JP6795505B2 - ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法 - Google Patents

ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法 Download PDF

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JP6795505B2
JP6795505B2 JP2017538182A JP2017538182A JP6795505B2 JP 6795505 B2 JP6795505 B2 JP 6795505B2 JP 2017538182 A JP2017538182 A JP 2017538182A JP 2017538182 A JP2017538182 A JP 2017538182A JP 6795505 B2 JP6795505 B2 JP 6795505B2
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antibody
cells
cancer
ccr4
antigen
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JP2017537972A5 (enExample
JP2017537972A (ja
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ウェイン エー． マラスコ
ウェイン エー． マラスコ
デ−クアン チャン
デ−クアン チャン
クアン チュー
クアン チュー
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デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/41—Vertebrate antigens
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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JP2017538182A 2014-10-06 2015-10-06 ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法 Active JP6795505B2 (ja)

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US201462060381P 2014-10-06 2014-10-06
US62/060,381 2014-10-06
PCT/US2015/054202 WO2016057488A1 (en) 2014-10-06 2015-10-06 Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof

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JP2017537972A5 JP2017537972A5 (enExample) 2018-11-15
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JP2020138331A Active JP7129449B2 (ja) 2014-10-06 2020-08-19 ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法
JP2022131610A Active JP7589204B2 (ja) 2014-10-06 2022-08-22 ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法

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JP2022131610A Active JP7589204B2 (ja) 2014-10-06 2022-08-22 ヒト化ｃｃケモカイン受容体４（ｃｃｒ４）抗体およびその使用法

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