JP6822981B2 - 安定した乳酸応答性のセンサ - Google Patents
安定した乳酸応答性のセンサ Download PDFInfo
- Publication number
- JP6822981B2 JP6822981B2 JP2017562296A JP2017562296A JP6822981B2 JP 6822981 B2 JP6822981 B2 JP 6822981B2 JP 2017562296 A JP2017562296 A JP 2017562296A JP 2017562296 A JP2017562296 A JP 2017562296A JP 6822981 B2 JP6822981 B2 JP 6822981B2
- Authority
- JP
- Japan
- Prior art keywords
- lactic acid
- lactate
- sensor
- enzyme
- stabilizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01006—Catalase (1.11.1.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
- C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
- C12Y113/12004—Lactate 2-monooxygenase (1.13.12.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/904—Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/908—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Spectroscopy & Molecular Physics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562175910P | 2015-06-15 | 2015-06-15 | |
| US62/175,910 | 2015-06-15 | ||
| PCT/US2016/037642 WO2016205378A1 (en) | 2015-06-15 | 2016-06-15 | Stabilized lactate responsive enzymes, electrodes and sensors, and methods for making and using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018519507A JP2018519507A (ja) | 2018-07-19 |
| JP2018519507A5 JP2018519507A5 (OSRAM) | 2019-06-27 |
| JP6822981B2 true JP6822981B2 (ja) | 2021-01-27 |
Family
ID=57516396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562296A Active JP6822981B2 (ja) | 2015-06-15 | 2016-06-15 | 安定した乳酸応答性のセンサ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9914952B2 (OSRAM) |
| EP (3) | EP3307164B1 (OSRAM) |
| JP (1) | JP6822981B2 (OSRAM) |
| CN (1) | CN107735027A (OSRAM) |
| AU (3) | AU2016280696B2 (OSRAM) |
| CA (1) | CA2987091A1 (OSRAM) |
| ES (1) | ES2882631T3 (OSRAM) |
| WO (1) | WO2016205378A1 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3307164B1 (en) * | 2015-06-15 | 2021-05-12 | Abbott Diabetes Care Inc. | Stabilized lactate responsive enzymes, electrodes and sensors, and methods for making and using the same |
| EP3954394A1 (en) | 2015-06-19 | 2022-02-16 | Centurion BioPharma Corporation | Delivery systems for controlled drug release |
| PL3423591T3 (pl) | 2016-03-04 | 2024-03-25 | Abbott Diabetes Care Inc. | Wrażliwe enzymy, elektrody i czujniki zależne od NAD i sposoby ich wytwarzania oraz zastosowania |
| CN111712263B (zh) | 2017-11-30 | 2024-12-17 | 拉德克斯公司 | 基于美登木素生物碱的药物递送系统 |
| DK3717503T3 (da) | 2017-11-30 | 2024-01-22 | Ladrx Corp | Albumin-bindende prodrugs af auristatin E derivater |
| CA3082369A1 (en) * | 2017-12-04 | 2019-06-13 | The General Hospital Corporation | Extracellular redox enzyme system to alleviate disease |
| US12076145B2 (en) | 2018-04-19 | 2024-09-03 | Abbott Diabetes Care Inc. | Lactate sensors and associated methods |
| WO2019216977A1 (en) * | 2018-05-08 | 2019-11-14 | Abbott Diabetes Care Inc. | Sensing systems and methods for identifying emotional stress events |
| MY198077A (en) | 2019-01-28 | 2023-07-31 | Abbott Diabetes Care Inc | Analyte sensors employing multiple enzymes and methods associated therewith |
| MY196781A (en) | 2019-01-28 | 2023-05-03 | Abbott Diabetes Care Inc | Analyte sensors and sensing methods featuring dual detection of glucose and ketones |
| US12290359B2 (en) | 2020-01-03 | 2025-05-06 | Abbott Diabetes Care Inc. | Sensor array systems and methods for detecting multiple analytes |
| WO2021167011A1 (ja) | 2020-02-21 | 2021-08-26 | キッコーマン株式会社 | 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ |
