JP6796593B2 - 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物 - Google Patents

細菌核酸を検出し細菌性膣炎を診断するための方法および組成物 Download PDF

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JP6796593B2
JP6796593B2 JP2017549041A JP2017549041A JP6796593B2 JP 6796593 B2 JP6796593 B2 JP 6796593B2 JP 2017549041 A JP2017549041 A JP 2017549041A JP 2017549041 A JP2017549041 A JP 2017549041A JP 6796593 B2 JP6796593 B2 JP 6796593B2
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lactobacillus
specific
sequence
target
vaginalis
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JP2018508225A (ja
JP2018508225A5 (enExample
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バーバラ エル． イートン，
バーバラ エル． イートン，
デイモン ケー． ゲットマン，
デイモン ケー． ゲットマン，
トレイシー ポロウスキー，
トレイシー ポロウスキー，
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ジェン−プローブ・インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017549041A 2015-03-16 2016-03-16 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物 Active JP6796593B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2020190284A JP6970268B2 (ja) 2015-03-16 2020-11-16 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物
JP2021176198A JP2022025106A (ja) 2015-03-16 2021-10-28 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物

Applications Claiming Priority (7)

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US201562133881P 2015-03-16 2015-03-16
US62/133,881 2015-03-16
US201562168688P 2015-05-29 2015-05-29
US201562168405P 2015-05-29 2015-05-29
US62/168,688 2015-05-29
US62/168,405 2015-05-29
PCT/US2016/022628 WO2016149357A1 (en) 2015-03-16 2016-03-16 Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis

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JP2020190284A Division JP6970268B2 (ja) 2015-03-16 2020-11-16 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物

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JP2018508225A5 JP2018508225A5 (enExample) 2019-04-11
JP6796593B2 true JP6796593B2 (ja) 2020-12-09

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JP2020190284A Active JP6970268B2 (ja) 2015-03-16 2020-11-16 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物
JP2021176198A Pending JP2022025106A (ja) 2015-03-16 2021-10-28 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物

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JP2021176198A Pending JP2022025106A (ja) 2015-03-16 2021-10-28 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物

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US (3) US10550438B2 (enExample)
EP (2) EP3910075B1 (enExample)
JP (3) JP6796593B2 (enExample)
CN (1) CN107429297A (enExample)
AU (2) AU2016233298B2 (enExample)
CA (1) CA2977821A1 (enExample)
WO (1) WO2016149357A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016233298B2 (en) * 2015-03-16 2021-09-02 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
EP3663410A4 (en) * 2017-07-31 2020-07-08 Toppan Printing Co., Ltd. NUCLEIC ACID DETECTION METHOD AND DETECTION REAGENT
AU2019274350B2 (en) * 2018-05-23 2022-04-07 Kobiolabs, Inc. Lactobacillus crispatus KBL693 strain and use thereof
WO2020033440A1 (en) * 2018-08-10 2020-02-13 The Regents Of The University Of California Methods and compositions for treating and preventing inflammatory diseases
KR102868953B1 (ko) * 2018-08-24 2025-10-13 젠-프로브 인코포레이티드 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
WO2020166708A1 (ja) * 2019-02-15 2020-08-20 コンビ株式会社 新規乳酸菌およびそれを含有する組成物
CN110283921A (zh) * 2019-07-12 2019-09-27 中生方政生物技术股份有限公司 加德纳杆菌、白色念珠菌双重检测的引物、探针组、试剂盒及检测方法
US20220205020A1 (en) * 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
JP7734205B2 (ja) * 2021-04-02 2025-09-04 宝山鋼鉄股▲分▼有限公司 引張強度≧１１８０ＭＰａの低炭素低合金Ｑ＆Ｐ鋼または溶融亜鉛めっきＱ＆Ｐ鋼及びその製造方法
EP4289964A4 (en) 2022-04-18 2024-10-09 Beijing OriginPoly Bio-Tec Co., Ltd. PRIMER-PROBE COMBINATION AND KIT FOR VAGINAL MICROECOSYSTEM DETECTION
CN114480694B (zh) * 2022-04-18 2022-06-17 北京起源聚禾生物科技有限公司 阴道微生态检测引物探针组合及试剂盒
WO2024006762A1 (en) * 2022-06-27 2024-01-04 The Uab Research Foundation Nucleic acid probes and their uses for the detection of prevotella bivia

