JP6816106B2 - ６−ピリジル−１，３，５−トリアジン−２，４−ジオール及び６−ピリジル−１，３，５−トリアジン−２，４−ジアミンを調製する方法 - Google Patents
６−ピリジル−１，３，５−トリアジン−２，４−ジオール及び６−ピリジル−１，３，５−トリアジン−２，４−ジアミンを調製する方法 Download PDFInfo
- Publication number
- JP6816106B2 JP6816106B2 JP2018505739A JP2018505739A JP6816106B2 JP 6816106 B2 JP6816106 B2 JP 6816106B2 JP 2018505739 A JP2018505739 A JP 2018505739A JP 2018505739 A JP2018505739 A JP 2018505739A JP 6816106 B2 JP6816106 B2 JP 6816106B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- acid
- certain embodiments
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- AYABEJGGSWJVPN-UHFFFAOYSA-N COC(c1cccc(C(F)(F)F)n1)=O Chemical compound COC(c1cccc(C(F)(F)F)n1)=O AYABEJGGSWJVPN-UHFFFAOYSA-N 0.000 description 2
- OHJMTUPIZMNBFR-UHFFFAOYSA-N NC(NC(N)=O)=O Chemical compound NC(NC(N)=O)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 2
- JBXAKQJKSGOFNP-UHFFFAOYSA-N O=C(NC(c1cccc(C(F)(F)F)n1)=N1)NC1=O Chemical compound O=C(NC(c1cccc(C(F)(F)F)n1)=N1)NC1=O JBXAKQJKSGOFNP-UHFFFAOYSA-N 0.000 description 2
- 0 *C(*)(*)Nc1nc(NC2=CC=CC=CC=CC=C2)nc([C@@]2C=CC=CC=C/C=C2)n1 Chemical compound *C(*)(*)Nc1nc(NC2=CC=CC=CC=CC=C2)nc([C@@]2C=CC=CC=C/C=C2)n1 0.000 description 1
- DYLUUSLLRIQKOE-UHFFFAOYSA-N CC(C)(CNc1nc(Nc2ccnc(C(F)(F)F)c2)nc(-c2cccc(C(F)(F)F)n2)n1)O Chemical compound CC(C)(CNc1nc(Nc2ccnc(C(F)(F)F)c2)nc(-c2cccc(C(F)(F)F)n2)n1)O DYLUUSLLRIQKOE-UHFFFAOYSA-N 0.000 description 1
- IIFDQFWIOYLEKN-UHFFFAOYSA-N CC(N1)(N=C(c2cccc(C(F)(F)F)n2)N=C1Cl)Cl Chemical compound CC(N1)(N=C(c2cccc(C(F)(F)F)n2)N=C1Cl)Cl IIFDQFWIOYLEKN-UHFFFAOYSA-N 0.000 description 1
- OKBHXGBLXDNJJD-UHFFFAOYSA-N OC(c1cccc(C(F)(F)F)n1)=O Chemical compound OC(c1cccc(C(F)(F)F)n1)=O OKBHXGBLXDNJJD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562201546P | 2015-08-05 | 2015-08-05 | |
| US62/201,546 | 2015-08-05 | ||
| PCT/US2016/045553 WO2017024134A1 (en) | 2015-08-05 | 2016-08-04 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020213670A Division JP2021063097A (ja) | 2015-08-05 | 2020-12-23 | ６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジオール及び６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジアミンを調製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528182A JP2018528182A (ja) | 2018-09-27 |
| JP2018528182A5 JP2018528182A5 (https=) | 2019-09-19 |
| JP6816106B2 true JP6816106B2 (ja) | 2021-01-20 |
Family
ID=56684781
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018505739A Active JP6816106B2 (ja) | 2015-08-05 | 2016-08-04 | ６−ピリジル−１，３，５−トリアジン−２，４−ジオール及び６−ピリジル−１，３，５−トリアジン−２，４−ジアミンを調製する方法 |
| JP2020213670A Pending JP2021063097A (ja) | 2015-08-05 | 2020-12-23 | ６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジオール及び６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジアミンを調製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020213670A Pending JP2021063097A (ja) | 2015-08-05 | 2020-12-23 | ６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジオール及び６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジアミンを調製する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9751863B2 (https=) |
| EP (1) | EP3331866B1 (https=) |
| JP (2) | JP6816106B2 (https=) |
| CN (1) | CN108349933A (https=) |
| AU (2) | AU2016303614A1 (https=) |
| CA (1) | CA2993615A1 (https=) |
| MX (1) | MX365590B (https=) |
| WO (1) | WO2017024134A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021063097A (ja) * | 2015-08-05 | 2021-04-22 | アジオス ファーマシューティカルズ， インコーポレイテッド | ６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジオール及び６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジアミンを調製する方法 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017529382A (ja) | 2014-09-29 | 2017-10-05 | アギオス ファーマシューティカルス，インコーポレーテッド | 治療活性を有する化合物及びその使用方法 |