| CN111518862B (zh) * | 2020-06-09 | 2022-02-18 | 南京工业大学 | 一种乳酸氧化酶生物电极的制备方法 |
| EP4382608A4 (en) | 2021-08-03 | 2025-07-16 | Kikkoman Corp | NOVEL FLAVIN-DEPENDENT LACTATE DEHYDROGENASE AND METHOD FOR IMPROVING THE STABILITY OF LACTATE DEHYDROGENASE |
| WO2025050007A1 (en) | 2023-09-01 | 2025-03-06 | Abbott Diabetes Care Inc. | Sensor for detecting glucose and lactate and methods for determining aerobic and anaerobic thresholds |
| US20250299818A1 (en) | 2024-03-25 | 2025-09-25 | Abbott Diabetes Care Inc. | Deployment and use of a continuous analyte monitoring system for improved home monitoring and readmission optimization |
| CN121027260B (zh) * | 2025-10-31 | 2026-01-23 | 江苏跃凯生物技术有限公司 | 一种持续乳酸监测传感器及其制备方法 |
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| US5262035A (en) | 1989-08-02 | 1993-11-16 | E. Heller And Company | Enzyme electrodes |
| DE4014109A1 (de) * | 1990-05-02 | 1991-11-07 | Siemens Ag | Elekrochemische bestimmung der sauerstoffkonzentration |
| JPH04278450A (ja) | 1991-03-04 | 1992-10-05 | Adam Heller | バイオセンサー及び分析物を分析する方法 |
| US5593852A (en) | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
| EP0859954B1 (en) * | 1995-11-08 | 2005-06-01 | Hypoguard Limited | Biosensors comprising a membrane |
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| JP2001165892A (ja) * | 1999-12-07 | 2001-06-22 | Toto Ltd | センサ素子およびその製造方法 |
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| WO2016065190A1 (en) | 2014-10-23 | 2016-04-28 | Abbott Diabetes Care Inc. | Electrodes having at least one sensing structure and methods for making and using the same |
| EP3307164B1 (en) * | 2015-06-15 | 2021-05-12 | Abbott Diabetes Care Inc. | Stabilized lactate responsive enzymes, electrodes and sensors, and methods for making and using the same |
-
2016
- 2016-06-15 EP EP16812345.3A patent/EP3307164B1/en active Active
- 2016-06-15 CN CN201680035003.6A patent/CN107735027A/zh active Pending
- 2016-06-15 JP JP2017562296A patent/JP6822981B2/ja active Active
- 2016-06-15 CA CA2987091A patent/CA2987091A1/en active Pending
- 2016-06-15 EP EP21172974.4A patent/EP3967227B1/en active Active
- 2016-06-15 WO PCT/US2016/037642 patent/WO2016205378A1/en not_active Ceased
- 2016-06-15 AU AU2016280696A patent/AU2016280696B2/en active Active
- 2016-06-15 ES ES16812345T patent/ES2882631T3/es active Active
- 2016-06-15 US US15/183,488 patent/US9914952B2/en active Active
- 2016-06-15 EP EP25184478.3A patent/EP4647504A3/en active Pending
-
2018
- 2018-01-26 US US15/880,914 patent/US10392647B2/en active Active
-
2022
- 2022-02-17 AU AU2022201057A patent/AU2022201057B2/en active Active
-
2024
- 2024-07-03 AU AU2024204622A patent/AU2024204622A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10392647B2 (en) | 2019-08-27 |
| EP4647504A2 (en) | 2025-11-12 |
| US20160362716A1 (en) | 2016-12-15 |
| US20180148758A1 (en) | 2018-05-31 |
| JP2018519507A (ja) | 2018-07-19 |
| AU2016280696A1 (en) | 2017-12-07 |
| CA2987091A1 (en) | 2016-12-22 |
| WO2016205378A1 (en) | 2016-12-22 |
| EP3307164A1 (en) | 2018-04-18 |
| AU2024204622A1 (en) | 2024-07-18 |
| EP3967227A1 (en) | 2022-03-16 |
| EP4647504A3 (en) | 2026-02-18 |
| US9914952B2 (en) | 2018-03-13 |
| EP3307164A4 (en) | 2018-11-21 |
| AU2022201057A1 (en) | 2022-03-10 |
| EP3967227B1 (en) | 2025-07-30 |
| AU2022201057B2 (en) | 2024-04-04 |
| AU2016280696B2 (en) | 2021-11-18 |
| EP3307164B1 (en) | 2021-05-12 |
| CN107735027A (zh) | 2018-02-23 |
| ES2882631T3 (es) | 2021-12-02 |
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