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4786600A (en) 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
ATE88762T1 (de) 1986-08-11 1993-05-15 Siska Diagnostics Inc Methoden und zusammensetzungen fuer tests mit nukleinsaeuresonden.
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
CA1340843C (en) 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
US5639604A (en) 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
DE3854029T2 (de) 1987-09-21 1995-10-26 Gen Probe Inc Homogener Abschirmungstest.
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5656207A (en) 1989-06-24 1997-08-12 Gen Probe Incorporated Detecting or quantifying multiple analytes using labelling techniques
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5516663A (en) 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
DK1695979T3 (da) 1991-12-24 2011-10-10 Isis Pharmaceuticals Inc Gappede modificerede oligonukleotider
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
CA2135073C (en) 1992-05-06 2002-11-19 Daniel L. Kacian Nucleic acid sequence amplification method, composition and kit
US5614402A (en) 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US5422252A (en) 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
CA2167838C (en) 1993-07-23 1999-11-23 Thomas B. Ryder Methods for enhancing nucleic acid amplification
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US6169169B1 (en) 1994-05-19 2001-01-02 Dako A/S PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis
DE69535240T2 (de) 1994-10-28 2007-06-06 Gen-Probe Inc., San Diego Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US6218529B1 (en) * 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
DE69738687D1 (de) 1996-04-12 2008-06-26 Phri Properties Inc Sonden, kits und assays
DK0975807T3 (da) 1997-05-02 2007-01-29 Gen Probe Inc To-trins hybridisering og indfangning af et polynukleotid
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
WO2000001850A2 (en) 1998-07-02 2000-01-13 Gen-Probe Incorporated Molecular torches
WO2003082306A1 (en) 2002-03-28 2003-10-09 Gregor Reid Lactobacillus iners for the enhancement of urogenital health
US20040022764A1 (en) * 2002-07-31 2004-02-05 Hanan Polansky Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease
JP5020818B2 (ja) 2004-07-01 2012-09-05 ジェン−プローブ・インコーポレーテッド 生物学的試料中の核酸を検出するための方法及び組成物
US7696337B2 (en) 2004-08-27 2010-04-13 Gen-Probe Incorporated Composition kits and methods for performing amplification reactions
US7627437B2 (en) 2005-01-14 2009-12-01 Idaho Research Foundation Categorization of microbial communities
EP1853732A2 (en) 2005-02-28 2007-11-14 Gen-Probe Incorporated Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
US7625704B2 (en) 2005-08-31 2009-12-01 Fred Hutchinson Cancer Research Center Methods and compositions for identifying bacteria associated with bacteria vaginosis
WO2008016988A1 (en) 2006-08-01 2008-02-07 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
FR2909099B1 (fr) 2006-11-24 2012-10-19 Univ Aix Marseille Ii Methode de diagnostic et de suivi d'une vaginose bacterienne par quantification moleculaire.
EP2188632A4 (en) 2007-09-10 2010-11-10 Becton Dickinson Co APPARATUS AND METHODS FOR DIAGNOSING BACTERIAL VAGINOSIS
WO2011068679A1 (en) * 2009-12-03 2011-06-09 Quest Diagnostics Investments Incorporated Methods for the diagnosis of bacterial vaginosis
EP2536849B1 (en) * 2010-02-17 2016-05-11 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
EP3604559A1 (en) * 2011-04-25 2020-02-05 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
EP2732054B1 (en) * 2011-07-15 2019-04-03 Gen-Probe Incorporated Method for detecting human parvovirus nucleic acid in single-plex or multiplex assays
EP3255155B1 (en) * 2011-09-08 2019-04-24 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
US9970060B2 (en) 2011-11-23 2018-05-15 Medical Diagnostic Laboratories, Llc Quantitation and profiling of vaginal microflora
US9057111B2 (en) 2012-02-20 2015-06-16 Laboratory Corporation Of America Holdings Diagnostic methods and markers for bacterial vaginosis
AU2016233298B2 (en) * 2015-03-16 2021-09-02 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
KR102868953B1 (ko) * 2018-08-24 2025-10-13 젠-프로브 인코포레이티드 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법

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Publication number Publication date
EP3910075A1 (en) 2021-11-17
EP3271484A1 (en) 2018-01-24
EP3271484B1 (en) 2021-06-02
JP6970268B2 (ja) 2021-11-24
AU2021277704A1 (en) 2021-12-23
CA2977821A1 (en) 2016-09-22
AU2016233298B2 (en) 2021-09-02
JP2018508225A (ja) 2018-03-29
US20200109444A1 (en) 2020-04-09
US11268156B2 (en) 2022-03-08
US20180291430A1 (en) 2018-10-11
US10550438B2 (en) 2020-02-04
US12031187B2 (en) 2024-07-09
AU2016233298A1 (en) 2017-09-14
CN107429297A (zh) 2017-12-01
EP3910075B1 (en) 2024-12-11
EP3271484A4 (en) 2018-11-14
WO2016149357A1 (en) 2016-09-22
EP3910075C0 (en) 2024-12-11
AU2021277704B2 (en) 2022-04-28
US20210277451A1 (en) 2021-09-09
JP2022025106A (ja) 2022-02-09
JP2021035391A (ja) 2021-03-04

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