| JP7220986B6 (ja) | 2015-02-04 | 2024-02-08 | アジオス ファーマシューティカルズ， インコーポレイテッド | 治療効果のある化合物及びその使用方法 |
| KR20180063125A (ko) | 2015-10-15 | 2018-06-11 | 아지오스 파마슈티컬스 아이엔씨. | 악성종양을 치료하기 위한 복합 요법 |
| US10695352B2 (en) | 2015-10-15 | 2020-06-30 | Celgene Corporation | Combination therapy for treating malignancies |
| ES2905915T3 (es) | 2015-12-04 | 2022-04-12 | Servier Lab | Procedimientos de tratamiento de neoplasias malignas |
| MA43640A (fr) | 2016-02-26 | 2018-11-28 | Agios Pharmaceuticals Inc | Inhibiteurs de idh1 pour le traitement de cancers hématologiques et de tumeurs solides |
| MX392941B (es) | 2016-09-07 | 2025-03-24 | Celgene Corp | Composiciones para comprimidos. |
| WO2018204787A1 (en) | 2017-05-05 | 2018-11-08 | Memorial Sloan Kettering Cancer Center | Methods of treatment of myeloproliferative neoplasm |
| US20220017490A1 (en) | 2018-11-02 | 2022-01-20 | Celgene Corporation | Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof |
| WO2020092894A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol |
| US20220017489A1 (en) | 2018-11-02 | 2022-01-20 | Celgene Corporation | Solid dispersions for treatment of cancer |
| JP2023503842A (ja) | 2019-11-14 | 2023-02-01 | セルジーン コーポレーション | がんを処置するための小児用製剤 |
| CN111592524B (zh) * | 2020-05-20 | 2023-11-17 | 温州市天聚万迅信息科技有限公司 | 恩西德尼的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2390529A (en) | 1942-02-03 | 1945-12-11 | Ernst A H Friedheim | Hydrazino-1,3,5-triazino derivatives of substituted phenylarsenic compounds |
| JPS5170779A (ja) * | 1974-12-17 | 1976-06-18 | Nippon Shinyaku Co Ltd | Shinkinaguanamidoruino seiho |
| JPS58186682A (ja) | 1982-04-27 | 1983-10-31 | 日本化薬株式会社 | セルロ−ス又はセルロ−ス含有繊維材料の染色法 |
| DE3512630A1 (de) | 1985-04-06 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zum faerben oder bedrucken von cellulosefasern oder cellulosemischfasern |
| DE59106971D1 (de) | 1990-07-12 | 1996-01-11 | Ciba Geigy Ag | Verfahren zur photochemischen und thermischen Stabilisierung von Polyamid-Fasermaterialien. |
| JPH11158073A (ja) | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンａ３拮抗剤 |
| AU5379900A (en) | 1999-06-07 | 2000-12-28 | Shire Biochem Inc. | Thiophene integrin inhibitors |
| EP2256108B1 (en) | 2002-07-18 | 2016-03-23 | Janssen Pharmaceutica NV | Substituted triazine kinase inhibitors |
| JP5450381B2 (ja) | 2007-04-30 | 2014-03-26 | プロメティック・バイオサイエンスィズ・インコーポレーテッド | 化合物、そのような化合物を含有する組成物、及びそのような化合物を用いるがん及び自己免疫疾患の治療法 |
| GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
| WO2010144338A1 (en) | 2009-06-08 | 2010-12-16 | Abraxis Bioscience, Llc | Triazine derivatives and their therapeutical applications |
| PE20142098A1 (es) * | 2012-01-06 | 2015-01-08 | Agios Pharmaceuticals Inc | Compuestos terapeuticamente activos y sus metodos de uso |
| KR20140131955A (ko) | 2012-03-09 | 2014-11-14 | 카나 바이오사이언스 인코포레이션 | 신규 트리아진 유도체 |
| WO2015003360A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| AU2014287122B9 (en) | 2013-07-11 | 2018-11-01 | Les Laboratoires Servier | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as IDH2 mutants inhibitors for the treatment of cancer |
| AU2014295938B2 (en) | 2013-08-02 | 2018-07-19 | Les Laboratoires Servier | Therapeutically active compounds and their methods of use |
| JP2017529382A (ja) | 2014-09-29 | 2017-10-05 | アギオス ファーマシューティカルス，インコーポレーテッド | 治療活性を有する化合物及びその使用方法 |
| JP7220986B6 (ja) | 2015-02-04 | 2024-02-08 | アジオス ファーマシューティカルズ， インコーポレイテッド | 治療効果のある化合物及びその使用方法 |
| US9751863B2 (en) * | 2015-08-05 | 2017-09-05 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
