novelmed Therapeutics, Inc. Humanized anti-factor C3b antibodies and uses thereof
SG10201913948PA (en) * 2016-08-24 2020-03-30 Sangamo Therapeutics Inc Engineered target specific nucleases
CN118955717A (zh) * 2019-07-11 2024-11-15 纪念斯隆凯特琳癌症中心 Dll3靶向抗体及其用途

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CA2949246C (en) 2023-06-27
ES2664179T3 (es) 2018-04-18
JP2017517261A (ja) 2017-06-29
CN106459979A (zh) 2017-02-22
CA2949246A1 (en) 2015-12-03
EP3149173B1 (en) 2018-02-07
US11466275B2 (en) 2022-10-11
US20170166895A1 (en) 2017-06-15
EP3149173A1 (en) 2017-04-05
WO2015184372A1 (en) 2015-12-03
NO2718257T3 (https=) 2018-04-14
CN110643610A (zh) 2020-01-03
US20230093170A1 (en) 2023-03-23
CN106459979B (zh) 2020-07-21

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