-
2016
- 2016-08-04 US US15/229,011 patent/US9751863B2/en active Active
- 2016-08-04 CN CN201680045391.6A patent/CN108349933A/zh active Pending
- 2016-08-04 WO PCT/US2016/045553 patent/WO2017024134A1/en not_active Ceased
- 2016-08-04 AU AU2016303614A patent/AU2016303614A1/en not_active Abandoned
- 2016-08-04 CA CA2993615A patent/CA2993615A1/en not_active Abandoned
- 2016-08-04 JP JP2018505739A patent/JP6816106B2/ja active Active
- 2016-08-04 MX MX2018001424A patent/MX365590B/es active IP Right Grant
- 2016-08-04 EP EP16751449.6A patent/EP3331866B1/en active Active
-
2020
- 2020-12-23 JP JP2020213670A patent/JP2021063097A/ja active Pending
-
2021
- 2021-01-27 AU AU2021200494A patent/AU2021200494A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021063097A (ja) * | 2015-08-05 | 2021-04-22 | アジオス ファーマシューティカルズ， インコーポレイテッド | ６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジオール及び６−（アリールまたはヘテロアリール）−１，３，５−トリアジン−２，４−ジアミンを調製する方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2993615A1 (en) | 2017-02-09 |
| WO2017024134A1 (en) | 2017-02-09 |
| US9751863B2 (en) | 2017-09-05 |
| JP2021063097A (ja) | 2021-04-22 |
| AU2021200494A1 (en) | 2021-03-11 |
| EP3331866A1 (en) | 2018-06-13 |
| CN108349933A (zh) | 2018-07-31 |
| EP3331866B1 (en) | 2023-07-26 |
| US20170037031A1 (en) | 2017-02-09 |
| AU2016303614A1 (en) | 2018-02-15 |
| MX2018001424A (es) | 2018-08-01 |
| MX365590B (es) | 2019-06-07 |
| JP2018528182A (ja) | 2018-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6816106B2 (ja) | ６−ピリジル−１，３，５−トリアジン−２，４−ジオール及び６−ピリジル−１，３，５−トリアジン−２，４−ジアミンを調製する方法 | |
| AU2013296627C9 (en) | Deuterated ibrutinib | |
| WO2025092986A1 (en) | Polycyclic compound, preparation methods and medicinal uses thereof | |
| US20110082147A1 (en) | Substituted imidazotriazines | |
| MX2011002278A (es) | Derivados de triazolo-piridazina sustituidos. | |
| US20220119370A1 (en) | Brd4-jak2 inhibitors | |
| WO2011116066A1 (en) | Derivatives of dimethylcurcumin | |
| AU2014235462A1 (en) | Deuterated palbociclib | |
| EP1446382B1 (en) | Anthranilic acid amides and their use as vegf receptor tyrosine kinase inhibitors | |
| JP2024543477A (ja) | ユビキチン特異的プロテアーゼ１（ｕｓｐ１）の小分子阻害剤及びその使用 | |
| JP2023522863A (ja) | Ｅｇｆｒ阻害剤としての三環式化合物 | |
| JP7691974B2 (ja) | アセチル補酵素ａシンテターゼ短鎖２（ａｃｓｓ２）の小分子阻害剤 | |
| JP7273030B6 (ja) | シクロオレフィン置換複素芳香族化合物およびそれらの使用 | |
| CN116514728A (zh) | 一种喹唑啉衍生物及其用途 | |
| CA3253274A1 (en) | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH THE ACTIVITY OF THE LPA RECIPIENT | |
| TWI874960B (zh) | 聯芳組成物和調控激酶級聯之方法 | |
| CN120590368A (zh) | 一种pcsk9抑制剂及其应用 | |
| CN117229292B (zh) | Ret抑制剂的制备及其应用 | |
| WO2009023495A2 (en) | Bisubstrate inhibitors of adenylosuccinate synthetase | |
| AU2024323272A1 (en) | Jak inhibitor compound and use thereof | |
| WO2025106691A9 (en) | Alpha 4 beta 7 integrin modulators and uses thereof | |
| CN105878243B (zh) | 吡非尼酮衍生物在制药中的应用 | |
| TW202610644A (zh) | Cbl-b抑制劑的前藥化合物 | |
| TW202128647A (zh) | 新的醯胺類化合物及其用途 | |
| EA043549B1 (ru) | Стимуляторы sgc |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190801 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190801 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200630 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200714 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201013 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20201124 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20201223 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6816106 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |